Constant Transmission Properties of Variant Creutzfeldt-Jakob Disease in 5 Countries

Diack, Abigail B.; Ritchie, Diane; Bishop, Matthew; Pinion, Victoria; Brandel, Jean-Philippe; Haik, Stephane; Tagliavini, Fabrizio; Van Duijn, Cornelia; Belay, Ermias D.; Gambetti, Pierluigi; Schonberger, Lawrence B.; Piccardo, Pedro; Will, Robert G.; Manson, Jean C.

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Constant Transmission Properties of Variant Creutzfeldt-Jakob Disease in 5 Countries

Supporting Files Public Domain

Oct 2012
By Diack, Abigail B. ; Ritchie, Diane ; Bishop, Matthew ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Diack, Abigail B. ; Ritchie, Diane ; Bishop, Matthew ; Pinion, Victoria ; Brandel, Jean-Philippe ; Haik, Stephane ; Tagliavini, Fabrizio ; Van Duijn, Cornelia ; Belay, Ermias D. ; Gambetti, Pierluigi ; Schonberger, Lawrence B. ; Piccardo, Pedro ; Will, Robert G. ; Manson, Jean C.
Description:

Variant Creutzfeldt-Jakob disease (vCJD) has been reported in 12 countries. We hypothesized that a common strain of agent is responsible for all vCJD cases, regardless of geographic origin. To test this hypothesis, we inoculated strain-typing panels of wild-type mice with brain material from human vCJD case-patients from France, the Netherlands, Europe, and the United States. Mice were assessed for clinical disease, neuropathologic changes, and glycoform profile; results were compared with those for 2 reference vCJD cases from the United Kingdom. Transmission to mice occurred from each sample tested, and data were similar between non-UK and UK cases, with the exception of the ranking of mean clinical incubation times of mouse lines. These findings support the hypothesis that a single strain of infectious agent is responsible for all vCJD infections. However, differences in incubation times require further subpassage in mice to establish any true differences in strain properties between cases.
Subjects:

Adult Animals Brain/metabolism Brain/pathology Creutzfeldt-Jakob Syndrome/pathology Creutzfeldt-Jakob Syndrome/transmission Female Humans Male Mice Mice, Inbred C57BL Prions PrPSc Proteins Research Young Adult
Source:

Emerg Infect Dis. 18(10):1574-1579.
Document Type:

Journal Article
Place as Subject:

France ; Europe ; Netherlands ; United Kingdom ; United States
Location:

Europe ; North America
Volume:

18
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:ea2bfeb4ff831a35f6c2ffdbd5c0c1154f187109b772a456d211b76b80aab3ab
Download URL:

https://stacks.cdc.gov/view/cdc/10979/cdc_10979_DS1.pdf
File Type:

[PDF - 274.02 KB ]

File Language:

English

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