Details:

Alternative Title:
Hum Genet
Publisher's site:
http://dx.doi.org/10.1007/s00439-010-0882-8
Personal Author:
Chonchaiya, Weerasak ; Tassone, Flora ; Ashwood, Paul ; Hessl, David ; Schneider, Andrea ; ... More +
Chonchaiya, Weerasak ; Tassone, Flora ; Ashwood, Paul ; Hessl, David ; Schneider, Andrea ; Campos, Luis ; Nguyen, Danh V. ; Hagerman, Randi J. Less -
Description:
An increased prevalence of autoimmune diseases in family members of children with autism spectrum disorders (ASD) has been previously reported. ASD is also a common problem co-occurring in children with fragile X syndrome (FXS). Why ASD occurs in some individuals with FXS, but not all, is largely unknown. Furthermore, in premutation carrier mothers, there is an increased risk for autoimmune diseases. This study compared the rate of ASD and other neurodevelopmental/behavioral problems in 61 children with FXS born to 41 carrier mothers who had autoimmune disease and in 97 children with FXS of 78 carrier mothers who did not have autoimmune disease. There were no significant differences in the mean age (9.61 ± 5.59 vs. 9.41 ± 6.31, P = 0.836), cognitive and adaptive functioning in children of mothers with and without autoimmune disease. Among children whose mothers had autoimmune disease, the odds ratio (OR) for ASD was 1.27 (95% CI 0.62-2.61, P = 0.5115). Interestingly, the OR for seizures and tics was 3.81 (95% CI 1.13-12.86, P = 0.031) and 2.94 (95% CI 1.19-7.24, P = 0.019), respectively, in children of mothers with autoimmune disease compared to children of mothers without autoimmune disease. In conclusion, autoimmune disease in carrier mothers was not associated with the presence of ASD in their children. However, seizures and tics were significantly increased in children of mothers with autoimmune disease. This suggests a potential new mechanism of seizure and tic exacerbation in FXS related to an intergenerational influence from autoimmunity in the carrier mother.
Subject:
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Adolescent Adult Aged Autoimmune Diseases Child Child, Preschool Child Development Disorders, Pervasive Comorbidity Conduct Disorder Female Fragile X Mental Retardation Protein Fragile X Syndrome Humans Infant Male Middle Aged Mothers Original Investigation RNA, Messenger Seizures Young Adult
Source:
Hum Genet. 128(5):539-548.
Pubmed ID:
20809278
Pubmed Central ID:
PMC2955238
Document Type:
Journal Article
Funding:
90DD05969/DD/NCBDD CDC HHS/United States ; AG032115/AG/NIA NIH HHS/United States ; AG032119/AG/NIA NIH HHS/United States ; DA024854/DA/NIDA NIH HHS/United States ; DE019583/DE/NIDCR NIH HHS/United States ; ... More +
90DD05969/DD/NCBDD CDC HHS/United States ; AG032115/AG/NIA NIH HHS/United States ; AG032119/AG/NIA NIH HHS/United States ; DA024854/DA/NIDA NIH HHS/United States ; DE019583/DE/NIDCR NIH HHS/United States ; HD02274/HD/NICHD NIH HHS/United States ; HD036071/HD/NICHD NIH HHS/United States ; MH77554/MH/NIMH NIH HHS/United States ; R01 HD036071/HD/NICHD NIH HHS/United States ; RL1 AG032115/AG/NIA NIH HHS/United States ; UL1RR024146/RR/NCRR NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a034156f5ad9aa554739810668b969852b9bc79cf3bad21227fcfa2addea0dcf
Download URL:
https://stacks.cdc.gov/view/cdc/22866/cdc_22866_DS1.pdf
File Type:

Supporting Files

• 	439_2010_Article_882.nxml	txt
  	license.txt	txt

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