Details:

Alternative Title:
Curr Opin Virol
Personal Author:
Stampfer, Samuel D. ; Heldwein, Ekaterina E.
Stampfer, Samuel D. ; Heldwein, Ekaterina E. Less -
Description:
Enveloped viruses enter cells by fusing the viral and cellular membranes, and most use a single viral envelope protein that combines receptor-binding and fusogenic functions. In herpesviruses, these functions are distributed among multiple proteins: the conserved fusion protein gB, various non-conserved receptor-binding proteins, and the conserved gH/gL heterodimer that curiously lacks an apparent counterpart in other enveloped viruses. Recent structural studies of gH/gL from HSV-2 and EBV revealed a unique complex with no structural or functional similarity to other viral proteins. Here we analyzed gH/gL structures and highlighted important functional regions. We propose that gH/gL functions as an adaptor that transmits the triggering signals from various non-conserved inputs to the highly conserved fusion protein gB.
Subject:
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Article
Herpesvirus 2, Human
Herpesvirus 4, Human
Humans
Models, Biological
Models, Molecular
Protein Conformation
Protein Multimerization
Viral Envelope Proteins
Virus Internalization

Source:
Curr Opin Virol. 2012; 3(1):13-19
Pubmed ID:
23107819
Pubmed Central ID:
PMC3562363
Document Type:
Journal Article
Funding:
DP2 OD001996/OD/NIH HHS/United States ; 1DP20D001996/DP/NCCDPHP CDC HHS/United States
DP2 OD001996/OD/NIH HHS/United States ; 1DP20D001996/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:b556ee80f260fc7562855ba9808320759d14875b0048ced82e95b4aecffbc61e
File Type:

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