New World Bats Harbor Diverse Influenza A Viruses

Details

• Alternative Title:
  PLoS Pathog
• Personal Author:
  Tong, Suxiang ; Zhu, Xueyong ; Li, Yan ; Shi, Mang ; Zhang, Jing ; Bourgeois, Melissa ; Yang, Hua ; Chen, Xianfeng ; Recuenco, Sergio ; Gomez, Jorge ; Chen, Li-Mei ; Johnson, Adam ; Tao, Ying ; Dreyfus, Cyrille ; Yu, Wenli ; McBride, Ryan ; Carney, Paul J. ; Gilbert, Amy T. ; Chang, Jessie ; Guo, Zhu ; Davis, Charles T. ; Paulson, James C. ; Stevens, James ; Rupprecht, Charles E. ; Holmes, Edward C. ; Wilson, Ian A. ; Donis, Ruben O.
• Description:
  Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit bats suggests that other New World species may similarly carry divergent influenza viruses. Using consensus degenerate RT-PCR, we identified a novel influenza A virus, designated as H18N11, in a flat-faced fruit bat (Artibeus planirostris) from Peru. Serologic studies with the recombinant H18 protein indicated that several Peruvian bat species were infected by this virus. Phylogenetic analyses demonstrate that, in some gene segments, New World bats harbor more influenza virus genetic diversity than all other mammalian and avian species combined, indicative of a long-standing host-virus association. Structural and functional analyses of the hemagglutinin and neuraminidase indicate that sialic acid is not a ligand for virus attachment nor a substrate for release, suggesting a unique mode of influenza A virus attachment and activation of membrane fusion for entry into host cells. Taken together, these findings indicate that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses.
• Subjects:
  Animals Chiroptera Disease Reservoirs Hemagglutinin Glycoproteins, Influenza Virus Influenza A Virus Orthomyxoviridae Infections Phylogeny
• Source:
  PLoS Pathog. 2013; 9(10).
• Document Type:
  Journal Article
• Funding:
  AI058113/AI/NIAID NIH HHS/United States ; GM062116/GM/NIGMS NIH HHS/United States ; GM080533-06/GM/NIGMS NIH HHS/United States ; GM098791/GM/NIGMS NIH HHS/United States ; P41RR001209/RR/NCRR NIH HHS/United States ; R01 GM080533/GM/NIGMS NIH HHS/United States ; Y1-CO-1020/CO/NCI NIH HHS/United States ; Y1-GM-1104/GM/NIGMS NIH HHS/United States
• Place as Subject:
  Peru
• Volume:
  9
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:434ce4ca4b53fb492dbd0773f037d2cab81b4140974f9d410a3aed838cf0cc8b
• Download URL:
  https://stacks.cdc.gov/view/cdc/21184/cdc_21184_DS1.pdf
• File Type:
  [PDF - 2.21 MB ]