Comorbidities in a Nationwide, Heterogenous Population of Veterans with Interstitial Cystitis/Bladder Pain Syndrome

Details

• Alternative Title:
  Urology
• Personal Author:
  Laden, Bethany F. ; Bresee, Catherine ; De Hoedt, Amanda ; Dallas, Kai B. ; Scharfenberg, April ; Saxena, Roopali ; Senechal, Justin F. ; Barbour, Kamil E. ; Kim, Jayoung ; Freedland, Stephen J. ; Anger, Jennifer T.
• Description:
  OBJECTIVE
  
  To examine the prevalence of comorbid conditions in a nationwide population of men and women with IC/BPS utilizing a more heterogeneous sample than most studies to date.
  
  METHODS
  
  Using the Veterans Affairs Informatics and Computing Infrastructure, we identified random samples of male and female patients with and without an ICD-9/ICD-10 diagnosis of IC/BPS. Presence of comorbidities (NUAS chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, migraines, back pain, diabetes, and smoking) and psychosocial factors (alcohol abuse, post-traumatic stress disorder, sexual trauma, and history of depression) were determined using ICD-9 and ICD-IO codes. Associations between these variables and IC/BPS status were evaluated while adjusting for the potential confounding impact of race/ethnicity, age, and gender.
  
  RESULTS
  
  Data was analyzed from 872 IC/BPS patients (355 41% men, 517 59% women) and 558 non-IC/BPS patients (291 52% men, 267 48% women). IC/BPS patients were more likely than non-IC/BPS patients to have a greater number of comorbidities (2.72+/−1.77 vs 1.73+/−1.30, P < 0.001), experience one or more NUAS (chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, and migraines) (45% 388/872 vs. 18% 101/558; P < 0.001) and had a higher prevalence of at least one psychosocial factor (61 % 529/872 v. 46% 256/558; P < 0.001). Differences in the frequencies of comorbidities between patients with and without IC/BPS were more pronounced in female patients.
  
  CONCLUSION
  
  These findings validate the findings of previous comorbidity studies of IC/BPS in a more diverse population.
• Subjects:
  • Adult
  • Aged
  • Cohort Studies
  • Comorbidity
  • Cystitis, Interstitial
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  More +
• Source:
  Urology. 156:37-43
• Pubmed ID:
  33901534
• Pubmed Central ID:
  PMC8536792
• Document Type:
  Journal Article
• Funding:
  U01 DP006079/DP/NCCDPHP CDC HHSUnited States/
• Place as Subject:
  United States
• Volume:
  156
• Download URL:
  https://stacks.cdc.gov/view/cdc/110948/cdc_110948_DS1.pdf
• File Type:
  [PDF - 492.65 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8696c1a65d211c6fd6bf959297c08b3e24bf3c3b926c9fbde876e4d56caeb6dc