Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Munnink, Bas B. Oude ; Nijhuis, Roel H.T. ; Worp, Nathalie ; Boter, Marjan ; Weller, Babette ; Verstrepen, Babs E. ; GeurtsvanKessel, Corine ; Corsten, Maarten L. ; Russcher, Anne ; Koopmans, Marion
• Description:
  We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.
• Subjects:
  COVID-19 Humans Immunocompromised Host Mutation SARS-COV-2 Spike Glycoprotein, Coronavirus
• Source:
  Emerg Infect Dis. 2022; 28(9):1920-1923
• Pubmed ID:
  35925013
• Pubmed Central ID:
  PMC9423911
• Document Type:
  Journal Article
• Genre:
  Letter
• Place as Subject:
  Netherlands
• Volume:
  28
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3c6c0e89252d321ea15b230ea205f92dc17b6ff1f53d421fff8950e6daf2d257
• Download URL:
  https://stacks.cdc.gov/view/cdc/121062/cdc_121062_DS1.pdf
• File Type:
  [PDF - 1.07 MB ]