Associations of hair dye and relaxer use with breast tumor clinicopathologic features: findings from the Women’s Circle of Health Study

Details

• Alternative Title:
  Environ Res
• Personal Author:
  Rao, Rohan ; McDonald, Jasmine A. ; Barrett, Emily S. ; Greenberg, Patricia ; Teteh, Dede K. ; Montgomery, Susanne B. ; Qin, Bo ; Lin, Yong ; Hong, Chi-Chen ; Ambrosone, Christine B. ; Demissie, Kitaw ; Bandera, Elisa V. ; Llanos, Adana A.M.
• Description:
  BACKGROUND:
  
  Building upon our earlier findings of significant associations between hair dye and relaxer use with increased breast cancer risk, we evaluated associations of select characteristics of use with breast tumor clinicopathology.
  
  METHODS:
  
  Using multivariable-adjusted models we examined the associations of interest in a case-only study of 2,998 women with breast cancer, overall and stratified by race and estrogen receptor (ER) status, addressing multiple comparisons using Bonferroni correction.
  
  RESULTS:
  
  Compared to salon application of permanent hair dye, home kit and combination application (both salon and home kit application) were associated with increased odds of poorly differentiated tumors in the overall sample. This association was consistent among Black (home kit: OR 2.22, 95% CI: 1.21–5.00; combination: OR 2.46, 95% CI: 1.21–5.00), but not White women, and among ER+ (home kit: OR 1.47, 95% CI: 0.82–2.63; combination: OR 2.98, 95% CI: 1.62–5.49) but not ER− cases. Combination application of relaxers was associated with increased odds of tumors >2.0 cm vs. <1.0 cm (OR = 1.82, 95% CI: 1.23–2.69). Longer duration and earlier use of relaxers and combination application of permanent hair dyes and relaxers were associated with breast tumor features including higher tumor grade and larger tumor size, which often denote more aggressive phenotypes, although the findings did not maintain significance with Bonferroni correction.
  
  CONCLUSIONS:
  
  These novel data support reported associations between hair dye and relaxer use with breast cancer, showing for the first time, associations with breast tumor clinicopathologic features. Improved hair product exposure measurement is essential for fully understanding the impact of these environmental exposure with breast cancer and to guide risk reduction strategies in the future.
  
  
• Subjects:
  Article Breast Cancer Breast Neoplasms Breast Tumor Features Female Hair Dye Hair Dyes Hair Products Hair Relaxer Humans Personal Care Products Risk Factors Time Factors

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• Source:
  Environ Res. 203:111863
• Pubmed ID:
  34390715
• Pubmed Central ID:
  PMC8616798
• Document Type:
  Journal Article
• Funding:
  U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; K01 CA193527/CA/NCI NIH HHSUnited States/ ; P30 CA072720/CA/NCI NIH HHSUnited States/ ; K01 CA186943/CA/NCI NIH HHSUnited States/ ; P01 CA151135/CA/NCI NIH HHSUnited States/ ; P30 ES005022/ES/NIEHS NIH HHSUnited States/ ; HHSN261201300021C/CA/NCI NIH HHSUnited States/ ; R01 CA185623/CA/NCI NIH HHSUnited States/ ; P30 ES009089/ES/NIEHS NIH HHSUnited States/ ; R01 CA100598/CA/NCI NIH HHSUnited States/
• Volume:
  203
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:26076480bae93e59f59794cbd5852dc5e1c3c91e6923a29b567c6f36b0243fdf
• Download URL:
  https://stacks.cdc.gov/view/cdc/112043/cdc_112043_DS1.pdf
• File Type:
  [PDF - 198.76 KB ]