Identification of Intermediate in Evolutionary Model of Enterohemorrhagic Escherichia coli O157
Published Date:Apr 2012
Source:Emerg Infect Dis. 18(4):582-588.
Enterohemorrhagic Escherichia Coli
Escherichia Coli O157
Et Al. Identification Of Intermediate In Evolutionary Model Of Enterohemorrhagic Escherichia Coli O157. Emerg Infect Dis [serial On The Internet]. 2012 Apr [date Cited]. Http://dx.doi.org/10.3201/eid1804.111414
Multilocus Sequence Typing
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Single Nucleotide Polymorphism
Suggested Citation For This Article: Jenke C
Description:Highly pathogenic enterohemorrhagic Escherichia coli (EHEC) O157 cause a spectrum of clinical signs that include diarrhea, bloody diarrhea, and hemolytic uremic syndrome. The current evolutionary model of EHEC O157:H7/H(-) consists of a stepwise evolution scenario proceeding from O55:H7 to a node (hypothetical intermediate) that then branches into sorbitol-fermenting (SF) O157:H(-) and non-SF (NSF) O157:H7. To identify this hypothetical intermediate, we performed single nucleotide polymorphism analysis by sequencing of 92 randomly distributed backbone genomic regions of 40 O157:H7/H(-) isolates. Overall, 111 single nucleotide polymorphisms were identified in 75/92 partial open reading frames after sequencing 51,041 nt/strain. The EHEC O157:H7 strain LSU-61 from deer occupied an intermediate position between O55:H7 and both O157 branches (SF and NSF O157), complementing the stepwise evolutionary model of EHEC O157:H7/H(-). The animal origin of this intermediate emphasizes the value of nonhuman reservoirs in the clarification of the evolution of human pathogens.
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