Asynchronous Onset of Clinical Disease in BSE-Infected Macaques

Montag, Judith; Schulz-Schaeffer, Walter; Schrod, Annette; Hunsmann, Gerhard; Motzkus, Dirk

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Asynchronous Onset of Clinical Disease in BSE-Infected Macaques

Supporting Files Public Domain

Jul 2013
By Montag, Judith ; Schulz-Schaeffer, Walter ; Schrod, Annette ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Montag, Judith ; Schulz-Schaeffer, Walter ; Schrod, Annette ; Hunsmann, Gerhard ; Motzkus, Dirk
Description:

To estimate the effect of the variability of prion disease onset on primary bovine spongiform encephalopathy transmission to humans, we studied 6 cynomolgus macaques. The preclinical incubation period was significantly prolonged in 2 animals, implying that onset of variant Creutzfeldt-Jacob disease in humans could be more diverse than previously expected.
Subjects:

Animals Bovine Spongiform Encephalopathy Brain BSE Cattle Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome Disease Progression Dispatch Encephalopathy, Bovine Spongiform Female Humans Macaca Fascicularis Prion Disease Transmission Prions PrPSc Proteins
Source:

Emerg Infect Dis. 19(7):1125-1127.
Document Type:

Journal Article
Volume:

19
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:9af9a4502e81273f2022c99b9c5e1349e0275e7d2ea6a6e6a5b9ac73e9d7a99b
Download URL:

https://stacks.cdc.gov/view/cdc/21602/cdc_21602_DS1.pdf
File Type:

[PDF - 357.95 KB ]

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