Self-management For People With Epilepsy and a History of Negative Health Events (SMART): a Randomized Controlled Effectiveness Trial.

Details

• Alternative Title:
  Epilepsy & Behavior : E&B, 2025, v. 171: Self-management For People With Epilepsy and a History of Negative Health Events (SMART): a Randomized Controlled Effectiveness Trial.
• Journal Article:
  Epilepsy & Behavior : E&B
• Personal Author:
  Sajatovic, Martha ; Ghearing, Gena R. ; Tyrrell, Maegan ; Black, Jessica ; Krehel-Montgomery, Jacqueline ; Barigye, Richard ; Yala, Joy ; Adeniyi, Clara ; Privitera, Michael ; Rossi, Marvin A. ; Briggs, Farren
• Description:
  This 2-site, 6-month randomized controlled trial of an epilepsy self-management (ESM) curriculum (SMART) vs. 6-month waitlist (WL) control assessed effects on epilepsy outcomes in 160 people with epilepsy (PWE).
  
  PWE had at least 1 negative health event (NHE) defined as a seizure, emergency department visit, hospitalization or self-harm attempt in the last 6 months. Primary outcomes were differences in proportions of PWE with reductions in NHEs from baseline to 6 months follow up and change in NHE/seizure counts between SMART and WL. Secondary outcomes included the Patient Health Questionnaire (PHQ-9), 36-Item Short Form Survey (SF-36), Quality of Life in Epilepsy (QOLIE-31), Epilepsy Self-Management Scale (ESMS), Epilepsy Stigma Scale (ESS), Multidimensional Scale of Perceived Social Support (MSPSS) and Epilepsy Self-Efficacy Scale (ESES).
  
  Mean age was 39.4 (SD 12.2), 66.9 % (N = 107) women, and 31 % (N = 50) rural. Mean PHQ-9 of 10.5 (SD 7) suggested mild/moderate depression. Seizures were the most common NHE with mean baseline past 6-month seizure count of 20.6 (SD 41.0). SMART was significantly associated with a 2-fold increase in odds of having at least 10-30 % improvement in NHEs vs. WL (p < 0.05). SMART was associated with significant seizure reduction (p < 0.05), significantly improved PHQ-9 (p = 0.014), QOLIE-31 seizure worry (p = <0.001) and social functioning (p = 0.021), ESES (p = 0.046) and ESMS (p < 0.001).
  
  Compared to WL, SMART participants had improvement in NHEs and seizures, depressive symptoms, self-management competency and self-efficacy and selected elements of quality of life. Inclusion of effective ESMs into a comprehensive care of model for PWE may be warranted.
• Content Notes:
  Author manuscript
• Subjects:
  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Epilepsy
  • Quality of Life
  • Self Efficacy
  • Self-Management
  • Social Stigma
  More +
• Keywords:
  • epilepsy
  • seizures
  • stigma
  • depression
  • quality of life
• Source:
  Epilepsy & Behavior : E&B, 2025, v. 171
• DOI:
  https://doi.org/10.1016/j.yebeh.2025.110495
• ISSN:
  1525-5050 ; 1525-5069
• Pubmed ID:
  40412342
• Pubmed Central ID:
  PMC13482782
• Document Type:
  Text
• Funding:
  U48 DP006389/DP/NCCDPHP CDC HHSUnited States/ ; UM1 TR004528/TR/NCATS NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  110495 (21 pdf pages)
• Volume:
  171
• Download URL:
  https://stacks.cdc.gov/view/cdc/261388/cdc_261388_DS1.pdf
• File Type:
  [PDF - 629.62 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:3cf20ecfbab1e3d833d787db341956a29ae1e01e608fbf8151c15e680c07ff1e611e7fd542e4afcc9ba2bb8afbd3a85101d6fa94819e96be72468e0359c5233d