Human Coronavirus NL63, France

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Vabret, Astrid ; Mourez, Thomas ; Dina, Julia ; van der Hoek, Lia ; Gouarin, Stéphanie ; Petitjean, Joëlle ; Brouard, Jacques ; Freymuth, François
• Description:
  The human coronavirus NL63 (HCoV-NL63) was first identified in The Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. Of the 300 samples, 28 (9.3%) were positive for HCoV-NL63. The highest prevalence was found in February (18%). The main symptoms were fever (61%), rhinitis (39%), bronchiolitis (39%), digestive problems (33%), otitis (28%), pharyngitis (22%), and conjunctivitis (17%). A fragment of the spike protein gene was sequenced to determine the variety of circulating HCoV-NL63. Phylogenetic analysis indicated that strains with different genetic markers cocirculate in France.
• Subjects:
  Adolescent Amino Acid Sequence Base Sequence Child Child, Preschool Coronavirus Coronavirus Infections Humans Infant Phylogeny Respiratory Tract Infections Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction Rna, Viral Sequence Alignment Sequence Analysis, DNA

  More +
• Source:
  Emerg Infect Dis. 11(8):1225-1229.
• Document Type:
  Journal Article
• Place as Subject:
  France
• Volume:
  11
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a7cb2a5e903c32bd31b203475a2469b866417038e51d146c04da20f711c4b1b2
• Download URL:
  https://stacks.cdc.gov/view/cdc/14757/cdc_14757_DS1.pdf
• File Type:
  [PDF - 240.19 KB ]