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Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses

CITE Title : Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses Personal Author(s) : Sui, Jianhua;Hwang, William C.;Perez, Sandra;Wei, Ge;Aird, Daniel;Chen, Li-mei;Santelli, Eugenio;Stec, Boguslaw;Cadwell, Greg;Ali, Maryam;Wan, Hongquan;Murakami, Akikazu;Yammanuru, Anuradha;Han, Thomas;Cox, Nancy J.;Bankston, Laurie A.;Donis, Ruben O.;Liddington, Robert C.;Marasco, Wayne A.; Published Date : February 22 2009;3-2009; Source : Nat Struct Mol Biol. 16(3):265-273 URL : https://stacks.cdc.gov/view/cdc/84982 Sui, Jianhua et al. (2009). Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses. 16(3). Sui, Jianhua et al. "Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses" 16, no. 3 (2009) Sui, Jianhua et al. "Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses" vol. 16, no. 3, 2009 Export RIS Citation Information.

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Sui, Jianhua ;

Hwang, William C.

February 22 2009 | Nat Struct Mol Biol. 16(3):265-273

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Influenza virus remains a serious health threat, owing to its ability to evade immune surveillance through rapid genetic drift and reassortment. Here ...
A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus

CITE Title : A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus Personal Author(s) : Flint, Mike;Chatterjee, Payel;Lin, David L.;McMullan, Laura K.;Shrivastava-Ranjan, Punya;Bergeron, Éric;Lo, Michael K.;Welch, Stephen R.;Nichol, Stuart T.;Tai, Andrew W.;Spiropoulou, Christina F.; Published Date : January 17 2019 Source : Nat Commun. 10 URL : https://stacks.cdc.gov/view/cdc/75846 Flint, Mike et al. (2019). A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus. 10 Flint, Mike et al. "A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus" 10 (2019) Flint, Mike et al. "A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus" vol. 10, 2019 Export RIS Citation Information.

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Flint, Mike ;

Chatterjee, Payel

January 17 2019 | Nat Commun. 10

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There are no approved therapies for Ebola virus infection. Here, to find potential therapeutic targets, we perform a screen for genes essential for Eb...
Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement

CITE Title : Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement Personal Author(s) : Hughes, Holly R;Crill, Wayne D;Chang, Gwong-Jen J; Published Date : Jun 18 2012 Source : Virol J. 2012; 9:115. URL : https://stacks.cdc.gov/view/cdc/10848 Hughes, Holly R et al. (2012). Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement. 9 Hughes, Holly R and Crill, Wayne D and Chang, Gwong-Jen J "Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement" 9 (2012) Hughes, Holly R et al. "Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement" vol. 9, 2012 Export RIS Citation Information.

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Hughes, Holly R ;

Crill, Wayne D

Jun 18 2012 | Virol J. 2012; 9:115.

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BackgroundDengue viruses (DENV) are the most important arboviruses of humans and cause significant disease. Infection with DENV elicits antibody respo...
Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form

CITE Title : Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form Personal Author(s) : Vitu, Elvira;Sharma, Sapna;Stampfer, Samuel D.;Heldwein, Ekaterina E.; Published Date : March 13 2013;6-12-; Source : J Mol Biol. 2013; 425(11):2056-2071 URL : https://stacks.cdc.gov/view/cdc/29660 Vitu, Elvira et al. (2013). Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form. 425(11). Vitu, Elvira et al. "Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form" 425, no. 11 (2013) Vitu, Elvira et al. "Extensive mutagenesis of the HSV-1 gB ectodomain reveals remarkable stability of its postfusion form" vol. 425, no. 11, 2013 Export RIS Citation Information.

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Vitu, Elvira ;

Sharma, Sapna

March 13 2013 | J Mol Biol. 2013; 425(11):2056-2071

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Viral fusogens mediate the merger of the viral envelope and cellular membrane during viral entry. These proteins share little sequence similarity but ...
Stuck in the middle: structural insights into the role of gH/gL heterodimer in herpesvirus entry

CITE Title : Stuck in the middle: structural insights into the role of gH/gL heterodimer in herpesvirus entry Personal Author(s) : Stampfer, Samuel D.;Heldwein, Ekaterina E.; Published Date : October 26 2012;2-2013; Source : Curr Opin Virol. 2012; 3(1):13-19 URL : https://stacks.cdc.gov/view/cdc/33509 Stampfer, Samuel D. and Heldwein, Ekaterina E. (2012). Stuck in the middle: structural insights into the role of gH/gL heterodimer in herpesvirus entry. 3(1). Stampfer, Samuel D. and Heldwein, Ekaterina E. "Stuck in the middle: structural insights into the role of gH/gL heterodimer in herpesvirus entry" 3, no. 1 (2012) Stampfer, Samuel D. and Heldwein, Ekaterina E. "Stuck in the middle: structural insights into the role of gH/gL heterodimer in herpesvirus entry" vol. 3, no. 1, 2012 Export RIS Citation Information.

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Stampfer, Samuel D. ;

Heldwein, Ekaterina E.

October 26 2012 | Curr Opin Virol. 2012; 3(1):13-19

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Enveloped viruses enter cells by fusing the viral and cellular membranes, and most use a single viral envelope protein that combines receptor-binding ...
Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts

CITE Title : Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts Personal Author(s) : Zhu, Wuyang;Fu, Shihong;He, Ying;Li, Jinping;Liang, Guodong; Published Date : Sep 14 2010 Source : Virol J. 2010; 7:225. URL : https://stacks.cdc.gov/view/cdc/3635 Zhu, Wuyang et al. (2010). Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts. 7 Zhu, Wuyang et al. "Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts" 7 (2010) Zhu, Wuyang et al. "Amino acid substitutions in the E2 glycoprotein of Sindbis-like virus XJ-160 confer the ability to undergo heparan sulfate-dependent infection of mouse embryonic fibroblasts" vol. 7, 2010 Export RIS Citation Information.

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Zhu, Wuyang ;

Fu, Shihong

Sep 14 2010 | Virol J. 2010; 7:225.

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We have recently demonstrated an essential role of the domain of 145-150 amino acid in the E2 glycoprotein of Sindbis virus in the interaction with ce...
Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing

CITE Title : Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing Personal Author(s) : Shrivastava-Ranjan, Punya;Flint, Mike;Bergeron, Éric;McElroy, Anita K.;Chatterjee, Payel;Albariño, César G.;Nichol, Stuart T.;Spiropoulou, Christina F.; Published Date : May 01 2018 Source : mBio. 9(3). URL : https://stacks.cdc.gov/view/cdc/53865 Shrivastava-Ranjan, Punya et al. (2018). Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing. 9(3). Shrivastava-Ranjan, Punya et al. "Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing" 9, no. 3 (2018) Shrivastava-Ranjan, Punya et al. "Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing" vol. 9, no. 3, 2018 Export RIS Citation Information.

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Shrivastava-Ranjan, Punya ;

Flint, Mike

May 01 2018 | mBio. 9(3).

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Ebola virus (EBOV) infection is a major public health concern due to high fatality rates and limited effective treatments. Statins, widely used choles...
Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells

CITE Title : Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells Personal Author(s) : Chiang, Cheng-Feng;Flint, Mike;Lin, Jin-Mann S.;Spiropoulou, Christina F.; Published Date : Oct 25 2016 Source : PLoS One. 11(10). URL : https://stacks.cdc.gov/view/cdc/42981 Chiang, Cheng-Feng et al. (2016). Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells. 11(10). Chiang, Cheng-Feng et al. "Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells" 11, no. 10 (2016) Chiang, Cheng-Feng et al. "Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells" vol. 11, no. 10, 2016 Export RIS Citation Information.

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Chiang, Cheng-Feng ;

Flint, Mike

Oct 25 2016 | PLoS One. 11(10).

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Andes virus (ANDV) is the major cause of hantavirus pulmonary syndrome (HPS) in South America. Despite a high fatality rate (up to 40%), no vaccines o...
IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry

CITE Title : IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry Personal Author(s) : Feeley, Eric M.;Sims, Jennifer S.;John, Sinu P.;Chin, Christopher R.;Pertel, Thomas;Chen, Li-Mei;Gaiha, Gaurav D.;Ryan, Bethany J.;Donis, Ruben O.;Elledge, Stephen J.;Brass, Abraham L.; Published Date : 10 27 2011 Source : PLoS Pathog. 2011; 7(10) URL : https://stacks.cdc.gov/view/cdc/122151 Feeley, Eric M. et al. (2011). IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry. 7(10). Feeley, Eric M. et al. "IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry" 7, no. 10 (2011) Feeley, Eric M. et al. "IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry" vol. 7, no. 10, 2011 Export RIS Citation Information.

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Feeley, Eric M. ;

Sims, Jennifer S.

10 27 2011 | PLoS Pathog. 2011; 7(10)

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To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effect...
Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections

CITE Title : Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections Personal Author(s) : Gaisina, Irina N.;Peet, Norton P.;Wong, Letitia;Schafer, Adam M.;Cheng, Han;Anantpadma, Manu;Davey, Robert A.;Thatcher, Gregory R. J.;Rong, Lijun; Published Date : July 09 2020 Source : J Med Chem. 63(13):7211-7225 URL : https://stacks.cdc.gov/view/cdc/97471 Gaisina, Irina N. et al. (2020). Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. 63(13). Gaisina, Irina N. et al. "Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections" 63, no. 13 (2020) Gaisina, Irina N. et al. "Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections" vol. 63, no. 13, 2020 Export RIS Citation Information.

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Gaisina, Irina N. ;

Peet, Norton P.

July 09 2020 | J Med Chem. 63(13):7211-7225

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The recent Ebola epidemics in West Africa underscore the great need for effective and practical therapies for future Ebola virus outbreaks. We have di...
Molecular Determinants of Dengue Virus 2 Envelope Protein Important for Virus Entry in FcγRIIA-Mediated Antibody-Dependent Enhancement of Infection

CITE Title : Molecular Determinants of Dengue Virus 2 Envelope Protein Important for Virus Entry in FcγRIIA-Mediated Antibody-Dependent Enhancement of Infection Personal Author(s) : Chotiwan, Nunya;Roehrig, John T.;Schlesinger, Jacob J.;Blair, Carol D.;Huang, Claire Y.-H.; Published Date : Apr 18 2014 Source : Virology. 0:238-246. URL : https://stacks.cdc.gov/view/cdc/34516 Chotiwan, Nunya et al. (2014). Molecular Determinants of Dengue Virus 2 Envelope Protein Important for Virus Entry in FcγRIIA-Mediated Antibody-Dependent Enhancement of Infection. 0 Chotiwan, Nunya et al. "Molecular Determinants of Dengue Virus 2 Envelope Protein Important for Virus Entry in FcγRIIA-Mediated Antibody-Dependent Enhancement of Infection" 0 (2014) Chotiwan, Nunya et al. "Molecular Determinants of Dengue Virus 2 Envelope Protein Important for Virus Entry in FcγRIIA-Mediated Antibody-Dependent Enhancement of Infection" vol. 0, 2014 Export RIS Citation Information.

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Chotiwan, Nunya ;

Roehrig, John T.

Apr 18 2014 | Virology. 0:238-246.

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Antibody-dependent enhancement (ADE) of infection may cause severe illness in patients suffering a secondary infection by a heterologous dengue virus ...
A Fusion-Inhibiting Peptide against Rift Valley Fever Virus Inhibits Multiple, Diverse Viruses

CITE Title : A Fusion-Inhibiting Peptide against Rift Valley Fever Virus Inhibits Multiple, Diverse Viruses Personal Author(s) : Koehler, Jeffrey W.;Smith, Jeffrey M.;Ripoll, Daniel R.;Spik, Kristin W.;Taylor, Shannon L.;Badger, Catherine V.;Grant, Rebecca J.;Ogg, Monica M.;Wallqvist, Anders;Guttieri, Mary C.;Garry, Robert F.;Schmaljohn, Connie S.; Published Date : Sep 12 2013 Source : PLoS Negl Trop Dis. 2013; 7(9). URL : https://stacks.cdc.gov/view/cdc/21154 Koehler, Jeffrey W. et al. (2013). A Fusion-Inhibiting Peptide against Rift Valley Fever Virus Inhibits Multiple, Diverse Viruses. 7(9). Koehler, Jeffrey W. et al. "A Fusion-Inhibiting Peptide against Rift Valley Fever Virus Inhibits Multiple, Diverse Viruses" 7, no. 9 (2013) Koehler, Jeffrey W. et al. "A Fusion-Inhibiting Peptide against Rift Valley Fever Virus Inhibits Multiple, Diverse Viruses" vol. 7, no. 9, 2013 Export RIS Citation Information.

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Koehler, Jeffrey W. ;

Smith, Jeffrey M.

Sep 12 2013 | PLoS Negl Trop Dis. 2013; 7(9).

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For enveloped viruses, fusion of the viral envelope with a cellular membrane is critical for a productive infection to occur. This fusion process is m...
Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity

CITE Title : Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity Personal Author(s) : Rajasekaran, Dhivya;Palombo, Enzo A.;Chia Yeo, Tiong;Lim Siok Ley, Diana;Lee Tu, Chu;Malherbe, Francois;Grollo, Lara; Published Date : Nov 27 2013 Source : PLoS One. 2013; 8(11). URL : https://stacks.cdc.gov/view/cdc/21382 Rajasekaran, Dhivya et al. (2013). Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity. 8(11). Rajasekaran, Dhivya et al. "Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity" 8, no. 11 (2013) Rajasekaran, Dhivya et al. "Identification of Traditional Medicinal Plant Extracts with Novel Anti-Influenza Activity" vol. 8, no. 11, 2013 Export RIS Citation Information.

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Rajasekaran, Dhivya ;

Palombo, Enzo A.

Nov 27 2013 | PLoS One. 2013; 8(11).

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The emergence of drug resistant variants of the influenza virus has led to a need to identify novel and effective antiviral agents. As an alternative ...
25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation

CITE Title : 25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation Personal Author(s) : Shrivastava-Ranjan, Punya;Bergeron, Éric;Chakrabarti, Ayan K.;Albariño, César G.;Flint, Mike;Nichol, Stuart T.;Spiropoulou, Christina F.; Published Date : Dec 20 2016 Source : mBio. 2016; 7(6). URL : https://stacks.cdc.gov/view/cdc/43661 Shrivastava-Ranjan, Punya et al. (2016). 25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation. 7(6). Shrivastava-Ranjan, Punya et al. "25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation" 7, no. 6 (2016) Shrivastava-Ranjan, Punya et al. "25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation" vol. 7, no. 6, 2016 Export RIS Citation Information.

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Shrivastava-Ranjan, Punya ;

Bergeron, Éric

Dec 20 2016 | mBio. 2016; 7(6).

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Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated ge...
Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan

CITE Title : Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan Personal Author(s) : Murakami, Shin;Kitamura, Tomoya;Suzuki, Jin;Sato, Ryouta;Aoi, Toshiki;Fujii, Marina;Matsugo, Hiromichi;Kamiki, Haruhiko;Ishida, Hiroho;Takenaka-Uema, Akiko;Shimojima, Masayuki;Horimoto, Taisuke; Published Date : December 2020 Source : Emerg Infect Dis. 26(12):3025-3029 URL : https://stacks.cdc.gov/view/cdc/98453 Murakami, Shin et al. (2020). Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan. 26(12). Murakami, Shin et al. "Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan" 26, no. 12 (2020) Murakami, Shin et al. "Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan" vol. 26, no. 12, 2020 Export RIS Citation Information.

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Murakami, Shin ;

Kitamura, Tomoya

December 2020 | Emerg Infect Dis. 26(12):3025-3029

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Epidemiology of bat Betacoronavirus, subgenus Sarbecovirus is largely unknown, especially outside China. We detected a sarbecovirus phylogenetically r...