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CDC Public Access
Items in this collection are manuscripts and articles written by CDC or CDC-funded authors, and published in scholarly journals outside CDC. These items are available in compliance with the 2024 update of CDC-GA-2013-01 CDC Public Access to CDC-Funded Publications, available at: https://stacks.cdc.gov/view/cdc/159734.
We have recently demonstrated an essential role of the domain of 145-150 amino acid in the E2 glycoprotein of Sindbis virus in the interaction with cellular heparan sulfate (HS) and in the infection of mouse embryonic fibroblasts (MEF) cells. In this study, we constructed and characterized the mutants of Sindbis-like virus XJ-160 in which Tyr-146 a
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Serovar identification of clinical isolates of Leptospira is generally not performed on a routine basis, yet the identity of an infecting serovar is valuable from both epidemiologic and public health standpoints. Only a small number of reference laboratories worldwide have the capability to perform the cross agglutinin absorption test (CAAT), the r
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Human infections with subtype H7 avian influenza viruses have been reported as early as 1979. In 1996, a genetically stable 24-nucleotide deletion emerged in North American H7 influenza virus hemagglutinins, resulting in an eight amino acid deletion in the receptor-binding site. The continuous circulation of these viruses in live bird markets, as w
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BackgroundAutism is a common heritable neurodevelopmental disorder with complex etiology. Several genome-wide linkage and association scans have been carried out to identify regions harboring genes related to autism or autism spectrum disorders, with mixed results. Given the overlap in autism features with genetic abnormalities known to be associat
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Sep 2010
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Influenza Other Respir Viruses. 4(5):259-266.
We investigated the first known outbreak of pandemic 2009 influenza A (H1N1) at a primary school in China.|To describe epidemiologic findings, identify risk factors associated with 2009 H1N1 illness, and inform national policy including school outbreak control and surveillance strategies.|We conducted retrospective case finding by reviewing the sch
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An increased prevalence of autoimmune diseases in family members of children with autism spectrum disorders (ASD) has been previously reported. ASD is also a common problem co-occurring in children with fragile X syndrome (FXS). Why ASD occurs in some individuals with FXS, but not all, is largely unknown. Furthermore, in premutation carrier mothers
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Background. The Hispanic population in the United States is growing, and disparities in the receipt of healthcare services as a result of limited English proficiency have been demonstrated. We set out to determine if Spanish language preference was a barrier to receiving influenza vaccinations among Hispanic persons 65 years and older in the USA. M
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OBJECTIVETo estimate allele frequencies and the marginal and combined effects of novel fasting glucose (FG)-associated single nucleotide polymorphisms (SNPs) on FG levels and on risk of impaired FG (IFG) among non-Hispanic white, non-Hispanic black, and Mexican Americans.RESEARCH DESIGN AND METHODSDNA samples from 3,024 adult fasting participants i
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BackgroundMutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes of Plasmodium falciparum are associated with resistance to anti-folate drugs, most notably sulphadoxine-pyrimethamine (SP). Molecular studies document the prevalence of these mutations in parasite populations across the African continent. However, th
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BackgroundThe current study was undertaken to determine the optimal wash-drying regimen and the effects of different washing procedures on the efficacy, and durability of four brands of newly introduced long-lasting insecticide-treated nets (LLINs) under tropical conditions.MethodsIn the current study, the following four LLINs were tested: Olyset®,
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BackgroundMale circumcision has been shown to reduce the transmission of HIV from women to men through vaginal sex by approximately 60%. There is concern that men may engage in risk compensation after becoming circumcised, diminishing the benefits of male circumcision.Methods and FindingsWe conducted qualitative interviews with 30 sexually active c
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Aug 25 2010
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Environ Health Perspect. 118(12):1748-1754.
BackgroundPhthalates are metabolized and eliminated in urine within hours after exposure. Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months.ObjectivesWe examined inter- and intraperson and inter- and intraday variability in
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BackgroundSubstance use during sex is associated with sexual risk behavior among men who have sex with men (MSM), and MSM continue to be the group at highest risk for incident HIV in the United States. The objective of this study is to test the efficacy of a group-based, cognitive-behavioral intervention to reduce risk behavior of substance-using M
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BackgroundThe association between HIV infection and invasive cervical cancer that has been reported may reflect differential prevalence of human papillomavirus (HPV) infection or uncontrolled confounding. We conducted a case-control study in a West African population to assess the relationship between HIV infection and invasive cervical cancer, tak
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Botulinum neurotoxins (BoNTs) are extremely potent toxins that are capable of causing respiratory failure leading to long-term intensive care or death. The best treatment for botulism includes serotype-specific antitoxins, which are most effective when administered early in the course of the intoxication. Early confirmation of human exposure to any
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International Circumpolar Surveillance (ICS) is a population-based surveillance system for invasive bacterial diseases established in the US Arctic, Northern Canada, Greenland, Iceland, Norway, Finland, and Northern Sweden Data collection began in 1999 and includes information on disease caused by Streptococcus pneumoniae, Haemophilus influenzae, N
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International Circumpolar Surveillance (ICS) is a population-based surveillance system for invasive bacterial diseases established in the US Arctic, Northern Canada, Greenland, Iceland, Norway, Finland, and Northern Sweden Data collection began in 1999 and includes information on disease caused by Streptococcus pneumoniae, Haemophilus influenzae, N
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OBJECTIVEWe examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes.RESEARCH DESIGN AND METHODSIndividuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years.RESULTSAmong the 1,850 diabetic parti
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Aug 05 2010
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Am J Epidemiol. 2010; 172(5):517-524.
Recent emphasis on translational research (TR) is highlighting the role of epidemiology in translating scientific discoveries into population health impact. The authors present applications of epidemiology in TR through 4 phases designated T1-T4, illustrated by examples from human genomics. In T1, epidemiology explores the role of a basic scientifi
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