Human Parechovirus Infections in Canada

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Abed, Yacine ; Boivin, Guy
• Description:
  A new reverse transcription-polymerase chain reaction assay was developed for identification of 28 Canadian human parechovirus (HPeV) isolates, including 20 HPeV-1, 3 HPeV-2, and 5 HPeV-3, recovered from 1985 to 2004. All HPeV-1 isolates but 1 were genetically distinct from the Harris reference strain. One HPeV-2 isolate was related to the Williamson strain; the other 2 were related to the Connecticut strain. HPeV-3 isolates clustered together. Seventy-five percent of isolates were recovered during the typical enterovirus season. All patients but 1 were children with a mean age of 14.6 months, 6.3 months, and 0.7 months for HPeV-1, HPeV-2, and HPeV-3 patients, respectively. All HPeV-2- and HPeV-3-infected children were hospitalized with a diagnosis of viremia or sepsis. HPeV-1- infected children had bronchiolitis diagnosed in 50% of the cases, with few cases of pneumonia and enteritis. Two infected patients (1 child with leukemia and a 78-year-old woman) died of septic shock and severe pneumonia, respectively.
• Subjects:
  Aged Amino Acid Sequence Base Sequence Cytopathogenic Effect, Viral Hospitalization HT29 Cells Human Parechoviruses Humans Infant Infant, Newborn Molecular Sequence Data Parechovirus Pediatric Infections Phylogenetic Tree Phylogeny Picornaviridae Infections Picornaviruses Quebec Research Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction RNA, Viral RT-PCR Sequence Alignment Sequence Analysis, DNA

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• Source:
  Emerg Infect Dis. 12(6):969-975.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ca6a733f3cd4b0c6b2e00457cacb3cb872bb90d54920de38a4d0619a6edd6740
• Download URL:
  https://stacks.cdc.gov/view/cdc/16194/cdc_16194_DS1.pdf
• File Type:
  [PDF - 242.02 KB ]