Molecular Determinants of Dengue Virus 2 Envelope Protein Important for Virus Entry in FcγRIIA-Mediated Antibody-Dependent Enhancement of Infection

Chotiwan, Nunya; Roehrig, John T.; Schlesinger, Jacob J.; Blair, Carol D.; Huang, Claire Y.-H.

doi:10.1016/j.virol.2014.03.031

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Molecular Determinants of Dengue Virus 2 Envelope Protein Important for Virus Entry in FcγRIIA-Mediated Antibody-Dependent Enhancement of Infection

Published Date:

Apr 18 2014

Publisher's site:

http://dx.doi.org/10.1016/j.virol.2014.03.031 New Site Icon

Source:

Virology. 0:238-246.

[PDF-868.49 KB]

Details:

Personal Authors:

Chotiwan, Nunya ; Roehrig, John T. ; Schlesinger, Jacob J. ; Blair, Carol D. ; Huang, Claire Y.-H. ;

Keywords:

[+]

Pubmed ID:

24889243

Pubmed Central ID:

PMC4583201

Description:

Antibody-dependent enhancement (ADE) of infection may cause severe illness in patients suffering a secondary infection by a heterologous dengue virus (DENV) serotype. During ADE of infection, cross-reactive non- or poorly-neutralizing antibodies form infectious virus-Ab complexes with the newly infecting serotype and enhance virus infection by binding to the Fcγ receptors (FcγR) on FcγR-bearing cells. In this study, we determined that molecular determinants of DENV2 envelope protein critical for virus entry during non-ADE infection are also required for ADE infection mediated by FcγRIIA, and binding of virus-Ab complexes with FcγRIIA alone is not sufficient for ADE of infection. The FcγRIIA mainly plays an auxiliary role in concentrating the virus-Ab complex to the cell surface, and other primary cellular receptors are required for virus entry. Understanding the viral entry pathway in ADE of DENV infection will greatly facilitate rational designs of anti-viral therapeutics against severe dengue disease associated with ADE.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Main Document Checksum:

[+]

Supporting Files:

	nihms-724193.nxml	application/octet-stream
	nihms-724193-f0001.gif	image/gif
	nihms-724193-f0001.jpg	image/jpeg
	nihms-724193-f0002.gif	image/gif
	nihms-724193-f0002.jpg	image/jpeg
	nihms-724193-f0003.gif	image/gif
	nihms-724193-f0003.jpg	image/jpeg
	nihms-724193-f0004.gif	image/gif
	nihms-724193-f0004.jpg	image/jpeg

No Related Documents.

You May Also Like:

Development of a Humanized Antibody with High Therapeutic Potential against Dengue Virus Type 2

Personal Author:

Li, Pi-Chun; Liao, Mei-Ying; Cheng, Ping-Chang; Liang, Jian-Jong; Liu, I-Ju; Chiu, Chien-Yu; Lin, Yi-Ling; Chang, Gwong-Jen J.; Wu, Han-Chung;

Published:

May 01 2012

Source:

PLoS Negl Trop Dis. 2012; 6(5).

Description:

Background : Dengue virus (DENV) is a significant public health threat in tropical and subtropical regions of the world. A therapeutic antibody against the viral envelope (E) protein represents a promising immunotherapy for disease control. : Methodo...

File Type:

[PDF - 2.31 MB]
Development and Evaluation of an Enzyme-Linked Immunosorbent Assay for Dengue Capsid

Personal Author:

Selvarajah, Suganya; Chatterji, Udayan; Kuhn, Richard; Kinney, Richard; Vasudevan, Subhash G; Gallay, Philippe;

Published:

Mar 29 2012

Source:

Open Virol J. 2012; 6:29-37.

Description:

The astonishing speed with which Dengue has spread across the world and the severity of its infection make Dengue a prime threat to human life worldwide. Unfortunately, to date there are no effective vaccines or treatments against Dengue. Since only ...

File Type:

[PDF - 2.36 MB]
Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement

Personal Author:

Hughes, Holly R; Crill, Wayne D; Chang, Gwong-Jen J;

Published:

Jun 18 2012

Source:

Virol J. 2012; 9:115.

Description:

Background : Dengue viruses (DENV) are the most important arboviruses of humans and cause significant disease. Infection with DENV elicits antibody responses to the envelope glycoprotein, predominantly against immunodominant, cross-reactive, weakly-n...

File Type:

[PDF - 677.43 KB]
Dengue Hemorrhagic Fever in Infants: Research Opportunities Ignored

Personal Author:

Halstead, Scott B.; Lan, Nguyen Trong; Myint, Thein Thein; Shwe, Than Nu; Nisalak, Ananda; Kalyanarooj, Siripen; Nimmannitya, Suchitra; Soegijanto, Soegeng; Vaughn, David W.; Endy, Timothy P.;

Published:

Dec 2002

Source:

Emerg Infect Dis. 8(12):1474-1479.

Description:

The age distribution of cases of dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) in infants under the age of 1 year are reported from Bangkok, Thailand, and for the first time for Ho Chi Minh City, Vietnam; Yangon, Myanmar; and Surabaya,...

File Type:

[PDF - 1.04 MB]
The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system

Personal Author:

Clark, David C.; Brault, Aaron C.; Hunsperger, Elizabeth;

Published:

May 17 2012

Source:

Arch Virol. 157(8):1423-1440.

Description:

Members of the genus Flavivirus are responsible for a spectrum of important neurological syndromes in humans and animals. Rodent models have been used extensively to model flavivirus neurological disease, to discover host-pathogen interactions that i...

File Type:

[PDF - 225.16 KB]