Effect of Intrauterine Diabetes Exposure on the Incidence of End-Stage Renal Disease in Young Adults With Type 2 Diabetes

Details

• Alternative Title:
  Diabetes Care
• Personal Author:
  Pavkov, Meda E. ; Hanson, Robert L. ; Knowler, William C. ; Sievers, Maurice L. ; Bennett, Peter H. ; Nelson, Robert G.
• Description:
  OBJECTIVE
  
  We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes.
  
  RESEARCH DESIGN AND METHODS
  
  Individuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years.
  
  RESULTS
  
  Among the 1,850 diabetic participants, 102 had IDE. ESRD developed in 57, 5 of whom had IDE. Cumulative incidence of ESRD by age 45 was 19.3% in participants with IDE and 5.1% in those without; the age- and sex-adjusted incidence rate ratio was 4.12 (95% CI 1.54–11.02). After additional adjustment for age at diabetes onset, ESRD incidence was similar in the two groups (incidence rate ratio 1.38, 95% CI 0.45–4.24).
  
  CONCLUSIONS
  
  IDE increases the age- and sex-adjusted incidence of ESRD fourfold in young adults with type 2 diabetes, mediated primarily by the earlier onset of type 2 diabetes in those with IDE.
  
  
• Subjects:
  Adult Diabetes Mellitus, Type 2 Female Humans Kidney Failure, Chronic Original Research Pregnancy Prenatal Exposure Delayed Effects Young Adult
• Source:
  Diabetes Care. 33(11):2396-2398.
• Document Type:
  Journal Article
• Volume:
  33
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6d850dbb90164cc59f841bd4985191dd5b9dca7d4cd9742063e54570268c8943
• Download URL:
  https://stacks.cdc.gov/view/cdc/4404/cdc_4404_DS1.pdf
• File Type:
  [PDF - 86.54 KB ]