Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1804.111414
Personal Author:
Jenke, Christian ; Leopold, Shana R. ; Weniger, Thomas ; Rothgänger, Jörg ; Harmsen, Dag ; ... More +
Jenke, Christian ; Leopold, Shana R. ; Weniger, Thomas ; Rothgänger, Jörg ; Harmsen, Dag ; Karch, Helge ; Mellmann, Alexander Less -
Description:
Highly pathogenic enterohemorrhagic Escherichia coli (EHEC) O157 cause a spectrum of clinical signs that include diarrhea, bloody diarrhea, and hemolytic uremic syndrome. The current evolutionary model of EHEC O157:H7/H(-) consists of a stepwise evolution scenario proceeding from O55:H7 to a node (hypothetical intermediate) that then branches into sorbitol-fermenting (SF) O157:H(-) and non-SF (NSF) O157:H7. To identify this hypothetical intermediate, we performed single nucleotide polymorphism analysis by sequencing of 92 randomly distributed backbone genomic regions of 40 O157:H7/H(-) isolates. Overall, 111 single nucleotide polymorphisms were identified in 75/92 partial open reading frames after sequencing 51,041 nt/strain. The EHEC O157:H7 strain LSU-61 from deer occupied an intermediate position between O55:H7 and both O157 branches (SF and NSF O157), complementing the stepwise evolutionary model of EHEC O157:H7/H(-). The animal origin of this intermediate emphasizes the value of nonhuman reservoirs in the clarification of the evolution of human pathogens.
Subject:
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Animals
Bacteria
Deer
E. Coli
EHEC O157
Enterohemorrhagic Escherichia Coli
Escherichia Coli
Escherichia Coli O157
Et Al. Identification Of Intermediate In Evolutionary Model Of Enterohemorrhagic Escherichia Coli O157. Emerg Infect Dis [serial On The Internet]. 2012 Apr [date Cited]. Http://dx.doi.org/10.3201/eid1804.111414
Evolution
Evolution, Molecular
Feces
Genetic Speciation
Genome, Bacterial
Genotype
Harmsen D
Human
Humans
Karch H
Leopold SR
Models, Genetic
Multilocus Sequence Typing
Pathogen
Phylogeny
Polymorphism, Single Nucleotide
Research
Rothgänger J
Sequence Analysis, DNA
Single Nucleotide Polymorphism
SNP Typing
Sorbitol Fermentation
Suggested Citation For This Article: Jenke C
Weniger T

Source:
Emerg Infect Dis. 18(4):582-588.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:fca91bce46b7efd558eabb8d7f99ee4ef25a8ef466e964cb55abb43d1e81d94f
File Type:

Supporting Files

• 	11-1414-F.gif	gif
  	11-1414-F.jpg	jpeg
  	11-1414-Techapp_21p.pdf	pdf
  	11-1414_finalR.nxml	txt
  	license.txt	txt

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