Comorbidities in a Nationwide, Heterogenous Population of Veterans with Interstitial Cystitis/Bladder Pain Syndrome

Details

• Alternative Title:
  Urology
• Personal Author:
  Laden, Bethany F. ; Bresee, Catherine ; De Hoedt, Amanda ; Dallas, Kai B. ; Scharfenberg, April ; Saxena, Roopali ; Senechal, Justin F. ; Barbour, Kamil E. ; Kim, Jayoung ; Freedland, Stephen J. ; Anger, Jennifer T.
• Description:
  OBJECTIVE
  
  To examine the prevalence of comorbid conditions in a nationwide population of men and women with IC/BPS utilizing a more heterogeneous sample than most studies to date.
  
  METHODS
  
  Using the Veterans Affairs Informatics and Computing Infrastructure, we identified random samples of male and female patients with and without an ICD-9/ICD-10 diagnosis of IC/BPS. Presence of comorbidities (NUAS [chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, migraines], back pain, diabetes, and smoking) and psychosocial factors (alcohol abuse, post-traumatic stress disorder, sexual trauma, and history of depression) were determined using ICD-9 and ICD-IO codes. Associations between these variables and IC/BPS status were evaluated while adjusting for the potential confounding impact of race/ethnicity, age, and gender.
  
  RESULTS
  
  Data was analyzed from 872 IC/BPS patients (355 [41%] men, 517 [59%] women) and 558 non-IC/BPS patients (291 [52%] men, 267 [48%] women). IC/BPS patients were more likely than non-IC/BPS patients to have a greater number of comorbidities (2.72+/−1.77 vs 1.73+/−1.30, P < 0.001), experience one or more NUAS (chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, and migraines) (45% [388/872] vs. 18% [101/558]; P < 0.001) and had a higher prevalence of at least one psychosocial factor (61 % [529/872] v. 46% [256/558]; P < 0.001). Differences in the frequencies of comorbidities between patients with and without IC/BPS were more pronounced in female patients.
  
  CONCLUSION
  
  These findings validate the findings of previous comorbidity studies of IC/BPS in a more diverse population.
  
  
• Subjects:
  Adult Aged Cohort Studies Comorbidity Cystitis, Interstitial Female Humans Male Middle Aged Prevalence Veterans Health

  More +
• Source:
  Urology. 156:37-43
• Pubmed ID:
  33901534
• Pubmed Central ID:
  PMC8536792
• Document Type:
  Journal Article
• Funding:
  U01 DP006079/DP/NCCDPHP CDC HHSUnited States/
• Place as Subject:
  United States
• Volume:
  156
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8696c1a65d211c6fd6bf959297c08b3e24bf3c3b926c9fbde876e4d56caeb6dc
• Download URL:
  https://stacks.cdc.gov/view/cdc/110948/cdc_110948_DS1.pdf
• File Type:
  [PDF - 492.65 KB ]