Accumulation of L-type Bovine Prions in Peripheral Nerve Tissues

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Iwamaru, Yoshifumi ; Imamura, Morikazu ; Matsuura, Yuichi ; Masujin, Kentaro ; Shimizu, Yoshihisa ; Shu, Yujing ; Kurachi, Megumi ; Kasai, Kazuo ; Murayama, Yuichi ; Fukuda, Shigeo ; Onoe, Sadao ; Hagiwara, Ken’ichi ; Yamakawa, Yoshio ; Sata, Tetsutaro ; Mohri, Shirou ; Okada, Hiroyuki ; Yokoyama, Takashi
• Description:
  We recently reported the intraspecies transmission of L-type atypical bovine spongiform encephalopathy (BSE). To clarify the peripheral pathogenesis of L-type BSE, we studied prion distribution in nerve and lymphoid tissues obtained from experimentally challenged cattle. As with classical BSE prions, L-type BSE prions accumulated in central and peripheral nerve tissues.
• Subjects:
  Animals Atypical Bovine Spongiform Encephalopathy Cattle Creutzfeldt-Jacob Disease Dispatch Distribution Encephalopathy, Bovine Spongiform L-type Nerve Tissues Neurodegenerative Disorder Peripheral Nerves Prion Prions Transmissibility Zoonoses

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• Source:
  Emerg Infect Dis. 16(7):1151-1154.
• Document Type:
  Journal Article
• Volume:
  16
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:43723e48b919ce3cfe52597503e9db73b8fe6897ed7f5d26e3d7da16c64da246
• Download URL:
  https://stacks.cdc.gov/view/cdc/18192/cdc_18192_DS1.pdf
• File Type:
  [PDF - 559.97 KB ]