Effects of Thyroid Status on Lung Damage and Activities of Lung Phagocytes Under Basal Conditions and Following LPS Exposure

Details

• Personal Author:
  Frazer DG ; Goldsmith WT ; Huffman LJ ; Judy DJ ; Rao KMK
• Description:
  The objectives of this investigation were to study the effects of hypo- and hyperthyroidism on lung cell damage and the activity of lung phagocytes under basal conditions and during inflammatory responses induced by exposure to lipopolysaccharide (LPS). Thyroid status is adult male rats was altered by thyroidectomy or thyroxine injections for 15 days. Rats were studied 18 h after inhalation exposures to air or to LPS (100 ug/ml; 3 h). In a hyperthyroid state alone, there was a greater degree of lung cell damage and alveolar-capillary barrier disruption, an incre3ase in the number of phagocytes which could be harvested from the lungs by bronchoalveolar lavage, and an increase in nitric oxide production by lung phagocytes. On the other hand, hypothyroidism alone was associated with opposite effects. Similar effects of thyroid status on lung cell damage and lung phagocytes were also observed following inhalation exposures to LPS. These results suggest that thyroid status can modulate the overall state of oxidant balance in mature lungs and that increased thyroid hormone levels are associated with pro-oxidant pulmonary effects. As a consequence of this, lung inflammatory reactions to LPS appear to be relatively more pronounced in a hyperthyroid state and less pronounced in a hypothyroid state. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Exposure Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal Studies Cell Damage Exposure Assessment Exposure Levels Inhalation Studies Laboratory Animals Lung Disorders Phagocytes Pulmonary System Disorders Respiratory System Disorders Thyroid Gland Thyroid Gland Disorders

  More +
• ISSN:
  0892-6638
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  4
• NIOSHTIC Number:
  nn:20020958
• Citation:
  FASEB J 2000 Mar; 14(4):A190
• CAS Registry Number:
  Nitric oxide (CAS RN 10102-43-9)
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  False
• Source Full Name:
  The FASEB Journal. Experimental Biology 2000, San Diego, California, April 15-18, 2000
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ce2e46f83061f374d1649d437bfa3bc271450cff042c7e211d436a380da0a6463395cce3900e9668cd2e8c2297a62058000dcc3e046b361a378a9f99ea17e82a
• Download URL:
  https://stacks.cdc.gov/view/cdc/198573/cdc_198573_DS1.pdf
• File Type:
  [PDF - 449.82 KB ]