Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

Béringue, Vincent; Herzog, Laëtitia; Reine, Fabienne; Le Dur, Annick; Casalone, Cristina; Vilotte, Jean-Luc; Laude, Hubert

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Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

Published Date:

Dec 2008

Source:

Emerg Infect Dis. 14(12):1898-1901

Language:

English

[PDF-301.38 KB]

Details:

Personal Authors:

Béringue, Vincent ; Herzog, Laëtitia ; Reine, Fabienne ; Le Dur, Annick ; Casalone, Cristina ; ... More ▼

Keywords:

[+]

Pubmed ID:

19046515

Pubmed Central ID:

PMC2634647

Description:

To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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