Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care

Rowan, Courtney M.; LaBere, Brenna; Young, Cameron C.; Zambrano, Laura D.; Newhams, Margaret M.; Kucukak, Suden; McNamara, Elizabeth R.; Mack, Elizabeth H.; Fitzgerald, Julie C.; Irby, Katherine; Maddux, Aline B.; Schuster, Jennifer E.; Kong, Michele; Dapul, Heda; Schwartz, Stephanie P.; Bembea, Melania M.; Loftis, Laura L.; Kolmar, Amanda R.; Babbitt, Christopher J.; Nofziger, Ryan A.; Hall, Mark W.; Gertz, Shira J.; Cvijanovich, Natalie Z.; Zinter, Matt S.; Halasa, Natasha B.; Bradford, Tamara T.; McLaughlin, Gwenn E.; Singh, Aalok R.; Hobbs, Charlotte V.; Wellnitz, Kari; Staat, Mary A.; Coates, Bria M.; Crandall, Hillary R.; Maamari, Mia; Havlin, Kevin M.; Schwarz, Adam J.; Carroll, Christopher L.; Levy, Emily R.; Moffitt, Kristin L.; Campbell, Angela P.; Randolph, Adrienne G.; Chou, Janet

doi:10.1093/cid/ciae133

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Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care

3 11 2024
By Rowan, Courtney M. ; LaBere, Brenna ; Young, Cameron C. ; ...
http://dx.doi.org/10.1093/cid/ciae133
Source: Clin Infect Dis. 79(2):395-404

[PDF-493.02 KB]

English

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Details:

Alternative Title:

Clin Infect Dis
Personal Author:

Rowan, Courtney M. ; LaBere, Brenna ; Young, Cameron C. ; Zambrano, Laura D. ; Newhams, Margaret M. ; ... More +

Rowan, Courtney M. ; LaBere, Brenna ; Young, Cameron C. ; Zambrano, Laura D. ; Newhams, Margaret M. ; Kucukak, Suden ; McNamara, Elizabeth R. ; Mack, Elizabeth H. ; Fitzgerald, Julie C. ; Irby, Katherine ; Maddux, Aline B. ; Schuster, Jennifer E. ; Kong, Michele ; Dapul, Heda ; Schwartz, Stephanie P. ; Bembea, Melania M. ; Loftis, Laura L. ; Kolmar, Amanda R. ; Babbitt, Christopher J. ; Nofziger, Ryan A. ; Hall, Mark W. ; Gertz, Shira J. ; Cvijanovich, Natalie Z. ; Zinter, Matt S. ; Halasa, Natasha B. ; Bradford, Tamara T. ; McLaughlin, Gwenn E. ; Singh, Aalok R. ; Hobbs, Charlotte V. ; Wellnitz, Kari ; Staat, Mary A. ; Coates, Bria M. ; Crandall, Hillary R. ; Maamari, Mia ; Havlin, Kevin M. ; Schwarz, Adam J. ; Carroll, Christopher L. ; Levy, Emily R. ; Moffitt, Kristin L. ; Campbell, Angela P. ; Randolph, Adrienne G. ; Chou, Janet Less -
Corporate Authors:

Overcoming COVID-19 Investigators
Description:

Background.

We aimed to determine if pre-existing immunocompromising conditions (ICCs) were associated with the presentation or outcome of patients with acute coronavirus disease 2019 (COVID-19) admitted for pediatric intensive care.

Methods.

Fifty-five hospitals in 30 US states reported cases through the Overcoming COVID-19 public health surveillance registry. Patients <21 years admitted 12 March 2020–30 December 2021 to the pediatric intensive care unit (PICU) or high-acuity unit for acute COVID-19 were included.

Results.

Of 1274 patients, 105 (8.2%) had an ICC, including 33 (31.4%) hematologic malignancies, 24 (22.9%) primary immunodeficiencies and disorders of hematopoietic cells, 19 (18.1%) nonmalignant organ failure with solid-organ transplantation, 16 (15.2%) solid tumors, and 13 (12.4%) autoimmune disorders. Patients with ICCs were older, had more underlying renal conditions, and had lower white blood cell and platelet counts than those without ICCs, but had similar clinical disease severity upon admission. In-hospital mortality from COVID-19 was higher (11.4% vs 4.6%, P = .005) and hospitalization was longer (P = .01) in patients with ICCs. New major morbidities upon discharge were not different between those with and without ICC (10.5% vs 13.9%, P = .40). In patients with ICCs, bacterial coinfection was more common in those with life-threatening COVID-19.

Conclusions.

In this national case series of patients <21 years of age with acute COVID-19 admitted for intensive care, existence of a prior ICCs were associated with worse clinical outcomes. Reassuringly, most patients with ICCs hospitalized in the PICU for severe acute COVID-19 survived and were discharged home without new severe morbidities.
Subjects:

[+]

Adolescent Child Child, Preschool COVID-19 Female Hospitalization Hospital Mortality Humans Immunocompromised Host Infant Intensive Care Units, Pediatric Male SARS-CoV-2 United States
Keywords:

[+]

Bacterial Coinfection Critical Care Immunocompromised Host Pediatrics
Source:

Clin Infect Dis. 79(2):395-404
Pubmed ID:

38465976
Pubmed Central ID:

PMC11327788
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; NH/NIH HHSUnited States/ ; US Centers for Disease Control and Prevention/

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; NH/NIH HHSUnited States/ ; US Centers for Disease Control and Prevention/ Less -
Volume:

79
Issue:

2
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:53ac742d16739e1452c467e1d62635c47c6ab05d74c0af40e6bf10f45713415ce356769b9c7e64bb6dca121ad5546ad683faf10d49f5de5a74b5601d3d257de4
Download URL:

https://stacks.cdc.gov/view/cdc/160177/cdc_160177_DS1.pdf
File Type:

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	NIHMS2009584-supplement-Supplementary_data.docx	docx

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