Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

Béringue, Vincent; Herzog, Laëtitia; Reine, Fabienne; Le Dur, Annick; Casalone, Cristina; Vilotte, Jean-Luc; Laude, Hubert

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

Dec 2008
By Béringue, Vincent ; Herzog, Laëtitia ; Reine, Fabienne ; ...
Source: Emerg Infect Dis. 14(12):1898-1901

[PDF-301.38 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Béringue, Vincent ; Herzog, Laëtitia ; Reine, Fabienne ; Le Dur, Annick ; Casalone, Cristina ; ... More +

Béringue, Vincent ; Herzog, Laëtitia ; Reine, Fabienne ; Le Dur, Annick ; Casalone, Cristina ; Vilotte, Jean-Luc ; Laude, Hubert Less -
Description:

To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
Subjects:

[+]

Animals Brain Cattle Dispatch Encephalopathy, Bovine Spongiform Humans Mice Mice, Inbred C57BL Mice, Transgenic Prions PrPSc Proteins Transgenes
Source:

Emerg Infect Dis. 14(12):1898-1901
Pubmed ID:

19046515
Pubmed Central ID:

PMC2634647
Document Type:

Journal Article
Volume:

14
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:46e49ed5483068d21a461f0d45a0543942dfb8035412561eebb51984e9a73af4
Download URL:

https://stacks.cdc.gov/view/cdc/17390/cdc_17390_DS1.pdf
File Type:

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