Prevalence and Genetic Diversity of Adenovirus 40/41, Astrovirus, and Sapovirus in Children With Acute Gastroenteritis in Kansas City, 2011-2016.

Details

• Alternative Title:
  The Journal of Infectious Diseases, 2025, v. 231, no. 1: Prevalence and Genetic Diversity of Adenovirus 40/41, Astrovirus, and Sapovirus in Children With Acute Gastroenteritis in Kansas City, 2011-2016.
• Journal Article:
  The Journal of Infectious Diseases
• Personal Author:
  Diez-Valcarce, Marta ; Cannon, Jennifer L. ; Browne, Hannah ; Nguyen, Kenny ; Harrison, Christopher J. ; Moffatt, Mary E. ; Weltmer, Kirsten ; Lee, Brian R. ; Hassan, Ferdaus ; Dhar, Debarpan ; Wikswo, Mary E. ; Payne, Daniel C. ; Curns, Aaron T. ; Selvarangan, Rangaraj ; Vinjé, Jan
• Description:
  Most acute gastroenteritis (AGE) episodes in children in the United States are attributed to norovirus, whereas very little information is available on adenovirus 40/41 (AdV40/41), astrovirus, or sapovirus. The New Vaccine Surveillance Network (NVSN) conducted prospective, active, population-based AGE surveillance in young children.
  
  We tested and typed stool specimens collected between December 2011 and June 2016 from 1 NVSN site in Kansas City for the 3 viruses, and calculated hospitalization and emergency department (ED) detection rates.
  
  Of 3205 collected specimens, 2453 (76.5%) were from AGE patients (339 inpatients and 2114 ED patients) and 752 (23.5%) were from healthy controls. In patients with AGE, astrovirus was detected in 94 (3.8%), sapovirus in 252 (10.3%), and AdV40/41 in 101 (4.5%) of 2249 patients. In healthy controls, astrovirus was detected in 13 (1.7%) and sapovirus in 15 (2.0%) specimens. Astrovirus type 1 (37.7%) and genogroup I sapoviruses (59.3%) were most prevalent. Hospitalization rates were 5 (AdV40/41), 4 (astrovirus), and 8 (sapovirus) per 100 000 children <11 years old, whereas ED rates were 2.4 (AdV40/41), 1.9 (astrovirus), and 5.3 (sapovirus) per 1000 children <5 years old.
  
  Overall, AdV40/41, astrovirus, and sapovirus were detected in 18.6% of AGE in a large pediatric hospital in Kansas City.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Gastroenteritis
  • Sapovirus
  • Child, Preschool
  • Infant
  • Male
  • Female
  • Astroviridae Infections
  • Prevalence
  • Genetic Variation
  More +
• Keywords:
  • acute gastroenteritis
  • adenovirus 40/41
  • astrovirus
  • sapovirus
  • genetic diversity
• Source:
  The Journal of Infectious Diseases, 2025, v. 231, no. 1
• DOI:
  https://doi.org/10.1093/infdis/jiae251
• ISSN:
  0022-1899 ; 1537-6613
• Pubmed ID:
  38718103
• Pubmed Central ID:
  PMC11840860
• Document Type:
  Text
• Funding:
  U01 IP001057/IP/NCIRD CDC HHSUnited States/ ; U01 IP001154/IP/NCIRD CDC HHSUnited States/ ; CDC-RFA-IP16-004/US Centers for Disease Control and Prevention/ ; U01 IP000460/IP/NCIRD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Kansas
• Pages in Document:
  186-195 (18 pdf pages)
• Volume:
  231
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/262098/cdc_262098_DS1.pdf
• File Type:
  [PDF - 569.84 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:d29e981cf2da7834cfb673624017e91a9035538820b6a8e94ed69a7bd6d61ed7973c115c338a945fa32fea2dc6ee9a2174d0dc17b7dbee222bf11d2cdcaf10e5