Details:

Alternative Title:
Diabetes Care
Personal Author:
Pavkov, Meda E. ; Hanson, Robert L. ; Knowler, William C. ; Sievers, Maurice L. ; Bennett, Peter H. ; ... More +
Pavkov, Meda E. ; Hanson, Robert L. ; Knowler, William C. ; Sievers, Maurice L. ; Bennett, Peter H. ; Nelson, Robert G. Less -
Description:
OBJECTIVE

We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes.

RESEARCH DESIGN AND METHODS

Individuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years.

RESULTS

Among the 1,850 diabetic participants, 102 had IDE. ESRD developed in 57, 5 of whom had IDE. Cumulative incidence of ESRD by age 45 was 19.3% in participants with IDE and 5.1% in those without; the age- and sex-adjusted incidence rate ratio was 4.12 (95% CI 1.54–11.02). After additional adjustment for age at diabetes onset, ESRD incidence was similar in the two groups (incidence rate ratio 1.38, 95% CI 0.45–4.24).

CONCLUSIONS

IDE increases the age- and sex-adjusted incidence of ESRD fourfold in young adults with type 2 diabetes, mediated primarily by the earlier onset of type 2 diabetes in those with IDE.


Subject:
[+]
Adult
Diabetes Mellitus, Type 2
Female
Humans
Kidney Failure, Chronic
Original Research
Pregnancy
Prenatal Exposure Delayed Effects
Young Adult

Source:
Diabetes Care. 33(11):2396-2398.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:6d850dbb90164cc59f841bd4985191dd5b9dca7d4cd9742063e54570268c8943
File Type:

Supporting Files

• 	license.txt	txt
  	zdc0111085340001.gif	gif
  	zdc0111085340001.jpg	jpeg
  	zdc2396.nxml	txt

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