Prevalence and Risk Factors Associated With Herpes Simplex Virus-2 Infection in a Contemporary Cohort of HIV-Infected Persons in the United States

Patel, Pragna; Bush, Tim; Mayer, Kenneth H.; Desai, Sheila; Henry, Keith; Overton, Edgar Turner; Conley, Lois; Hammer, John; Brooks, John T.

doi:10.1097/OLQ.0b013e318239d7fd

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Prevalence and Risk Factors Associated With Herpes Simplex Virus-2 Infection in a Contemporary Cohort of HIV-Infected Persons in the United States

Published Date:

Feb 2012

Publisher's site:

http://dx.doi.org/10.1097/OLQ.0b013e318239d7fd New Site Icon

Source:

Sex Transm Dis. 39(2):154-160.

[PDF-486.94 KB]

Details:

Personal Authors:

Patel, Pragna ; Bush, Tim ; Mayer, Kenneth H. ; Desai, Sheila ; Henry, Keith ; ... More ▼

Corporate Authors:

SUN Study Investigators

Keywords:

[+]

Pubmed ID:

22249305

Pubmed Central ID:

PMC5476946

Description:

Background

We compared the herpes simplex virus type 2 (HSV-2) seroprevalence in a contemporary HIV cohort with the general US population and determined risk factors for HSV-2 infection among HIV-infected persons.

Methods

The Study to Understand the Natural History of HIV and AIDS in the Era of Effective Therapy (SUN) Study is a prospective observational cohort of 700 HIV-infected adults enrolled in 4 US cities between 2004 and 2006. At baseline, participants completed a behavioral risk questionnaire and provided specimens for HSV-2 serology. We calculated HSV-2 seroprevalence, standardized by age, gender, and race among HIV-infected persons compared with the general US adult population, using data from the National Health and Nutrition Examination Survey from 2003 to 2006. We examined risk factors associated with HSV-2 infection among HIV-infected persons using multivariate logistic regression.

Results

Among 660 (94%) SUN participants with adequate specimens for HSV-2 serologic testing, 548 (83%) were 20 to 49 years old (median age, 39 years; 77% male; 59% non-Hispanic white; median CD4 count, 470 cells/mm3; 74% with HIV RNA viral loads <400 copies/mL). HSV-2 seroprevalence was significantly higher among HIV-infected adults (59.7%, 95% confidence interval: 55.8-63.6) compared with the general US population (19.2%, 95% confidence interval: 17.5-21.1). In multivariate analysis, we found that older age, female gender, black non-Hispanic race/ethnicity, being currently unemployed, high-risk anal HPV infection, and longer duration since HIV diagnosis were associated with significantly higher odds of HSV-2 infection.

Conclusion

HSV-2 seroprevalence is 3 times as high among HIV-infected adults as in the general US population. Clinicians should be aware that increased risk for HSV-2 infection was distributed broadly among HIV-infected persons and not limited to those with high-risk sexual behaviors.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

200-2007-23634/PHS HHS/United States
200-2002-00611/PHS HHS/United States
200-2002-00612/PHS HHS/United States
200-2007-23635/PHS HHS/United States
200-2002-00613/PHS HHS/United States
CC999999/Intramural CDC HHS/United States
200-2002-00610/PHS HHS/United States
200-2007-23636/PHS HHS/United States
200-2007-23633/PHS HHS/United States

Main Document Checksum:

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