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Stuck in the middle: structural insights into the role of gH/gL heterodimer in herpesvirus entry
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October 26 2012
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Source: Curr Opin Virol. 2012; 3(1):13-19
[PDF-2.34 MB]
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Alternative Title:Curr Opin Virol
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Description:Enveloped viruses enter cells by fusing the viral and cellular membranes, and most use a single viral envelope protein that combines receptor-binding and fusogenic functions. In herpesviruses, these functions are distributed among multiple proteins: the conserved fusion protein gB, various non-conserved receptor-binding proteins, and the conserved gH/gL heterodimer that curiously lacks an apparent counterpart in other enveloped viruses. Recent structural studies of gH/gL from HSV-2 and EBV revealed a unique complex with no structural or functional similarity to other viral proteins. Here we analyzed gH/gL structures and highlighted important functional regions. We propose that gH/gL functions as an adaptor that transmits the triggering signals from various non-conserved inputs to the highly conserved fusion protein gB.
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Pubmed ID:23107819
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Pubmed Central ID:PMC3562363
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