Life-Threatening Infantile Diarrhea from Fluoroquinolone-Resistant Salmonella enteric Typhimurium with Mutations in Both gyrA and parC

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nakaya, Hideo ; Yasuhara, Akihiro ; Yoshimura, Ken ; Oshihoi, Yukio ; Izumiya, Hidemasa ; Watanabe, Haruo
• Description:
  Salmonella Typhimurium DT12, isolated from a 35-day-old infant with diarrhea, was highly resistant to ampicillin, tetracycline, chloramphenicol, streptomycin, gentamycin, sulfamethoxazole/trimethoprim, nalidixic acid, and fluoroquinolones. The patient responded to antibiotic therapy with fosfomycin. Multidrug-resistance may become prevalent in Salmonella infections in Japan, as shown in this first case of a patient infected with fluoroquinolone-resistant Salmonella.
• Subjects:
  Anti-Infective Agents Diarrhea, Infantile Dispatch DNA Gyrase DNA Topoisomerase IV Drug Resistance, Multiple, Bacterial Fluoroquinolone Fluoroquinolones Fosfomycin Genes, Bacterial Humans Infant Male Mutation Salmonella Food Poisoning Salmonella Infections Salmonella Typhimurium

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• Source:
  Emerg Infect Dis. 9(2):255-257
• Pubmed ID:
  12604000
• Pubmed Central ID:
  PMC2901941
• Document Type:
  Journal Article
• Volume:
  9
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3c7b3904be0a403e943c663701dc5a636af0c83dd67697f5aa33618fdf5f35ae
• Download URL:
  https://stacks.cdc.gov/view/cdc/13983/cdc_13983_DS1.pdf
• File Type:
  [PDF - 226.41 KB ]