Azithromycin Failure in Mycoplasma genitalium Urethritis

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bradshaw, Catriona S. ; Jensen, Jorgen S. ; Tabrizi, Sepehr N. ; Read, Timothy R.H. ; Garland, Suzanne M. ; Hopkins, Carol A. ; Moss, Lorna M. ; Fairley, Christopher K.
• Description:
  We report significant failure rates (28%, 95% confidence interval 15%-45%) after administering 1 g azithromycin to men with Mycoplasma genitalium-positive nongonococcal urethritis. In vitro evidence supported reduced susceptibility of M. genitalium to macrolides. Moxifloxacin administration resulted in rapid symptom resolution and eradication of infection in all cases. These findings have implications for management of urethritis.
• Subjects:
  Adult Anti-Bacterial Agents Aza Compounds Azithromycin Dispatch Female Humans Male Middle Aged Moxifloxacin Mycoplasma Genitalium Mycoplasma Infections Non-gonococcal Urethritis Quinolines Treatment Failure Urethritis

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• Source:
  Emerg Infect Dis. 12(7):1149-1152.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b75ee2a88c8c7ffeba71d393154dc158b2385ed18240c3e76c70ff0eb002678c
• Download URL:
  https://stacks.cdc.gov/view/cdc/16171/cdc_16171_DS1.pdf
• File Type:
  [PDF - 199.16 KB ]