Standard-Dose Intradermal Influenza Vaccine Elicits Cellular Immune Responses Similar to Those of Intramuscular Vaccine in Men With and Those Without HIV Infection

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Amoah, Samuel ; Mishina, Margarita ; Praphasiri, Prabda ; Cao, Weiping ; Kim, Jin Hyang ; Liepkalns, Justine S. ; Guo, Zhu ; Carney, Paul J. ; Chang, Jessie C. ; Fernandez, Stefan ; Garg, Shikha ; Beacham, Lauren ; Holtz, Timothy H. ; Curlin, Marcel E. ; Dawood, Fatimah ; Olsen, Sonja J. ; Gangappa, Shivaprakash ; Stevens, James ; Sambhara, Suryaprakash
• Description:
  Background.
  
  Human immunodeficiency virus (HIV)–infected persons are at a higher risk of severe influenza. Although we have shown that a standard-dose intradermal influenza vaccine versus a standard-dose intramuscular influenza vaccine does not result in differences in hemagglutination-inhibition titers in this population, a comprehensive examination of cell-mediated immune responses remains lacking.
  
  Methods.
  
  Serological, antigen-specific B-cell, and interleukin 2–, interferon γ–, and tumor necrosis factor α–secreting T-cell responses were assessed in 79 HIV-infected men and 79 HIV-uninfected men.
  
  Results.
  
  The route of vaccination did not affect the immunoglobulin A and immunoglobulin G (IgG) plasmablast or memory B-cell response, although these were severely impaired in the group with a CD4+ T-cell count of <200 cells/μL. The frequencies of IgG memory B cells measured on day 28 after vaccination were highest in the HIV-uninfected group, followed by the group with a CD4+ T-cell count of ≥200 cells/μL and the group with a CD4+ T-cell count of <200 cells/μL. The route of vaccination did not affect the CD4+ or CD8+ T-cell responses measured at various times after vaccination.
  
  Conclusions.
  
  The route of vaccination had no effect on antibody responses, antibody avidity, T-cell responses, or B-cell responses in HIV-infected or HIV-uninfected subjects. With the serological and cellular immune responses to influenza vaccination being impaired in HIV-infected individuals with a CD4+ T-cell count of <200 cells/μL, passive immunization strategies need to be explored to protect this population.
  
  Clinical trials registration.
  
  NCT01538940.
  
  
• Subjects:
  Adult Antibodies, Viral Antibody Formation B-Lymphocytes CD4 Lymphocyte Count CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Hemagglutination Inhibition Tests Hemagglutinin Glycoproteins, Influenza Virus HIV Infections Humans Immunity, Cellular Immunoglobulin A Immunoglobulin G Influenza, Human Influenza A Virus, H1N1 Subtype Influenza Vaccines Interferon-gamma Interleukin-2 Male Middle Aged Thailand Tumor Necrosis Factor-alpha Vaccination

  More +
• Keywords:
  Cell-mediated HIV Influenza Intradermal Intramuscular Vaccination
• Source:
  J Infect Dis. 220(5):743-751
• Pubmed ID:
  31045222
• Pubmed Central ID:
  PMC11298778
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 GH000152/GH/CGH CDC HHSUnited States/
• Volume:
  220
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f0e30bb0cb445c96c4c7c4a8092f15a39dce39f01e738fdeee62ead36a641fe5030125c2a8ecfc0844e30647bd0275eae0b23d8a964e87d380033770a54514ba
• Download URL:
  https://stacks.cdc.gov/view/cdc/159565/cdc_159565_DS1.pdf
• File Type:
  [PDF - 1.32 MB ]