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Showing 47001 - 47020 of 82803 results
  • TCDDInduced Degradation of Ah Receptor by the UbiquitinProteasome Pathway
    TCDD-Induced Degradation of Ah Receptor by the Ubiquitin-Proteasome Pathway
    Baldwin KT ;
    Ma Q
    2000/03/26 | National Institute for Occupational Safety and Health (NIOSH)
    The aryl hydrocarbon receptor (AhA), a ligand-activated Bhlh/PAS transcription factor, mediates a broad range of biological responses to halogenated aromatic hydrocarbons. TCDD, a potent agonist for AhA, induces a rapid reduction of the steady state AhA. In this study, we analyzed the mechanism of the agonist-induced down regulation of AhA. We show ...
    Public Domain
  • Diagnostic Immunobiochemistry Interpretation and Reproducibility of FDACleared Diagnostic Immunoassays for Latex Allergy
    Diagnostic Immunobiochemistry: Interpretation and Reproducibility of FDA-Cleared Diagnostic Immunoassays for Latex Allergy
    Biagini, Raymond E. ;
    Hamilton, Robert G.
    2000/03/26 | National Institute for Occupational Safety and Health (NIOSH)
    The absence of an FDA-licensed Hevea brasiliensis latex extract in the USA has restricted its use and serological tests have become critically important as diagnostic tools (JACI, 103:925-930, 1999). Three manufacturers (Pharmacia-UpJohn [CAP], Diagnostic Products Corporation [Ala] and HYCOR Biomedical [HY]) currently have FDA clearance for their i ...
    Public Domain
  • Clinical Biological Monitoring Using Immunobiochemical Methods
    Clinical Biological Monitoring Using Immunobiochemical Methods
    Biagini, Raymond E. ;
    Hines CJ
    2000/03/26 | National Institute for Occupational Safety and Health (NIOSH)
    Monitoring of urinary metabolites from pesticide applicators' has been routinely used in NIOSH field studies. Commercially available enzyme linked immunosorbant assays (ELISAs) have been successfully used for screening. Currently we are investigating immunochemical biological monitoring methods for organophosphate pesticides including chlorpyrifos. ...
    Public Domain
  • 23 78TetrachlorodibenzoPDioxinInduced Degradation of Aryl Hydrocarbon Receptor AhR by the UbiquitinProteasome Pathway Role of the Transcription Activaton and DNA Binding of AhR
    2,3, 7,8-Tetrachlorodibenzo-P-Dioxin-Induced Degradation of Aryl Hydrocarbon Receptor (AhR) by the Ubiquitin-Proteasome Pathway: Role of the Transcription Activaton and DNA Binding of AhR
    Baldwin KT ;
    Ma Q
    2000/03/24 | National Institute for Occupational Safety and Health (NIOSH)
    Activation of the aryl hydrocarbon receptor (AhR) by 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD), a potent agonist of AhR, induces a marked reduction in steady state AhR. To analyze the mechanism of regulation of ligand-activated AhR, we examined the biochemical pathway and function of the down-regulation of the receptor by TCDD. Pulse-chase experi ...
    Public Domain
  • Sewer maintenance worker killed by nozzle tip on jetvac hose
    Sewer maintenance worker killed by nozzle tip on jet/vac hose
    Etre, Lois A. ;
    Johnson, Wayne
    2000/03/23 | Fatality Assessment and Control Evaluation Reports (FACE)
    On August 6, 1999, a 29 year old male public works employee died when he was struck by the nozzle of a high pressure water hose. Two employees were doing routine cleaning of the sanitary sewer line using a combination jet/vac truck equipped with a water-powered hose and nozzle. The nozzle somehow came back up through the manhole and struck the vict ...
  • Heavy Equipment Operator Pinned After Bulldozer Slides off Flatbed Trailer
    Heavy Equipment Operator Pinned After Bulldozer Slides off Flatbed Trailer
    Wisconsin Fatality Assessment and Control Evaluation Program (Wisconsin FACE)  ...
    2000/03/22 | Fatality Assessment and Control Evaluation Reports (FACE)
    A 45-year-old male supervisor (the victim) for an excavation construction company was loading a Caterpillar D4 bulldozer to return it to the company shop when it slid sideways as he pulled it onto a flatbed trailer attached to a truck. The truck and trailer were parked with the right wheels on the sloped shoulder of the road, and the left wheels on ...
  • 16yearold Farmworker Dies in a Cotton Packing Machine After Being Covered with a Load of CottonGeorgia
    16-year-old Farmworker Dies in a Cotton Packing Machine After Being Covered with a Load of Cotton--Georgia
    National Institute for Occupational Safety and Health. Fatality Assessment and Control Evaluation (FACE) Program
    2000/03/21 | Fatality Assessment and Control Evaluation Reports (FACE)
    On November 22, 1999, a 16-year-old male farmworker (the victim) died in a cotton packing machine after a load of cotton was dumped on top of him, causing compression asphyxiation and suffocation. Prior to the incident, the victim had been riding with a coworker who was operating a cotton picker. When the picker was nearly full of cotton, the picke ...
    Public Domain
  • Sex Differences in Principal Farm Operators Tractor Driving Safety Beliefs and Behaviors
    Sex Differences in Principal Farm Operators’ Tractor Driving Safety Beliefs and Behaviors
    Browning SR ;
    Cole, Henry P.
    2000/03/20 | National Institute for Occupational Safety and Health (NIOSH)
    Objective: to examine the widely accepted hypothesis that farm women are more concerned with safety issues and behaviors than their male counterparts are. Methods: A telephone survey was administered to a random sample of Kentucky principal farm operators, 90 of whom were women. Participants were questioned about their tractor safety beliefs and pr ...
  • Maintainability Design Checklist
    Maintainability Design Checklist
    National Institute for Occupational Safety and Health. Pittsburgh Research Laboratory
    03/20/2000 | National Institute for Occupational Safety and Health (NIOSH)
    The following is a Maintainability Design Checklist for coal mining equipment. The purpose of the checklist is to provide a summary of design review points for the maintainability assessment of new or existing underground equipment. It specifically focuses on the identification of equipment design features, tasks, or procedures that impact equipmen ...
    Public Domain
  • Fire Fighter Dies as a Result of a Cardiac Arrest During a Trench Rescue Georgia
    Fire Fighter Dies as a Result of a Cardiac Arrest During a Trench Rescue – Georgia
    Sexson, Kristen
    2000/03/20 | Fire Fighter Fatality Investigation and Prevention Program (FFFIPP)
    Death in the Line of Duty…a Summary of a NIOSH Fire Fighter Fatality InvestigationOn May 14, 1999, a 47-year-old male fire fighter collapsed while assisting with command at a trench rescue. After being on scene for approximately 60 minutes, the fire fighter collapsed. Despite cardiopulmonary resuscitation (CPR) and advanced life support (ALS) admin ...
    Public Domain
  • Farm Youth Suffocated in Corn Bin
    Farm Youth Suffocated in Corn Bin
    Hetzler, William E. ;
    Hirsh, Gary L.
    2000/03/17 | Fatality Assessment and Control Evaluation Reports (FACE)
    A 15-year-old male was killed while working on the family farm. He had crawled into a 20,000 bushel corn bin, through a door on the top. He had gone in to scoop corn away from the front lower door of the grain bin so a sweep auger could be installed. The bin had corn in it which sloped from the sides to the center take-out. The center take-out area ...
  • Three Tower Painters Die After Falling 1200 Feet When Riding the Hoist Line North Carolina
    Three Tower Painters Die After Falling 1,200 Feet When Riding the Hoist Line - North Carolina
    National Institute for Occupational Safety and Health. Fatality Assessment and Control Evaluation (FACE) Program
    2000/03/16 | Fatality Assessment and Control Evaluation Reports (FACE)
    A 40-year-old tower-painting-company owner, his 10-year-old stepson, and a 19-year-old employee died after falling 1,200 feet when the hoist line on a portable capstan hoist used to raise them up the side of a 1,500-foot -high radio tower began slipping around the capstan, causing the hoist operator to lose control of the hoist line. The company ha ...
    Public Domain
  • Volunteer Fire Fighter Killed During WildlandField Fire Indiana
    Volunteer Fire Fighter Killed During Wildland/Field Fire – Indiana
    Braddee, Richard W. ;
    Romano, Nancy T.
    2000/03/16 | Fire Fighter Fatality Investigation and Prevention Program (FFFIPP)
    Death in the Line of Duty…a Summary of a NIOSH Fire Fighter Fatality InvestigationOn September 15, 1999, a 31-year-old female volunteer fire fighter (the victim) died after being struck by an engine at the scene of a wildland/field fire. The victim was part of an initial-attack fire fighting crew which had been dispatched to a 430-acre wildland/fie ...
    Public Domain
  • Construction Contractor Killed by Fall from a Ladder Washington State
    Construction Contractor Killed by Fall from a Ladder -- Washington State
    Washington (State). Fatality Assessment and Control Evaluation (WA FACE)  ...
    2000/03/16 | Fatality Assessment and Control Evaluation Reports (FACE)
    On April 21, 1998, a 59-year-old painter/independent contractor (the victim) died of injuries after he fell while working from a metal extension ladder. The victim was working alone on a 90-foot by 20-foot addition to a farm equipment storage building. The building was metal roofed with closed sides and back, and open in the front. The building sat ...
  • Effects of Asphalt Fume Condensate AFC Exposure on the Pulmonary Cytochrome P450 CYP450 System
    Effects of Asphalt Fume Condensate (AFC) Exposure on the Pulmonary Cytochrome P450 (CYP450) System
    Barger M ;
    Castranova, Vincent
    2000/03/15 | National Institute for Occupational Safety and Health (NIOSH)
    Exposure to asphalt fumes is a concern due to the presence of polycyclic aromatic hydrocarbons (PAH) in asphalt. Bioactivation of many PAH requires metabolism by the CYP450 system. The objective of this study was to evaluate the effects of exposure of rats to AFC on the pulmonary CYP450 system. Rats were intratracheally instilled with saline, 0.1, ...
    Public Domain
  • Nitric Oxide UpRegulates DNABinding Activity of Nuclear FactorkB in Macrophages Stimulated with Silica and Inflammatory Stimulants
    Nitric Oxide Up-Regulates DNA-Binding Activity of Nuclear Factor-kB in Macrophages Stimulated with Silica and Inflammatory Stimulants
    Castranova, Vincent ;
    Kang JL
    2000/03/15 | National Institute for Occupational Safety and Health (NIOSH)
    Nitric oxide (NO), a reactive nitrogen species, plays an important role in inflammatory lung damage. In the present study, we investigated the role of NO in DNA-binding activity of NF-kappaB in macrophages stimulated with silica or other inflammatory stimulants. Treatment of mouse macrophages (RAW264.7 cells) with a selective inhibitor of inducible ...
    Public Domain
  • Effects of Thyroid Status on Lung Damage and Activities of Lung Phagocytes Under Basal Conditions and Following LPS Exposure
    Effects of Thyroid Status on Lung Damage and Activities of Lung Phagocytes Under Basal Conditions and Following LPS Exposure
    Frazer DG ;
    Goldsmith WT
    2000/03/15 | National Institute for Occupational Safety and Health (NIOSH)
    The objectives of this investigation were to study the effects of hypo- and hyperthyroidism on lung cell damage and the activity of lung phagocytes under basal conditions and during inflammatory responses induced by exposure to lipopolysaccharide (LPS). Thyroid status is adult male rats was altered by thyroidectomy or thyroxine injections for 15 da ...
    Public Domain
  • AgeDependent Effects of Ozone on Substance PInnervation in Airways of Postnatal Rats
    Age-Dependent Effects of Ozone on Substance P-Innervation in Airways of Postnatal Rats
    Dey RD ;
    Fedan, Jeffery S.
    2000/03/15 | National Institute for Occupational Safety and Health (NIOSH)
    Exposure to airway irritants during early postnatal periods may contribute to asthma during childhood especially if the initial exposure occurs at critical periods of growth and development. Asthma in children is exacerbated by air pollution that may be partly attributed to neural mechanisms. This study examines the effects of ozone on SP nerve fib ...
    Public Domain
  • Lipopolysaccharide LPSInduced Alterations in Airway Smooth Muscle Reactivity to EpitheliumDerived Relaxing Factor EpDRF Are OsmolyteDependent
    Lipopolysaccharide (LPS)-Induced Alterations in Airway Smooth Muscle Reactivity to Epithelium-Derived Relaxing Factor (EpDRF) Are Osmolyte-Dependent
    Fedan, Jeffery S. ;
    Johnstonn RA
    2000/03/15 | National Institute for Occupational Safety and Health (NIOSH)
    Contractile and relaxant responses of guinea-pig tracheal smooth muscle can be measured in vitro using the isolated, perfused trachea (IPT) preparation, which allows agents to be added separately to the serosal (extraluminal; EL) or mucosal (intraluminal; IL) surfaces. In response to hyperosmolarity at the EL or IL surfaces, the epithelium releases ...
    Public Domain
  • Aryl Radicals from Arenediazonium Ions Induce AP1 In Vitro and In Vivo
    Aryl Radicals from Arenediazonium Ions Induce AP-1 In Vitro and In Vivo
    Daft J ;
    Gannett PM
    2000/03/15 | National Institute for Occupational Safety and Health (NIOSH)
    Agaricus bisporus the mushroom of commerce, contains genotoxic arylhydrazines and arenediazonium ions. In vitro, in cellular systems, and in vivo, arylhydrazines which are metabolically converted to arenediazonium ions and aryl radicals cause DNA damage that correlates with arylhydrazine or arenediazonium ion genotoxicity. The biochemical processes ...
    Public Domain
47001 - 47020 / 82803