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Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
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Dec 2008
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Source: Emerg Infect Dis. 14(12):1898-1901
[PDF-301.38 KB]
Details:
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Alternative Title:Emerg Infect Dis
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Personal Author:
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Description:To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
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Pubmed ID:19046515
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Pubmed Central ID:PMC2634647
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Document Type:
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Volume:14
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Issue:12
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