Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Béringue, Vincent ; Herzog, Laëtitia ; Reine, Fabienne ; Le Dur, Annick ; Casalone, Cristina ; ... More +
Béringue, Vincent ; Herzog, Laëtitia ; Reine, Fabienne ; Le Dur, Annick ; Casalone, Cristina ; Vilotte, Jean-Luc ; Laude, Hubert ; Less -
Description:
To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
Subject:
[+]
Animals
Brain
Cattle
Dispatch
Encephalopathy, Bovine Spongiform
Humans
Mice
Mice, Inbred C57BL
Mice, Transgenic
Prions
PrPSc Proteins
Transgenes

Source:
Emerg Infect Dis. 14(12):1898-1901 ;
Pubmed ID:
19046515
Pubmed Central ID:
PMC2634647
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:46e49ed5483068d21a461f0d45a0543942dfb8035412561eebb51984e9a73af4
File Type:

Supporting Files

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