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Advancing Methods For Program Evaluation in Substance Use by Strengthening the Application of Epidemiology, Economic Evaluation, and Implementation Science: Reflections on the Opportunities For Synergy.

Blackburn, Natalie A. ;

Philbrick, Sarah

August 2025 | Evaluation and Program Planning, 2025, v. 111

Program evaluation is necessary to assess the success of evidence-based programs in real-world, non-trial settings. In its most basic form, it involves understanding processes that impact the health and well-being of individuals and communities. Increasingly, robust program evaluations are integrating approaches from implementation science and econ ...

10/09/2026

Supporting Files

Title : Advancing Methods For Program Evaluation in Substance Use by Strengthening the Application of Epidemiology, Economic Evaluation, and Implementation Science: Reflections on the Opportunities For Synergy. Personal Author(s) : Blackburn, Natalie A.;Philbrick, Sarah;Patel, Sheila V.;Cance, Jessica D.;Elek, Elvira;Gibbons, Brent;Khan, Sazid;Lambdin, Barrot H.;Graham, Phillip W.; Published Date : August 2025 Pages in Document : 102610 (22 pdf pages) Source : Evaluation and Program Planning, 2025, v. 111 DOI : https://doi.org/10.1016/j.evalprogplan.2025.102610 Journal Title : Evaluation and Program Planning
Blackburn, N. A., Philbrick, S., Patel, S. V., Cance, J. D., Elek, E., Gibbons, B., Khan, S., Lambdin, B. H., & Graham, P. W. (2025). Advancing Methods For Program Evaluation in Substance Use by Strengthening the Application of Epidemiology, Economic Evaluation, and Implementation Science: Reflections on the Opportunities For Synergy. Evaluation and Program Planning, 111. https://doi.org/10.1016/j.evalprogplan.2025.102610

Blackburn, Natalie A., Sarah Philbrick, Sheila V. Patel, Jessica D. Cance, Elvira Elek, Brent Gibbons, Sazid Khan, Barrot H. Lambdin, and Phillip W. Graham. "Advancing Methods For Program Evaluation in Substance Use by Strengthening the Application of Epidemiology, Economic Evaluation, and Implementation Science: Reflections on the Opportunities For Synergy." Evaluation and Program Planning 111 (2025). https://doi.org/10.1016/j.evalprogplan.2025.102610.

Blackburn, Natalie A., et al. "Advancing Methods For Program Evaluation in Substance Use by Strengthening the Application of Epidemiology, Economic Evaluation, and Implementation Science: Reflections on the Opportunities For Synergy." Evaluation and Program Planning, vol. 111, 2025. Stacks. https://doi.org/10.1016/j.evalprogplan.2025.102610.
Export RIS Citation Information. TY - Journal Article AU - Blackburn, Natalie A. AU - Philbrick, Sarah AU - Patel, Sheila V. AU - Cance, Jessica D. AU - Elek, Elvira AU - Gibbons, Brent AU - Khan, Sazid AU - Lambdin, Barrot H. AU - Graham, Phillip W. AB - Program evaluation is necessary to assess the success of evidence-based programs in real-world, non-trial settings. In its most basic form, it involves understanding processes that impact the health and well-being of individuals and communities. Increasingly, robust program evaluations are integrating approaches from implementation science and economic evaluation to strengthen assessment, achievement, and sustainment of the intended impacts of evidence-based programs, while traditionally employing epidemiological methods to assess outcomes. Epidemiology, economic evaluation, and implementation science operate in overlapping yet siloed arenas, which can make it challenging for program evaluators to effectively engage all three disciplines. Furthermore, given their overlap, practitioners in these disciplines must understand differences in their purpose and lexicon to foster synergies. We use the Centers for Disease Control and Prevention Evaluation Framework and an example from substance use prevention to reflect on specific concepts and terminology within each of these disciplines and how distinctions impact the ability of multidisciplinary teams to collaborate on evaluations. The implications apply to those designing, testing, implementing, and evaluating evidence-based programs-all of whom have the opportunity to consider and strengthen these elements when developing processes and measuring impact. The substance use prevention field needs to better understand how these disciplines can complement one another to enrich process, outcome, and impact evaluations, given the complexities of substance use behaviors and evidence-based programs to address them. With this synergy, clearer communication of findings from the different components can be achieved. AB - Author manuscript AN - cdc:261380 C4 - PMC12439252 DO - https://doi.org/10.1016/j.evalprogplan.2025.102610 J2 - Evaluation and Program Planning KW - Implementation Science KW - Program Evaluation KW - Humans KW - Cost-Benefit Analysis KW - Substance-Related Disorders KW - Evidence-Based Practice KW - Centers for Disease Control and Prevention, U.S. KW - economic evaluation KW - epidemiology KW - implementation science KW - program evaluation KW - substance use prevention KW - Humans KW - Substance-Related Disorders KW - Implementation Science KW - Program Evaluation KW - Centers for Disease Control and Prevention, U.S. KW - Evidence-Based Practice KW - Cost-Benefit Analysis LA - eng PY - 2025 T2 - Evaluation and Program Planning T2 - Evaluation and Program Planning, 2025, v. 111 TI - Advancing Methods For Program Evaluation in Substance Use by Strengthening the Application of Epidemiology, Economic Evaluation, and Implementation Science: Reflections on the Opportunities For Synergy. VL - 111 UR - https://stacks.cdc.gov/view/cdc/261380 ER -
Swine Production Intensity and Swine-specific Fecal Contamination of Household Surfaces at Residences of Industrial Livestock Operation Workers and Community Residents, North Carolina, USA.

Kurowski, Kathleen M ;

Pisanic, Nora

July 2025 | The Science of the Total Environment, 2025, v. 985

In North Carolina (NC), industrial livestock operations (ILOs) that produce swine concentrate fecal waste in lagoons and sprayfields, which are disproportionately located in low-income communities of color. Although swine-specific fecal contamination of surface waters proximal to swine ILOs has been documented, less is known about contamination of ...

10/09/2026

Supporting Files

Title : Swine Production Intensity and Swine-specific Fecal Contamination of Household Surfaces at Residences of Industrial Livestock Operation Workers and Community Residents, North Carolina, USA. Personal Author(s) : Kurowski, Kathleen M;Pisanic, Nora;Spicer, Kristoffer;Kruczynski, Kate;Gigot, Carolyn;Hall, Devon J.;Aune, Kyle T.;Salmerón, Bonita;Rule, Ana M.;Heaney, Christopher D.; Published Date : July 2025 Pages in Document : 179591 (28 pdf pages) Source : The Science of the Total Environment, 2025, v. 985 DOI : https://doi.org/10.1016/j.scitotenv.2025.179591 Journal Title : The Science of the Total Environment
Kurowski, K. M., Pisanic, N., Spicer, K., Kruczynski, K., Gigot, C., Hall, D. J., Aune, K. T., Salmerón, B., Rule, A. M., & Heaney, C. D. (2025). Swine Production Intensity and Swine-specific Fecal Contamination of Household Surfaces at Residences of Industrial Livestock Operation Workers and Community Residents, North Carolina, USA. The Science of the Total Environment, 985. https://doi.org/10.1016/j.scitotenv.2025.179591

Kurowski, Kathleen M, Nora Pisanic, Kristoffer Spicer, Kate Kruczynski, Carolyn Gigot, Devon J. Hall, Kyle T. Aune, Bonita Salmerón, Ana M. Rule, and Christopher D. Heaney. "Swine Production Intensity and Swine-specific Fecal Contamination of Household Surfaces at Residences of Industrial Livestock Operation Workers and Community Residents, North Carolina, USA." The Science of the Total Environment 985 (2025). https://doi.org/10.1016/j.scitotenv.2025.179591.

Kurowski, Kathleen M, et al. "Swine Production Intensity and Swine-specific Fecal Contamination of Household Surfaces at Residences of Industrial Livestock Operation Workers and Community Residents, North Carolina, USA." The Science of the Total Environment, vol. 985, 2025. Stacks. https://doi.org/10.1016/j.scitotenv.2025.179591.
Export RIS Citation Information. TY - Journal Article AU - Kurowski, Kathleen M AU - Pisanic, Nora AU - Spicer, Kristoffer AU - Kruczynski, Kate AU - Gigot, Carolyn AU - Hall, Devon J. AU - Aune, Kyle T. AU - Salmerón, Bonita AU - Rule, Ana M. AU - Heaney, Christopher D. AB - In North Carolina (NC), industrial livestock operations (ILOs) that produce swine concentrate fecal waste in lagoons and sprayfields, which are disproportionately located in low-income communities of color. Although swine-specific fecal contamination of surface waters proximal to swine ILOs has been documented, less is known about contamination of homes proximal to swine ILOs. Up to 6 outdoor and 6 indoor surface settled dust samples were collected from households: 1) with >= 1 ILO worker (ILO-W); 2) neighboring ILOs without occupational exposure to livestock (ILO-N); and 3) in metropolitan areas of NC (Metro). Using quantitative real-time PCR, the DNA copy number of Pig-2-Bac, a swine-specific fecal microbial source tracking (MST) marker, per square inch of household surfaces sampled was measured. We used permits of swine ILOs and steady state live weight to assign swine production intensity (SPI) exposure values to each household. We estimated associations between household group (Metro as reference), outdoor versus indoor household surface, and log AB - SPI with Pig-2-Bac DNA detection frequency (logistic) and quantity (linear) via regression modeling. Prevalence of household Pig-2-Bac positivity was 38 % (40/105) at ILO-W (159/536 swabs; 30 %); 44 % (47/107) at ILO-N (142/557 swabs; 25 %), and 1 % (1/81) at Metro (1/321 swabs; 1 %) households. Pig-2-Bac DNA was detected more often (odds ratio [OR] = 2.2; 95 % confidence interval [CI] = 1.6, 3.0) and in higher quantity (β = 0.30; 95 % CI = 0.19, 0.41) on outdoor compared to indoor surfaces. For every log AB - unit increase in SPI, the Pig-2-Bac DNA detection frequency (OR = 5.4; 95 % CI = 2.8, 10.4) and quantity (β = 0.21; 95 % CI = 0.13, 0.29) increased. Results demonstrate the utility of Pig-2-Bac DNA measurement in household surface dust and suggest that swine ILOs contribute to the contamination of NC community residents' households with swine fecal material. AB - Author manuscript AN - cdc:261379 C4 - PMC13140102 DO - https://doi.org/10.1016/j.scitotenv.2025.179591 J2 - The Science of the Total Environment KW - Occupational Exposure KW - Swine KW - Dust KW - Animals KW - Feces KW - Humans KW - Environmental Monitoring KW - Environmental Exposure KW - Animal Husbandry KW - Livestock KW - Concentrated animal feeding operations (CAFOs) KW - Hog production KW - Swine KW - Pig-2-Bac KW - Environmental justice KW - fecal contamination KW - Microbial source tracking KW - Animals KW - Swine KW - Feces KW - Environmental Monitoring KW - Animal Husbandry KW - Humans KW - Dust KW - Livestock KW - Occupational Exposure KW - Environmental Exposure LA - eng PY - 2025 T2 - The Science of the Total Environment T2 - The Science of the Total Environment, 2025, v. 985 TI - Swine Production Intensity and Swine-specific Fecal Contamination of Household Surfaces at Residences of Industrial Livestock Operation Workers and Community Residents, North Carolina, USA. VL - 985 UR - https://stacks.cdc.gov/view/cdc/261379 ER -
Maternal Area of Residence and Outcomes For Mother-Infant Dyads With Perinatal Opioid Exposure.

Pahl, Adrienne ;

Hu, Zhuopei

February 2026 | American Journal of Perinatology, 2026, v. 43, no. 3

Determine the relationship between maternal Social Deprivation Index (SDI), a composite measure of area-level deprivation, and maternal characteristics and infant outcomes for mother-infant dyads with perinatal opioid exposure.Post hoc secondary analysis of 1,298 mother-infant dyads in the ESC-NOW study, a multicenter, stepped-wedge cluster-randomi ...

10/09/2026

Supporting Files

Title : Maternal Area of Residence and Outcomes For Mother-Infant Dyads With Perinatal Opioid Exposure. Personal Author(s) : Pahl, Adrienne;Hu, Zhuopei;Young, Leslie W.;Ramsey, Kara Wong;Whalen, Bonny L.;Akshatha, Akshatha;Benninger, Kristen L.;Fung, Camille M.;Howell, Meghan P.;Markee, Sofia;Das, Abhik;Crawford, Margaret M.;Trochinski, Lillian;Greenberg, Rachel G.;Smith, Brian;Ounpraseuth, Songthip T.;Merhar, Stephanie L.;Devlin, Lori A.;MacMillan, Kathryn Dee L.; Published Date : February 2026 Pages in Document : 383-395 (22 pdf pages) Source : American Journal of Perinatology, 2026, v. 43, no. 3 DOI : https://doi.org/10.1055/a-2622-3839 Journal Title : American Journal of Perinatology
Pahl, A., Hu, Z., Young, L. W., Ramsey, K. W., Whalen, B. L., Akshatha, A., Benninger, K. L., Fung, C. M., Howell, M. P., Markee, S., Das, A., Crawford, M. M., Trochinski, L., Greenberg, R. G., Smith, B., Ounpraseuth, S. T., Merhar, S. L., Devlin, L. A., & MacMillan, K. D. L. (2026). Maternal Area of Residence and Outcomes For Mother-Infant Dyads With Perinatal Opioid Exposure. American Journal of Perinatology, 43(3). https://doi.org/10.1055/a-2622-3839

Pahl, Adrienne, Zhuopei Hu, Leslie W. Young, Kara Wong Ramsey, Bonny L. Whalen, Akshatha Akshatha, and Kristen L. Benninger, et al.. "Maternal Area of Residence and Outcomes For Mother-Infant Dyads With Perinatal Opioid Exposure." American Journal of Perinatology 43, no. 3 (2026). https://doi.org/10.1055/a-2622-3839.

Pahl, Adrienne, et al. "Maternal Area of Residence and Outcomes For Mother-Infant Dyads With Perinatal Opioid Exposure." American Journal of Perinatology, vol. 43, no. 3, 2026. Stacks. https://doi.org/10.1055/a-2622-3839.
Export RIS Citation Information. TY - Journal Article AU - Pahl, Adrienne AU - Hu, Zhuopei AU - Young, Leslie W. AU - Ramsey, Kara Wong AU - Whalen, Bonny L. AU - Akshatha, Akshatha AU - Benninger, Kristen L. AU - Fung, Camille M. AU - Howell, Meghan P. AU - Markee, Sofia AU - Das, Abhik AU - Crawford, Margaret M. AU - Trochinski, Lillian AU - Greenberg, Rachel G. AU - Smith, Brian AU - Ounpraseuth, Songthip T. AU - Merhar, Stephanie L. AU - Devlin, Lori A. AU - MacMillan, Kathryn Dee L. AB - Determine the relationship between maternal Social Deprivation Index (SDI), a composite measure of area-level deprivation, and maternal characteristics and infant outcomes for mother-infant dyads with perinatal opioid exposure.Post hoc secondary analysis of 1,298 mother-infant dyads in the ESC-NOW study, a multicenter, stepped-wedge cluster-randomized controlled trial (2020-2022) conducted at 26 U.S. study hospitals. The 2016 American Community Survey was used to develop SDI scores based on the maternal zip code of residence at the time of delivery. Outcomes evaluated included receipt of pharmacologic treatment for neonatal opioid withdrawal syndrome (PT), receipt of breastmilk during hospital stay, direct breastfeeding at discharge, discharge disposition, and length of stay for infants who received PT (length of hospital stay, LOS).The median SDI score was 62 on a scale of 100. The high SDI group, with a score above the SDI median and more social deprivation, was less likely to receive adequate prenatal care or medication for opioid use disorder and more likely to be Black and/or Hispanic. The mean proportion of infants in the high SDI group was 6.2% points (relative risk [RR]: 0.89; 95% confidence interval [CI]: 0.80, 0.98) less likely to receive breastmilk during the newborn hospitalization and 7.3% points (RR: 0.91; 95% CI: 0.87, 0.96) less likely to be discharged home with a biological parent. There was no difference between the high and low SDI groups in receipt of PT, direct breastfeeding at discharge, or LOS.Mothers from high SDI communities with opioid exposure during pregnancy were less likely to receive the established standard of care and more likely to be Black and/or Hispanic. Infants born to these mothers were less likely to receive breastmilk and/or to be discharged home with a biological parent. Targeting interventions to mitigate the impact of social deprivation in high SDI communities may improve outcomes for opioid-exposed infants and their mothers. · Living in an area with high social deprivation was associated with differences in health outcomes.. · Mothers were more likely to be Black and/or Hispanic.. · Mothers were less likely to receive the standard of care during pregnancy.. · Infants were less likely to receive breastmilk and/or be discharged home with a biological parent.. · Interventions designed to address community social deprivation may improve outcomes.. AB - Author manuscript AN - cdc:261378 C4 - PMC12246980 DO - https://doi.org/10.1055/a-2622-3839 IS - 3 J2 - American Journal of Perinatology KW - Pregnancy KW - Female KW - Neonatal Abstinence Syndrome KW - Residence Characteristics KW - Infant, Newborn KW - Opioid-Related Disorders KW - Breast Feeding KW - Socioeconomic Factors KW - Prenatal Care KW - Mothers KW - Analgesics, Opioid KW - Length of Stay KW - Male KW - Humans KW - Adult KW - Social Deprivation KW - Neonatal Abstinence Syndrome KW - Opioid KW - Perinatal Care KW - Neonatal Opioid Withdrawal Syndrome KW - Residence Characteristics KW - Sociodemographic Factors KW - Humans KW - Female KW - Pregnancy KW - Neonatal Abstinence Syndrome KW - Infant, Newborn KW - Adult KW - Opioid-Related Disorders KW - Breast Feeding KW - Length of Stay KW - Residence Characteristics KW - Analgesics, Opioid KW - Mothers KW - Socioeconomic Factors KW - Male KW - Prenatal Care LA - eng PY - 2026 T2 - American Journal of Perinatology T2 - American Journal of Perinatology, 2026, v. 43, no. 3 TI - Maternal Area of Residence and Outcomes For Mother-Infant Dyads With Perinatal Opioid Exposure. VL - 43 UR - https://stacks.cdc.gov/view/cdc/261378 ER -
Efficacy of Bismuth Subsalicylate on the Prevention of Travellers' Diarrhoea, 2018-2023.

Angelo, Kristina M. ;

Salah, Zainab

October 2025 | Journal of Travel Medicine, 2025, v. 32, no. 6

Travellers' diarrhoea (TD) is the most common travel-related illness. Bismuth subsalicylate (BSS) is indicated for the treatment of TD. BSS is also used off-label for the prevention of TD, based on studies from the 1980s indicating TD protection; however, these studies have limitations. The objective of this study was to determine the efficacy of B ...

10/09/2026

Supporting Files

Title : Efficacy of Bismuth Subsalicylate on the Prevention of Travellers' Diarrhoea, 2018-2023. Personal Author(s) : Angelo, Kristina M.;Salah, Zainab;Rogova, Marina;Plumb, Ian D.;Walker, Allison T.;Prentice-Mott, Graeme;Waraich, Charandeep;Kim, Sunkyung;Ryan, Edward;LaRocque, Regina C.;Oliver, Elizabeth;Heitzinger, Kristen;Allison Perry-Dow, K.;Connor, Bradley A.; Published Date : October 2025 Pages in Document : taaf047(17 pdf pages) Source : Journal of Travel Medicine, 2025, v. 32, no. 6 DOI : https://doi.org/10.1093/jtm/taaf047 Journal Title : Journal of Travel Medicine
Angelo, K. M., Salah, Z., Rogova, M., Plumb, I. D., Walker, A. T., Prentice-Mott, G., Waraich, C., Kim, S., Ryan, E., LaRocque, R. C., Oliver, E., Heitzinger, K., Allison Perry-Dow, K., & Connor, B. A. (2025). Efficacy of Bismuth Subsalicylate on the Prevention of Travellers' Diarrhoea, 2018-2023. Journal of Travel Medicine, 32(6). https://doi.org/10.1093/jtm/taaf047

Angelo, Kristina M., Zainab Salah, Marina Rogova, Ian D. Plumb, Allison T. Walker, Graeme Prentice-Mott, and Charandeep Waraich, et al.. "Efficacy of Bismuth Subsalicylate on the Prevention of Travellers' Diarrhoea, 2018-2023." Journal of Travel Medicine 32, no. 6 (2025). https://doi.org/10.1093/jtm/taaf047.

Angelo, Kristina M., et al. "Efficacy of Bismuth Subsalicylate on the Prevention of Travellers' Diarrhoea, 2018-2023." Journal of Travel Medicine, vol. 32, no. 6, 2025. Stacks. https://doi.org/10.1093/jtm/taaf047.
Export RIS Citation Information. TY - Journal Article AU - Angelo, Kristina M. AU - Salah, Zainab AU - Rogova, Marina AU - Plumb, Ian D. AU - Walker, Allison T. AU - Prentice-Mott, Graeme AU - Waraich, Charandeep AU - Kim, Sunkyung AU - Ryan, Edward AU - LaRocque, Regina C. AU - Oliver, Elizabeth AU - Heitzinger, Kristen AU - Allison Perry-Dow, K. AU - Connor, Bradley A. AB - Travellers' diarrhoea (TD) is the most common travel-related illness. Bismuth subsalicylate (BSS) is indicated for the treatment of TD. BSS is also used off-label for the prevention of TD, based on studies from the 1980s indicating TD protection; however, these studies have limitations. The objective of this study was to determine the efficacy of BSS in the prevention of TD. AB - This study was a prospective, double-blinded, placebo-controlled, randomized clinical trial (NCT03535272) with two arms: BSS 4 tablets twice daily (2.1 grams of BSS total) vs placebo. Travellers were included if they were ≥ 18 and < 70 years of age at the time of enrollment, were leaving for an international trip ≥7 days after their pretravel consultation, travelling in country for ≥7 days but ≤ 21 days, and travelling to either Southeast Asia, South Central Asia, North Africa, or Sub-Saharan Africa. Self-completed web-based questionnaires were administered before, during, and after travel. AB - 270 participants were included. The median age was 32 years (Interquartile range [IQR]: 27-44); 63% were female. Travellers were most frequently White (144; 61%) and non-Hispanic (239; 94%). The most frequent country of travel was Kenya (n = 87; 32%). The median total trip duration was 10 days ([IQR]: 8-13). The most frequent reason for travel was leisure/tourism (230, 85%). There was no significant difference among the groups for symptoms of loose stool and/or diarrhoea, although target sample size was not reached. AB - This study provides the first new data since the 1980s about the potential use of BSS in the prevention of TD. These data should not be viewed as evidence in isolation because of sample size constraints; further studies are needed to determine if there is a benefit in certain traveller groups or under certain circumstances. AB - Author manuscript AN - cdc:261377 C4 - PMC12439095 DO - https://doi.org/10.1093/jtm/taaf047 IS - 6 J2 - Journal of Travel Medicine KW - Double-Blind Method KW - Treatment Outcome KW - Female KW - Antidiarrheals KW - Prospective Studies KW - Young Adult KW - Organometallic Compounds KW - Salicylates KW - Diarrhea KW - Travel-Related Illness KW - Male KW - Middle Aged KW - Humans KW - Bismuth KW - Travel KW - Adult KW - Travellers' diarrhoea KW - travel KW - prevention KW - Humans KW - Diarrhea KW - Bismuth KW - Female KW - Salicylates KW - Male KW - Adult KW - Organometallic Compounds KW - Double-Blind Method KW - Prospective Studies KW - Travel KW - Middle Aged KW - Travel-Related Illness KW - Antidiarrheals KW - Treatment Outcome KW - Young Adult LA - eng PY - 2025 T2 - Journal of Travel Medicine T2 - Journal of Travel Medicine, 2025, v. 32, no. 6 TI - Efficacy of Bismuth Subsalicylate on the Prevention of Travellers' Diarrhoea, 2018-2023. VL - 32 UR - https://stacks.cdc.gov/view/cdc/261377 ER -
Estimating the Long-term Health Impact and Program Cost-effectiveness of Providing Direct Screening Services to Low-income, Medically Underserved Patients Through the Colorectal Cancer Control Program (CRCCP).

O'Leary, Meghan C. ;

Koutouan, Priscille R.

August 4, 2025 | Cancer Causes & Control: CCC, 2025, v. 36, no. 10

The Colorectal Cancer Control Program (CRCCP) aimed to increase colorectal cancer (CRC) screening among U.S. medically underserved populations through promotion and provision of CRC screening. We used simulation modeling to estimate the lifelong health impact and program cost-effectiveness of direct screening services, typically a single cycle of r ...

10/09/2026

Supporting Files

Title : Estimating the Long-term Health Impact and Program Cost-effectiveness of Providing Direct Screening Services to Low-income, Medically Underserved Patients Through the Colorectal Cancer Control Program (CRCCP). Personal Author(s) : O'Leary, Meghan C.;Koutouan, Priscille R.;Mayorga, Maria E.;Sharma, Krishna P.;DeGroff, Amy;Richardson, Lisa C.;Lich, Kristen Hassmiller; Published Date : August 4, 2025 Pages in Document : 1175-1195 (23 pdf pages) Source : Cancer Causes & Control: CCC, 2025, v. 36, no. 10 DOI : https://doi.org/10.1007/s10552-025-01994-5 Journal Title : Cancer Causes & Control: CCC
O'Leary, M. C., Koutouan, P. R., Mayorga, M. E., Sharma, K. P., DeGroff, A., Richardson, L. C., & Lich, K. H. (2025). Estimating the Long-term Health Impact and Program Cost-effectiveness of Providing Direct Screening Services to Low-income, Medically Underserved Patients Through the Colorectal Cancer Control Program (CRCCP). Cancer Causes & Control: CCC, 36(10). https://doi.org/10.1007/s10552-025-01994-5

O'Leary, Meghan C., Priscille R. Koutouan, Maria E. Mayorga, Krishna P. Sharma, Amy DeGroff, Lisa C. Richardson, and Kristen Hassmiller Lich. "Estimating the Long-term Health Impact and Program Cost-effectiveness of Providing Direct Screening Services to Low-income, Medically Underserved Patients Through the Colorectal Cancer Control Program (CRCCP)." Cancer Causes & Control: CCC 36, no. 10 (2025). https://doi.org/10.1007/s10552-025-01994-5.

O'Leary, Meghan C., et al. "Estimating the Long-term Health Impact and Program Cost-effectiveness of Providing Direct Screening Services to Low-income, Medically Underserved Patients Through the Colorectal Cancer Control Program (CRCCP)." Cancer Causes & Control: CCC, vol. 36, no. 10, 2025. Stacks. https://doi.org/10.1007/s10552-025-01994-5.
Export RIS Citation Information. TY - Journal Article AU - O'Leary, Meghan C. AU - Koutouan, Priscille R. AU - Mayorga, Maria E. AU - Sharma, Krishna P. AU - DeGroff, Amy AU - Richardson, Lisa C. AU - Lich, Kristen Hassmiller AB - The Colorectal Cancer Control Program (CRCCP) aimed to increase colorectal cancer (CRC) screening among U.S. medically underserved populations through promotion and provision of CRC screening. We used simulation modeling to estimate the lifelong health impact and program cost-effectiveness of direct screening services, typically a single cycle of routine screening/follow-up testing provided through the CRCCP ("intervention"). AB - Data for this study were from CDC's Colorectal Clinical Data Elements (CCDE), which captured screening and follow-up services received from CRCCP between 2009 and 2020. We used microsimulation to model the evolution of polyps and CRC for average-risk individuals in intervention and "counterfactual" (control) groups, under multiple scenarios. We calculated and compared lifetime CRC outcomes (cases, deaths, life-years) for individuals with and without the CRCCP intervention. Clinical and implementation costs incurred by the CRCCP were used to estimate programmatic/intervention costs. Results are reported overall and by initial screening modality received (colonoscopy or stool testing) and assumed lower vs. higher "background" (non-intervention) screening scenarios. AB - With conservative assumptions, our findings suggest that CRCCP-provided screening averted 806 CRC cases, avoided 392 CRC deaths, and added 5,368 life-years per 100,000 individuals vs. no intervention. Cost-effectiveness analysis revealed that the program's cost per life-year gained varied by screening modality and scenario assumptions-ranging from $25,740 to $27,583 for colonoscopy screening and $70,410 to $75,979 for stool testing. AB - CRCCP-provided screening/testing services were found to produce substantial potential health gains. Our analysis estimates the cost-effectiveness of providing one cycle of screening/testing to medically underserved individuals to inform programmatic decisions. AB - Author manuscript AN - cdc:261376 C4 - PMC12320612 DO - https://doi.org/10.1007/s10552-025-01994-5 IS - 10 J2 - Cancer Causes & Control: CCC KW - Female KW - Colonoscopy KW - Colorectal Neoplasms KW - Mass Screening KW - Medically Underserved Area KW - Male KW - Aged KW - Humans KW - Poverty KW - Cost-Benefit Analysis KW - Middle Aged KW - Early Detection of Cancer KW - Colorectal cancer screening KW - Simulation KW - Economic evaluation KW - Medically underserved populations KW - Humans KW - Colorectal Neoplasms KW - Cost-Benefit Analysis KW - Early Detection of Cancer KW - Female KW - Male KW - Middle Aged KW - Poverty KW - Aged KW - Medically Underserved Area KW - Mass Screening KW - Colonoscopy LA - eng PY - 2025 T2 - Cancer Causes & Control: CCC T2 - Cancer Causes & Control: CCC, 2025, v. 36, no. 10 TI - Estimating the Long-term Health Impact and Program Cost-effectiveness of Providing Direct Screening Services to Low-income, Medically Underserved Patients Through the Colorectal Cancer Control Program (CRCCP). VL - 36 UR - https://stacks.cdc.gov/view/cdc/261376 ER -
Acute Gastroenteritis Among Household Contacts of Children With Severe Norovirus Gastroenteritis, United States, 2011-2016.

Moran, Mary C. ;

Wikswo, Mary E.

June 2025 | Journal of the Pediatric Infectious Diseases Society, 2025, v. 14, no. 6

Norovirus-associated acute gastroenteritis (AGE) in children <11 years resulted in substantial AGE illness among household contacts (HHCs). Vomiting (≥5 episodes in 24 hours) was the greatest risk factor (aOR, 2.85, [95% CI, 1.91-4.26]) for AGE symptoms among HHCs of norovirus-positive index cases. HHCs age 0-4 years had the highest attack rates (22%).

10/09/2026

Supporting Files

Title : Acute Gastroenteritis Among Household Contacts of Children With Severe Norovirus Gastroenteritis, United States, 2011-2016. Personal Author(s) : Moran, Mary C.;Wikswo, Mary E.;Selvarangan, Rangaraj;Harrison, Christopher J.;Sahni, Leila C.;Boom, Julie A.;Halasa, Natasha;Stewart, Laura S.;Payne, Daniel C.;Staat, Mary Allen;Weinberg, Geoffrey A.;Szilagyi, Peter G.;Englund, Janet A.;Klein, Eileen J.;Vinjé, Jan;Parashar, Umesh D.;Tate, Jaqueline E.;Mirza, Sara A.; Published Date : June 2025 Pages in Document : piaf049(13 pdf pages) Source : Journal of the Pediatric Infectious Diseases Society, 2025, v. 14, no. 6 DOI : https://doi.org/10.1093/jpids/piaf049 Journal Title : Journal of the Pediatric Infectious Diseases Society
Moran, M. C., Wikswo, M. E., Selvarangan, R., Harrison, C. J., Sahni, L. C., Boom, J. A., Halasa, N., Stewart, L. S., Payne, D. C., Staat, M. A., Weinberg, G. A., Szilagyi, P. G., Englund, J. A., Klein, E. J., Vinjé, J., Parashar, U. D., Tate, J. E., & Mirza, S. A. (2025). Acute Gastroenteritis Among Household Contacts of Children With Severe Norovirus Gastroenteritis, United States, 2011-2016. Journal of the Pediatric Infectious Diseases Society, 14(6). https://doi.org/10.1093/jpids/piaf049

Moran, Mary C., Mary E. Wikswo, Rangaraj Selvarangan, Christopher J. Harrison, Leila C. Sahni, Julie A. Boom, and Natasha Halasa, et al.. "Acute Gastroenteritis Among Household Contacts of Children With Severe Norovirus Gastroenteritis, United States, 2011-2016." Journal of the Pediatric Infectious Diseases Society 14, no. 6 (2025). https://doi.org/10.1093/jpids/piaf049.

Moran, Mary C., et al. "Acute Gastroenteritis Among Household Contacts of Children With Severe Norovirus Gastroenteritis, United States, 2011-2016." Journal of the Pediatric Infectious Diseases Society, vol. 14, no. 6, 2025. Stacks. https://doi.org/10.1093/jpids/piaf049.
Export RIS Citation Information. TY - Journal Article AU - Moran, Mary C. AU - Wikswo, Mary E. AU - Selvarangan, Rangaraj AU - Harrison, Christopher J. AU - Sahni, Leila C. AU - Boom, Julie A. AU - Halasa, Natasha AU - Stewart, Laura S. AU - Payne, Daniel C. AU - Staat, Mary Allen AU - Weinberg, Geoffrey A. AU - Szilagyi, Peter G. AU - Englund, Janet A. AU - Klein, Eileen J. AU - Vinjé, Jan AU - Parashar, Umesh D. AU - Tate, Jaqueline E. AU - Mirza, Sara A. AB - Norovirus-associated acute gastroenteritis (AGE) in children <11 years resulted in substantial AGE illness among household contacts (HHCs). Vomiting (≥5 episodes in 24 hours) was the greatest risk factor (aOR, 2.85, [95% CI, 1.91-4.26]) for AGE symptoms among HHCs of norovirus-positive index cases. HHCs age 0-4 years had the highest attack rates (22%). AB - Author manuscript AN - cdc:261375 C4 - PMC12928128 DO - https://doi.org/10.1093/jpids/piaf049 IS - 6 J2 - Journal of the Pediatric Infectious Diseases Society KW - Adolescent KW - Female KW - Gastroenteritis KW - Family Characteristics KW - Infant, Newborn KW - Norovirus KW - Child KW - Risk Factors KW - Infant KW - Acute Disease KW - Vomiting KW - Male KW - Humans KW - Child, Preschool KW - Caliciviridae Infections KW - Adult KW - Norovirus KW - acute gastroenteritis KW - household transmission KW - Humans KW - Gastroenteritis KW - Caliciviridae Infections KW - Child, Preschool KW - Infant KW - Norovirus KW - Male KW - Female KW - Child KW - Acute Disease KW - Family Characteristics KW - Risk Factors KW - Infant, Newborn KW - Adolescent KW - Adult KW - Vomiting LA - eng PY - 2025 T2 - Journal of the Pediatric Infectious Diseases Society T2 - Journal of the Pediatric Infectious Diseases Society, 2025, v. 14, no. 6 TI - Acute Gastroenteritis Among Household Contacts of Children With Severe Norovirus Gastroenteritis, United States, 2011-2016. VL - 14 UR - https://stacks.cdc.gov/view/cdc/261375 ER -
Evaluation of 7 Urinary Metabolites of Polycyclic Aromatic Hydrocarbons During a Wildfire Response as Part of the Wildland Firefighter Exposure and Health Effects Study.

Mayer, Alexander C. ;

Fent, Kenneth W.

June 2025 | Annals of Work Exposures and Health, 2025, v. 69, no. 5

The occupation of firefighting, including wildland firefighting, has been classified as a known human carcinogen by the International Agency for Research on Cancer. Wildland firefighters (WFFs) can be exposed to polycyclic aromatic hydrocarbons (PAHs) present in wildfire smoke, some of which are known or probable carcinogens. Currently, there is no ...

10/09/2026

Supporting Files

Title : Evaluation of 7 Urinary Metabolites of Polycyclic Aromatic Hydrocarbons During a Wildfire Response as Part of the Wildland Firefighter Exposure and Health Effects Study. Personal Author(s) : Mayer, Alexander C.;Fent, Kenneth W.;Chen, I-Chen;DuBose, Kathleen Navarro;Butler, Corey R.;West, Molly;Calafat, Antonia M.;Botelho, Julianne Cook;Toennis, Christine;Meadows, Juliana;Sammons, Deborah; Published Date : June 2025 Pages in Document : 559-567 (11 pdf pages) Source : Annals of Work Exposures and Health, 2025, v. 69, no. 5 DOI : https://doi.org/10.1093/annweh/wxaf024 Journal Title : Annals of Work Exposures and Health
Mayer, A. C., Fent, K. W., Chen, I. C., DuBose, K. N., Butler, C. R., West, M., Calafat, A. M., Botelho, J. C., Toennis, C., Meadows, J., & Sammons, D. (2025). Evaluation of 7 Urinary Metabolites of Polycyclic Aromatic Hydrocarbons During a Wildfire Response as Part of the Wildland Firefighter Exposure and Health Effects Study. Annals of Work Exposures and Health, 69(5). https://doi.org/10.1093/annweh/wxaf024

Mayer, Alexander C., Kenneth W. Fent, I-Chen Chen, Kathleen Navarro DuBose, Corey R. Butler, Molly West, and Antonia M. Calafat, et al.. "Evaluation of 7 Urinary Metabolites of Polycyclic Aromatic Hydrocarbons During a Wildfire Response as Part of the Wildland Firefighter Exposure and Health Effects Study." Annals of Work Exposures and Health 69, no. 5 (2025). https://doi.org/10.1093/annweh/wxaf024.

Mayer, Alexander C., et al. "Evaluation of 7 Urinary Metabolites of Polycyclic Aromatic Hydrocarbons During a Wildfire Response as Part of the Wildland Firefighter Exposure and Health Effects Study." Annals of Work Exposures and Health, vol. 69, no. 5, 2025. Stacks. https://doi.org/10.1093/annweh/wxaf024.
Export RIS Citation Information. TY - Journal Article AU - Mayer, Alexander C. AU - Fent, Kenneth W. AU - Chen, I-Chen AU - DuBose, Kathleen Navarro AU - Butler, Corey R. AU - West, Molly AU - Calafat, Antonia M. AU - Botelho, Julianne Cook AU - Toennis, Christine AU - Meadows, Juliana AU - Sammons, Deborah AB - The occupation of firefighting, including wildland firefighting, has been classified as a known human carcinogen by the International Agency for Research on Cancer. Wildland firefighters (WFFs) can be exposed to polycyclic aromatic hydrocarbons (PAHs) present in wildfire smoke, some of which are known or probable carcinogens. Currently, there is no approved respiratory protection for WFFs against wildfire smoke, making inhalation exposure to PAHs a health concern. Recent studies have also highlighted the risk of dermal exposure to PAHs for WFFs due to factors like elevated skin temperature, sweat, and the inability to shower or routinely conduct good skin hygiene practices during wildfire incidents. This pilot study aimed to assess PAH exposure among 19 WFFs in different job positions during a wildfire incident by determining urine concentrations of 7 PAH metabolites in samples collected before and after shifts across 3 days. Overall, we observed increases from pre- to post-shift for all 7 PAH metabolites when we combined all WFF samples across the 3 days. When we stratified by job position and by day, concentrations of the PAH metabolites significantly increased from pre- to post-shift for 88% (37/42) of the comparisons (P-values <0.05). Additionally, median post-shift creatinine-corrected concentrations of 2-hydroxynaphthalene exceeded the 95th percentile of the nonsmoking US general population in 67% (4/6) of comparisons. Post-shift concentrations of hydroxynaphthalenes also exceeded concentrations measured in structural firefighters responding to training fires. Overall, 2-hydroxynaphthalene was highest on Day 2 (median creatinine-corrected concentrations of 2-hydroxynaphthalene from pre- to post-shift increased 425% for crew member/overhead; 146% for saw team). Despite this finding, we did not observe significant differences by job position. However, future studies could evaluate how job position affects WFF exposures while also exploring how dermal and inhalation contribute to WFFs' PAH exposure burden. AB - Author manuscript AN - cdc:261374 C4 - PMC12230813 DO - https://doi.org/10.1093/annweh/wxaf024 IS - 5 J2 - Annals of Work Exposures and Health KW - Occupational Exposure KW - Adolescent KW - Smoke KW - Prospective Studies KW - Inhalation Exposure KW - Young Adult KW - Skin Absorption KW - Polycyclic Aromatic Hydrocarbons KW - Wildfires KW - Air Pollutants, Occupational KW - Firefighters KW - Carcinogens, Environmental KW - Male KW - Pilot Projects KW - Humans KW - Middle Aged KW - Adult KW - Wildfires KW - Firefighters KW - Occupational Exposure KW - Polycyclic Aromatic Hydrocarbons KW - Carcinogens, Environmental KW - Smoke KW - Air Pollutants, Occupational KW - Inhalation Exposure KW - Skin Absorption KW - Prospective Studies KW - Pilot Projects KW - Humans KW - Male KW - Adolescent KW - Young Adult KW - Adult KW - Middle Aged LA - eng PY - 2025 T2 - Annals of Work Exposures and Health T2 - Annals of Work Exposures and Health, 2025, v. 69, no. 5 TI - Evaluation of 7 Urinary Metabolites of Polycyclic Aromatic Hydrocarbons During a Wildfire Response as Part of the Wildland Firefighter Exposure and Health Effects Study. VL - 69 UR - https://stacks.cdc.gov/view/cdc/261374 ER -
Prioritizing Interventions to Address Healthcare Worker Barriers to Reporting Adverse Events Following Immunization in Ghana.

Laryea, Sharon ;

Blau, Erin

July 2025 | Vaccine, 2025, v. 60

Despite increasing global efforts to enhance vaccine safety, there are still major gaps in the African subregion's capacity to adequately monitor and respond to vaccine concerns. In 2017 and 2019, two assessments were conducted in Ghana to identify barriers to adverse events following immunization (AEFI) reporting among healthcare workers (HCWs), w ...

10/09/2026

Supporting Files

Title : Prioritizing Interventions to Address Healthcare Worker Barriers to Reporting Adverse Events Following Immunization in Ghana. Personal Author(s) : Laryea, Sharon;Blau, Erin;Dodoo, Alexander;Addo, Evelyn;Owusu-Boakye, Bernice;Amponsa-Achiano, Kwame;Mohammed, Naziru Tanko;Asamoa-Amoakohene, Abena;Gidudu, Jane; Published Date : July 2025 Pages in Document : 127324 (11 pdf pages) Source : Vaccine, 2025, v. 60 DOI : https://doi.org/10.1016/j.vaccine.2025.127324 Journal Title : Vaccine
Laryea, S., Blau, E., Dodoo, A., Addo, E., Owusu-Boakye, B., Amponsa-Achiano, K., Mohammed, N. T., Asamoa-Amoakohene, A., & Gidudu, J. (2025). Prioritizing Interventions to Address Healthcare Worker Barriers to Reporting Adverse Events Following Immunization in Ghana. Vaccine, 60. https://doi.org/10.1016/j.vaccine.2025.127324

Laryea, Sharon, Erin Blau, Alexander Dodoo, Evelyn Addo, Bernice Owusu-Boakye, Kwame Amponsa-Achiano, Naziru Tanko Mohammed, Abena Asamoa-Amoakohene, and Jane Gidudu. "Prioritizing Interventions to Address Healthcare Worker Barriers to Reporting Adverse Events Following Immunization in Ghana." Vaccine 60 (2025). https://doi.org/10.1016/j.vaccine.2025.127324.

Laryea, Sharon, et al. "Prioritizing Interventions to Address Healthcare Worker Barriers to Reporting Adverse Events Following Immunization in Ghana." Vaccine, vol. 60, 2025. Stacks. https://doi.org/10.1016/j.vaccine.2025.127324.
Export RIS Citation Information. TY - Journal Article AU - Laryea, Sharon AU - Blau, Erin AU - Dodoo, Alexander AU - Addo, Evelyn AU - Owusu-Boakye, Bernice AU - Amponsa-Achiano, Kwame AU - Mohammed, Naziru Tanko AU - Asamoa-Amoakohene, Abena AU - Gidudu, Jane AB - Despite increasing global efforts to enhance vaccine safety, there are still major gaps in the African subregion's capacity to adequately monitor and respond to vaccine concerns. In 2017 and 2019, two assessments were conducted in Ghana to identify barriers to adverse events following immunization (AEFI) reporting among healthcare workers (HCWs), which revealed multiple barriers and significant gaps in the reporting process, underscoring the need to evaluate approaches to enhance training and support for frontline HCWs. Building upon these assessment findings, in 2021 key immunization safety stakeholders in Ghana met to address the persistent barriers hindering effective reporting practices. Using a feasibility-impact matrix and other qualitative factors, structured discussions allowed stakeholders to identify four innovative strategies to improve AEFI reporting: AEFI reporting toolkit and job aid, HCW protection policy, and new hire training package. Design and implementation of these interventions will allow Ghana to address ongoing barriers to AEFI reporting. AB - Author manuscript AN - cdc:261373 C4 - PMC12230940 DO - https://doi.org/10.1016/j.vaccine.2025.127324 J2 - Vaccine KW - Adverse Drug Reaction Reporting Systems KW - Immunization KW - Vaccines KW - Vaccination KW - Humans KW - Health Personnel KW - Reporting barriers KW - Adverse events following immunization KW - Frontline immunization healthcare workers KW - Humans KW - Health Personnel KW - Adverse Drug Reaction Reporting Systems KW - Immunization KW - Vaccines KW - Vaccination LA - eng PY - 2025 T2 - Vaccine T2 - Vaccine, 2025, v. 60 TI - Prioritizing Interventions to Address Healthcare Worker Barriers to Reporting Adverse Events Following Immunization in Ghana. VL - 60 UR - https://stacks.cdc.gov/view/cdc/261373 ER -
Review of Cannabis-Related Programmatic Activities For Drug-Free Communities (DFC) Support Program Coalitions.

Mallory, Vanessa ;

Guarnizo, Julie

October 2025 | Journal of Community Health, 2025, v. 50, no. 5

Legalization by states of medical and non-medical cannabis use is increasing the accessibility of cannabis to Americans. While cannabis use remains illegal for youth, enhanced effective approaches preventing youth's cannabis use are important. The Drug-Free Communities (DFC) Support Program is administered by the White House Office of National Drug ...

10/09/2026

Supporting Files

Title : Review of Cannabis-Related Programmatic Activities For Drug-Free Communities (DFC) Support Program Coalitions. Personal Author(s) : Mallory, Vanessa;Guarnizo, Julie;Holland, Kristin;Fogarty, Hannah;Voetsch, Karen;Roehler, Douglas; Published Date : October 2025 Pages in Document : 965-974 (16 pdf pages) Source : Journal of Community Health, 2025, v. 50, no. 5 DOI : https://doi.org/10.1007/s10900-025-01477-3 Journal Title : Journal of Community Health
Mallory, V., Guarnizo, J., Holland, K., Fogarty, H., Voetsch, K., & Roehler, D. (2025). Review of Cannabis-Related Programmatic Activities For Drug-Free Communities (DFC) Support Program Coalitions. Journal of Community Health, 50(5). https://doi.org/10.1007/s10900-025-01477-3

Mallory, Vanessa, Julie Guarnizo, Kristin Holland, Hannah Fogarty, Karen Voetsch, and Douglas Roehler. "Review of Cannabis-Related Programmatic Activities For Drug-Free Communities (DFC) Support Program Coalitions." Journal of Community Health 50, no. 5 (2025). https://doi.org/10.1007/s10900-025-01477-3.

Mallory, Vanessa, et al. "Review of Cannabis-Related Programmatic Activities For Drug-Free Communities (DFC) Support Program Coalitions." Journal of Community Health, vol. 50, no. 5, 2025. Stacks. https://doi.org/10.1007/s10900-025-01477-3.
Export RIS Citation Information. TY - Journal Article AU - Mallory, Vanessa AU - Guarnizo, Julie AU - Holland, Kristin AU - Fogarty, Hannah AU - Voetsch, Karen AU - Roehler, Douglas AB - Legalization by states of medical and non-medical cannabis use is increasing the accessibility of cannabis to Americans. While cannabis use remains illegal for youth, enhanced effective approaches preventing youth's cannabis use are important. The Drug-Free Communities (DFC) Support Program is administered by the White House Office of National Drug Control Policy and represents the nation's leading effort to mobilize communities to prevent and reduce youth substance use. Coalitions use the Seven Strategies for Community Change to ensure the creation of comprehensive action plans and a community-wide approach for preventing youth substance use. This study's objective is to review the cannabis programmatic activities implemented by DFC coalitions, identify common themes, and assess whether activities align with the Seven Strategies for Community Change. Review of biannual progress report (PR) data collected from August 2020 to February 2021 was conducted to determine common themes, strengths, and areas of improvement among cannabis programmatic activities. Of the 727 funded coalitions, 73% (n = 532) identified cannabis as a substance they focused their activities on in their PR submissions, and 488 unique cannabis programmatic activities were reviewed. Cannabis programmatic activities were assigned to one of six common themes: 1) dissemination (n = 167), 2) training and education (n = 147), 3) community partnerships (n = 99), 4) policy and enforcement (n = 51), 5) miscellaneous (n = 15), and 6) communities of focus (n = 9). Findings could inform local organizations about common types of youth cannabis-related prevention activities implemented at the community-level. The least commonly reported strategies, such as communities of focus, may highlight opportunities for expanded prevention efforts for coalitions. AB - Author manuscript AN - cdc:261372 C4 - PMC13478901 DO - https://doi.org/10.1007/s10900-025-01477-3 IS - 5 J2 - Journal of Community Health KW - Cannabis KW - Adolescent KW - Marijuana Use KW - Drug and Narcotic Control KW - Humans KW - Substance-Related Disorders KW - United States KW - Cannabis Use KW - Youth Substance Use KW - Community Coalitions KW - Substance Use Prevention KW - Adolescent KW - Humans KW - Cannabis KW - United States KW - Marijuana Use KW - Drug and Narcotic Control KW - Substance-Related Disorders LA - eng PY - 2025 T2 - Journal of Community Health T2 - Journal of Community Health, 2025, v. 50, no. 5 TI - Review of Cannabis-Related Programmatic Activities For Drug-Free Communities (DFC) Support Program Coalitions. VL - 50 UR - https://stacks.cdc.gov/view/cdc/261372 ER -
Hearing and Neurodevelopmental Outcomes Among Children With Congenital Cytomegalovirus.

Stout, Jordan C. ;

Leung, Jessica

August 2025 | International Journal of Pediatric Otorhinolaryngology, 2025, v. 195

Congenital cytomegalovirus (cCMV) infection is the most common congenital infection and the leading non-genetic cause of sensorineural hearing loss. We assessed demographics, clinical characteristics, hearing and neurodevelopmental outcomes by 6 years of age among U.S. children with possible cCMV.Retrospective cohort design.The Audiological and Gen ...

10/09/2026

Supporting Files

Title : Hearing and Neurodevelopmental Outcomes Among Children With Congenital Cytomegalovirus. Personal Author(s) : Stout, Jordan C.;Leung, Jessica;Kfoury, Peter;Germiller, John A.;Park, Albert H.;Lanzieri, Tatiana M.; Published Date : August 2025 Pages in Document : 112408 (14 pdf pages) Source : International Journal of Pediatric Otorhinolaryngology, 2025, v. 195 DOI : https://doi.org/10.1016/j.ijporl.2025.112408 Journal Title : International Journal of Pediatric Otorhinolaryngology
Stout, J. C., Leung, J., Kfoury, P., Germiller, J. A., Park, A. H., & Lanzieri, T. M. (2025). Hearing and Neurodevelopmental Outcomes Among Children With Congenital Cytomegalovirus. International Journal of Pediatric Otorhinolaryngology, 195. https://doi.org/10.1016/j.ijporl.2025.112408

Stout, Jordan C., Jessica Leung, Peter Kfoury, John A. Germiller, Albert H. Park, and Tatiana M. Lanzieri. "Hearing and Neurodevelopmental Outcomes Among Children With Congenital Cytomegalovirus." International Journal of Pediatric Otorhinolaryngology 195 (2025). https://doi.org/10.1016/j.ijporl.2025.112408.

Stout, Jordan C., et al. "Hearing and Neurodevelopmental Outcomes Among Children With Congenital Cytomegalovirus." International Journal of Pediatric Otorhinolaryngology, vol. 195, 2025. Stacks. https://doi.org/10.1016/j.ijporl.2025.112408.
Export RIS Citation Information. TY - Journal Article AU - Stout, Jordan C. AU - Leung, Jessica AU - Kfoury, Peter AU - Germiller, John A. AU - Park, Albert H. AU - Lanzieri, Tatiana M. AB - Congenital cytomegalovirus (cCMV) infection is the most common congenital infection and the leading non-genetic cause of sensorineural hearing loss. We assessed demographics, clinical characteristics, hearing and neurodevelopmental outcomes by 6 years of age among U.S. children with possible cCMV. AB - Retrospective cohort design. AB - The Audiological and Genetic Database (AudGenDB) includes 175,216 pediatric patients who underwent audiology, otology or genetic visits during 2006-2019 in Children's Hospital of Philadelphia, Vanderbilt Children's Hospital, or Boston Children's Hospital. AB - Children with possible cCMV were identified by diagnostic codes for cCMV infection and CMV disease up to 6 years of age. We examined clinical signs of cCMV during 0-45 days of birth and neurodevelopmental conditions (including hearing loss) up to 6 years of age. Hearing loss was defined as pure tone average or any frequency threshold ≥25 dB. AB - A total of 180 (0.1 %) children with possible cCMV were identified; 70 % had diagnosis codes after 45 days of life. The proportions of Black and Hispanic/Latino children comprised a higher proportion in the possible cCMV group compared to the non-cCMV group. Overall, 129 (72 %) children with possible cCMV had diagnoses codes for neurodevelopmental conditions, including hearing loss (56), communication delays (45) and cerebral palsy (22). Hearing loss was diagnosed at a median age of 2 (1-4) years. AB - Neurodevelopmental delays were common among children with possible cCMV included in this study. AudGenDB provides access to longitudinal outcomes for a large and diverse cohort that remains helpful in lieu of state-mandated screenings. AB - Author manuscript AN - cdc:261371 C4 - PMC12875388 DO - https://doi.org/10.1016/j.ijporl.2025.112408 J2 - International Journal of Pediatric Otorhinolaryngology KW - Retrospective Studies KW - Neurodevelopmental Disorders KW - Child KW - Cytomegalovirus Infections KW - Female KW - Infant KW - Male KW - Humans KW - Infant, Newborn KW - Hearing Loss, Sensorineural KW - Child, Preschool KW - Congenital Cytomegalovirus Infection KW - Sensorineural Hearing Loss KW - Neurodevelopmental Disorders KW - Pediatric Audiology KW - Hearing Loss, Bilateral KW - Hearing Loss, Unilateral KW - Neurological Sequelae KW - Humans KW - Cytomegalovirus Infections KW - Retrospective Studies KW - Female KW - Male KW - Child, Preschool KW - Infant KW - Child KW - Hearing Loss, Sensorineural KW - Infant, Newborn KW - Neurodevelopmental Disorders LA - eng PY - 2025 T2 - International Journal of Pediatric Otorhinolaryngology T2 - International Journal of Pediatric Otorhinolaryngology, 2025, v. 195 TI - Hearing and Neurodevelopmental Outcomes Among Children With Congenital Cytomegalovirus. VL - 195 UR - https://stacks.cdc.gov/view/cdc/261371 ER -
Progestin-only Contraception and Thrombosis: an Updated Systematic Review.

Tepper, Naomi K. ;

Nguyen, Antoinette T.

July 2026 | Contraception, 2026, v. 159

Evidence is limited on whether the use of progestin-only contraception (POC) is associated with the risk of thrombosis. Our objective was to update an earlier systematic review on POC and thrombosis risk.We searched for articles that examined risk of venous thromboembolism (VTE) (e.g., deep venous thrombosis or pulmonary embolism) or arterial throm ...

10/09/2026

Supporting Files

Title : Progestin-only Contraception and Thrombosis: an Updated Systematic Review. Personal Author(s) : Tepper, Naomi K.;Nguyen, Antoinette T.;Whiteman, Maura K.;Curtis, Kathryn M.; Published Date : July 2026 Pages in Document : 110978 (24 pdf pages) Source : Contraception, 2026, v. 159 DOI : https://doi.org/10.1016/j.contraception.2025.110978 Journal Title : Contraception
Tepper, N. K., Nguyen, A. T., Whiteman, M. K., & Curtis, K. M. (2026). Progestin-only Contraception and Thrombosis: an Updated Systematic Review. Contraception, 159. https://doi.org/10.1016/j.contraception.2025.110978

Tepper, Naomi K., Antoinette T. Nguyen, Maura K. Whiteman, and Kathryn M. Curtis. "Progestin-only Contraception and Thrombosis: an Updated Systematic Review." Contraception 159 (2026). https://doi.org/10.1016/j.contraception.2025.110978.

Tepper, Naomi K., et al. "Progestin-only Contraception and Thrombosis: an Updated Systematic Review." Contraception, vol. 159, 2026. Stacks. https://doi.org/10.1016/j.contraception.2025.110978.
Export RIS Citation Information. TY - Journal Article AU - Tepper, Naomi K. AU - Nguyen, Antoinette T. AU - Whiteman, Maura K. AU - Curtis, Kathryn M. AB - Evidence is limited on whether the use of progestin-only contraception (POC) is associated with the risk of thrombosis. Our objective was to update an earlier systematic review on POC and thrombosis risk. AB - We searched for articles that examined risk of venous thromboembolism (VTE) (e.g., deep venous thrombosis or pulmonary embolism) or arterial thromboembolism (ATE) (e.g., myocardial infarction or stroke) among women with thrombogenic conditions or characteristics or in the general population using POC, compared with women using nonhormonal or no contraception, published during February 1, 2016 through November 30, 2022. We also included articles from a previous systematic review, with articles published through January 2016. We assessed quality for each study and certainty of evidence for all outcomes. AB - Thirty-three articles met inclusion criteria; one was good quality, 20 were fair quality, and 12 were poor quality. Seven articles were newly identified, and 26 were included in the previous review. Risk of VTE, but not ATE, was generally elevated with depot medroxyprogesterone acetate (DMPA) use among women with certain thrombogenic conditions or characteristics (e.g., diabetes or postpartum) and women in the general population. Risks of VTE and ATE were generally not elevated with use of other POC, including levonorgestrel intrauterine devices, implants, or progestin-only pills. AB - Evidence suggests that risk of VTE, but not ATE, is increased with DMPA use compared with nonuse among women with certain thrombogenic conditions and women in the general population. Evidence does not suggest increased risk of VTE or ATE with use of other POC. While several studies examined thrombosis risk with POC use and thrombogenic conditions or characteristics, data are limited for individual conditions or characteristics and no evidence was identified for most conditions. The certainty of evidence is low or very low for all outcomes. AB - Use of DMPA might increase the risk of VTE among women with medical conditions associated with thrombosis and among women in the general population. Evidence does not suggest an increased risk of thrombosis with other POC. Further study is needed on safety of POC use by women with thrombogenic conditions. AB - Author manuscript AN - cdc:261370 C4 - PMC12381897 DO - https://doi.org/10.1016/j.contraception.2025.110978 J2 - Contraception KW - Thromboembolism KW - Systematic Review KW - Contraception KW - contraception KW - progestin-only contraception KW - thromboembolism KW - systematic review KW - Contraception KW - Thromboembolism KW - Systematic Review LA - eng PY - 2026 T2 - Contraception T2 - Contraception, 2026, v. 159 TI - Progestin-only Contraception and Thrombosis: an Updated Systematic Review. VL - 159 UR - https://stacks.cdc.gov/view/cdc/261370 ER -
Risk Factors For HCV Infection in Georgia: a Case-control Study.

Butsashvili, Maia ;

Kanchelashvili, Giorgi

May 2025 | Journal of Infection in Developing Countries, 2025, v. 19, no. 5

Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, including cirrhosis and liver cancer. Prior studies in Georgia identified risk factors such as injection drug use (IDU), tattoos, dental cleanings, medical injections, and blood transfusion. This study explored risk factors associated with HCV seroconversion in Georgia.A ...

10/09/2026

Supporting Files

Title : Risk Factors For HCV Infection in Georgia: a Case-control Study. Personal Author(s) : Butsashvili, Maia;Kanchelashvili, Giorgi;Galdavadze, Ketevan;Tsereteli, Maia;Baliashvili, Davit;Handanagic, Senad;Armstrong, Paige A;Shadaker, Shaun;Kamkamidze, George; Published Date : May 2025 Pages in Document : 792-796 (8 pdf pages) Source : Journal of Infection in Developing Countries, 2025, v. 19, no. 5 DOI : https://doi.org/10.3855/jidc.20658 Journal Title : Journal of Infection in Developing Countries
Butsashvili, M., Kanchelashvili, G., Galdavadze, K., Tsereteli, M., Baliashvili, D., Handanagic, S., Armstrong, P. A., Shadaker, S., & Kamkamidze, G. (2025). Risk Factors For HCV Infection in Georgia: a Case-control Study. Journal of Infection in Developing Countries, 19(5). https://doi.org/10.3855/jidc.20658

Butsashvili, Maia, Giorgi Kanchelashvili, Ketevan Galdavadze, Maia Tsereteli, Davit Baliashvili, Senad Handanagic, Paige A Armstrong, Shaun Shadaker, and George Kamkamidze. "Risk Factors For HCV Infection in Georgia: a Case-control Study." Journal of Infection in Developing Countries 19, no. 5 (2025). https://doi.org/10.3855/jidc.20658.

Butsashvili, Maia, et al. "Risk Factors For HCV Infection in Georgia: a Case-control Study." Journal of Infection in Developing Countries, vol. 19, no. 5, 2025. Stacks. https://doi.org/10.3855/jidc.20658.
Export RIS Citation Information. TY - Journal Article AU - Butsashvili, Maia AU - Kanchelashvili, Giorgi AU - Galdavadze, Ketevan AU - Tsereteli, Maia AU - Baliashvili, Davit AU - Handanagic, Senad AU - Armstrong, Paige A AU - Shadaker, Shaun AU - Kamkamidze, George AB - Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, including cirrhosis and liver cancer. Prior studies in Georgia identified risk factors such as injection drug use (IDU), tattoos, dental cleanings, medical injections, and blood transfusion. This study explored risk factors associated with HCV seroconversion in Georgia. AB - A case-control study was conducted among adults aged ≥ 18 years. A total of 299 Cases (persons who seroconverted after ≥ 2 screenings) and 436 controls (persons with ≥ 2 negative anti-HCV test results dated 90 to 364 days apart) were randomly selected from the national HCV screening database from January 2019 to November 2020. Data were collected through telephone interviews and analyzed using descriptive statistics and logistic regression. AB - Among 206/299 (68.9%) cases and 229/436 (52.5%) controls who agreed to participate, 53.8% were female and 60.5% were aged > 40 years. After adjusting for covariates, independent predictors of HCV seroconversion were age > 40 years (adjusted odds ratio [aOR] = 2.47, 95% confidence interval [CI]: 1.52-4.01), male sex (aOR = 2.12, 95% CI: 1.34-3.34), IDU (aOR = 26.24, 95% CI: 3.27-210.43), history of invasive medical procedure (aOR = 3.19, 95% CI: 1.96-5.19), ≥ 24 hours of hospitalization (aOR = 2.01, 95% CI: 1.12-3.59), and occupational performance of any invasive medical procedure (aOR = 2.70, 95% CI: 1.12-6.53). AB - Our findings suggest that HCV seroconversions in Georgia are associated with IDU, hospitalization, and invasive medical procedures. These identified risk factors provide opportunities to further improve the prevention of HCV infection in Georgia. AB - Author manuscript AN - cdc:261369 C4 - PMC12146773 DO - https://doi.org/10.3855/jidc.20658 IS - 5 J2 - Journal of Infection in Developing Countries KW - Adolescent KW - Female KW - Aged KW - Young Adult KW - Risk Factors KW - Seroconversion KW - Hepatitis C KW - Case-Control Studies KW - Male KW - Middle Aged KW - Humans KW - Georgia (Republic) KW - Hepacivirus KW - Substance Abuse, Intravenous KW - Adult KW - Hepatitis C KW - HCV transmission KW - injection drug use KW - invasive medical procedures KW - Georgia KW - Humans KW - Male KW - Female KW - Case-Control Studies KW - Risk Factors KW - Adult KW - Georgia (Republic) KW - Hepatitis C KW - Middle Aged KW - Young Adult KW - Hepacivirus KW - Substance Abuse, Intravenous KW - Seroconversion KW - Aged KW - Adolescent LA - eng PY - 2025 T2 - Journal of Infection in Developing Countries T2 - Journal of Infection in Developing Countries, 2025, v. 19, no. 5 TI - Risk Factors For HCV Infection in Georgia: a Case-control Study. VL - 19 UR - https://stacks.cdc.gov/view/cdc/261369 ER -
Human Papillomavirus Vaccine Effectiveness by Age, Age at Vaccination, and Timing of Vaccination Relative to Age at First Sex Among Men Who Have Sex With Men-Seattle, Washington, 2018 to 2020.

Buchbinder, Stephanie A. ;

Lin, John

October 2025 | Sexually Transmitted Diseases, 2025, v. 52, no. 10

We evaluated human papillomavirus (HPV) vaccine effectiveness (VE) against prevalent anal HPV among men who have sex with men (MSM) by age, age at vaccination, and age at vaccination relative to age at first sex.Residual anal specimens from 1092 MSM aged 18 to 45 years attending a Seattle, Washington, sexual health clinic in 2018 to 2020 were teste ...

10/09/2026

Supporting Files

Title : Human Papillomavirus Vaccine Effectiveness by Age, Age at Vaccination, and Timing of Vaccination Relative to Age at First Sex Among Men Who Have Sex With Men-Seattle, Washington, 2018 to 2020. Personal Author(s) : Buchbinder, Stephanie A.;Lin, John;Markowitz, Lauri E.;Hughes, James P.;Querec, Troy D.;Unger, Elizabeth R.;Dada, Damilola;Iqbal, Alfred;Golden, Matthew R.;Meites, Elissa;DeSisto, Carla L.;Winer, Rachel L.; Published Date : October 2025 Pages in Document : 631-640 (21 pdf pages) Source : Sexually Transmitted Diseases, 2025, v. 52, no. 10 DOI : https://doi.org/10.1097/OLQ.0000000000002192 Journal Title : Sexually Transmitted Diseases
Buchbinder, S. A., Lin, J., Markowitz, L. E., Hughes, J. P., Querec, T. D., Unger, E. R., Dada, D., Iqbal, A., Golden, M. R., Meites, E., DeSisto, C. L., & Winer, R. L. (2025). Human Papillomavirus Vaccine Effectiveness by Age, Age at Vaccination, and Timing of Vaccination Relative to Age at First Sex Among Men Who Have Sex With Men-Seattle, Washington, 2018 to 2020. Sexually Transmitted Diseases, 52(10). https://doi.org/10.1097/OLQ.0000000000002192

Buchbinder, Stephanie A., John Lin, Lauri E. Markowitz, James P. Hughes, Troy D. Querec, Elizabeth R. Unger, and Damilola Dada, et al.. "Human Papillomavirus Vaccine Effectiveness by Age, Age at Vaccination, and Timing of Vaccination Relative to Age at First Sex Among Men Who Have Sex With Men-Seattle, Washington, 2018 to 2020." Sexually Transmitted Diseases 52, no. 10 (2025). https://doi.org/10.1097/OLQ.0000000000002192.

Buchbinder, Stephanie A., et al. "Human Papillomavirus Vaccine Effectiveness by Age, Age at Vaccination, and Timing of Vaccination Relative to Age at First Sex Among Men Who Have Sex With Men-Seattle, Washington, 2018 to 2020." Sexually Transmitted Diseases, vol. 52, no. 10, 2025. Stacks. https://doi.org/10.1097/OLQ.0000000000002192.
Export RIS Citation Information. TY - Journal Article AU - Buchbinder, Stephanie A. AU - Lin, John AU - Markowitz, Lauri E. AU - Hughes, James P. AU - Querec, Troy D. AU - Unger, Elizabeth R. AU - Dada, Damilola AU - Iqbal, Alfred AU - Golden, Matthew R. AU - Meites, Elissa AU - DeSisto, Carla L. AU - Winer, Rachel L. AB - We evaluated human papillomavirus (HPV) vaccine effectiveness (VE) against prevalent anal HPV among men who have sex with men (MSM) by age, age at vaccination, and age at vaccination relative to age at first sex. AB - Residual anal specimens from 1092 MSM aged 18 to 45 years attending a Seattle, Washington, sexual health clinic in 2018 to 2020 were tested for 28 HPV types. Demographic, clinical, sexual behavioral, and HPV vaccination data were extracted from clinic and electronic medical records. We calculated adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) for associations between vaccination (≥1 dose of any HPV vaccine) and quadrivalent HPV vaccine (4vHPV)-type infection, by age group (18-26, 27-35, 36-45 years), vaccination age (among age groups 18-26, 27-35 years), and vaccination age relative to first sex (among those 18-26 years). Analyses were adjusted for race and ethnicity, preexposure prophylaxis use for HIV prevention, and lifetime number of sex partners. Vaccine effectiveness was calculated as (1 - aPR) × 100. AB - Among persons aged 18 to 26 years, 4vHPV-type HPV prevalence was lower among those vaccinated before first sex (aPR, 0.12 [95% CI, 0.02-0.87]; VE, 88%) or at <18 years of age (aPR, 0.22 [95% CI, 0.07-0.68]; VE, 78%) versus unvaccinated, but no VE was observed in those vaccinated at 18 to 26 years of age. Among persons aged 27 to 35 years, 4vHPV-type HPV prevalence was lower among those vaccinated at 18 to 26 years of age versus unvaccinated (aPR, 0.56 [95% CI, 0.36-0.87]; VE, 44%). No VE was observed in persons aged 27 to 35 or 36 to 45 years who were vaccinated at >26 years of age. AB - Results highlight the importance of routine HPV vaccination in adolescence and support efforts to increase catch-up vaccination among MSM. AB - Author manuscript AN - cdc:261368 C4 - PMC12258699 DO - https://doi.org/10.1097/OLQ.0000000000002192 IS - 10 J2 - Sexually Transmitted Diseases KW - Adolescent KW - Vaccination KW - Papillomavirus Vaccines KW - Young Adult KW - Homosexuality, Male KW - Age Factors KW - Papillomaviridae KW - Papillomavirus Infections KW - Vaccine Efficacy KW - Prevalence KW - Male KW - Humans KW - Middle Aged KW - Adult KW - Sexual Behavior KW - Humans KW - Male KW - Adult KW - Papillomavirus Infections KW - Adolescent KW - Young Adult KW - Papillomavirus Vaccines KW - Homosexuality, Male KW - Middle Aged KW - Vaccination KW - Vaccine Efficacy KW - Age Factors KW - Prevalence KW - Sexual Behavior KW - Papillomaviridae LA - eng PY - 2025 T2 - Sexually Transmitted Diseases T2 - Sexually Transmitted Diseases, 2025, v. 52, no. 10 TI - Human Papillomavirus Vaccine Effectiveness by Age, Age at Vaccination, and Timing of Vaccination Relative to Age at First Sex Among Men Who Have Sex With Men-Seattle, Washington, 2018 to 2020. VL - 52 UR - https://stacks.cdc.gov/view/cdc/261368 ER -
Economic Burden of Fungal Diseases in the United States.

Benedict, Kaitlin ;

Gold, Jeremy A. W.

June 2025 | Medical Mycology, 2025, v. 63, no. 6

We conservatively estimated the annual US fungal disease-related economic burden as $19.4 billion, including direct medical costs ($13.4 billion) of hospitalizations (n = 133 555) and outpatient visits (n = 13.4 million), $1.7 billion from absenteeism, and $4.3 billion from deaths (n = 7288). These findings underscore the need for fungal disease su ...

10/09/2026

Supporting Files

Title : Economic Burden of Fungal Diseases in the United States. Personal Author(s) : Benedict, Kaitlin;Gold, Jeremy A. W.;Chiller, Tom;Lyman, Meghan; Published Date : June 2025 Pages in Document : myaf049(8 pdf pages) Source : Medical Mycology, 2025, v. 63, no. 6 DOI : https://doi.org/10.1093/mmy/myaf049 Journal Title : Medical Mycology
Benedict, K., Gold, J. A. W., Chiller, T., & Lyman, M. (2025). Economic Burden of Fungal Diseases in the United States. Medical Mycology, 63(6). https://doi.org/10.1093/mmy/myaf049

Benedict, Kaitlin, Jeremy A. W. Gold, Tom Chiller, and Meghan Lyman. "Economic Burden of Fungal Diseases in the United States." Medical Mycology 63, no. 6 (2025). https://doi.org/10.1093/mmy/myaf049.

Benedict, Kaitlin, et al. "Economic Burden of Fungal Diseases in the United States." Medical Mycology, vol. 63, no. 6, 2025. Stacks. https://doi.org/10.1093/mmy/myaf049.
Export RIS Citation Information. TY - Journal Article AU - Benedict, Kaitlin AU - Gold, Jeremy A. W. AU - Chiller, Tom AU - Lyman, Meghan AB - We conservatively estimated the annual US fungal disease-related economic burden as $19.4 billion, including direct medical costs ($13.4 billion) of hospitalizations (n = 133 555) and outpatient visits (n = 13.4 million), $1.7 billion from absenteeism, and $4.3 billion from deaths (n = 7288). These findings underscore the need for fungal disease surveillance, treatment, and prevention efforts. AB - Author manuscript AN - cdc:261367 C4 - PMC12281149 DO - https://doi.org/10.1093/mmy/myaf049 IS - 6 J2 - Medical Mycology KW - Adolescent KW - Female KW - Cost of Illness KW - Mycoses KW - Aged KW - Young Adult KW - Child KW - Aged, 80 and over KW - Infant KW - Hospitalization KW - Male KW - Humans KW - Middle Aged KW - Child, Preschool KW - Adult KW - Health Care Costs KW - mycoses KW - costs and cost analysis KW - outpatients KW - hospitalization KW - death KW - Humans KW - Mycoses KW - Cost of Illness KW - Health Care Costs KW - Middle Aged KW - Hospitalization KW - Adult KW - Male KW - Aged KW - Female KW - Young Adult KW - Adolescent KW - Child KW - Child, Preschool KW - Aged, 80 and over KW - Infant LA - eng PY - 2025 T2 - Medical Mycology T2 - Medical Mycology, 2025, v. 63, no. 6 TI - Economic Burden of Fungal Diseases in the United States. VL - 63 UR - https://stacks.cdc.gov/view/cdc/261367 ER -
Post-mortem Study of Endemic Human Coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in Deaths of Children Under Five in Low- and Middle-income Countries: Findings From the Child Health and Mortality Prevention Surveillance (CHAMPS) Study.

Baillie, Vicky ;

Dangor, Ziyaad

June 2025 | Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 2025, v. 178

Endemic human coronaviruses (HCoV-229E, HKU1, NL63, and OC43) are common causes of mild or asymptomatic respiratory infections in children but are considered rare causes of death.We evaluated pediatric deaths from January 2017 through December 2022. A panel of experts determined the cause of death (CoD) by reviewing available data, including pathol ...

10/09/2026

Supporting Files

Title : Post-mortem Study of Endemic Human Coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in Deaths of Children Under Five in Low- and Middle-income Countries: Findings From the Child Health and Mortality Prevention Surveillance (CHAMPS) Study. Personal Author(s) : Baillie, Vicky;Dangor, Ziyaad;Blau, Dianna M.;Mahtab, Sana;du Toit, Jeanie;Assefa, Nega;Oundo, Joseph;Kidanemariam, Zelalem Teklemariam;Scott, J. Anthony G.;Ameh, Soter;Ogbuanu, Ikechukwu Udo;Ojulong, Julius;Bunn, James;Kotloff, Karen L.;Sow, Samba O.;Tapia, Milagritos D.;Keita, Adama Mamby;Garrine, Marcelino;Mandomando, Inacio;Varo, Rosauro;Xerinda, Elisio G.;Rakislova, Natalia;Alam, Muntasir;El Arifeen, Shams;Gurley, Emily S.;Hossain, Mohammad Zahid;Rahman, Afruna;Akelo, Victor;Onyango, Clayton;Onyango, Dickens;Mutevedzi, Portia C.;Whitney, Cynthia G.;Bassat, Quique;Madhi, Shabir A.; Published Date : June 2025 Pages in Document : 105804 (11 pdf pages) Source : Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 2025, v. 178 DOI : https://doi.org/10.1016/j.jcv.2025.105804 Journal Title : Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Baillie, V., Dangor, Z., Blau, D. M., Mahtab, S., du Toit, J., Assefa, N., Oundo, J., Kidanemariam, Z. T., Scott, J. A. G., Ameh, S., Ogbuanu, I. U., Ojulong, J., Bunn, J., Kotloff, K. L., Sow, S. O., Tapia, M. D., Keita, A. M., Garrine, M., Mandomando, I., ... Madhi, S. A. (2025). Post-mortem Study of Endemic Human Coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in Deaths of Children Under Five in Low- and Middle-income Countries: Findings From the Child Health and Mortality Prevention Surveillance (CHAMPS) Study. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 178. https://doi.org/10.1016/j.jcv.2025.105804

Baillie, Vicky, Ziyaad Dangor, Dianna M. Blau, Sana Mahtab, Jeanie du Toit, Nega Assefa, and Joseph Oundo, et al.. "Post-mortem Study of Endemic Human Coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in Deaths of Children Under Five in Low- and Middle-income Countries: Findings From the Child Health and Mortality Prevention Surveillance (CHAMPS) Study." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology 178 (2025). https://doi.org/10.1016/j.jcv.2025.105804.

Baillie, Vicky, et al. "Post-mortem Study of Endemic Human Coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in Deaths of Children Under Five in Low- and Middle-income Countries: Findings From the Child Health and Mortality Prevention Surveillance (CHAMPS) Study." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 178, 2025. Stacks. https://doi.org/10.1016/j.jcv.2025.105804.
Export RIS Citation Information. TY - Journal Article AU - Baillie, Vicky AU - Dangor, Ziyaad AU - Blau, Dianna M. AU - Mahtab, Sana AU - du Toit, Jeanie AU - Assefa, Nega AU - Oundo, Joseph AU - Kidanemariam, Zelalem Teklemariam AU - Scott, J. Anthony G. AU - Ameh, Soter AU - Ogbuanu, Ikechukwu Udo AU - Ojulong, Julius AU - Bunn, James AU - Kotloff, Karen L. AU - Sow, Samba O. AU - Tapia, Milagritos D. AU - Keita, Adama Mamby AU - Garrine, Marcelino AU - Mandomando, Inacio AU - Varo, Rosauro AU - Xerinda, Elisio G. AU - Rakislova, Natalia AU - Alam, Muntasir AU - El Arifeen, Shams AU - Gurley, Emily S. AU - Hossain, Mohammad Zahid AU - Rahman, Afruna AU - Akelo, Victor AU - Onyango, Clayton AU - Onyango, Dickens AU - Mutevedzi, Portia C. AU - Whitney, Cynthia G. AU - Bassat, Quique AU - Madhi, Shabir A. AB - Endemic human coronaviruses (HCoV-229E, HKU1, NL63, and OC43) are common causes of mild or asymptomatic respiratory infections in children but are considered rare causes of death. AB - We evaluated pediatric deaths from January 2017 through December 2022. A panel of experts determined the cause of death (CoD) by reviewing available data, including pathological and molecular findings from minimally invasive tissue sampling (lung tissues, blood, CSF, and nasopharyngeal swabs), clinical records, and verbal autopsies. AB - Endemic HCoV were detected in the respiratory samples of 3 % (n = 86/3357) of enrolled decedents: 1 % (n = 12/2043) of neonates, 5 % (n = 35/681) of infants and 6 % (n = 39/633) of children deaths. However, HCoVs were attributed as the CoD in only two cases - both involving young infants with underlying birth defects and severe wasting, who succumbed to polymicrobial hospital-acquired infections involving HCoV-OC43, Klebsiella pneumoniae, and Acinetobacter baumannii. Amongst the remaining 84 decedents in whom an HCoV was detected, 82 % (n = 69/84; median Ct of 25.34; range: 15.28-36.17) were deaths attributed to other infections, including 54 % (n = 32/69; median Ct of 23.86; range: 15.28-35.2) with lower respiratory infections determined to be the CoD. The bulk of these deaths (96 %, n = 66/69) were attributed to other pathogens - Plasmodium falciparum (27 %, n = 19/69), K. pneumoniae (23 %, n = 16/69), Streptococcus pneumoniae (20 %, n = 14/69), Escherichia coli (16 %, n = 11/69) and Cytomegalovirus (10 %, n = 7/69). AB - Although endemic HCoV was identified in children who died of respiratory infections, it was rarely attributed to being in the CoD. Nevertheless, further research is warranted to explore the potential role of HCoVs in LRTI pathogenesis and their impact on facilitating more pathogenic infections. AB - Author manuscript AN - cdc:261366 C4 - PMC13066964 DO - https://doi.org/10.1016/j.jcv.2025.105804 J2 - Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology KW - Female KW - Autopsy KW - Coronavirus OC43, Human KW - Respiratory Tract Infections KW - Coronavirus NL63, Human KW - Infant, Newborn KW - Coronavirus KW - Cause of Death KW - Coronavirus 229E, Human KW - Infant KW - Developing Countries KW - Coronavirus Infections KW - Male KW - Humans KW - Child, Preschool KW - Coronavirus KW - Child mortality KW - Cause of death KW - Minimally invasive tissue sampling KW - Humans KW - Infant KW - Coronavirus Infections KW - Child, Preschool KW - Infant, Newborn KW - Male KW - Female KW - Autopsy KW - Respiratory Tract Infections KW - Coronavirus KW - Cause of Death KW - Developing Countries KW - Coronavirus OC43, Human KW - Coronavirus NL63, Human KW - Coronavirus 229E, Human LA - eng PY - 2025 T2 - Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology T2 - Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 2025, v. 178 TI - Post-mortem Study of Endemic Human Coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in Deaths of Children Under Five in Low- and Middle-income Countries: Findings From the Child Health and Mortality Prevention Surveillance (CHAMPS) Study. VL - 178 UR - https://stacks.cdc.gov/view/cdc/261366 ER -
Clinical and Sociodemographic Factors Associated With Ocular Mpox in California, May 2022 to September 2023.

Hanft, Wyatt ;

Saadeh, Kayla

November 2025 | Sexually Transmitted Diseases, 2025, v. 52, no. 11

Inoculation of the eye with monkeypox virus can cause vision-threatening disease necessitating hospitalization and urgent treatment. Ocular mpox is poorly understood, including who is most affected.We performed a cross-sectional study comparing ocular and non-ocular mpox cases reported to the California Department of Public Health from May 1, 2022, ...

10/09/2026

Supporting Files

Title : Clinical and Sociodemographic Factors Associated With Ocular Mpox in California, May 2022 to September 2023. Personal Author(s) : Hanft, Wyatt;Saadeh, Kayla;Snyder, Robert E.;Watson, Jessica;Tang, Eric C.;Chapman, Eric;Ramos, Marisa;Johnson, Kelly A.; Published Date : November 2025 Pages in Document : 684-689 (15 pdf pages) Source : Sexually Transmitted Diseases, 2025, v. 52, no. 11 DOI : https://doi.org/10.1097/OLQ.0000000000002195 Journal Title : Sexually Transmitted Diseases
Hanft, W., Saadeh, K., Snyder, R. E., Watson, J., Tang, E. C., Chapman, E., Ramos, M., & Johnson, K. A. (2025). Clinical and Sociodemographic Factors Associated With Ocular Mpox in California, May 2022 to September 2023. Sexually Transmitted Diseases, 52(11). https://doi.org/10.1097/OLQ.0000000000002195

Hanft, Wyatt, Kayla Saadeh, Robert E. Snyder, Jessica Watson, Eric C. Tang, Eric Chapman, Marisa Ramos, and Kelly A. Johnson. "Clinical and Sociodemographic Factors Associated With Ocular Mpox in California, May 2022 to September 2023." Sexually Transmitted Diseases 52, no. 11 (2025). https://doi.org/10.1097/OLQ.0000000000002195.

Hanft, Wyatt, et al. "Clinical and Sociodemographic Factors Associated With Ocular Mpox in California, May 2022 to September 2023." Sexually Transmitted Diseases, vol. 52, no. 11, 2025. Stacks. https://doi.org/10.1097/OLQ.0000000000002195.
Export RIS Citation Information. TY - Journal Article AU - Hanft, Wyatt AU - Saadeh, Kayla AU - Snyder, Robert E. AU - Watson, Jessica AU - Tang, Eric C. AU - Chapman, Eric AU - Ramos, Marisa AU - Johnson, Kelly A. AB - Inoculation of the eye with monkeypox virus can cause vision-threatening disease necessitating hospitalization and urgent treatment. Ocular mpox is poorly understood, including who is most affected. AB - We performed a cross-sectional study comparing ocular and non-ocular mpox cases reported to the California Department of Public Health from May 1, 2022, to September 30, 2023. χ2 and t tests were used to compare between-group sociodemographic characteristics, HIV status, and vaccine status. Bivariate and multivariate logistic regressions adjusting for HIV and race/ethnicity were used to calculate odds ratios and 95% confidence intervals for the association between JYNNEOS vaccination and ocular mpox. AB - Of 5878 mpox infections, 2403 (40.9%) had complete ocular symptom reporting and were included in this analysis. Of these, 260 (10.8%) were ocular cases. Among the 2403 included cases, most were cisgender men (94.6%) and reported male-to-male sexual contact (72.0%). The proportion of non-ocular versus ocular mpox cases differed significantly by race/ethnicity and HIV status ( P < 0.05), with more ocular cases being Hispanic/Latinx (50.8% vs. 41.8%), Black (14.2% vs. 8.9%), and with HIV (50.8% vs. 40.4%). After adjusting for race/ethnicity and HIV status, people with ≥1 dose of JYNNEOS had approximately half the odds of having ocular symptoms compared with people who were unvaccinated (adjusted odds ratio, 0.52; 95% confidence interval, 0.24-0.97). AB - A higher proportion of Black, Latinx, or people living with HIV had ocular mpox symptoms, suggesting that these groups may benefit from focused interventions to prevent infection and this complication. JYNNEOS before mpox exposure may protect against ocular complications, stressing the importance of vaccination to prevent severe sequelae, especially for vulnerable populations. AB - Author manuscript AN - cdc:261365 C4 - PMC12306453 DO - https://doi.org/10.1097/OLQ.0000000000002195 IS - 11 J2 - Sexually Transmitted Diseases KW - Adolescent KW - Female KW - Vaccination KW - Eye Infections, Viral KW - Racial Groups KW - Monkeypox virus KW - Young Adult KW - Cross-Sectional Studies KW - Ethnicity KW - Risk Factors KW - Male KW - Humans KW - Middle Aged KW - Sociodemographic Factors KW - Mpox, Monkeypox KW - Adult KW - HIV Infections KW - mpox KW - monkeypox KW - virus KW - ocular mpox KW - JYNNEOS vaccination KW - Adolescent KW - Adult KW - Female KW - Humans KW - Male KW - Middle Aged KW - Young Adult KW - Cross-Sectional Studies KW - Ethnicity KW - HIV Infections KW - Risk Factors KW - Sociodemographic Factors KW - Vaccination KW - Racial Groups KW - Mpox, Monkeypox KW - Monkeypox virus KW - Eye Infections, Viral LA - eng PY - 2025 T2 - Sexually Transmitted Diseases T2 - Sexually Transmitted Diseases, 2025, v. 52, no. 11 TI - Clinical and Sociodemographic Factors Associated With Ocular Mpox in California, May 2022 to September 2023. VL - 52 UR - https://stacks.cdc.gov/view/cdc/261365 ER -
Access to Language Interpretation Services at Health Care Facilities Providing Care to Adults Diagnosed With HIV in the United States, 2019.

Padilla, Mabel ;

Beer, Linda

January 1, 2026 | Current HIV Research, 2026, v. 23, no. 3

People with limited English proficiency (LEP) experience barriers to healthcare access and optimal outcomes. Language interpretation services can facilitate clear communication- which is key to effective HIV care and treatment.We analyzed weighted data from the 2019 cycle of the Medical Monitoring Project (MMP), a cross-sectional, complex sample su ...

10/09/2026

Supporting Files

Title : Access to Language Interpretation Services at Health Care Facilities Providing Care to Adults Diagnosed With HIV in the United States, 2019. Personal Author(s) : Padilla, Mabel;Beer, Linda;Luna-Gierke, Ruth E.;Tie, Tracy;Lu, Jen-Feng;Weiser, John; Published Date : January 1, 2026 Pages in Document : 203-213 (17 pdf pages) Source : Current HIV Research, 2026, v. 23, no. 3 DOI : https://doi.org/10.2174/011570162X362664250527051957 Journal Title : Current HIV Research
Padilla, M., Beer, L., Luna-Gierke, R. E., Tie, T., Lu, J. F., & Weiser, J. (2026). Access to Language Interpretation Services at Health Care Facilities Providing Care to Adults Diagnosed With HIV in the United States, 2019. Current HIV Research, 23(3). https://doi.org/10.2174/011570162X362664250527051957

Padilla, Mabel, Linda Beer, Ruth E. Luna-Gierke, Tracy Tie, Jen-Feng Lu, and John Weiser. "Access to Language Interpretation Services at Health Care Facilities Providing Care to Adults Diagnosed With HIV in the United States, 2019." Current HIV Research 23, no. 3 (2026). https://doi.org/10.2174/011570162X362664250527051957.

Padilla, Mabel, et al. "Access to Language Interpretation Services at Health Care Facilities Providing Care to Adults Diagnosed With HIV in the United States, 2019." Current HIV Research, vol. 23, no. 3, 2026. Stacks. https://doi.org/10.2174/011570162X362664250527051957.
Export RIS Citation Information. TY - Journal Article AU - Padilla, Mabel AU - Beer, Linda AU - Luna-Gierke, Ruth E. AU - Tie, Tracy AU - Lu, Jen-Feng AU - Weiser, John AB - People with limited English proficiency (LEP) experience barriers to healthcare access and optimal outcomes. Language interpretation services can facilitate clear communication- which is key to effective HIV care and treatment. AB - We analyzed weighted data from the 2019 cycle of the Medical Monitoring Project (MMP), a cross-sectional, complex sample survey of U.S. adults with diagnosed HIV, and data from the 2021 MMP Facility Survey, a survey of facilities providing care to 2019 MMP respondents. We estimated the percentage of people with HIV (PWH) with LEP who received care at facilities offering language interpretation services and facilities providing language interpretation services, overall and by selected characteristics. AB - Overall, 89.9% of PWH with LEP received care at a facility with language interpretation services, and 83.6% of facilities provided language interpretation services. PWH with LEP who were unemployed were less likely than those who were employed to receive care at a facility with language interpretation services. Facilities that were Federally Qualified Health Centers, were not private practices, received Ryan White HIV/AIDS Program funding, and accepted public health care coverage were more likely to provide language interpretation services than facilities without these characteristics. AB - Most PWH with LEP obtained HIV care at health care facilities providing language interpretation services, a positive finding as language is a common barrier to accessing care for people with LEP. Most facilities also provided language interpretation services, an important step towards ensuring meaningful access for people with LEP, as required by law. AB - Our findings demonstrate that most HIV care facilities are providing access to language services to PWH with LEP in the United States. AB - Author manuscript AN - cdc:261364 C4 - PMC12402997 DO - https://doi.org/10.2174/011570162X362664250527051957 IS - 3 J2 - Current HIV Research KW - Communication Barriers KW - Female KW - Limited English Proficiency KW - Young Adult KW - Cross-Sectional Studies KW - Surveys and Questionnaires KW - Language KW - Male KW - Middle Aged KW - Humans KW - Health Services Accessibility KW - Health Facilities KW - Adult KW - HIV Infections KW - HIV KW - language KW - limited English proficiency KW - communication KW - interpretation services KW - Good health and well-being KW - reduced inequalities KW - Humans KW - HIV Infections KW - Health Services Accessibility KW - Adult KW - Cross-Sectional Studies KW - Male KW - Female KW - Middle Aged KW - Health Facilities KW - Language KW - Limited English Proficiency KW - Communication Barriers KW - Young Adult KW - Surveys and Questionnaires LA - eng PY - 2026 T2 - Current HIV Research T2 - Current HIV Research, 2026, v. 23, no. 3 TI - Access to Language Interpretation Services at Health Care Facilities Providing Care to Adults Diagnosed With HIV in the United States, 2019. VL - 23 UR - https://stacks.cdc.gov/view/cdc/261364 ER -
Incidence of AIDS-Defining Conditions Among Adults With Perinatally Acquired HIV After Transition to Adult HIV Care in the United States and Canada, 2000-2022.

Haw, Nel Jason L. ;

Lesko, Catherine R.

December 24, 2025 | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 2025, v. 81, no. 5

Little is known about the incidence of AIDS-defining conditions (ADCs) among people with perinatally acquired human immunodeficiency virus (PHIV) who transitioned to adult human immunodeficiency virus (HIV) care in the United States and Canada. We described the incidence among PHIV and compared it with that among those with non-perinatally acquired ...

10/09/2026

Supporting Files

Title : Incidence of AIDS-Defining Conditions Among Adults With Perinatally Acquired HIV After Transition to Adult HIV Care in the United States and Canada, 2000-2022. Personal Author(s) : Haw, Nel Jason L.;Lesko, Catherine R.;Ng, Derek K.;Lam, Jennifer O.;Gebo, Kelly;Sterling, Timothy R.;Rabkin, Charles S.;Li, Jun;Buchacz, Kate;Agwu, Allison;Althoff, Keri; Corporate Authors(s) : North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) Published Date : December 24, 2025 Pages in Document : 962-969 (15 pdf pages) Source : Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 2025, v. 81, no. 5 DOI : https://doi.org/10.1093/cid/ciaf300 Journal Title : Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Haw, N. J. L., Lesko, C. R., Ng, D. K., Lam, J. O., Gebo, K., Sterling, T. R., Rabkin, C. S., Li, J., Buchacz, K., Agwu, A., & Althoff, K. (2025). Incidence of AIDS-Defining Conditions Among Adults With Perinatally Acquired HIV After Transition to Adult HIV Care in the United States and Canada, 2000-2022. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 81(5). https://doi.org/10.1093/cid/ciaf300

Haw, Nel Jason L., Catherine R. Lesko, Derek K. Ng, Jennifer O. Lam, Kelly Gebo, Timothy R. Sterling, and Charles S. Rabkin, et al.. "Incidence of AIDS-Defining Conditions Among Adults With Perinatally Acquired HIV After Transition to Adult HIV Care in the United States and Canada, 2000-2022." Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 81, no. 5 (2025). https://doi.org/10.1093/cid/ciaf300.

Haw, Nel Jason L., et al. "Incidence of AIDS-Defining Conditions Among Adults With Perinatally Acquired HIV After Transition to Adult HIV Care in the United States and Canada, 2000-2022." Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, vol. 81, no. 5, 2025. Stacks. https://doi.org/10.1093/cid/ciaf300.
Export RIS Citation Information. TY - Journal Article AU - Haw, Nel Jason L. AU - Lesko, Catherine R. AU - Ng, Derek K. AU - Lam, Jennifer O. AU - Gebo, Kelly AU - Sterling, Timothy R. AU - Rabkin, Charles S. AU - Li, Jun AU - Buchacz, Kate AU - Agwu, Allison AU - Althoff, Keri A2 - North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) AB - Little is known about the incidence of AIDS-defining conditions (ADCs) among people with perinatally acquired human immunodeficiency virus (PHIV) who transitioned to adult human immunodeficiency virus (HIV) care in the United States and Canada. We described the incidence among PHIV and compared it with that among those with non-perinatally acquired HIV (non-PHIV) and across calendar era. AB - Using data from the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) from 2000-2022, we estimated weighted mean cumulative counts (MCCs) of ADCs, comparing people with PHIV and non-PHIV acquisition risk groups aged 18-40 years engaged in adult HIV care. The weights accounted for differences in characteristics among HIV acquisition risk groups as well as informative censoring. We calculated 95% confidence intervals using bootstrapping. We stratified results before and after 2012, when the immediate start of antiretroviral therapy was first recommended. AB - There were 5429 ADCs among 22 950 people with HIV. Among those with PHIV, the MCC of ADCs by 3 years in adult HIV care was 26 per 100 persons (95% confidence interval, 15-40) in 2000-2011 and 16 per 100 (5-21) in 2012-2022. Within each calendar era, weighted MCCs of ADCs among people with PHIV were similar or lower than in non-PHIV groups. Within each HIV acquisition risk group, weighted MCCs of ADCs were lower in 2000-2011 than in 2012-2022. AB - People with PHIV who transitioned to adult HIV care did not experience a greater ADC incidence than those with non-PHIV. This emphasizes the importance of continued engagement in adult HIV care, as it provides critical opportunities for ADC prevention and management. AB - Author manuscript AN - cdc:261363 C4 - PMC12375960 DO - https://doi.org/10.1093/cid/ciaf300 IS - 5 J2 - Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America KW - Adolescent KW - Cohort Studies KW - Female KW - Infectious Disease Transmission, Vertical KW - Incidence KW - Transition to Adult Care KW - Male KW - Humans KW - Young Adult KW - Adult KW - Acquired Immunodeficiency Syndrome KW - HIV Infections KW - HIV KW - perinatally acquired KW - AIDS-defining conditions KW - lifetime survivors KW - Humans KW - Adult KW - Incidence KW - Male KW - Female KW - Young Adult KW - Adolescent KW - HIV Infections KW - Transition to Adult Care KW - Acquired Immunodeficiency Syndrome KW - Cohort Studies KW - Infectious Disease Transmission, Vertical LA - eng PY - 2025 T2 - Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America T2 - Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 2025, v. 81, no. 5 TI - Incidence of AIDS-Defining Conditions Among Adults With Perinatally Acquired HIV After Transition to Adult HIV Care in the United States and Canada, 2000-2022. VL - 81 UR - https://stacks.cdc.gov/view/cdc/261363 ER -
Placental Abruption and Perinatal Mortality: Abnormal Placentation and Spontaneous Abortion as Contributors to Left Truncation Bias.

Kinlaw, Alan C. ;

Graham, Hillary L.

February 2026 | Paediatric and Perinatal Epidemiology, 2026, v. 40, no. 2

Generally, studies in perinatal epidemiology restrict cohort entry to 20 weeks of gestation, but exposures and outcomes may occur earlier. This restriction may introduce left truncation bias.To examine the impact of left truncation bias when estimating the causal effect of abruption on perinatal mortality in the context of abnormal placentation, wi ...

10/09/2026

Supporting Files

Title : Placental Abruption and Perinatal Mortality: Abnormal Placentation and Spontaneous Abortion as Contributors to Left Truncation Bias. Personal Author(s) : Kinlaw, Alan C.;Graham, Hillary L.;Ananth, Cande V.; Published Date : February 2026 Pages in Document : 133-143 (18 pdf pages) Source : Paediatric and Perinatal Epidemiology, 2026, v. 40, no. 2 DOI : https://doi.org/10.1111/ppe.70010 Journal Title : Paediatric and Perinatal Epidemiology
Kinlaw, A. C., Graham, H. L., & Ananth, C. V. (2026). Placental Abruption and Perinatal Mortality: Abnormal Placentation and Spontaneous Abortion as Contributors to Left Truncation Bias. Paediatric and Perinatal Epidemiology, 40(2). https://doi.org/10.1111/ppe.70010

Kinlaw, Alan C., Hillary L. Graham, and Cande V. Ananth. "Placental Abruption and Perinatal Mortality: Abnormal Placentation and Spontaneous Abortion as Contributors to Left Truncation Bias." Paediatric and Perinatal Epidemiology 40, no. 2 (2026). https://doi.org/10.1111/ppe.70010.

Kinlaw, Alan C., et al. "Placental Abruption and Perinatal Mortality: Abnormal Placentation and Spontaneous Abortion as Contributors to Left Truncation Bias." Paediatric and Perinatal Epidemiology, vol. 40, no. 2, 2026. Stacks. https://doi.org/10.1111/ppe.70010.
Export RIS Citation Information. TY - Journal Article AU - Kinlaw, Alan C. AU - Graham, Hillary L. AU - Ananth, Cande V. AB - Generally, studies in perinatal epidemiology restrict cohort entry to 20 weeks of gestation, but exposures and outcomes may occur earlier. This restriction may introduce left truncation bias. AB - To examine the impact of left truncation bias when estimating the causal effect of abruption on perinatal mortality in the context of abnormal placentation, with spontaneous abortion (SAB) as a censoring event. AB - Through 80 Monte Carlo simulation scenarios based on realistic clinical assumptions, we estimated risk differences (RD), risk ratios (RR) and bias parameters for the abruption-perinatal mortality association. AB - Censoring by SAB ranged from 5.6% to 7.6% across simulation setups. The risk of mortality was overestimated in observable (left-truncated) data at ≥ 20 weeks compared to an unobservable cohort starting follow-up at placental implantation (conception cohort). Underestimation of risks was stronger among abruption pregnancies. RDs for the abruption-mortality association were biased by +1% to +3% among conceptions with normal implantation and by +5% to +43% among abnormal placentation. Due to the disproportionate underestimation of mortality among nonabruption pregnancies, RRs were overestimated by 1.1 to 1.2-fold for normal implantations and by 1.1 to 8.4-fold for abnormal implantations. AB - The findings of this simulation study highlight the critical importance of placentation in successful pregnancy. Abnormal placentation has profound consequences for unsuccessful pregnancies, remarkably increasing the risks of early losses, placental abruption and other obstetrical complications. This study underscores that left truncation can bias the abruption-perinatal mortality association, differentially by whether the placentation was normal or abnormal. However, defining the causal question regarding the abruption-perinatal mortality association requires consideration of the target population, which may include all conceptions. In studies of these effects, outcome follow-up capability may introduce left truncation bias. We do not prescribe one analytic approach to account for left truncation, but rather, the approach should be guided by the causal question. AB - Author manuscript AN - cdc:261362 C4 - PMC12353283 DO - https://doi.org/10.1111/ppe.70010 IS - 2 J2 - Paediatric and Perinatal Epidemiology KW - Pregnancy KW - Perinatal Mortality KW - Female KW - Bias KW - Abruptio Placentae KW - Placentation KW - Monte Carlo Method KW - Humans KW - Infant, Newborn KW - Abortion, Spontaneous KW - Placental abruption KW - Perinatal mortality KW - Abnormal placentation KW - Left truncation KW - Selection bias KW - Spontaneous abortion KW - Depletion of susceptible KW - Monte-Carlo simulation KW - abnormal placentation KW - depletion of susceptible KW - left truncation KW - Monte‐Carlo simulation KW - perinatal mortality KW - placental abruption KW - selection bias KW - spontaneous abortion KW - Humans KW - Female KW - Pregnancy KW - Abruptio Placentae KW - Abortion, Spontaneous KW - Perinatal Mortality KW - Infant, Newborn KW - Bias KW - Monte Carlo Method KW - Placentation LA - eng PY - 2026 T2 - Paediatric and Perinatal Epidemiology T2 - Paediatric and Perinatal Epidemiology, 2026, v. 40, no. 2 TI - Placental Abruption and Perinatal Mortality: Abnormal Placentation and Spontaneous Abortion as Contributors to Left Truncation Bias. VL - 40 UR - https://stacks.cdc.gov/view/cdc/261362 ER -
Prevalence and Impact of Social Risk in Patients With Inflammatory Bowel Diseases: National Estimates From the United States.

Kim, Seo Hyun ;

Qi, Yuchen

December 2025 | Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association, 2025, v. 23, no. 13

Social risks are individual-level factors associated with adverse health outcomes. We determined the prevalence and impact of social risks on healthcare use among patients with inflammatory bowel diseases (IBDs) in the United States.In the U.S. National Health Interview Survey 2023, we estimated social risks across 6 domains (food insecurity, finan ...

10/09/2026

Supporting Files

Title : Prevalence and Impact of Social Risk in Patients With Inflammatory Bowel Diseases: National Estimates From the United States. Personal Author(s) : Kim, Seo Hyun;Qi, Yuchen;Banegas, Matthew P.;Kappelman, Michael D.;Nguyen, Nghia H.;Boland, Brigid S.;Hernandez, Carlos Lago;Xu, Ronghui;Singh, Siddharth; Published Date : December 2025 Pages in Document : 2588-2596 (16 pdf pages) Source : Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association, 2025, v. 23, no. 13 DOI : https://doi.org/10.1016/j.cgh.2025.03.031 Journal Title : Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association
Kim, S. H., Qi, Y., Banegas, M. P., Kappelman, M. D., Nguyen, N. H., Boland, B. S., Hernandez, C. L., Xu, R., & Singh, S. (2025). Prevalence and Impact of Social Risk in Patients With Inflammatory Bowel Diseases: National Estimates From the United States. Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association, 23(13). https://doi.org/10.1016/j.cgh.2025.03.031

Kim, Seo Hyun, Yuchen Qi, Matthew P. Banegas, Michael D. Kappelman, Nghia H. Nguyen, Brigid S. Boland, Carlos Lago Hernandez, Ronghui Xu, and Siddharth Singh. "Prevalence and Impact of Social Risk in Patients With Inflammatory Bowel Diseases: National Estimates From the United States." Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association 23, no. 13 (2025). https://doi.org/10.1016/j.cgh.2025.03.031.

Kim, Seo Hyun, et al. "Prevalence and Impact of Social Risk in Patients With Inflammatory Bowel Diseases: National Estimates From the United States." Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 23, no. 13, 2025. Stacks. https://doi.org/10.1016/j.cgh.2025.03.031.
Export RIS Citation Information. TY - Journal Article AU - Kim, Seo Hyun AU - Qi, Yuchen AU - Banegas, Matthew P. AU - Kappelman, Michael D. AU - Nguyen, Nghia H. AU - Boland, Brigid S. AU - Hernandez, Carlos Lago AU - Xu, Ronghui AU - Singh, Siddharth AB - Social risks are individual-level factors associated with adverse health outcomes. We determined the prevalence and impact of social risks on healthcare use among patients with inflammatory bowel diseases (IBDs) in the United States. AB - In the U.S. National Health Interview Survey 2023, we estimated social risks across 6 domains (food insecurity, financial hardship, housing instability, transportation needs, education and employment, discrimination) in adults with IBD. We evaluated the association between burden of social risk (0 of 6 domains [none], 1 of 6 domains [mild], 2 of 6 domains [moderate], and ≥3 of 6 domains [severe]), unplanned healthcare utilization (emergency department and/or hospitalization), and medication nonadherence, accounting for differences in age, sex, race/ethnicity, insurance, income, and comorbidities. AB - Of 572 people included in the survey (mean age 56 years; 57% female; 81% non-Hispanic White [NHW], 12.9% Hispanic), 64% (95% confidence interval [CI], 59%-69%) experienced social risk across 1 or more domains (food insecurity, 22%; financial hardship, 28%; housing instability, 14%; transportation needs, 9%; education and employment, 9%; discrimination, 41%). Prevalence of severe social risk was higher in racial and ethnic minority groups (non-Hispanic Black vs Hispanic vs NHW: 37% vs 28% vs 12%). A higher burden of social risk was associated with higher risk of unplanned healthcare utilization (severe vs none: odds ratio, 3.5; 95% CI, 1.2-10.2) and cost-related medication nonadherence (OR, 11.8; 95% CI, 2.7-52.1), after accounting for income and insurance status. AB - Social risks are prevalent in adults with IBD and negatively impact healthcare utilization and medication nonadherence. Efforts to routinely identify and address social risks in patients with IBD should be part of standard clinical care. AB - Author manuscript AN - cdc:261361 C4 - PMC12354202 DO - https://doi.org/10.1016/j.cgh.2025.03.031 IS - 13 J2 - Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association KW - Female KW - Aged KW - Inflammatory Bowel Diseases KW - Young Adult KW - Socioeconomic Factors KW - Patient Acceptance of Health Care KW - Risk Factors KW - Prevalence KW - Food Insecurity KW - Male KW - Humans KW - Middle Aged KW - Adult KW - Social determinants of health KW - health disparities KW - Crohn's disease KW - ulcerative colitis KW - financial toxicity KW - Humans KW - Female KW - Male KW - Middle Aged KW - Inflammatory Bowel Diseases KW - Prevalence KW - Adult KW - Aged KW - Patient Acceptance of Health Care KW - Food Insecurity KW - Young Adult KW - Socioeconomic Factors KW - Risk Factors LA - eng PY - 2025 T2 - Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association T2 - Clinical Gastroenterology and Hepatology: the Official Clinical Practice Journal of the American Gastroenterological Association, 2025, v. 23, no. 13 TI - Prevalence and Impact of Social Risk in Patients With Inflammatory Bowel Diseases: National Estimates From the United States. VL - 23 UR - https://stacks.cdc.gov/view/cdc/261361 ER -

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