Stuck in the middle: structural insights into the role of gH/gL heterodimer in herpesvirus entry

Stampfer, Samuel D.; Heldwein, Ekaterina E.

doi:10.1016/j.coviro.2012.10.005

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Stuck in the middle: structural insights into the role of gH/gL heterodimer in herpesvirus entry

Published Date:

Oct 26 2012

Publisher's site:

http://dx.doi.org/10.1016/j.coviro.2012.10.005 New Site Icon

Source:

Curr Opin Virol. 2012; 3(1):13-19.

[PDF-2.34 MB]

Details:

Personal Authors:

Stampfer, Samuel D. ; Heldwein, Ekaterina E. ;

Keywords:

[+]

Pubmed ID:

23107819

Pubmed Central ID:

PMC3562363

Description:

Enveloped viruses enter cells by fusing the viral and cellular membranes, and most use a single viral envelope protein that combines receptor-binding and fusogenic functions. In herpesviruses, these functions are distributed among multiple proteins: the conserved fusion protein gB, various non-conserved receptor-binding proteins, and the conserved gH/gL heterodimer that curiously lacks an apparent counterpart in other enveloped viruses. Recent structural studies of gH/gL from HSV-2 and EBV revealed a unique complex with no structural or functional similarity to other viral proteins. Here we analyzed gH/gL structures and highlighted important functional regions. We propose that gH/gL functions as an adaptor that transmits the triggering signals from various non-conserved inputs to the highly conserved fusion protein gB.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

1DP20D001996/DP/NCCDPHP CDC HHS/United States
DP2 OD001996/OD/NIH HHS/United States

Supporting Files:

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