Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Murakami, Shin ; Kitamura, Tomoya ; Suzuki, Jin ; Sato, Ryouta ; Aoi, Toshiki ; Fujii, Marina ; Matsugo, Hiromichi ; Kamiki, Haruhiko ; Ishida, Hiroho ; Takenaka-Uema, Akiko ; Shimojima, Masayuki ; Horimoto, Taisuke
• Description:
  Epidemiology of bat Betacoronavirus, subgenus Sarbecovirus is largely unknown, especially outside China. We detected a sarbecovirus phylogenetically related to severe acute respiratory syndrome coronavirus 2 from Rhinolophus cornutus bats in Japan. The sarbecovirus' spike protein specifically recognizes angiotensin-converting enzyme 2 of R. cornutus, but not humans, as an entry receptor.
• Subjects:
  Angiotensin-Converting Enzyme 2 / Metabolism Animals Betacoronavirus Chiroptera/virology Coronavirus Infections Coronavirus Infections/veterinary COVID-19 HEK293 Cells Humans Phylogeny SARS-CoV-2 Spike Glycoprotein, Coronavirus Virus Internalization

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• Source:
  Emerg Infect Dis. 26(12):3025-3029
• Pubmed ID:
  33219796
• Pubmed Central ID:
  PMC7706965
• Document Type:
  Journal Article
• Place as Subject:
  Japan
• Location:
  Asia
• Volume:
  26
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ebc8548c89ff92656970112aeb8be977d18f9a788e8d01891b941f8396f33c81
• Download URL:
  https://stacks.cdc.gov/view/cdc/98453/cdc_98453_DS1.pdf
• File Type:
  [PDF - 3.18 MB ]