Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Hughes, Austin L. ; Friedman, Robert ; Murray, Megan
Hughes, Austin L. ; Friedman, Robert ; Murray, Megan Less -
Description:
Comparison of the pattern of synonymous nucleotide substitution between two complete genomes of Mycobacterium tuberculosis at 3298 putatively orthologous loci showed a mean percent difference per synonymous site of 0.000328 0.000022. Although 80.5% of loci showed no synonymous or nonsynonymous nucleotide differences, the level of polymorphism observed at other loci was greater than suggested by previous studies of a small number of loci. This level of nucleotide difference leads to the conservative estimate that the common ancestor of these two genotypes occurred approximately 35000 ago, which is twice as high as some recent estimates of the time of origin of this species. Our results suggest that a large number of loci should be examined for an accurate assessment of the level of nucleotide diversity in natural populations of pathogenic microorganisms.
Subjects:
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Base Sequence Dispatch Evolution, Molecular Genome, Bacterial Genome Evolution Genotype Humans Molecular Sequence Data Mycobacterium Tuberculosis Nucleotide Diversity Polymorphism, Single Nucleotide Sequence Analysis, DNA Sequence Homology, Nucleic Acid Synonymous Substitution
Source:
Emerg Infect Dis. 8(11):1342-1346.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:6c0d93c8ffddbb911342219b96d3a1e5e9d48aad66a7ae83b23543faccc00af4
Download URL:
https://stacks.cdc.gov/view/cdc/13934/cdc_13934_DS1.pdf
File Type:

Supporting Files

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