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Using an Electronic Self-Administered Survey Among First Responders to Evaluate the Potential Human Health Effects of Hazardous Substances Released as a Result of a Train Derailment Incident-East Palestine, Ohio, USA, February-March 2023.

Crisp, Carolyn A. ;

Parasram, Vidisha D.

May 2025 | Disaster Medicine and Public Health Preparedness, 2025, v. 19

To understand the potential human health effects of exposure to hazardous substances among first responders from the East Palestine train derailment, an electronic self-administered Assessment of Chemical Exposures (ACE) survey was created and available to first responders between February-March 2023. Among the 339 completed responder surveys analy ...

10/09/2026

Supporting Files

Title : Using an Electronic Self-Administered Survey Among First Responders to Evaluate the Potential Human Health Effects of Hazardous Substances Released as a Result of a Train Derailment Incident-East Palestine, Ohio, USA, February-March 2023. Personal Author(s) : Crisp, Carolyn A.;Parasram, Vidisha D.;Shi, Dallas S.;Omari, Amel;Madera-Garcia, Valerie;Faherty, Emily A.G.;Dulcey, Melissa;Burr, Kathryn;Gichuhi, Beatrice;Goldsworthy, Lisa A.;Dowell, Chad H.;Chiu, Sophia K.;Dickerson, Kristen;Dewart, Courtney M.;Watkins, Sharon M.;Harduar-Morano, Laurel;Babich, Remy;Shugart, Jill;Orr, Maureen F.; Published Date : May 2025 Pages in Document : e121 (9 pdf pages) Source : Disaster Medicine and Public Health Preparedness, 2025, v. 19 DOI : https://doi.org/10.1017/dmp.2024.291 Journal Title : Disaster Medicine and Public Health Preparedness
Crisp, C. A., Parasram, V. D., Shi, D. S., Omari, A., Madera-Garcia, V., Faherty, E. A., Dulcey, M., Burr, K., Gichuhi, B., Goldsworthy, L. A., Dowell, C. H., Chiu, S. K., Dickerson, K., Dewart, C. M., Watkins, S. M., Harduar-Morano, L., Babich, R., Shugart, J., & Orr, M. F. (2025). Using an Electronic Self-Administered Survey Among First Responders to Evaluate the Potential Human Health Effects of Hazardous Substances Released as a Result of a Train Derailment Incident-East Palestine, Ohio, USA, February-March 2023. Disaster Medicine and Public Health Preparedness, 19. https://doi.org/10.1017/dmp.2024.291

Crisp, Carolyn A., Vidisha D. Parasram, Dallas S. Shi, Amel Omari, Valerie Madera-Garcia, Emily A.G. Faherty, and Melissa Dulcey, et al.. "Using an Electronic Self-Administered Survey Among First Responders to Evaluate the Potential Human Health Effects of Hazardous Substances Released as a Result of a Train Derailment Incident-East Palestine, Ohio, USA, February-March 2023." Disaster Medicine and Public Health Preparedness 19 (2025). https://doi.org/10.1017/dmp.2024.291.

Crisp, Carolyn A., et al. "Using an Electronic Self-Administered Survey Among First Responders to Evaluate the Potential Human Health Effects of Hazardous Substances Released as a Result of a Train Derailment Incident-East Palestine, Ohio, USA, February-March 2023." Disaster Medicine and Public Health Preparedness, vol. 19, 2025. Stacks. https://doi.org/10.1017/dmp.2024.291.
Export RIS Citation Information. TY - Journal Article AU - Crisp, Carolyn A. AU - Parasram, Vidisha D. AU - Shi, Dallas S. AU - Omari, Amel AU - Madera-Garcia, Valerie AU - Faherty, Emily A.G. AU - Dulcey, Melissa AU - Burr, Kathryn AU - Gichuhi, Beatrice AU - Goldsworthy, Lisa A. AU - Dowell, Chad H. AU - Chiu, Sophia K. AU - Dickerson, Kristen AU - Dewart, Courtney M. AU - Watkins, Sharon M. AU - Harduar-Morano, Laurel AU - Babich, Remy AU - Shugart, Jill AU - Orr, Maureen F. AB - To understand the potential human health effects of exposure to hazardous substances among first responders from the East Palestine train derailment, an electronic self-administered Assessment of Chemical Exposures (ACE) survey was created and available to first responders between February-March 2023. Among the 339 completed responder surveys analyzed, most reported working at least 1 day during the incident between February 3-8, 2023. Most (79%) reported inhaling, touching, or swallowing potentially harmful substances and did not report using a face mask or respirator while working (75%). Nearly half reported at least 1 new or worsening physical symptom after incident response. These findings support several recommendations to mitigate exposure to hazardous substances among first responders during future incidents, including using a hierarchy of controls framework to reduce exposure to hazards, timely communication of possible hazardous substances involved in the event, and using the Emergency Responder Health Monitoring Surveillance (ERHMS) framework. AB - Author manuscript AN - cdc:261400 C4 - PMC12628510 DO - https://doi.org/10.1017/dmp.2024.291 J2 - Disaster Medicine and Public Health Preparedness KW - Occupational Exposure KW - Surveys and Questionnaires KW - Railroads KW - Female KW - Chemical Hazard Release KW - Emergency Responders KW - Male KW - Middle Aged KW - Humans KW - Adult KW - Hazardous Substances KW - first responders KW - personal protective equipment KW - chemical exposure KW - occupational health KW - Emergency Responder Health Monitoring Surveillance (ERHMS) KW - Humans KW - Surveys and Questionnaires KW - Male KW - Adult KW - Hazardous Substances KW - Emergency Responders KW - Female KW - Railroads KW - Middle Aged KW - Occupational Exposure KW - Chemical Hazard Release LA - eng PY - 2025 T2 - Disaster Medicine and Public Health Preparedness T2 - Disaster Medicine and Public Health Preparedness, 2025, v. 19 TI - Using an Electronic Self-Administered Survey Among First Responders to Evaluate the Potential Human Health Effects of Hazardous Substances Released as a Result of a Train Derailment Incident-East Palestine, Ohio, USA, February-March 2023. VL - 19 UR - https://stacks.cdc.gov/view/cdc/261400 ER -
Mothers' Ideas About Causes of Autism Spectrum Disorder (ASD): Differences Over Time and by Household Experience With ASD.

Bradley, Chyrise B. ;

Ashner, Marissa C.

May 22, 2025 | Journal of Autism and Developmental Disorders, May 2025

To understand trends in mothers' causal ideas about autism spectrum disorder (ASD) that may be important in targeting education efforts for parents and healthcare providers, as these may be associated with healthcare choices. Data from the Study to Explore Early Development (SEED) was used to examine the causal ideas mothers had, sociodemographic c ...

10/09/2026

Supporting Files

Title : Mothers' Ideas About Causes of Autism Spectrum Disorder (ASD): Differences Over Time and by Household Experience With ASD. Personal Author(s) : Bradley, Chyrise B.;Ashner, Marissa C.;Kepner, Marti W.;Garcia, Tanya P.;Grosser, Kyle F.;Hightshoe, Kristina;Moody, Eric J.;Reyes, Nuri;Rosenberg, Steven A.;Tapia, Amanda L.;Daniels, Julie L.; Published Date : May 22, 2025 Pages in Document : 22 pdf pages Source : Journal of Autism and Developmental Disorders, May 2025 DOI : https://doi.org/10.1007/s10803-025-06862-4 Journal Title : Journal of Autism and Developmental Disorders
Bradley, C. B., Ashner, M. C., Kepner, M. W., Garcia, T. P., Grosser, K. F., Hightshoe, K., Moody, E. J., Reyes, N., Rosenberg, S. A., Tapia, A. L., & Daniels, J. L. (2025). Mothers' Ideas About Causes of Autism Spectrum Disorder (ASD): Differences Over Time and by Household Experience With ASD. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-025-06862-4

Bradley, Chyrise B., Marissa C. Ashner, Marti W. Kepner, Tanya P. Garcia, Kyle F. Grosser, Kristina Hightshoe, and Eric J. Moody, et al.. "Mothers' Ideas About Causes of Autism Spectrum Disorder (ASD): Differences Over Time and by Household Experience With ASD." Journal of Autism and Developmental Disorders (2025). https://doi.org/10.1007/s10803-025-06862-4.

Bradley, Chyrise B., et al. "Mothers' Ideas About Causes of Autism Spectrum Disorder (ASD): Differences Over Time and by Household Experience With ASD." Journal of Autism and Developmental Disorders, 2025. Stacks. https://doi.org/10.1007/s10803-025-06862-4.
Export RIS Citation Information. TY - Journal Article AU - Bradley, Chyrise B. AU - Ashner, Marissa C. AU - Kepner, Marti W. AU - Garcia, Tanya P. AU - Grosser, Kyle F. AU - Hightshoe, Kristina AU - Moody, Eric J. AU - Reyes, Nuri AU - Rosenberg, Steven A. AU - Tapia, Amanda L. AU - Daniels, Julie L. AB - To understand trends in mothers' causal ideas about autism spectrum disorder (ASD) that may be important in targeting education efforts for parents and healthcare providers, as these may be associated with healthcare choices. Data from the Study to Explore Early Development (SEED) was used to examine the causal ideas mothers had, sociodemographic characteristics associated with causal ideas, and whether reported ideas differed over time. SEED included 8307 mothers of pre-school children, with and without ASD, who completed a maternal phone interview between 2007 and 2020. Less than half of mothers (39.3%) offered a causal idea. The most frequently offered causal ideas were genetics, vaccines, environment, parent lifestyle issues, pre/peri-pregnancy maternal medical issues, labor/delivery experiences, and child diet. Some aspects of sociodemographic characteristics, particularly ethno-cultural background, were significantly associated with reporting several causal ideas. Odds of reporting vaccines decreased over time while odds of reporting genetics, parent lifestyle, maternal medical, or labor/delivery issues increased over time. There were significant differences in odds of reporting several causal ideas between those with and those without a child with ASD in the household. Causal ideas reported were consistent with prior research but important differences between those with and those without household ASD as well as significant time trends for certain causes were noted. Implications for public health communication and future research are discussed. AB - Author manuscript AN - cdc:261399 C4 - PMC12766908 DO - https://doi.org/10.1007/s10803-025-06862-4 J2 - Journal of Autism and Developmental Disorders KW - Health Communication KW - Life Style KW - Child KW - Delivery of Health Care KW - Female KW - Vaccines KW - Autism Spectrum Disorder KW - Parents KW - Health Personnel KW - Diet KW - Autism etiology (cause) KW - Parental perspectives KW - Lay beliefs KW - Ethnicity KW - Culture KW - Socioeconomic factors KW - Female KW - Child KW - Autism Spectrum Disorder KW - Health Communication KW - Health Personnel KW - Delivery of Health Care KW - Life Style KW - Vaccines KW - Parents KW - Diet LA - eng PY - 2025 T2 - Journal of Autism and Developmental Disorders T2 - Journal of Autism and Developmental Disorders, May 2025 TI - Mothers' Ideas About Causes of Autism Spectrum Disorder (ASD): Differences Over Time and by Household Experience With ASD. UR - https://stacks.cdc.gov/view/cdc/261399 ER -
Detection of Cancers Three Years Prior to Diagnosis Using Plasma Cell-Free DNA.

Wang, Yuxuan ;

Joshu, Corinne E.

September 2025 | Cancer Discovery, 2025, v. 15, no. 9

To explore how early cancers can be detected prior to clinical signs or symptoms, we assessed prospectively collected serial plasma samples from the Atherosclerosis Risk in Communities study, including 26 participants diagnosed with cancer and 26 matched controls. At the index time point, 8 of these 52 participants scored positively with a multican ...

10/09/2026

Supporting Files

Title : Detection of Cancers Three Years Prior to Diagnosis Using Plasma Cell-Free DNA. Personal Author(s) : Wang, Yuxuan;Joshu, Corinne E.;Curtis, Samuel D.;Douville, Christopher;Burk, Vernon A.;Ru, Meng;Popoli, Maria;Ptak, Janine;Dobbyn, Lisa;Silliman, Natalie;Coresh, Josef;Boerwinkle, Eric;Prizment, Anna;Bettegowda, Chetan;Kinzler, Kenneth W.;Papadopoulos, Nickolas;Platz, Elizabeth A.;Vogelstein, Bert; Published Date : September 2025 Pages in Document : 1794-1802 (18 pdf pages) Source : Cancer Discovery, 2025, v. 15, no. 9 DOI : https://doi.org/10.1158/2159-8290.CD-25-0375 Journal Title : Cancer Discovery
Wang, Y., Joshu, C. E., Curtis, S. D., Douville, C., Burk, V. A., Ru, M., Popoli, M., Ptak, J., Dobbyn, L., Silliman, N., Coresh, J., Boerwinkle, E., Prizment, A., Bettegowda, C., Kinzler, K. W., Papadopoulos, N., Platz, E. A., & Vogelstein, B. (2025). Detection of Cancers Three Years Prior to Diagnosis Using Plasma Cell-Free DNA. Cancer Discovery, 15(9). https://doi.org/10.1158/2159-8290.CD-25-0375

Wang, Yuxuan, Corinne E. Joshu, Samuel D. Curtis, Christopher Douville, Vernon A. Burk, Meng Ru, and Maria Popoli, et al.. "Detection of Cancers Three Years Prior to Diagnosis Using Plasma Cell-Free DNA." Cancer Discovery 15, no. 9 (2025). https://doi.org/10.1158/2159-8290.CD-25-0375.

Wang, Yuxuan, et al. "Detection of Cancers Three Years Prior to Diagnosis Using Plasma Cell-Free DNA." Cancer Discovery, vol. 15, no. 9, 2025. Stacks. https://doi.org/10.1158/2159-8290.CD-25-0375.
Export RIS Citation Information. TY - Journal Article AU - Wang, Yuxuan AU - Joshu, Corinne E. AU - Curtis, Samuel D. AU - Douville, Christopher AU - Burk, Vernon A. AU - Ru, Meng AU - Popoli, Maria AU - Ptak, Janine AU - Dobbyn, Lisa AU - Silliman, Natalie AU - Coresh, Josef AU - Boerwinkle, Eric AU - Prizment, Anna AU - Bettegowda, Chetan AU - Kinzler, Kenneth W. AU - Papadopoulos, Nickolas AU - Platz, Elizabeth A. AU - Vogelstein, Bert AB - To explore how early cancers can be detected prior to clinical signs or symptoms, we assessed prospectively collected serial plasma samples from the Atherosclerosis Risk in Communities study, including 26 participants diagnosed with cancer and 26 matched controls. At the index time point, 8 of these 52 participants scored positively with a multicancer early detection test. All eight participants were diagnosed with cancer within 4 months after blood collection. In six of these eight participants, we were able to assess an earlier plasma sample collected 3.1 to 3.5 years prior to clinical diagnosis. In four of these six participants, the same mutations detected by the multicancer early detection test could be identified but at 8.6- to 79-fold lower mutant allele fractions. These results demonstrate that it is possible to detect ctDNA more than 3 years prior to clinical diagnosis and provide benchmark sensitivities required for this purpose. AB - Earlier detection is a promising strategy to reduce cancer mortality. For cancers of all stages, therapies are more effective with a lower disease burden. In this study, we demonstrate that ctDNA is detectable 3 years or more before cancer diagnosis and provide estimates for the sensitivity required to achieve such very early detection. See related commentary by Crisafulli et al., p. 1774. AB - Author manuscript AN - cdc:261398 C4 - PMC12354160 DO - https://doi.org/10.1158/2159-8290.CD-25-0375 IS - 9 J2 - Cancer Discovery KW - Female KW - Prospective Studies KW - Aged KW - Early Detection of Cancer KW - Circulating Tumor DNA KW - Cell-Free Nucleic Acids KW - Neoplasms KW - Case-Control Studies KW - Male KW - Middle Aged KW - Humans KW - Biomarkers, Tumor KW - Mutation KW - Humans KW - Neoplasms KW - Male KW - Early Detection of Cancer KW - Female KW - Middle Aged KW - Aged KW - Circulating Tumor DNA KW - Cell-Free Nucleic Acids KW - Biomarkers, Tumor KW - Mutation KW - Prospective Studies KW - Case-Control Studies LA - eng PY - 2025 T2 - Cancer Discovery T2 - Cancer Discovery, 2025, v. 15, no. 9 TI - Detection of Cancers Three Years Prior to Diagnosis Using Plasma Cell-Free DNA. VL - 15 UR - https://stacks.cdc.gov/view/cdc/261398 ER -
Development of a New Framework to Address Public Health Ethical Considerations in Wastewater Surveillance.

West, Rachel ;

Moore, Jazmyn

November 17, 2025 | Journal of Public Health Management and Practice : JPHMP, 2025, v. 31, no. 4

Wastewater surveillance (WWS) provides valuable information about infectious disease trends in communities. The Centers for Disease Control and Prevention (CDC) created the National Wastewater Surveillance System (NWSS) in 2020 to coordinate and inform WWS programs in state, tribal, local, and territorial (STLT) health departments.1 As this system ...

10/09/2026

Supporting Files

Title : Development of a New Framework to Address Public Health Ethical Considerations in Wastewater Surveillance. Personal Author(s) : West, Rachel;Moore, Jazmyn;Chillag, Kata;Fenton, Elizabeth;Laird, Erin;Boyea, Alyssa; Corporate Authors(s) : Wastewater Ethical Framework Development Workgroup Published Date : November 17, 2025 Pages in Document : 683-685 (5 pdf pages) Source : Journal of Public Health Management and Practice : JPHMP, 2025, v. 31, no. 4 DOI : https://doi.org/10.1097/PHH.0000000000002167 Journal Title : Journal of Public Health Management and Practice : JPHMP
West, R., Moore, J., Chillag, K., Fenton, E., Laird, E., & Boyea, A. (2025). Development of a New Framework to Address Public Health Ethical Considerations in Wastewater Surveillance. Journal of Public Health Management and Practice : JPHMP, 31(4). https://doi.org/10.1097/PHH.0000000000002167

West, Rachel, Jazmyn Moore, Kata Chillag, Elizabeth Fenton, Erin Laird, and Alyssa Boyea. "Development of a New Framework to Address Public Health Ethical Considerations in Wastewater Surveillance." Journal of Public Health Management and Practice : JPHMP 31, no. 4 (2025). https://doi.org/10.1097/PHH.0000000000002167.

West, Rachel, et al. "Development of a New Framework to Address Public Health Ethical Considerations in Wastewater Surveillance." Journal of Public Health Management and Practice : JPHMP, vol. 31, no. 4, 2025. Stacks. https://doi.org/10.1097/PHH.0000000000002167.
Export RIS Citation Information. TY - Journal Article AU - West, Rachel AU - Moore, Jazmyn AU - Chillag, Kata AU - Fenton, Elizabeth AU - Laird, Erin AU - Boyea, Alyssa A2 - Wastewater Ethical Framework Development Workgroup AB - Wastewater surveillance (WWS) provides valuable information about infectious disease trends in communities. The Centers for Disease Control and Prevention (CDC) created the National Wastewater Surveillance System (NWSS) in 2020 to coordinate and inform WWS programs in state, tribal, local, and territorial (STLT) health departments.1 As this system grew from eight initial implementing partner jurisdictions to implementers in all 50 states, seven territories, and some tribal communities, so too did ethical questions and a need for clear, shared priorities for the WWS field. Geographic coverage and pathogen testing capabilities expanded quickly over time, emphasizing the need for a standard set of ethical priorities at a national level. These priorities are essential to ensure the responsible use of WWS data for public health action while addressing potential ethical risks. Academic, international, and independent implementers have previously defined ethical priorities and considerations for WWS.2-4 This foundation of work also highlighted the need for a practical, applied ethical framework for WWS that incorporates the perspectives of WWS expert groups. AB - Author manuscript AN - cdc:261397 C4 - PMC12610892 DO - https://doi.org/10.1097/PHH.0000000000002167 IS - 4 J2 - Journal of Public Health Management and Practice : JPHMP KW - Public Health KW - Communicable Diseases KW - Wastewater-Based Epidemiological Monitoring KW - Wastewater KW - Public Health KW - Wastewater KW - Wastewater-Based Epidemiological Monitoring KW - Communicable Diseases LA - eng PY - 2025 T2 - Journal of Public Health Management and Practice : JPHMP T2 - Journal of Public Health Management and Practice : JPHMP, 2025, v. 31, no. 4 TI - Development of a New Framework to Address Public Health Ethical Considerations in Wastewater Surveillance. VL - 31 UR - https://stacks.cdc.gov/view/cdc/261397 ER -
Access to Paid Sick Leave and COVID-19 Vaccination Status Among Employed Adults Aged 18-64 Years in the United States, 2021-2022.

Lundstrom, Eric W. ;

Asfaw, Abay

August 2025 | American Journal of Public Health, 2025, v. 115, no. 8

To measure the associations between access to paid sick leave (PSL) and COVID-19 vaccination status in the United States, both overall and stratified by occupation and industry of employment.We extracted data on employed adults aged 18 to 64 years from the 2021 and 2022 US Medical Expenditure Panel Survey. We assessed associations between PSL and C ...

10/09/2026

Supporting Files

Title : Access to Paid Sick Leave and COVID-19 Vaccination Status Among Employed Adults Aged 18-64 Years in the United States, 2021-2022. Personal Author(s) : Lundstrom, Eric W.;Asfaw, Abay;Tsai, Rebecca; Published Date : August 2025 Pages in Document : 1308-1311 (6 pdf pages) Source : American Journal of Public Health, 2025, v. 115, no. 8 DOI : https://doi.org/10.2105/AJPH.2025.308095 Journal Title : American Journal of Public Health
Lundstrom, E. W., Asfaw, A., & Tsai, R. (2025). Access to Paid Sick Leave and COVID-19 Vaccination Status Among Employed Adults Aged 18-64 Years in the United States, 2021-2022. American Journal of Public Health, 115(8). https://doi.org/10.2105/AJPH.2025.308095

Lundstrom, Eric W., Abay Asfaw, and Rebecca Tsai. "Access to Paid Sick Leave and COVID-19 Vaccination Status Among Employed Adults Aged 18-64 Years in the United States, 2021-2022." American Journal of Public Health 115, no. 8 (2025). https://doi.org/10.2105/AJPH.2025.308095.

Lundstrom, Eric W., et al. "Access to Paid Sick Leave and COVID-19 Vaccination Status Among Employed Adults Aged 18-64 Years in the United States, 2021-2022." American Journal of Public Health, vol. 115, no. 8, 2025. Stacks. https://doi.org/10.2105/AJPH.2025.308095.
Export RIS Citation Information. TY - Journal Article AU - Lundstrom, Eric W. AU - Asfaw, Abay AU - Tsai, Rebecca AB - To measure the associations between access to paid sick leave (PSL) and COVID-19 vaccination status in the United States, both overall and stratified by occupation and industry of employment. AB - We extracted data on employed adults aged 18 to 64 years from the 2021 and 2022 US Medical Expenditure Panel Survey. We assessed associations between PSL and COVID-19 vaccination status using logistic regression. We used marginal effects analyses to estimate associations within occupation and industry groups. AB - Our analytic sample (n = 15 089) represented more than 114 million employed US adults. Access to PSL was significantly associated with receipt of a COVID-19 vaccination (adjusted odds ratio = 1.33; 95% confidence interval = 1.14, 1.55). Marginal effects analyses indicated that this association was significant within most occupation and industry groups. AB - These findings suggest PSL is associated with higher COVID-19 vaccination rates among US workers. PSL remains an important tool for improving preventive health care access and reducing rates of infectious disease in the United States. ( AB - . 2025;115(8):1308-1311. https://doi.org/10.2105/AJPH.2025.308095). AB - Author manuscript AN - cdc:261396 C4 - PMC12243643 DO - https://doi.org/10.2105/AJPH.2025.308095 IS - 8 J2 - American Journal of Public Health KW - Sick Leave KW - Adolescent KW - Female KW - Vaccination KW - COVID-19 Vaccines KW - Male KW - Humans KW - Middle Aged KW - Young Adult KW - Employment KW - COVID-19 KW - Adult KW - Humans KW - Sick Leave KW - Adult KW - Adolescent KW - COVID-19 KW - Young Adult KW - Male KW - Female KW - Middle Aged KW - COVID-19 Vaccines KW - Employment KW - Vaccination LA - eng PY - 2025 T2 - American Journal of Public Health T2 - American Journal of Public Health, 2025, v. 115, no. 8 TI - Access to Paid Sick Leave and COVID-19 Vaccination Status Among Employed Adults Aged 18-64 Years in the United States, 2021-2022. VL - 115 UR - https://stacks.cdc.gov/view/cdc/261396 ER -
Short-Term Impact of Changes in Public Health Information Systems on Sexually Transmitted Infection Surveillance Data Quality.

Angles, John S. ;

Torrone, Elizabeth A.

November 2025 | Sexually Transmitted Diseases, 2025, v. 52, no. 11

Jurisdictional health departments use public health information systems to maintain and transmit their surveillance data for national surveillance. We investigated if changes to a public health information systems had an impact on sexually transmitted infection case-based surveillance data and document short-term issues that resulted in decreased d ...

10/09/2026

Supporting Files

Title : Short-Term Impact of Changes in Public Health Information Systems on Sexually Transmitted Infection Surveillance Data Quality. Personal Author(s) : Angles, John S.;Torrone, Elizabeth A.;Pondo, Tracy;Pagaoa, Melissa A.;Martin, Erika G.; Published Date : November 2025 Pages in Document : e77-e79 (7 pdf pages) Source : Sexually Transmitted Diseases, 2025, v. 52, no. 11 DOI : https://doi.org/10.1097/OLQ.0000000000002180 Journal Title : Sexually Transmitted Diseases
Angles, J. S., Torrone, E. A., Pondo, T., Pagaoa, M. A., & Martin, E. G. (2025). Short-Term Impact of Changes in Public Health Information Systems on Sexually Transmitted Infection Surveillance Data Quality. Sexually Transmitted Diseases, 52(11). https://doi.org/10.1097/OLQ.0000000000002180

Angles, John S., Elizabeth A. Torrone, Tracy Pondo, Melissa A. Pagaoa, and Erika G. Martin. "Short-Term Impact of Changes in Public Health Information Systems on Sexually Transmitted Infection Surveillance Data Quality." Sexually Transmitted Diseases 52, no. 11 (2025). https://doi.org/10.1097/OLQ.0000000000002180.

Angles, John S., et al. "Short-Term Impact of Changes in Public Health Information Systems on Sexually Transmitted Infection Surveillance Data Quality." Sexually Transmitted Diseases, vol. 52, no. 11, 2025. Stacks. https://doi.org/10.1097/OLQ.0000000000002180.
Export RIS Citation Information. TY - Journal Article AU - Angles, John S. AU - Torrone, Elizabeth A. AU - Pondo, Tracy AU - Pagaoa, Melissa A. AU - Martin, Erika G. AB - Jurisdictional health departments use public health information systems to maintain and transmit their surveillance data for national surveillance. We investigated if changes to a public health information systems had an impact on sexually transmitted infection case-based surveillance data and document short-term issues that resulted in decreased data quality. AB - Author manuscript AN - cdc:261395 C4 - PMC12232487 DO - https://doi.org/10.1097/OLQ.0000000000002180 IS - 11 J2 - Sexually Transmitted Diseases KW - Female KW - Health Information Systems KW - Public Health Surveillance KW - Sexually Transmitted Diseases KW - Public Health KW - Data Accuracy KW - Humans KW - Population Surveillance KW - Humans KW - Sexually Transmitted Diseases KW - Data Accuracy KW - Population Surveillance KW - Public Health KW - Health Information Systems KW - Public Health Surveillance KW - Female LA - eng PY - 2025 T2 - Sexually Transmitted Diseases T2 - Sexually Transmitted Diseases, 2025, v. 52, no. 11 TI - Short-Term Impact of Changes in Public Health Information Systems on Sexually Transmitted Infection Surveillance Data Quality. VL - 52 UR - https://stacks.cdc.gov/view/cdc/261395 ER -
The Impact of Monetary Compensation on Responsiveness to Ecological Momentary Assessments: a Pilot Study of Sexual Minority Men in One Midwestern City.

Liebhard, Brittany ;

Spahnie, Morgan

September 2025 | Sexually Transmitted Diseases, 2025, v. 52, no. 9

We conducted a pilot ecological momentary assessment (EMA) study in preparation for a prospective cohort study of the drivers of syphilis transmission among sexual minority men. Our objectives were: (1) evaluate the effect of monetary compensation (any versus no compensation and amount paid per survey) on participant responsiveness, and (2) evaluat ...

10/09/2026

Supporting Files

Title : The Impact of Monetary Compensation on Responsiveness to Ecological Momentary Assessments: a Pilot Study of Sexual Minority Men in One Midwestern City. Personal Author(s) : Liebhard, Brittany;Spahnie, Morgan;Ricks, JaNelle M.;Miller, William C.;Turner, Abigail Norris; Published Date : September 2025 Pages in Document : 563-568 (16 pdf pages) Source : Sexually Transmitted Diseases, 2025, v. 52, no. 9 DOI : https://doi.org/10.1097/OLQ.0000000000002179 Journal Title : Sexually Transmitted Diseases
Liebhard, B., Spahnie, M., Ricks, J. M., Miller, W. C., & Turner, A. N. (2025). The Impact of Monetary Compensation on Responsiveness to Ecological Momentary Assessments: a Pilot Study of Sexual Minority Men in One Midwestern City. Sexually Transmitted Diseases, 52(9). https://doi.org/10.1097/OLQ.0000000000002179

Liebhard, Brittany, Morgan Spahnie, JaNelle M. Ricks, William C. Miller, and Abigail Norris Turner. "The Impact of Monetary Compensation on Responsiveness to Ecological Momentary Assessments: a Pilot Study of Sexual Minority Men in One Midwestern City." Sexually Transmitted Diseases 52, no. 9 (2025). https://doi.org/10.1097/OLQ.0000000000002179.

Liebhard, Brittany, et al. "The Impact of Monetary Compensation on Responsiveness to Ecological Momentary Assessments: a Pilot Study of Sexual Minority Men in One Midwestern City." Sexually Transmitted Diseases, vol. 52, no. 9, 2025. Stacks. https://doi.org/10.1097/OLQ.0000000000002179.
Export RIS Citation Information. TY - Journal Article AU - Liebhard, Brittany AU - Spahnie, Morgan AU - Ricks, JaNelle M. AU - Miller, William C. AU - Turner, Abigail Norris AB - We conducted a pilot ecological momentary assessment (EMA) study in preparation for a prospective cohort study of the drivers of syphilis transmission among sexual minority men. Our objectives were: (1) evaluate the effect of monetary compensation (any versus no compensation and amount paid per survey) on participant responsiveness, and (2) evaluate acceptability and feasibility of the EMA smartphone app to capture sexual and other behaviors in the last 24 hours. AB - We enrolled 40 men in the 4-week pilot and assigned them to 1 of 2 groups (higher vs lower compensation). Participants completed daily surveys by responding to push notifications or self-initiating in the app. Participants received $5, $3, or $0 per survey depending on compensation group, survey type, and study week. We evaluated response rates overall, by compensation group, and over time, and described responses to a follow-up survey assessing acceptability and feasibility. AB - The overall median completion rate was 60.7%. The higher compensation group had higher completion rates for self-initiated surveys, which only they were paid for (median 75% vs 43%, P < 0.001). For study-initiated surveys, which both groups were paid for (but the higher compensation group slightly more), the lower compensation group had somewhat higher completion rates (median 94% vs 75%; P = 0.13). Response rates among both groups decreased over time. AB - Responsiveness to daily EMA surveys was higher when participants received compensation. The amount received per survey appeared to be less important. Ecological momentary assessment may be a resource-effective supplement to traditional data collection methodologies in sexual health research. AB - Author manuscript AN - cdc:261394 C4 - PMC12291536 DO - https://doi.org/10.1097/OLQ.0000000000002179 IS - 9 J2 - Sexually Transmitted Diseases KW - Smartphone KW - Mobile Applications KW - Prospective Studies KW - Feasibility Studies KW - Young Adult KW - Sexual and Gender Minorities KW - Syphilis KW - Surveys and Questionnaires KW - Male KW - Pilot Projects KW - Humans KW - Middle Aged KW - Adult KW - Sexual Behavior KW - Ecological Momentary Assessment KW - ecological momentary assessment KW - research compensation KW - men who have sex with men KW - syphilis KW - sexually transmitted infection KW - Humans KW - Male KW - Pilot Projects KW - Ecological Momentary Assessment KW - Sexual and Gender Minorities KW - Adult KW - Sexual Behavior KW - Prospective Studies KW - Mobile Applications KW - Middle Aged KW - Surveys and Questionnaires KW - Smartphone KW - Feasibility Studies KW - Syphilis KW - Young Adult LA - eng PY - 2025 T2 - Sexually Transmitted Diseases T2 - Sexually Transmitted Diseases, 2025, v. 52, no. 9 TI - The Impact of Monetary Compensation on Responsiveness to Ecological Momentary Assessments: a Pilot Study of Sexual Minority Men in One Midwestern City. VL - 52 UR - https://stacks.cdc.gov/view/cdc/261394 ER -
Improvements in School Professionals' Knowledge and Self-Efficacy After Completing CDC HEADS up To Schools Online Training.

Chang, Daniel ;

Sarmiento, Kelly

July 2025 | The Journal of School Health, 2025, v. 95, no. 7

School professionals, including classroom teachers, school administrators, psychologists, teachers' aides, and nurses, often interact with students with concussions. To ensure they have the knowledge to identify and manage concussions, the U.S. Centers of Disease Control and Prevention developed the HEADS UP to Schools online training.The HEADS UP ...

10/09/2026

Supporting Files

Title : Improvements in School Professionals' Knowledge and Self-Efficacy After Completing CDC HEADS up To Schools Online Training. Personal Author(s) : Chang, Daniel;Sarmiento, Kelly;Waltzman, Dana; Published Date : July 2025 Pages in Document : 510-521 (19 pdf pages) Source : The Journal of School Health, 2025, v. 95, no. 7 DOI : https://doi.org/10.1111/josh.70022 Journal Title : The Journal of School Health
Chang, D., Sarmiento, K., & Waltzman, D. (2025). Improvements in School Professionals' Knowledge and Self-Efficacy After Completing CDC HEADS up To Schools Online Training. The Journal of School Health, 95(7). https://doi.org/10.1111/josh.70022

Chang, Daniel, Kelly Sarmiento, and Dana Waltzman. "Improvements in School Professionals' Knowledge and Self-Efficacy After Completing CDC HEADS up To Schools Online Training." The Journal of School Health 95, no. 7 (2025). https://doi.org/10.1111/josh.70022.

Chang, Daniel, et al. "Improvements in School Professionals' Knowledge and Self-Efficacy After Completing CDC HEADS up To Schools Online Training." The Journal of School Health, vol. 95, no. 7, 2025. Stacks. https://doi.org/10.1111/josh.70022.
Export RIS Citation Information. TY - Journal Article AU - Chang, Daniel AU - Sarmiento, Kelly AU - Waltzman, Dana AB - School professionals, including classroom teachers, school administrators, psychologists, teachers' aides, and nurses, often interact with students with concussions. To ensure they have the knowledge to identify and manage concussions, the U.S. Centers of Disease Control and Prevention developed the HEADS UP to Schools online training. AB - The HEADS UP to Schools training includes a pre-test and post-test consisting of 16 knowledge questions in three areas (symptom recognition, school support and accommodation, and guidance and recommendations for school staff) and five self-efficacy questions. Pre- and post-test responses of 8750 individuals were compared and analyzed to evaluate the effectiveness of the training. AB - Respondent scores significantly improved between pre- and post-test responses for all knowledge questions and self-efficacy questions. AB - Schools and school districts may consider offering this training to staff to help ensure that at least one person at each school is trained on concussion and to increase awareness of evidence-based practices. AB - Knowledge and self-efficacy on concussion identification and management improved among school professionals who completed the HEADS UP to Schools training. Future research to assess whether concussion knowledge and self-efficacy are maintained long term may be beneficial. AB - Author manuscript AN - cdc:261393 C4 - PMC13107550 DO - https://doi.org/10.1111/josh.70022 IS - 7 J2 - The Journal of School Health KW - Self Efficacy KW - Schools KW - Female KW - Health Knowledge, Attitudes, Practice KW - School Teachers KW - Brain Concussion KW - Male KW - Humans KW - Centers for Disease Control and Prevention, U.S. KW - concussion KW - education KW - school professionals KW - training KW - traumatic brain injury KW - Humans KW - Self Efficacy KW - Brain Concussion KW - Health Knowledge, Attitudes, Practice KW - Centers for Disease Control and Prevention, U.S. KW - Male KW - Female KW - Schools KW - School Teachers LA - eng PY - 2025 T2 - The Journal of School Health T2 - The Journal of School Health, 2025, v. 95, no. 7 TI - Improvements in School Professionals' Knowledge and Self-Efficacy After Completing CDC HEADS up To Schools Online Training. VL - 95 UR - https://stacks.cdc.gov/view/cdc/261393 ER -
A 2024 Global Report on National Policies, Programmes, and Progress Towards Hepatitis C Elimination: Findings From 33 Hepatitis Elimination Profiles.

Hiebert-Suwondo, Lindsey ;

Manning, Jana

July 2025 | The Lancet. Gastroenterology & Hepatology, 2025, v. 10, no. 7

The Coalition for Global Hepatitis Elimination's National Hepatitis Elimination Profiles assess the status of national data, policy, and programme development for the elimination of viral hepatitis. To date, profiles from 33 countries and territories have been developed. These profiles reveal that 30 (91%) countries and territories have hepatitis C ...

10/09/2026

Supporting Files

Title : A 2024 Global Report on National Policies, Programmes, and Progress Towards Hepatitis C Elimination: Findings From 33 Hepatitis Elimination Profiles. Personal Author(s) : Hiebert-Suwondo, Lindsey;Manning, Jana;Tohme, Rania A;Buti, Maria;Kondili, Loreta A;Spearman, C Wendy;Hajarizadeh, Behzad;Turnier, Victoria;Lazarus, Jeffrey V;Grebely, Jason;Dore, Gregory J;Waked, Imam;Ward, John W; Corporate Authors(s) : the National Hepatitis Elimination Profile Collaborators Published Date : July 2025 Pages in Document : 685-700 (33 pdf pages) Source : The Lancet. Gastroenterology & Hepatology, 2025, v. 10, no. 7 DOI : https://doi.org/10.1016/S2468-1253(25)00068-8 Journal Title : The Lancet. Gastroenterology & Hepatology
Hiebert-Suwondo, L., Manning, J., Tohme, R. A., Buti, M., Kondili, L. A., Spearman, C. W., Hajarizadeh, B., Turnier, V., Lazarus, J. V., Grebely, J., Dore, G. J., Waked, I., & Ward, J. W. (2025). A 2024 Global Report on National Policies, Programmes, and Progress Towards Hepatitis C Elimination: Findings From 33 Hepatitis Elimination Profiles. The Lancet. Gastroenterology & Hepatology, 10(7). https://doi.org/10.1016/S2468-1253(25)00068-8

Hiebert-Suwondo, Lindsey, Jana Manning, Rania A Tohme, Maria Buti, Loreta A Kondili, C Wendy Spearman, and Behzad Hajarizadeh, et al.. "A 2024 Global Report on National Policies, Programmes, and Progress Towards Hepatitis C Elimination: Findings From 33 Hepatitis Elimination Profiles." The Lancet. Gastroenterology & Hepatology 10, no. 7 (2025). https://doi.org/10.1016/S2468-1253(25)00068-8.

Hiebert-Suwondo, Lindsey, et al. "A 2024 Global Report on National Policies, Programmes, and Progress Towards Hepatitis C Elimination: Findings From 33 Hepatitis Elimination Profiles." The Lancet. Gastroenterology & Hepatology, vol. 10, no. 7, 2025. Stacks. https://doi.org/10.1016/S2468-1253(25)00068-8.
Export RIS Citation Information. TY - Journal Article AU - Hiebert-Suwondo, Lindsey AU - Manning, Jana AU - Tohme, Rania A AU - Buti, Maria AU - Kondili, Loreta A AU - Spearman, C Wendy AU - Hajarizadeh, Behzad AU - Turnier, Victoria AU - Lazarus, Jeffrey V AU - Grebely, Jason AU - Dore, Gregory J AU - Waked, Imam AU - Ward, John W A2 - the National Hepatitis Elimination Profile Collaborators AB - The Coalition for Global Hepatitis Elimination's National Hepatitis Elimination Profiles assess the status of national data, policy, and programme development for the elimination of viral hepatitis. To date, profiles from 33 countries and territories have been developed. These profiles reveal that 30 (91%) countries and territories have hepatitis C national action plans, 11 (33%) have systems to monitor hepatitis C-related mortality, 16 (48%) have systems to monitor hepatitis C incidence, and 18 (55%) have systems to track the number of people tested and treated. Some countries and territories continue to uphold barriers to hepatitis C treatment, with 12 (36%) still having partial or full restrictions on prescribing authority for non-specialists. Ten (30%) countries and territories have met the WHO 2025 diagnosis coverage target of 60%, five (15%) have met the treatment target of 50%, and seven (21%) have met the needle and syringe exchange target. Although there are examples of countries and territories across the income spectrum meeting these targets, policy development in low-income and middle-income countries and territories generally lags behind that in high-income countries and territories. AB - Author manuscript AN - cdc:261392 C4 - PMC12308979 DO - https://doi.org/10.1016/S2468-1253(25)00068-8 IS - 7 J2 - The Lancet. Gastroenterology & Hepatology KW - Antiviral Agents KW - Global Health KW - Disease Eradication KW - Hepatitis C KW - Health Policy KW - Humans KW - World Health Organization KW - Humans KW - Hepatitis C KW - Global Health KW - Disease Eradication KW - Health Policy KW - World Health Organization KW - Antiviral Agents LA - eng PY - 2025 T2 - The Lancet. Gastroenterology & Hepatology T2 - The Lancet. Gastroenterology & Hepatology, 2025, v. 10, no. 7 TI - A 2024 Global Report on National Policies, Programmes, and Progress Towards Hepatitis C Elimination: Findings From 33 Hepatitis Elimination Profiles. VL - 10 UR - https://stacks.cdc.gov/view/cdc/261392 ER -
A 2024 Global Report on National Policy, Programmes, and Progress Towards Hepatitis B Elimination: Findings From 33 Hepatitis Elimination Profiles.

Hiebert-Suwondo, Lindsey ;

Manning, Jana

July 2025 | The Lancet. Gastroenterology & Hepatology, 2025, v. 10, no. 7

The Coaltion for Global Hepatitis Elimination's National Hepatitis Elimination Profiles assess the status of national data, policy, and programme development the elimination of viral hepatitis. Profiles from 33 countries and territories show progress, towards elimination of hepatitis B with 24 (73%) of them meeting the 2025 WHO interim target of 0· ...

10/09/2026

Supporting Files

Title : A 2024 Global Report on National Policy, Programmes, and Progress Towards Hepatitis B Elimination: Findings From 33 Hepatitis Elimination Profiles. Personal Author(s) : Hiebert-Suwondo, Lindsey;Manning, Jana;Tohme, Rania A;Buti, Maria;Kondili, Loreta A;Spearman, C Wendy;Prabdial-Sing, Nishi;Turnier, Victoria;Lazarus, Jeffrey V;Waked, Imam;Ward, John W; Corporate Authors(s) : the National Hepatitis Elimination Profile Collaborators Published Date : July 2025 Pages in Document : 671-684 (28 pdf pages) Source : The Lancet. Gastroenterology & Hepatology, 2025, v. 10, no. 7 DOI : https://doi.org/10.1016/S2468-1253(25)00069-X Journal Title : The Lancet. Gastroenterology & Hepatology
Hiebert-Suwondo, L., Manning, J., Tohme, R. A., Buti, M., Kondili, L. A., Spearman, C. W., Prabdial-Sing, N., Turnier, V., Lazarus, J. V., Waked, I., & Ward, J. W. (2025). A 2024 Global Report on National Policy, Programmes, and Progress Towards Hepatitis B Elimination: Findings From 33 Hepatitis Elimination Profiles. The Lancet. Gastroenterology & Hepatology, 10(7). https://doi.org/10.1016/S2468-1253(25)00069-X

Hiebert-Suwondo, Lindsey, Jana Manning, Rania A Tohme, Maria Buti, Loreta A Kondili, C Wendy Spearman, and Nishi Prabdial-Sing, et al.. "A 2024 Global Report on National Policy, Programmes, and Progress Towards Hepatitis B Elimination: Findings From 33 Hepatitis Elimination Profiles." The Lancet. Gastroenterology & Hepatology 10, no. 7 (2025). https://doi.org/10.1016/S2468-1253(25)00069-X.

Hiebert-Suwondo, Lindsey, et al. "A 2024 Global Report on National Policy, Programmes, and Progress Towards Hepatitis B Elimination: Findings From 33 Hepatitis Elimination Profiles." The Lancet. Gastroenterology & Hepatology, vol. 10, no. 7, 2025. Stacks. https://doi.org/10.1016/S2468-1253(25)00069-X.
Export RIS Citation Information. TY - Journal Article AU - Hiebert-Suwondo, Lindsey AU - Manning, Jana AU - Tohme, Rania A AU - Buti, Maria AU - Kondili, Loreta A AU - Spearman, C Wendy AU - Prabdial-Sing, Nishi AU - Turnier, Victoria AU - Lazarus, Jeffrey V AU - Waked, Imam AU - Ward, John W A2 - the National Hepatitis Elimination Profile Collaborators AB - The Coaltion for Global Hepatitis Elimination's National Hepatitis Elimination Profiles assess the status of national data, policy, and programme development the elimination of viral hepatitis. Profiles from 33 countries and territories show progress, towards elimination of hepatitis B with 24 (73%) of them meeting the 2025 WHO interim target of 0·5% or less HBsAg prevalence in children younger than 5 years. 22 (67%) of countries and territories profiled have policies for universal hepatitis B birth-dose vaccination of newborns. Access to hepatitis B testing and treatment, including removing HBsAg screening and hepatitis B treatment patient co-payments and simplifying treatment algorithms, remains suboptimal, especially in low-income and middle-income countries and territories. Of the seven profiled countries and territories meeting the 60% WHO 2025 diagnosis coverage target, all but one (Rwanda) is a high-income country or territory. No country or territory has met the WHO 2025 treatment target of at least 50% of people living with hepatitis B receiving treatment. The profiles guide national planning and identify priorities for resource mobilisation to further accelerate hepatitis B elimination. AB - Author manuscript AN - cdc:261391 C4 - PMC12308976 DO - https://doi.org/10.1016/S2468-1253(25)00069-X IS - 7 J2 - The Lancet. Gastroenterology & Hepatology KW - Antiviral Agents KW - Disease Eradication KW - Hepatitis B Surface Antigens KW - Global Health KW - Hepatitis B KW - Health Policy KW - Humans KW - Child, Preschool KW - Infant, Newborn KW - Hepatitis B Vaccines KW - World Health Organization KW - Humans KW - Hepatitis B KW - Disease Eradication KW - Global Health KW - Health Policy KW - Hepatitis B Vaccines KW - World Health Organization KW - Antiviral Agents KW - Hepatitis B Surface Antigens KW - Child, Preschool KW - Infant, Newborn LA - eng PY - 2025 T2 - The Lancet. Gastroenterology & Hepatology T2 - The Lancet. Gastroenterology & Hepatology, 2025, v. 10, no. 7 TI - A 2024 Global Report on National Policy, Programmes, and Progress Towards Hepatitis B Elimination: Findings From 33 Hepatitis Elimination Profiles. VL - 10 UR - https://stacks.cdc.gov/view/cdc/261391 ER -
Spirometric Pattern Transitions in a World Trade Center Occupational Cohort on Longitudinal Surveillance.

Weber, Jonathan ;

Zhang, Zitong

August 2025 | Respiratory Medicine, 2025, v. 244

Many workers and volunteers who participated in the rescue and recovery of the World Trade Center (WTC) disaster site in 2001-2002 manifest a heterogeneous group of chronic lower airway diseases, with variable spirometric patterns on longitudinal surveillance. We examined systematically the observed transitions among those spirometric patterns and ...

10/09/2026

Supporting Files

Title : Spirometric Pattern Transitions in a World Trade Center Occupational Cohort on Longitudinal Surveillance. Personal Author(s) : Weber, Jonathan;Zhang, Zitong;Doucette, John T.;Sood, Akshay;Celedón, Juan C.;de la Hoz, Rafael E.; Published Date : August 2025 Pages in Document : 108170 (17 pdf pages) Source : Respiratory Medicine, 2025, v. 244 DOI : https://doi.org/10.1016/j.rmed.2025.108170 Journal Title : Respiratory Medicine
Weber, J., Zhang, Z., Doucette, J. T., Sood, A., Celedón, J. C., & de la Hoz, R. E. (2025). Spirometric Pattern Transitions in a World Trade Center Occupational Cohort on Longitudinal Surveillance. Respiratory Medicine, 244. https://doi.org/10.1016/j.rmed.2025.108170

Weber, Jonathan, Zitong Zhang, John T. Doucette, Akshay Sood, Juan C. Celedón, and Rafael E. de la Hoz. "Spirometric Pattern Transitions in a World Trade Center Occupational Cohort on Longitudinal Surveillance." Respiratory Medicine 244 (2025). https://doi.org/10.1016/j.rmed.2025.108170.

Weber, Jonathan, et al. "Spirometric Pattern Transitions in a World Trade Center Occupational Cohort on Longitudinal Surveillance." Respiratory Medicine, vol. 244, 2025. Stacks. https://doi.org/10.1016/j.rmed.2025.108170.
Export RIS Citation Information. TY - Journal Article AU - Weber, Jonathan AU - Zhang, Zitong AU - Doucette, John T. AU - Sood, Akshay AU - Celedón, Juan C. AU - de la Hoz, Rafael E. AB - Many workers and volunteers who participated in the rescue and recovery of the World Trade Center (WTC) disaster site in 2001-2002 manifest a heterogeneous group of chronic lower airway diseases, with variable spirometric patterns on longitudinal surveillance. We examined systematically the observed transitions among those spirometric patterns and assessed their association with BMI and occupational WTC exposure intensity. AB - We selected 10,810 Mount Sinai WTC General Responders' Cohort members with at least three acceptable quality periodic spirometries (n = 56,312) performed between July 2002 and November 2019. We defined three spirometric patterns: (1) normal: prebronchodilator first-second forced expiratory volume (FEV AB - ), forced vital capacity (FVC), and FEV AB - /FVC ratio > lower limit of normal (LLN); (2) obstruction: pre-bronchodilator FEV AB - /FVC ratio<LLN; (3) low FVC: FVC < LLN and FEV AB - /FVC > LLN. We built a multi-state Markov-like model to analyze probabilities of transition between those three spirometric patterns. AB - Low FVC is the most frequent abnormal spirometric pattern in the WTC workers. Substantial stationary probabilities of stability (0.88) were observed for normal, and less so for low FVC (0.73) and obstructive (0.65) pattern. At least 80 % of the observed transitions involved the normal and low FVC patterns, and both higher WTC exposure intensity (early arrival at the site), and body mass index (BMI) were predictors of transitions to low FVC in this cohort. AB - Low FVC is relatively stable, and both WTC exposure intensity and BMI are independently and significantly associated with transitions to it. Transitions to obstruction are generally infrequent among the WTC workers and have greater instability. AB - Author manuscript AN - cdc:261390 C4 - PMC13197207 DO - https://doi.org/10.1016/j.rmed.2025.108170 J2 - Respiratory Medicine KW - Occupational Exposure KW - Longitudinal Studies KW - Female KW - Emergency Responders KW - Vital Capacity KW - Forced Expiratory Volume KW - Occupational Diseases KW - Cohort Studies KW - Body Mass Index KW - Male KW - Rescue Work KW - Humans KW - Middle Aged KW - Spirometry KW - September 11 Terrorist Attacks KW - Adult KW - Occupational medicine KW - Occupational health KW - Inhalation injury KW - Chronic obstructive pulmonary disease KW - Asthma KW - Cohort study KW - World Trade Center attack KW - 2001 KW - Humans KW - Spirometry KW - September 11 Terrorist Attacks KW - Male KW - Female KW - Adult KW - Occupational Exposure KW - Longitudinal Studies KW - Middle Aged KW - Forced Expiratory Volume KW - Vital Capacity KW - Body Mass Index KW - Rescue Work KW - Cohort Studies KW - Emergency Responders KW - Occupational Diseases LA - eng PY - 2025 T2 - Respiratory Medicine T2 - Respiratory Medicine, 2025, v. 244 TI - Spirometric Pattern Transitions in a World Trade Center Occupational Cohort on Longitudinal Surveillance. VL - 244 UR - https://stacks.cdc.gov/view/cdc/261390 ER -
Reach of An Occupational Health and Safety Program to Improve Sleep and Fatigue Among Nurses.

Hittle, Beverly M. ;

Guerin, Rebecca

October 2025 | Western Journal of Nursing Research, 2025, v. 47, no. 10

Training and education may benefit nurses whose nonstandard work hours put them at risk of poor sleep, fatigue, and ensuing adverse health and safety outcomes. The National Institute for Occupational Safety and Health (NIOSH) published "Training for Nurses on Shift Work and Long Work Hours" in 2015 as a free online resource which remains one of the ...

10/09/2026

Supporting Files

Title : Reach of An Occupational Health and Safety Program to Improve Sleep and Fatigue Among Nurses. Personal Author(s) : Hittle, Beverly M.;Guerin, Rebecca;Wong, Imelda S.; Published Date : October 2025 Pages in Document : 932-941 (18 pdf pages) Source : Western Journal of Nursing Research, 2025, v. 47, no. 10 DOI : https://doi.org/10.1177/01939459251340273 Journal Title : Western Journal of Nursing Research
Hittle, B. M., Guerin, R., & Wong, I. S. (2025). Reach of An Occupational Health and Safety Program to Improve Sleep and Fatigue Among Nurses. Western Journal of Nursing Research, 47(10). https://doi.org/10.1177/01939459251340273

Hittle, Beverly M., Rebecca Guerin, and Imelda S. Wong. "Reach of An Occupational Health and Safety Program to Improve Sleep and Fatigue Among Nurses." Western Journal of Nursing Research 47, no. 10 (2025). https://doi.org/10.1177/01939459251340273.

Hittle, Beverly M., et al. "Reach of An Occupational Health and Safety Program to Improve Sleep and Fatigue Among Nurses." Western Journal of Nursing Research, vol. 47, no. 10, 2025. Stacks. https://doi.org/10.1177/01939459251340273.
Export RIS Citation Information. TY - Journal Article AU - Hittle, Beverly M. AU - Guerin, Rebecca AU - Wong, Imelda S. AB - Training and education may benefit nurses whose nonstandard work hours put them at risk of poor sleep, fatigue, and ensuing adverse health and safety outcomes. The National Institute for Occupational Safety and Health (NIOSH) published "Training for Nurses on Shift Work and Long Work Hours" in 2015 as a free online resource which remains one of the few trainings available on this topic. However, the extent to which nurses have completed the program and the characteristics of current learners have not been examined. AB - We aimed to describe the potential reach of the NIOSH Training for Nurses between May 2015 through December 2020. AB - Data were obtained on learners who received continuing education credits upon completion of the NIOSH Training for Nurses. We applied a widely used implementation and evaluation framework, RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance), to describe the potential reach of the nurses' training and provide descriptive statistics of learners. AB - From 2015 to 2020, 7899 learners from different occupations received continuing education credits for completing the training. Approximately 60% of learners were nurses and 30% were students. Among nurses, most were Registered Nurses (93%), with few Licensed Practical Nurses (6%) and Advanced Practice Nurses (2%). In 2020, the number of learners who were nurses represented only 0.09% of all licensed US nurses. AB - A renewed dissemination plan may help extend training reach to the larger population of licensed US nurses. The NIOSH training remains a seminal, freely available, online resource for nurses, filling a critical gap in training to manage work-related fatigue. AB - Author manuscript AN - cdc:261389 C4 - PMC13353418 DO - https://doi.org/10.1177/01939459251340273 IS - 10 J2 - Western Journal of Nursing Research KW - Sleep KW - Female KW - Fatigue KW - Male KW - Humans KW - National Institute for Occupational Safety and Health, U.S. KW - Occupational Health KW - Nurses KW - Adult KW - United States KW - nurses KW - fatigue KW - fatigue mitigation KW - long work hours KW - shift work KW - sleep hygiene KW - sleep training KW - Humans KW - Fatigue KW - United States KW - Occupational Health KW - National Institute for Occupational Safety and Health, U.S. KW - Nurses KW - Sleep KW - Female KW - Adult KW - Male LA - eng PY - 2025 T2 - Western Journal of Nursing Research T2 - Western Journal of Nursing Research, 2025, v. 47, no. 10 TI - Reach of An Occupational Health and Safety Program to Improve Sleep and Fatigue Among Nurses. VL - 47 UR - https://stacks.cdc.gov/view/cdc/261389 ER -
Self-management For People With Epilepsy and a History of Negative Health Events (SMART): a Randomized Controlled Effectiveness Trial.

Sajatovic, Martha ;

Ghearing, Gena R.

October 2025 | Epilepsy & Behavior : E&B, 2025, v. 171

This 2-site, 6-month randomized controlled trial of an epilepsy self-management (ESM) curriculum (SMART) vs. 6-month waitlist (WL) control assessed effects on epilepsy outcomes in 160 people with epilepsy (PWE).PWE had at least 1 negative health event (NHE) defined as a seizure, emergency department visit, hospitalization or self-harm attempt in th ...

10/09/2026

Supporting Files

Title : Self-management For People With Epilepsy and a History of Negative Health Events (SMART): a Randomized Controlled Effectiveness Trial. Personal Author(s) : Sajatovic, Martha;Ghearing, Gena R.;Tyrrell, Maegan;Black, Jessica;Krehel-Montgomery, Jacqueline;Barigye, Richard;Yala, Joy;Adeniyi, Clara;Privitera, Michael;Rossi, Marvin A.;Briggs, Farren; Published Date : October 2025 Pages in Document : 110495 (21 pdf pages) Source : Epilepsy & Behavior : E&B, 2025, v. 171 DOI : https://doi.org/10.1016/j.yebeh.2025.110495 Journal Title : Epilepsy & Behavior : E&B
Sajatovic, M., Ghearing, G. R., Tyrrell, M., Black, J., Krehel-Montgomery, J., Barigye, R., Yala, J., Adeniyi, C., Privitera, M., Rossi, M. A., & Briggs, F. (2025). Self-management For People With Epilepsy and a History of Negative Health Events (SMART): a Randomized Controlled Effectiveness Trial. Epilepsy & Behavior : E&B, 171. https://doi.org/10.1016/j.yebeh.2025.110495

Sajatovic, Martha, Gena R. Ghearing, Maegan Tyrrell, Jessica Black, Jacqueline Krehel-Montgomery, Richard Barigye, and Joy Yala, et al.. "Self-management For People With Epilepsy and a History of Negative Health Events (SMART): a Randomized Controlled Effectiveness Trial." Epilepsy & Behavior : E&B 171 (2025). https://doi.org/10.1016/j.yebeh.2025.110495.

Sajatovic, Martha, et al. "Self-management For People With Epilepsy and a History of Negative Health Events (SMART): a Randomized Controlled Effectiveness Trial." Epilepsy & Behavior : E&B, vol. 171, 2025. Stacks. https://doi.org/10.1016/j.yebeh.2025.110495.
Export RIS Citation Information. TY - Journal Article AU - Sajatovic, Martha AU - Ghearing, Gena R. AU - Tyrrell, Maegan AU - Black, Jessica AU - Krehel-Montgomery, Jacqueline AU - Barigye, Richard AU - Yala, Joy AU - Adeniyi, Clara AU - Privitera, Michael AU - Rossi, Marvin A. AU - Briggs, Farren AB - This 2-site, 6-month randomized controlled trial of an epilepsy self-management (ESM) curriculum (SMART) vs. 6-month waitlist (WL) control assessed effects on epilepsy outcomes in 160 people with epilepsy (PWE). AB - PWE had at least 1 negative health event (NHE) defined as a seizure, emergency department visit, hospitalization or self-harm attempt in the last 6 months. Primary outcomes were differences in proportions of PWE with reductions in NHEs from baseline to 6 months follow up and change in NHE/seizure counts between SMART and WL. Secondary outcomes included the Patient Health Questionnaire (PHQ-9), 36-Item Short Form Survey (SF-36), Quality of Life in Epilepsy (QOLIE-31), Epilepsy Self-Management Scale (ESMS), Epilepsy Stigma Scale (ESS), Multidimensional Scale of Perceived Social Support (MSPSS) and Epilepsy Self-Efficacy Scale (ESES). AB - Mean age was 39.4 (SD 12.2), 66.9 % (N = 107) women, and 31 % (N = 50) rural. Mean PHQ-9 of 10.5 (SD 7) suggested mild/moderate depression. Seizures were the most common NHE with mean baseline past 6-month seizure count of 20.6 (SD 41.0). SMART was significantly associated with a 2-fold increase in odds of having at least 10-30 % improvement in NHEs vs. WL (p < 0.05). SMART was associated with significant seizure reduction (p < 0.05), significantly improved PHQ-9 (p = 0.014), QOLIE-31 seizure worry (p = <0.001) and social functioning (p = 0.021), ESES (p = 0.046) and ESMS (p < 0.001). AB - Compared to WL, SMART participants had improvement in NHEs and seizures, depressive symptoms, self-management competency and self-efficacy and selected elements of quality of life. Inclusion of effective ESMs into a comprehensive care of model for PWE may be warranted. AB - Author manuscript AN - cdc:261388 C4 - PMC13482782 DO - https://doi.org/10.1016/j.yebeh.2025.110495 J2 - Epilepsy & Behavior : E&B KW - Self Efficacy KW - Female KW - Treatment Outcome KW - Social Stigma KW - Social Support KW - Self-Management KW - Surveys and Questionnaires KW - Epilepsy KW - Quality of Life KW - Male KW - Middle Aged KW - Humans KW - Adult KW - epilepsy KW - seizures KW - stigma KW - depression KW - quality of life KW - Adult KW - Female KW - Humans KW - Male KW - Middle Aged KW - Epilepsy KW - Quality of Life KW - Self Efficacy KW - Self-Management KW - Social Stigma KW - Social Support KW - Surveys and Questionnaires KW - Treatment Outcome LA - eng PY - 2025 T2 - Epilepsy & Behavior : E&B T2 - Epilepsy & Behavior : E&B, 2025, v. 171 TI - Self-management For People With Epilepsy and a History of Negative Health Events (SMART): a Randomized Controlled Effectiveness Trial. VL - 171 UR - https://stacks.cdc.gov/view/cdc/261388 ER -
Smooth Muscle Relaxants For Intrauterine Device Placement: a Systematic Review.

Snyder, Emily M. ;

Krishna, Gopika

July 2026 | Contraception, 2026, v. 159

To systematically review evidence on whether medications with smooth muscle relaxant properties improve patient and provider outcomes for intrauterine device (IUD) placement.We searched multiple databases through August 2022 for randomized clinical trials assessing smooth muscle relaxants for IUD placement. Primary outcomes were pain experienced wi ...

10/09/2026

Supporting Files

Title : Smooth Muscle Relaxants For Intrauterine Device Placement: a Systematic Review. Personal Author(s) : Snyder, Emily M.;Krishna, Gopika;Zapata, Lauren B.;Nguyen, Antoinette T.;Whiteman, Maura K.;Curtis, Kathryn M.; Published Date : July 2026 Pages in Document : 110971 (15 pdf pages) Source : Contraception, 2026, v. 159 DOI : https://doi.org/10.1016/j.contraception.2025.110971 Journal Title : Contraception
Snyder, E. M., Krishna, G., Zapata, L. B., Nguyen, A. T., Whiteman, M. K., & Curtis, K. M. (2026). Smooth Muscle Relaxants For Intrauterine Device Placement: a Systematic Review. Contraception, 159. https://doi.org/10.1016/j.contraception.2025.110971

Snyder, Emily M., Gopika Krishna, Lauren B. Zapata, Antoinette T. Nguyen, Maura K. Whiteman, and Kathryn M. Curtis. "Smooth Muscle Relaxants For Intrauterine Device Placement: a Systematic Review." Contraception 159 (2026). https://doi.org/10.1016/j.contraception.2025.110971.

Snyder, Emily M., et al. "Smooth Muscle Relaxants For Intrauterine Device Placement: a Systematic Review." Contraception, vol. 159, 2026. Stacks. https://doi.org/10.1016/j.contraception.2025.110971.
Export RIS Citation Information. TY - Journal Article AU - Snyder, Emily M. AU - Krishna, Gopika AU - Zapata, Lauren B. AU - Nguyen, Antoinette T. AU - Whiteman, Maura K. AU - Curtis, Kathryn M. AB - To systematically review evidence on whether medications with smooth muscle relaxant properties improve patient and provider outcomes for intrauterine device (IUD) placement. AB - We searched multiple databases through August 2022 for randomized clinical trials assessing smooth muscle relaxants for IUD placement. Primary outcomes were pain experienced with IUD placement, provider ease of placement, need for adjunctive placement measures, placement success, patient satisfaction with procedure, medication side effects occurring before clinic discharge, and adverse events occurring before clinic discharge. We extracted data from included articles, assessed risk of bias for each trial, narratively summarized results, and determined certainty of evidence for all outcomes. AB - Five placebo-controlled trials met inclusion criteria; four trials had low risk of bias and one had moderate risk. Two trials of topical nitroprusside gel or nitroglycerin ointment found no differences in patient pain, provider ease of placement, patient satisfaction, placement success, side effects, or adverse events. One trial suggested that drotaverine plus mefenamic acid reduced patient pain but did not improve placement success. Two trials suggested that isonicotinic acid hydrazide reduced patient pain, improved provider ease of placement and patient satisfaction, reduced need for analgesia and for cervical dilation (in one trial) and did not increase side effects; neither trial reported improved placement success. AB - Evidence on smooth muscle relaxants for IUD placement remains sparse with inconsistent findings across specific medications. Certainty of evidence for all outcomes was low for topical nitroprusside gel and nitroglycerin ointment, very low for drotaverine plus mefenamic acid, and mostly high for isonicotinic acid hydrazide. AB - Before IUD placement, healthcare providers can counsel patients on the potential for pain during placement and options for pain management. However, more evidence is needed on specific smooth muscle relaxants to determine their effectiveness as an intervention for IUD placement. AB - Author manuscript AN - cdc:261387 C4 - PMC12326637 DO - https://doi.org/10.1016/j.contraception.2025.110971 J2 - Contraception KW - Muscle, Smooth KW - Contraception KW - Intrauterine Devices KW - Systematic review KW - Contraception KW - Intrauterine device KW - Systematic review KW - Contraception KW - Intrauterine Devices KW - Systematic review KW - Muscle, Smooth LA - eng PY - 2026 T2 - Contraception T2 - Contraception, 2026, v. 159 TI - Smooth Muscle Relaxants For Intrauterine Device Placement: a Systematic Review. VL - 159 UR - https://stacks.cdc.gov/view/cdc/261387 ER -
Safety of NOPV2 Administered During a Supplementary Immunisation Activity in Uganda, 2022: Data Triangulation From a Prospective Cohort Event Monitoring Programme and Vaccine Safety Surveillance Reports.

Longley, Ashley T ;

Nsubuga, Fred

July 2025 | The Lancet. Global Health, 2025, v. 13, no. 7

In November, 2020, WHO authorised novel oral polio vaccine type 2 (nOPV2) use under Emergency Use Listing in response to outbreaks of circulating vaccine-derived poliovirus type 2 (cVDPV2). Although no concerns were identified in nOPV2 trials, the Global Advisory Committee on Vaccine Safety requested more extensive vaccine safety data during emerge ...

10/09/2026

Supporting Files

Title : Safety of NOPV2 Administered During a Supplementary Immunisation Activity in Uganda, 2022: Data Triangulation From a Prospective Cohort Event Monitoring Programme and Vaccine Safety Surveillance Reports. Personal Author(s) : Longley, Ashley T;Nsubuga, Fred;Gilani, Zunera;Tobolowsky, Farrell A;Kisakye, Annet;Greene, Sharon A;Ampeire, Immaculate;Ssennono, Vincent Fred;Gyasi, Samuel Ofori;Ntale, Ismail;Bammeke, Philip;Stewart, Brock;Ndagije, Helen Byomire;Kyabayinze, Daniel J;Gidudu, Jane F; Published Date : July 2025 Pages in Document : e1213-e1220 (18 pdf pages) Source : The Lancet. Global Health, 2025, v. 13, no. 7 DOI : https://doi.org/10.1016/S2214-109X(25)00110-X Journal Title : The Lancet. Global Health
Longley, A. T., Nsubuga, F., Gilani, Z., Tobolowsky, F. A., Kisakye, A., Greene, S. A., Ampeire, I., Ssennono, V. F., Gyasi, S. O., Ntale, I., Bammeke, P., Stewart, B., Ndagije, H. B., Kyabayinze, D. J., & Gidudu, J. F. (2025). Safety of NOPV2 Administered During a Supplementary Immunisation Activity in Uganda, 2022: Data Triangulation From a Prospective Cohort Event Monitoring Programme and Vaccine Safety Surveillance Reports. The Lancet. Global Health, 13(7). https://doi.org/10.1016/S2214-109X(25)00110-X

Longley, Ashley T, Fred Nsubuga, Zunera Gilani, Farrell A Tobolowsky, Annet Kisakye, Sharon A Greene, and Immaculate Ampeire, et al.. "Safety of NOPV2 Administered During a Supplementary Immunisation Activity in Uganda, 2022: Data Triangulation From a Prospective Cohort Event Monitoring Programme and Vaccine Safety Surveillance Reports." The Lancet. Global Health 13, no. 7 (2025). https://doi.org/10.1016/S2214-109X(25)00110-X.

Longley, Ashley T, et al. "Safety of NOPV2 Administered During a Supplementary Immunisation Activity in Uganda, 2022: Data Triangulation From a Prospective Cohort Event Monitoring Programme and Vaccine Safety Surveillance Reports." The Lancet. Global Health, vol. 13, no. 7, 2025. Stacks. https://doi.org/10.1016/S2214-109X(25)00110-X.
Export RIS Citation Information. TY - Journal Article AU - Longley, Ashley T AU - Nsubuga, Fred AU - Gilani, Zunera AU - Tobolowsky, Farrell A AU - Kisakye, Annet AU - Greene, Sharon A AU - Ampeire, Immaculate AU - Ssennono, Vincent Fred AU - Gyasi, Samuel Ofori AU - Ntale, Ismail AU - Bammeke, Philip AU - Stewart, Brock AU - Ndagije, Helen Byomire AU - Kyabayinze, Daniel J AU - Gidudu, Jane F AB - In November, 2020, WHO authorised novel oral polio vaccine type 2 (nOPV2) use under Emergency Use Listing in response to outbreaks of circulating vaccine-derived poliovirus type 2 (cVDPV2). Although no concerns were identified in nOPV2 trials, the Global Advisory Committee on Vaccine Safety requested more extensive vaccine safety data during emergency use. The Uganda Ministry of Health declared a cVDPV2 outbreak in 2021 and responded with an nOPV2 campaign in January, 2022. More than 9 million children aged 0-59 months were vaccinated, providing an opportunity to generate robust safety data. AB - We monitored the safety of nOPV2 for 42 days post-vaccination using: routine passive surveillance for adverse events following immunisation (AEFI); ongoing acute flaccid paralysis (AFP) surveillance; active, hospital-based surveillance for pre-specified adverse events of special interest (AESI); and active, cohort event monitoring. AFP cases were reviewed by the National Polio Expert Committee. Serious AEFI and all AESI and AFP cases with nOPV2 receipt underwent causality assessment by the National AEFI Committee. AB - Across surveillance systems, 1128 children vaccinated with nOPV2 experienced one or more AEFI: 43 children identified through passive surveillance, 128 suspected AFP cases, five AESI cases, and 952 children with reported AEFI through cohort event monitoring. Overall, 109 adverse events were considered serious; six (fever, gastroenteritis (n=3), acute disseminated encephalomyelitis, and encephalitis) were determined by the National AEFI Committee to be consistent with causal association to immunisation with nOPV2. No cases of vaccine-associated paralytic poliomyelitis were detected. One death was detected, considered inconsistent with causal association to immunisation with nOPV2, per the National AEFI Committee. AB - No new safety concerns were identified with nOPV2 use in Uganda following a national vaccination campaign, providing valuable data that informed WHO prequalification and product licensure. AB - Centers for Disease Control and Prevention. AB - For the French translation of the abstract see Supplementary Materials section. AB - Author manuscript AN - cdc:261386 C4 - PMC12213129 DO - https://doi.org/10.1016/S2214-109X(25)00110-X IS - 7 J2 - The Lancet. Global Health KW - Adverse Drug Reaction Reporting Systems KW - Female KW - Infant KW - Immunization Programs KW - Male KW - Prospective Studies KW - Humans KW - Child, Preschool KW - Infant, Newborn KW - Poliomyelitis KW - Poliovirus Vaccine, Oral KW - Humans KW - Infant KW - Child, Preschool KW - Poliomyelitis KW - Poliovirus Vaccine, Oral KW - Prospective Studies KW - Female KW - Infant, Newborn KW - Adverse Drug Reaction Reporting Systems KW - Male KW - Immunization Programs LA - eng PY - 2025 T2 - The Lancet. Global Health T2 - The Lancet. Global Health, 2025, v. 13, no. 7 TI - Safety of NOPV2 Administered During a Supplementary Immunisation Activity in Uganda, 2022: Data Triangulation From a Prospective Cohort Event Monitoring Programme and Vaccine Safety Surveillance Reports. VL - 13 UR - https://stacks.cdc.gov/view/cdc/261386 ER -
Influenza Vaccination During Early Pregnancy and Risk of Major Birth Defects, US Birth Defects Study to Evaluate Pregnancy ExposureS, 2014-2019.

Malange, Veronica ;

Mohaissen, Tasnim

June 2025 | Vaccine, 2025, v. 59

Studies of influenza vaccination during pregnancy and major birth defects generally provide reassuring findings. To maintain public confidence, it is important to continue evaluating the safety of maternal vaccination using well characterized, population-based data. This study extended previous research to examine associations between maternal infl ...

10/09/2026

Supporting Files

Title : Influenza Vaccination During Early Pregnancy and Risk of Major Birth Defects, US Birth Defects Study to Evaluate Pregnancy ExposureS, 2014-2019. Personal Author(s) : Malange, Veronica;Mohaissen, Tasnim;Conway, Kristin M.;Rhoads, Anthony;Morris, Joan K.;Ailes, Elizabeth C.;Hedley, Paula L.;Cragan, Janet D.;Nestoridi, Eirini;Papadopoulos, Eleni A.;Scholz, Thomas D.;Sidhu, Alpa;Christiansen, Michael;Romitti, Paul A.; Published Date : June 2025 Pages in Document : 127297 (21 pdf pages) Source : Vaccine, 2025, v. 59 DOI : https://doi.org/10.1016/j.vaccine.2025.127297 Journal Title : Vaccine
Malange, V., Mohaissen, T., Conway, K. M., Rhoads, A., Morris, J. K., Ailes, E. C., Hedley, P. L., Cragan, J. D., Nestoridi, E., Papadopoulos, E. A., Scholz, T. D., Sidhu, A., Christiansen, M., & Romitti, P. A. (2025). Influenza Vaccination During Early Pregnancy and Risk of Major Birth Defects, US Birth Defects Study to Evaluate Pregnancy ExposureS, 2014-2019. Vaccine, 59. https://doi.org/10.1016/j.vaccine.2025.127297

Malange, Veronica, Tasnim Mohaissen, Kristin M. Conway, Anthony Rhoads, Joan K. Morris, Elizabeth C. Ailes, and Paula L. Hedley, et al.. "Influenza Vaccination During Early Pregnancy and Risk of Major Birth Defects, US Birth Defects Study to Evaluate Pregnancy ExposureS, 2014-2019." Vaccine 59 (2025). https://doi.org/10.1016/j.vaccine.2025.127297.

Malange, Veronica, et al. "Influenza Vaccination During Early Pregnancy and Risk of Major Birth Defects, US Birth Defects Study to Evaluate Pregnancy ExposureS, 2014-2019." Vaccine, vol. 59, 2025. Stacks. https://doi.org/10.1016/j.vaccine.2025.127297.
Export RIS Citation Information. TY - Journal Article AU - Malange, Veronica AU - Mohaissen, Tasnim AU - Conway, Kristin M. AU - Rhoads, Anthony AU - Morris, Joan K. AU - Ailes, Elizabeth C. AU - Hedley, Paula L. AU - Cragan, Janet D. AU - Nestoridi, Eirini AU - Papadopoulos, Eleni A. AU - Scholz, Thomas D. AU - Sidhu, Alpa AU - Christiansen, Michael AU - Romitti, Paul A. AB - Studies of influenza vaccination during pregnancy and major birth defects generally provide reassuring findings. To maintain public confidence, it is important to continue evaluating the safety of maternal vaccination using well characterized, population-based data. This study extended previous research to examine associations between maternal influenza vaccination and selected birth defects using data from the Birth Defects Study To Evaluate Pregnancy exposureS, a US, multisite case-control study. AB - Mothers of case children (diagnosed with a birth defect) and control children (without a birth defect diagnosis) were identified from population-based birth defect surveillance programs and recruited to complete a telephone interview. Data from 2675 case and 1575 control mothers (participants) with deliveries during 2014-2019 were analyzed. Influenza vaccination exposure during the critical exposure period (one month before pregnancy through the first pregnancy month [B1P1] for spina bifida or through the third pregnancy month [B1P3] for other selected birth defects) was assessed controlling for several participant covariates. Logistic regression with propensity score adjustment was used to estimate adjusted odds ratios (aORs) and 95 % confidence intervals (CIs). Several secondary analyses were conducted. A probabilistic bias analysis examined the effect of exposure misclassification. AB - The aOR observed between B1P1 influenza vaccination exposure and spina bifida was 0.9 (95 % CI: 0.4-2.0). The aORs for B1P3 exposure and other selected birth defects examined ranged from 0.4 to 1.3, with 95 % CIs including the null except those for cleft lip ± cleft palate (aOR: 0.6; 95 % CI: 0.4-0.9) and gastroschisis (aOR: 0.4; 95 % CI: 0.2-0.7). Results from secondary analyses were similar to the primary analyses, and those from probabilistic bias analysis were similar to respective primary and secondary analyses. AB - Findings showed no statistically significant positive associations between influenza vaccination and the selected birth defects, supporting public health efforts to promote optimal vaccination coverage among pregnant women. AB - Author manuscript AN - cdc:261385 C4 - PMC12990147 DO - https://doi.org/10.1016/j.vaccine.2025.127297 J2 - Vaccine KW - Pregnancy KW - Pregnancy Complications, Infectious KW - Female KW - Vaccination KW - Case-Control Studies KW - Humans KW - Young Adult KW - Infant, Newborn KW - Influenza Vaccines KW - Adult KW - Influenza, Human KW - Congenital Abnormalities KW - Birth defects KW - Congenital abnormalities KW - Spina bifida KW - Influenza vaccines KW - Pregnancy KW - Humans KW - Female KW - Pregnancy KW - Influenza Vaccines KW - Congenital Abnormalities KW - Influenza, Human KW - Case-Control Studies KW - Adult KW - Vaccination KW - Young Adult KW - Pregnancy Complications, Infectious KW - Infant, Newborn LA - eng PY - 2025 T2 - Vaccine T2 - Vaccine, 2025, v. 59 TI - Influenza Vaccination During Early Pregnancy and Risk of Major Birth Defects, US Birth Defects Study to Evaluate Pregnancy ExposureS, 2014-2019. VL - 59 UR - https://stacks.cdc.gov/view/cdc/261385 ER -
Glycoprotein L-deleted Single-cycle Rhesus Cytomegalovirus Vectors Elicit MHC-E-restricted CD8+ T Cells That Protect Against SIV.

Hansen, Scott G. ;

Schell, John B.

May 2025 | Journal of Immunology (Baltimore, MD.: 1950), 2025, v. 214, no. 8

Strain 68-1 rhesus CMV (RhCMV) vectors induce immune responses that mediate early, complete replication arrest of SIV infection in ∼60% of vaccinated rhesus macaques (RMs). This unique efficacy depends on the ability of these vectors to elicit effector memory (EM)-biased CD8+ T cells recognizing SIV peptides presented by MHC-E, rather than MHC-Ia. ...

10/09/2026

Supporting Files

Title : Glycoprotein L-deleted Single-cycle Rhesus Cytomegalovirus Vectors Elicit MHC-E-restricted CD8+ T Cells That Protect Against SIV. Personal Author(s) : Hansen, Scott G.;Schell, John B.;Marshall, Emily E.;Ojha, Sohita;Feltham, Shana;Morrow, David;Hughes, Colette M.;Gilbride, Roxanne M.;Ford, Julia C.;Cleveland-Rubeor, Hilary C.;McArdle, Matthew R.;Whitmer, Travis;Barber-Axthelm, Aaron;Bochart, Rachelle;Smedley, Jeremy;Oswald, Kelli;Fast, Randy;Shoemaker, Rebecca;Kosmider, Ewelina;Edlefsen, Paul T.;Lifson, Jeffrey D.;Malouli, Daniel;Früh, Klaus;Picker, Louis J.; Published Date : May 2025 Pages in Document : 1969-1981 (25 pdf pages) Source : Journal of Immunology (Baltimore, MD.: 1950), 2025, v. 214, no. 8 DOI : https://doi.org/10.1093/jimmun/vkaf104 Journal Title : Journal of Immunology (Baltimore, MD.: 1950)
Hansen, S. G., Schell, J. B., Marshall, E. E., Ojha, S., Feltham, S., Morrow, D., Hughes, C. M., Gilbride, R. M., Ford, J. C., Cleveland-Rubeor, H. C., McArdle, M. R., Whitmer, T., Barber-Axthelm, A., Bochart, R., Smedley, J., Oswald, K., Fast, R., Shoemaker, R., Kosmider, E., ... Picker, L. J. (2025). Glycoprotein L-deleted Single-cycle Rhesus Cytomegalovirus Vectors Elicit MHC-E-restricted CD8+ T Cells That Protect Against SIV. Journal of Immunology (Baltimore, MD.: 1950), 214(8). https://doi.org/10.1093/jimmun/vkaf104

Hansen, Scott G., John B. Schell, Emily E. Marshall, Sohita Ojha, Shana Feltham, David Morrow, and Colette M. Hughes, et al.. "Glycoprotein L-deleted Single-cycle Rhesus Cytomegalovirus Vectors Elicit MHC-E-restricted CD8+ T Cells That Protect Against SIV." Journal of Immunology (Baltimore, MD.: 1950) 214, no. 8 (2025). https://doi.org/10.1093/jimmun/vkaf104.

Hansen, Scott G., et al. "Glycoprotein L-deleted Single-cycle Rhesus Cytomegalovirus Vectors Elicit MHC-E-restricted CD8+ T Cells That Protect Against SIV." Journal of Immunology (Baltimore, MD.: 1950), vol. 214, no. 8, 2025. Stacks. https://doi.org/10.1093/jimmun/vkaf104.
Export RIS Citation Information. TY - Journal Article AU - Hansen, Scott G. AU - Schell, John B. AU - Marshall, Emily E. AU - Ojha, Sohita AU - Feltham, Shana AU - Morrow, David AU - Hughes, Colette M. AU - Gilbride, Roxanne M. AU - Ford, Julia C. AU - Cleveland-Rubeor, Hilary C. AU - McArdle, Matthew R. AU - Whitmer, Travis AU - Barber-Axthelm, Aaron AU - Bochart, Rachelle AU - Smedley, Jeremy AU - Oswald, Kelli AU - Fast, Randy AU - Shoemaker, Rebecca AU - Kosmider, Ewelina AU - Edlefsen, Paul T. AU - Lifson, Jeffrey D. AU - Malouli, Daniel AU - Früh, Klaus AU - Picker, Louis J. AB - Strain 68-1 rhesus CMV (RhCMV) vectors induce immune responses that mediate early, complete replication arrest of SIV infection in ∼60% of vaccinated rhesus macaques (RMs). This unique efficacy depends on the ability of these vectors to elicit effector memory (EM)-biased CD8+ T cells recognizing SIV peptides presented by MHC-E, rather than MHC-Ia. These efficacious responses still occurred when spread of the 68-1 vector was impaired by deletion of the viral anti-host intrinsic immunity factor phosphoprotein 71 (pp71), but efficacy was lost with a more stringent attenuation strategy based on destabilization of Rh108, the ortholog of the essential human CMV (HCMV) transcription factor UL79 that is required for late viral gene expression. Although unable to produce infectious progeny (ie single-cycle infection), Rh108-deficient vectors elicited durable, high frequency, EM-biased, SIV-specific CD8+ T-cell responses in RMs, but these responses were MHC-Ia-restricted and therefore non-efficacious. Here, we tested a different single-cycle attenuation strategy based on deletion (Δ) of the glycoprotein L (gL) that is essential for viral entry but allows for late gene expression and viral assembly. ΔgL 68-1 RhCMV/SIV vectors, grown on gL-complementing fibroblasts, were robustly immunogenic at doses above 105 PFU, generating high frequency, EM-biased, SIV-specific CD8+ T-cell responses that were also unconventionally restricted, including the MHC-E restriction associated with efficacy. Indeed, these single-cycle vectors manifested replication arrest efficacy in 70% of vaccinated RMs, further linking MHC-E restriction with efficacy, and demonstrating that 68-1 RhCMV/SIV efficacy does not require vector dissemination within the host. AB - Author manuscript AN - cdc:261384 C4 - PMC12396747 DO - https://doi.org/10.1093/jimmun/vkaf104 IS - 8 J2 - Journal of Immunology (Baltimore, MD.: 1950) KW - Cytomegalovirus KW - CD8-Positive T-Lymphocytes KW - SAIDS Vaccines KW - Animals KW - Viral Envelope Proteins KW - Simian Immunodeficiency Virus KW - Simian Acquired Immunodeficiency Syndrome KW - Macaca mulatta KW - Humans KW - Genetic Vectors KW - Histocompatibility Antigens Class I KW - CD8 KW - + KW - T cells KW - CMV vectors KW - HIV vaccine KW - MHC-E KW - Animals KW - Macaca mulatta KW - CD8-Positive T-Lymphocytes KW - Cytomegalovirus KW - Simian Immunodeficiency Virus KW - Histocompatibility Antigens Class I KW - Genetic Vectors KW - Simian Acquired Immunodeficiency Syndrome KW - SAIDS Vaccines KW - Humans KW - Viral Envelope Proteins LA - eng PY - 2025 T2 - Journal of Immunology (Baltimore, MD.: 1950) T2 - Journal of Immunology (Baltimore, MD.: 1950), 2025, v. 214, no. 8 TI - Glycoprotein L-deleted Single-cycle Rhesus Cytomegalovirus Vectors Elicit MHC-E-restricted CD8+ T Cells That Protect Against SIV. VL - 214 UR - https://stacks.cdc.gov/view/cdc/261384 ER -
Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE.

Hsia, Daniel S. ;

Younes, Naji

May 2025 | Diabetes Care, 2025, v. 48, no. 7

To compare rates of and risk factors for hospitalizations among Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) participants taking metformin and randomly assigned to insulin glargine U-100, glimepiride, liraglutide, or sitagliptin.Intention-to-treat (ITT) (N = 5,047) and on-assigned-treatment (AT) (N = 4,830) d ...

10/09/2026

Supporting Files

Title : Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE. Personal Author(s) : Hsia, Daniel S.;Younes, Naji;Ghosh, Alokananda;Kazemi, Erin J.;Krause-Steinrauf, Heidi;Buse, John B.;Baker, Chelsea;Brown-Friday, Janet;Diaz, Elsa;Diner, Jamie;Groessl, Erik J.;Legowski, Elizabeth A.;Mariash, Cary N.;Waltje, Andrea H.;Wexler, Deborah J.;Martin, Catherine L.; Corporate Authors(s) : for the GRADE Research Group Published Date : May 2025 Pages in Document : 1288-1294 (15 pdf pages) Source : Diabetes Care, 2025, v. 48, no. 7 DOI : https://doi.org/10.2337/dc24-2839 Journal Title : Diabetes Care
Hsia, D. S., Younes, N., Ghosh, A., Kazemi, E. J., Krause-Steinrauf, H., Buse, J. B., Baker, C., Brown-Friday, J., Diaz, E., Diner, J., Groessl, E. J., Legowski, E. A., Mariash, C. N., Waltje, A. H., Wexler, D. J., & Martin, C. L. (2025). Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE. Diabetes Care, 48(7). https://doi.org/10.2337/dc24-2839

Hsia, Daniel S., Naji Younes, Alokananda Ghosh, Erin J. Kazemi, Heidi Krause-Steinrauf, John B. Buse, and Chelsea Baker, et al.. "Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE." Diabetes Care 48, no. 7 (2025). https://doi.org/10.2337/dc24-2839.

Hsia, Daniel S., et al. "Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE." Diabetes Care, vol. 48, no. 7, 2025. Stacks. https://doi.org/10.2337/dc24-2839.
Export RIS Citation Information. TY - Journal Article AU - Hsia, Daniel S. AU - Younes, Naji AU - Ghosh, Alokananda AU - Kazemi, Erin J. AU - Krause-Steinrauf, Heidi AU - Buse, John B. AU - Baker, Chelsea AU - Brown-Friday, Janet AU - Diaz, Elsa AU - Diner, Jamie AU - Groessl, Erik J. AU - Legowski, Elizabeth A. AU - Mariash, Cary N. AU - Waltje, Andrea H. AU - Wexler, Deborah J. AU - Martin, Catherine L. A2 - for the GRADE Research Group AB - To compare rates of and risk factors for hospitalizations among Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) participants taking metformin and randomly assigned to insulin glargine U-100, glimepiride, liraglutide, or sitagliptin. AB - Intention-to-treat (ITT) (N = 5,047) and on-assigned-treatment (AT) (N = 4,830) data sets were used. Baseline differences between those hospitalized versus those not hospitalized were assessed. Kaplan-Meier analysis was used to determine incidence for time to first hospitalization, and log-rank tests were used to determine treatment group differences. Time-to-event analyses were used to examine factors affecting subsequent hospitalization risk. AB - During GRADE, 1,636 participants (32.4%) were hospitalized at least once and 751 (14.9%) were hospitalized more than once. Hospitalized participants were older, less likely to be Hispanic, more likely to be White, and more likely to have a history of hypertension and had higher baseline BMI. There were no treatment group differences in incidence for time to first hospitalization in the ITT data set (P = 0.148), but a reduced hazard rate was observed for those taking liraglutide versus those taking glimepiride in the AT data set (hazard ratio 0.78 [95% CI 0.66, 0.92]; P = 0.022). Factors increasing the risk for subsequent hospitalizations included meeting the secondary outcome (HbA1c >7.5%, confirmed), each prior hospitalization, and change from assigned treatment (29%, 41%, and 56% increase in risk, respectively). Assignment to liraglutide versus glimepiride reduced this risk by 13%. AB - Hospitalizations were common in GRADE, and rates were nearly identical across treatment groups. The small, but significant, reduction in risk for subsequent hospitalizations among participants assigned to liraglutide versus glimepiride may influence treatment decisions in populations similar to GRADE participants. AB - Author manuscript AN - cdc:261383 C4 - PMC12178615 DO - https://doi.org/10.2337/dc24-2839 IS - 7 J2 - Diabetes Care KW - Female KW - Sulfonylurea Compounds KW - Sitagliptin Phosphate KW - Metformin KW - Aged KW - Diabetes Mellitus, Type 2 KW - Liraglutide KW - Hospitalization KW - Male KW - Hypoglycemic Agents KW - Middle Aged KW - Humans KW - Insulin Glargine KW - Blood Glucose KW - diabetes treatment KW - hospitalizations KW - serious adverse events KW - Aged KW - Female KW - Humans KW - Male KW - Middle Aged KW - Blood Glucose KW - Diabetes Mellitus, Type 2 KW - Hospitalization KW - Hypoglycemic Agents KW - Insulin Glargine KW - Liraglutide KW - Metformin KW - Sitagliptin Phosphate KW - Sulfonylurea Compounds LA - eng PY - 2025 T2 - Diabetes Care T2 - Diabetes Care, 2025, v. 48, no. 7 TI - Association of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE. VL - 48 UR - https://stacks.cdc.gov/view/cdc/261383 ER -
Longer-acting Preexposure Prophylaxis Product and Delivery Preferences Among U.S. Populations Disproportionately Affected by HIV: a Discrete Choice Experiment.

Roberts, Sarah T. ;

Browne, Erica N.

August 2025 | AIDS (London, England), 2025, v. 39, no. 10

Longer-acting preexposure prophylaxis (LA-PrEP) products have potential to increase PrEP uptake and continuation. This study sought to elicit preferences for LA-PrEP product and delivery program characteristics among populations disproportionately impacted by HIV to identify factors important to adoption and anticipate potential use challenges.Cros ...

10/09/2026

Supporting Files

Title : Longer-acting Preexposure Prophylaxis Product and Delivery Preferences Among U.S. Populations Disproportionately Affected by HIV: a Discrete Choice Experiment. Personal Author(s) : Roberts, Sarah T.;Browne, Erica N.;Denson, Damian;Moore, Emily;Mungo, Jackie;Mancuso, Noah;Diaz, Miranda;Patel, Rupa;Kourtis, Athena P.;Minnis, Alexandra M.;Hoover, Karen W.; Published Date : August 2025 Pages in Document : 1364-1374 (18 pdf pages) Source : AIDS (London, England), 2025, v. 39, no. 10 DOI : https://doi.org/10.1097/QAD.0000000000004247 Journal Title : AIDS (London, England)
Roberts, S. T., Browne, E. N., Denson, D., Moore, E., Mungo, J., Mancuso, N., Diaz, M., Patel, R., Kourtis, A. P., Minnis, A. M., & Hoover, K. W. (2025). Longer-acting Preexposure Prophylaxis Product and Delivery Preferences Among U.S. Populations Disproportionately Affected by HIV: a Discrete Choice Experiment. AIDS (London, England), 39(10). https://doi.org/10.1097/QAD.0000000000004247

Roberts, Sarah T., Erica N. Browne, Damian Denson, Emily Moore, Jackie Mungo, Noah Mancuso, and Miranda Diaz, et al.. "Longer-acting Preexposure Prophylaxis Product and Delivery Preferences Among U.S. Populations Disproportionately Affected by HIV: a Discrete Choice Experiment." AIDS (London, England) 39, no. 10 (2025). https://doi.org/10.1097/QAD.0000000000004247.

Roberts, Sarah T., et al. "Longer-acting Preexposure Prophylaxis Product and Delivery Preferences Among U.S. Populations Disproportionately Affected by HIV: a Discrete Choice Experiment." AIDS (London, England), vol. 39, no. 10, 2025. Stacks. https://doi.org/10.1097/QAD.0000000000004247.
Export RIS Citation Information. TY - Journal Article AU - Roberts, Sarah T. AU - Browne, Erica N. AU - Denson, Damian AU - Moore, Emily AU - Mungo, Jackie AU - Mancuso, Noah AU - Diaz, Miranda AU - Patel, Rupa AU - Kourtis, Athena P. AU - Minnis, Alexandra M. AU - Hoover, Karen W. AB - Longer-acting preexposure prophylaxis (LA-PrEP) products have potential to increase PrEP uptake and continuation. This study sought to elicit preferences for LA-PrEP product and delivery program characteristics among populations disproportionately impacted by HIV to identify factors important to adoption and anticipate potential use challenges. AB - Cross-sectional, online discrete choice experiment. AB - We recruited 940 men who have sex with men (MSM), people who inject drugs (PWID), and Black heterosexual men and women (BHMW) with PrEP indications. In a series of 10 tasks, participants chose between two hypothetical LA-PrEP options composed of 5 attributes (product type, side effects, clinic type, appointment duration, cost), or neither (their current HIV prevention method). Analysis used random-parameters logit models. AB - Respondents chose an LA-PrEP method over their current HIV prevention option in 96.8% of tasks. Cost was the most important determinant of LA-PrEP choice for all populations (relative importance [RI] of 10]. Side effects and product type were 1/3 to 1/2 as important as cost (RI 3.5-5.1). MSM and PWID most preferred the 12-month implant followed by semiannual dual injections and least preferred the monthly oral pill and 2-month single injection. BHMW most preferred the monthly pill and semiannual injections and least preferred the 12-month implant and 2-month injection. Clinic type and appointment duration had minimal influence (RI 0.1-2.1). AB - Results suggest high demand for LA-PrEP among populations with disproportionately high HIV incidence. To facilitate use, programs should offer a range of LA-PrEP products, minimize out-of-pocket costs, and counsel on side effects. AB - Author manuscript AN - cdc:261382 C4 - PMC12459700 DO - https://doi.org/10.1097/QAD.0000000000004247 IS - 10 J2 - AIDS (London, England) KW - Female KW - Anti-HIV Agents KW - Young Adult KW - Homosexuality, Male KW - Pre-Exposure Prophylaxis KW - Cross-Sectional Studies KW - Patient Preference KW - Chemoprevention KW - Male KW - Middle Aged KW - Humans KW - Adult KW - Choice Behavior KW - Disease Transmission, Infectious KW - HIV Infections KW - black heterosexual men and women KW - discrete choice experiment KW - HIV prevention KW - longer-acting preexposure prophylaxis KW - men who have sex with men KW - people who inject drugs KW - Humans KW - Pre-Exposure Prophylaxis KW - HIV Infections KW - Male KW - Cross-Sectional Studies KW - Female KW - Adult KW - Middle Aged KW - Young Adult KW - Anti-HIV Agents KW - Patient Preference KW - Disease Transmission, Infectious KW - Homosexuality, Male KW - Choice Behavior KW - Chemoprevention LA - eng PY - 2025 T2 - AIDS (London, England) T2 - AIDS (London, England), 2025, v. 39, no. 10 TI - Longer-acting Preexposure Prophylaxis Product and Delivery Preferences Among U.S. Populations Disproportionately Affected by HIV: a Discrete Choice Experiment. VL - 39 UR - https://stacks.cdc.gov/view/cdc/261382 ER -
Intrinsic Immunogenicity is a Major Determinant of Type-specific Responses in SARS-CoV-2 Infections.

Quirk, Grace E. ;

Schoenle, Marta V.

June 2025 | Nature Immunology, 2025, v. 26, no. 6

Few type-specific antibodies that recognize drifted epitopes are made during post-vaccination exposures to SARS-CoV-2 variants, perhaps due to suppression by previous immunity. We compared type-specific B cell responses in unvaccinated and vaccinated individuals with Delta and Omicron BA.1 SARS-CoV-2 variant infections. For both Delta, which is ant ...

10/09/2026

Supporting Files

Title : Intrinsic Immunogenicity is a Major Determinant of Type-specific Responses in SARS-CoV-2 Infections. Personal Author(s) : Quirk, Grace E.;Schoenle, Marta V.;Peyton, Kameron L.;Uhrlaub, Jennifer L.;Lau, Branden;Liang, Chieh-Yu;Burgess, Jefferey L.;Ellingson, Katherine;Beitel, Shawn;Romine, James;Lutrick, Karen;Fowlkes, Ashley;Britton, Amadea;Tyner, Harmony L.;Caban-Martinez, Alberto J.;Naleway, Allison;Gaglani, Manjusha;Yoon, Sarang;Edwards, Laura J.;Olsho, Lauren;Dake, Michael;Valdez, Riccardo;Gordon, Aubree;Diamond, Michael S.;LaFleur, Bonnie J.;Nikolich, Janko Ž.;Sprissler, Ryan;Worobey, Michael;Bhattacharya, Deepta; Published Date : June 2025 Pages in Document : 829-836 (26 pdf pages) Source : Nature Immunology, 2025, v. 26, no. 6 DOI : https://doi.org/10.1038/s41590-025-02162-2 Journal Title : Nature Immunology
Quirk, G. E., Schoenle, M. V., Peyton, K. L., Uhrlaub, J. L., Lau, B., Liang, C. Y., Burgess, J. L., Ellingson, K., Beitel, S., Romine, J., Lutrick, K., Fowlkes, A., Britton, A., Tyner, H. L., Caban-Martinez, A. J., Naleway, A., Gaglani, M., Yoon, S., Edwards, L. J., ... Bhattacharya, D. (2025). Intrinsic Immunogenicity is a Major Determinant of Type-specific Responses in SARS-CoV-2 Infections. Nature Immunology, 26(6). https://doi.org/10.1038/s41590-025-02162-2

Quirk, Grace E., Marta V. Schoenle, Kameron L. Peyton, Jennifer L. Uhrlaub, Branden Lau, Chieh-Yu Liang, and Jefferey L. Burgess, et al.. "Intrinsic Immunogenicity is a Major Determinant of Type-specific Responses in SARS-CoV-2 Infections." Nature Immunology 26, no. 6 (2025). https://doi.org/10.1038/s41590-025-02162-2.

Quirk, Grace E., et al. "Intrinsic Immunogenicity is a Major Determinant of Type-specific Responses in SARS-CoV-2 Infections." Nature Immunology, vol. 26, no. 6, 2025. Stacks. https://doi.org/10.1038/s41590-025-02162-2.
Export RIS Citation Information. TY - Journal Article AU - Quirk, Grace E. AU - Schoenle, Marta V. AU - Peyton, Kameron L. AU - Uhrlaub, Jennifer L. AU - Lau, Branden AU - Liang, Chieh-Yu AU - Burgess, Jefferey L. AU - Ellingson, Katherine AU - Beitel, Shawn AU - Romine, James AU - Lutrick, Karen AU - Fowlkes, Ashley AU - Britton, Amadea AU - Tyner, Harmony L. AU - Caban-Martinez, Alberto J. AU - Naleway, Allison AU - Gaglani, Manjusha AU - Yoon, Sarang AU - Edwards, Laura J. AU - Olsho, Lauren AU - Dake, Michael AU - Valdez, Riccardo AU - Gordon, Aubree AU - Diamond, Michael S. AU - LaFleur, Bonnie J. AU - Nikolich, Janko Ž. AU - Sprissler, Ryan AU - Worobey, Michael AU - Bhattacharya, Deepta AB - Few type-specific antibodies that recognize drifted epitopes are made during post-vaccination exposures to SARS-CoV-2 variants AB - , perhaps due to suppression by previous immunity. We compared type-specific B cell responses in unvaccinated and vaccinated individuals with Delta and Omicron BA.1 SARS-CoV-2 variant infections. For both Delta, which is antigenically similar to the vaccine strain, and the more distant BA.1 variant, neutralizing antibodies were greater in post-vaccination variant infections than in primary variant infections. Delta type-specific memory B cells were reduced in post-vaccination Delta infections relative to primary variant infections. Yet some drifted epitopes in the Delta variant elicited minimal responses even in primary infections. For BA.1 infections, type-specific antibodies and memory B cells were mostly undetectable, irrespective of previous immunity. Thus, poor intrinsic antigenicity of drifted epitopes in Delta and BA.1 infections superseded the impact of previous immunity. Enhancing the immunogenicity of vaccine antigens may promote type-specific responses. AB - Author manuscript AN - cdc:261381 C4 - PMC12198969 DO - https://doi.org/10.1038/s41590-025-02162-2 IS - 6 J2 - Nature Immunology KW - Memory B Cells KW - B-Lymphocytes KW - Antibodies, Neutralizing KW - Female KW - Vaccination KW - SARS-CoV-2 KW - Immunologic Memory KW - COVID-19 KW - Epitopes, B-Lymphocyte KW - Immunogenicity, Vaccine KW - COVID-19 Vaccines KW - Antibodies, Viral KW - Male KW - Spike Glycoprotein, Coronavirus KW - Humans KW - Middle Aged KW - Adult KW - Humans KW - SARS-CoV-2 KW - COVID-19 KW - Antibodies, Viral KW - Antibodies, Neutralizing KW - COVID-19 Vaccines KW - Memory B Cells KW - Spike Glycoprotein, Coronavirus KW - Female KW - Middle Aged KW - Male KW - Epitopes, B-Lymphocyte KW - Immunologic Memory KW - Adult KW - Vaccination KW - Immunogenicity, Vaccine KW - B-Lymphocytes LA - eng PY - 2025 T2 - Nature Immunology T2 - Nature Immunology, 2025, v. 26, no. 6 TI - Intrinsic Immunogenicity is a Major Determinant of Type-specific Responses in SARS-CoV-2 Infections. VL - 26 UR - https://stacks.cdc.gov/view/cdc/261381 ER -

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