Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin

Bett, Cyrus; Andrews, Omozusi; Asher, David M.; Pilant, Teresa; Keire, David; Gregori, Luisa

i

Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin

Supporting Files Public Domain

July 29 2020
By Bett, Cyrus ; Andrews, Omozusi ; Asher, David M. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Bett, Cyrus ; Andrews, Omozusi ; Asher, David M. ; Pilant, Teresa ; Keire, David ; Gregori, Luisa
Description:

US manufacturers, concerned about bovine spongiform encephalopathy (BSE), ceased marketing bovine heparin in the 1990s. Recent short supplies of safe porcine heparin suggest that reintroducing bovine heparin might benefit public health. We purified heparin from crude bovine extract spiked with BSE agent, removing substantial infectivity and abnormal prion proteins (PrP|).
Subjects:

Animals Brain Cattle Encephalopathy, Bovine Spongiform Heparin Prion Proteins Prions Swine
Source:

Emerg Infect Dis. 26(10):2478-2480
Pubmed ID:

32723431
Pubmed Central ID:

PMC7510749
Document Type:

Journal Article
Genre:

Letter
Volume:

26
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:e970262654a57698863279799790ee87f7fe9cc07e45fb5a3fbd6e7dff9de466
Download URL:

https://stacks.cdc.gov/view/cdc/94756/cdc_94756_DS1.pdf
File Type:

[PDF - 279.61 KB ]

20-0142.nxml

Download xml

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.