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Showing 781 - 800 of 1969 results

Survey Practice in Non-Survey-Literate Populations: Lessons Learned From a Cognitive Interview Study in Brazil.

Massey, Meredith

March 2025 | Survey Practice, 2025, v. 19

Survey research relies on cooperation and coordination between researchers and respondents. Survey-literate respondents possess a level of understanding of the survey process that facilitates their participation. Non-survey-literate respondents, on the other hand, are less equipped to provide accurate responses, which can lead to increased survey e ...

10/09/2026

Supporting Files

Title : Survey Practice in Non-Survey-Literate Populations: Lessons Learned From a Cognitive Interview Study in Brazil. Personal Author(s) : Massey, Meredith Published Date : March 2025 Pages in Document : 11 pdf pages Source : Survey Practice, 2025, v. 19 DOI : https://doi.org/10.29115/SP-2024-0035 Journal Title : Survey Practice
Massey, M. (2025). Survey Practice in Non-Survey-Literate Populations: Lessons Learned From a Cognitive Interview Study in Brazil. Survey Practice, 19. https://doi.org/10.29115/SP-2024-0035

Massey, Meredith. "Survey Practice in Non-Survey-Literate Populations: Lessons Learned From a Cognitive Interview Study in Brazil." Survey Practice 19 (2025). https://doi.org/10.29115/SP-2024-0035.

Massey, Meredith "Survey Practice in Non-Survey-Literate Populations: Lessons Learned From a Cognitive Interview Study in Brazil." Survey Practice, vol. 19, 2025. Stacks. https://doi.org/10.29115/SP-2024-0035.
Export RIS Citation Information. TY - Journal Article AU - Massey, Meredith AB - Survey research relies on cooperation and coordination between researchers and respondents. Survey-literate respondents possess a level of understanding of the survey process that facilitates their participation. Non-survey-literate respondents, on the other hand, are less equipped to provide accurate responses, which can lead to increased survey error. In this article, we present findings from a cognitive interview project conducted in Brazil to illustrate potential barriers to respondent participation and demonstrate how these barriers contribute to response error. To test questions on inclusive education, researchers from the Collaborating Center for Questionnaire Design and Evaluation Research at the National Center for Health Statistics facilitated the collection of data through 80 cognitive interviews conducted in various neighborhoods in Rio de Janeiro, Brazil. Recruitment targeted caregivers of children with and without disabilities, and respondents were predominantly female with low literacy levels. The results indicated that respondents with limited familiarity with the survey process (non-survey-literate) struggled to orient themselves to the survey task. They faced challenges in choosing response options, understanding scale relationships, and interpreting vocabulary. Additionally, many respondents expressed a need to share salient details of their lives, which the survey was not designed to capture. Understanding these barriers to participation and identifying ways to mitigate them can help reduce survey error, particularly in vulnerable populations. AB - Author manuscript AN - cdc:261482 C4 - PMC11987661 DO - https://doi.org/10.29115/SP-2024-0035 J2 - Survey Practice KW - Literacy KW - Vocabulary KW - Vulnerable Populations KW - Surveys and Questionnaires KW - Cognition KW - Caregivers KW - cross-cultural survey KW - survey methods KW - cognitive interviewing KW - Caregivers KW - Literacy KW - Vocabulary KW - Vulnerable Populations KW - Surveys and Questionnaires KW - Cognition LA - eng PY - 2025 T2 - Survey Practice T2 - Survey Practice, 2025, v. 19 TI - Survey Practice in Non-Survey-Literate Populations: Lessons Learned From a Cognitive Interview Study in Brazil. VL - 19 UR - https://stacks.cdc.gov/view/cdc/261482 ER -
Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023.

Rowh, Adam ;

Zwald, Marissa

May 2025 | Annals of Internal Medicine, 2025, v. 178, no. 5

Monitoring temporal trends in firearm injury-related emergency department (ED) visits is challenging because traditional surveillance systems lack detailed temporal information.To describe temporal patterns of ED visits for firearm injury using data from the Centers for Disease Control and Prevention's (CDC) Firearm Injury Surveillance Through Emer ...

10/09/2026

Supporting Files

Title : Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023. Personal Author(s) : Rowh, Adam;Zwald, Marissa;Sumner, Steven;George, Nisha;Sheppard, Michael;Holland, Kristin; Published Date : May 2025 Pages in Document : 663-670 (14 pdf pages) Source : Annals of Internal Medicine, 2025, v. 178, no. 5 DOI : https://doi.org/10.7326/ANNALS-24-02874 Journal Title : Annals of Internal Medicine
Rowh, A., Zwald, M., Sumner, S., George, N., Sheppard, M., & Holland, K. (2025). Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023. Annals of Internal Medicine, 178(5). https://doi.org/10.7326/ANNALS-24-02874

Rowh, Adam, Marissa Zwald, Steven Sumner, Nisha George, Michael Sheppard, and Kristin Holland. "Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023." Annals of Internal Medicine 178, no. 5 (2025). https://doi.org/10.7326/ANNALS-24-02874.

Rowh, Adam, et al. "Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023." Annals of Internal Medicine, vol. 178, no. 5, 2025. Stacks. https://doi.org/10.7326/ANNALS-24-02874.
Export RIS Citation Information. TY - Journal Article AU - Rowh, Adam AU - Zwald, Marissa AU - Sumner, Steven AU - George, Nisha AU - Sheppard, Michael AU - Holland, Kristin AB - Monitoring temporal trends in firearm injury-related emergency department (ED) visits is challenging because traditional surveillance systems lack detailed temporal information. AB - To describe temporal patterns of ED visits for firearm injury using data from the Centers for Disease Control and Prevention's (CDC) Firearm Injury Surveillance Through Emergency Rooms (FASTER) program. AB - Cross-sectional analysis of firearm injury-related ED visits. AB - 9 states (Florida, Georgia, New Mexico, North Carolina, Oregon, Utah, Virginia, Washington, and West Virginia) and the District of Columbia from 1 January 2018 to 31 August 2023. AB - ED visits for firearm injury ( AB - = 93 022) from CDC's FASTER program. AB - ED visits for firearm injury per 100 000 ED visits, analyzed by time of day (in 30-minute intervals), day of the week, day of the year, and holidays. AB - From January 2018 through August 2023, there were 93 022 firearm injury ED visits (73.9 per 100 000 ED visits), or approximately 1 firearm injury every 30 minutes overall. Rates of firearm injury ED visits were highest between 2:30 and 3:00 a.m. and lowest between 10:00 and 10:30 a.m. Nighttime peaks and daily rates were highest on Friday and Saturday. Monthly rates were highest in July and lowest in February; daily rates were disproportionately high on most holidays, especially Independence Day and New Year's Eve. AB - Data are limited to 9 states and the District of Columbia and are not nationally representative. The analysis of ED visits for firearm injury does not distinguish injury intent and is based on arrival time rather than actual injury time. AB - Distinct temporal patterns in firearm injury ED visits highlight resource allocation considerations for prevention and response efforts. AB - Centers for Disease Control and Prevention. AB - Author manuscript AN - cdc:261481 C4 - PMC12088878 DO - https://doi.org/10.7326/ANNALS-24-02874 IS - 5 J2 - Annals of Internal Medicine KW - Adolescent KW - Female KW - Aged KW - Young Adult KW - Emergency Service, Hospital KW - Wounds, Gunshot KW - Child KW - Cross-Sectional Studies KW - Firearms KW - Emergency Room Visits KW - Male KW - Middle Aged KW - Humans KW - Child, Preschool KW - Time Factors KW - Adult KW - Humans KW - Emergency Service, Hospital KW - Wounds, Gunshot KW - Cross-Sectional Studies KW - Male KW - Female KW - Adult KW - Adolescent KW - Middle Aged KW - Young Adult KW - Child KW - Time Factors KW - Firearms KW - Child, Preschool KW - Aged KW - Emergency Room Visits LA - eng PY - 2025 T2 - Annals of Internal Medicine T2 - Annals of Internal Medicine, 2025, v. 178, no. 5 TI - Patterns of U.S. Firearm Injury Emergency Department Visits by Month, Day, and Time During 2018 to 2023. VL - 178 UR - https://stacks.cdc.gov/view/cdc/261481 ER -
Review of Powered, Safe Patient-Handling Equipment For Emergency Medical Services Via an Insurance Safety Intervention Grant Program.

Hayden, Marie A. ;

Reichard, Audrey A.

April 2025 | Prehospital and Disaster Medicine, 2025, v. 40, no. 2

Powered equipment for patient handling was designed to alleviate Emergency Medical Service (EMS) clinician injuries while lifting patients. This project evaluated the organizational rationale for purchasing powered equipment and the outcomes from equipment use.This project analyzed secondary data obtained via an insurance Safety Intervention Grant ...

10/09/2026

Supporting Files

Title : Review of Powered, Safe Patient-Handling Equipment For Emergency Medical Services Via an Insurance Safety Intervention Grant Program. Personal Author(s) : Hayden, Marie A.;Reichard, Audrey A.;Lowe, Brian D.;Naber, Steven J.;Wurzelbacher, Steven J.; Published Date : April 2025 Pages in Document : 64-72 (19 pdf pages) Source : Prehospital and Disaster Medicine, 2025, v. 40, no. 2 DOI : https://doi.org/10.1017/S1049023X25000196 Journal Title : Prehospital and Disaster Medicine
Hayden, M. A., Reichard, A. A., Lowe, B. D., Naber, S. J., & Wurzelbacher, S. J. (2025). Review of Powered, Safe Patient-Handling Equipment For Emergency Medical Services Via an Insurance Safety Intervention Grant Program. Prehospital and Disaster Medicine, 40(2). https://doi.org/10.1017/S1049023X25000196

Hayden, Marie A., Audrey A. Reichard, Brian D. Lowe, Steven J. Naber, and Steven J. Wurzelbacher. "Review of Powered, Safe Patient-Handling Equipment For Emergency Medical Services Via an Insurance Safety Intervention Grant Program." Prehospital and Disaster Medicine 40, no. 2 (2025). https://doi.org/10.1017/S1049023X25000196.

Hayden, Marie A., et al. "Review of Powered, Safe Patient-Handling Equipment For Emergency Medical Services Via an Insurance Safety Intervention Grant Program." Prehospital and Disaster Medicine, vol. 40, no. 2, 2025. Stacks. https://doi.org/10.1017/S1049023X25000196.
Export RIS Citation Information. TY - Journal Article AU - Hayden, Marie A. AU - Reichard, Audrey A. AU - Lowe, Brian D. AU - Naber, Steven J. AU - Wurzelbacher, Steven J. AB - Powered equipment for patient handling was designed to alleviate Emergency Medical Service (EMS) clinician injuries while lifting patients. This project evaluated the organizational rationale for purchasing powered equipment and the outcomes from equipment use. AB - This project analyzed secondary data obtained via an insurance Safety Intervention Grant (SIG) program in Ohio USA. These data were primarily in reports from EMS organizations. Investigators applied a mixed-methods approach, analyzing quantitative data from 297 grants and qualitative data from a sample of 64 grants. Analysts abstracted data related to: work-related injuries or risk of musculoskeletal-disorders (MSD), employee feedback regarding acceptance or rejection, and impact on quality, productivity, staffing, and cost. AB - A total of $16.67 million (2018 adjusted USD) was spent from 2005 through 2018 for powered cots, powered loading systems, powered stair chairs, and non-patient handling equipment (eg, chest compression system, powered roller). Organizations purchased equipment to accommodate staff demographics (height, age, sex) and patient characteristics (weight, impairments). Grantees were fire departments ( AB - = 254) and public ( AB - = 19) and private ( AB - = 24) EMS organizations consisting of career (45%), volunteer (20%), and a combination of career and volunteer (35%) staff. Powered equipment reduced reported musculoskeletal injuries, and organizations reported it improved EMS clinicians' safety. Organization feedback was mostly positive, and no organization indicated outright rejection of the purchased equipment. Analyst-identified design advantages for powered cots included increased patient weight capacity and hydraulic features, but the greater weight of the powered cot was a disadvantage. The locking mechanism to hold the cot during transportation was reported as an advantage, but it was a disadvantage for older cots without a compatibility conversion kit. Around one-half of organizations described a positive impact on quality of care and patient safety resulting from the new equipment. AB - Overall, organizations reported improved EMS clinicians' safety but noted that not all safety concerns were addressed by the new equipment. AB - Author manuscript AN - cdc:261480 C4 - PMC12107376 DO - https://doi.org/10.1017/S1049023X25000196 IS - 2 J2 - Prehospital and Disaster Medicine KW - Emergency Medical Services KW - Occupational Injuries KW - Humans KW - Moving and Lifting Patients KW - ambulance stretcher KW - Emergency Medical Service KW - patient handling KW - Humans KW - Moving and Lifting Patients KW - Emergency Medical Services KW - Occupational Injuries LA - eng PY - 2025 T2 - Prehospital and Disaster Medicine T2 - Prehospital and Disaster Medicine, 2025, v. 40, no. 2 TI - Review of Powered, Safe Patient-Handling Equipment For Emergency Medical Services Via an Insurance Safety Intervention Grant Program. VL - 40 UR - https://stacks.cdc.gov/view/cdc/261480 ER -
Attention-Deficit/Hyperactivity Disorder and Teen Self-Report on Health Behaviors and Social-Emotional Wellbeing: United States, July 2021-December 2022.

Katz, Samuel M. ;

Claussen, Angelika H.

April 21, 2025 | Journal of Developmental and Behavioral Pediatrics : JDBP, 2025, v. 46, no. 2

Promoting health during adolescence can support long-term well-being, especially for teens diagnosed with attention-deficit/hyperactivity disorder (ADHD), who face increased risks due to the disorder's impact on development and health behaviors. ADHD is often associated with difficulties in social interactions, a higher likelihood of bullying invol ...

10/09/2026

Supporting Files

Title : Attention-Deficit/Hyperactivity Disorder and Teen Self-Report on Health Behaviors and Social-Emotional Wellbeing: United States, July 2021-December 2022. Personal Author(s) : Katz, Samuel M.;Claussen, Angelika H.;Black, Lindsey I.;Leeb, Rebecca T.;Newsome, Kimberly;Danielson, Melissa L.;Zablotsky, Benjamin; Published Date : April 21, 2025 Pages in Document : e155-e161 (16 pdf pages) Source : Journal of Developmental and Behavioral Pediatrics : JDBP, 2025, v. 46, no. 2 DOI : https://doi.org/10.1097/DBP.0000000000001350 Journal Title : Journal of Developmental and Behavioral Pediatrics : JDBP
Katz, S. M., Claussen, A. H., Black, L. I., Leeb, R. T., Newsome, K., Danielson, M. L., & Zablotsky, B. (2025). Attention-Deficit/Hyperactivity Disorder and Teen Self-Report on Health Behaviors and Social-Emotional Wellbeing: United States, July 2021-December 2022. Journal of Developmental and Behavioral Pediatrics : JDBP, 46(2). https://doi.org/10.1097/DBP.0000000000001350

Katz, Samuel M., Angelika H. Claussen, Lindsey I. Black, Rebecca T. Leeb, Kimberly Newsome, Melissa L. Danielson, and Benjamin Zablotsky. "Attention-Deficit/Hyperactivity Disorder and Teen Self-Report on Health Behaviors and Social-Emotional Wellbeing: United States, July 2021-December 2022." Journal of Developmental and Behavioral Pediatrics : JDBP 46, no. 2 (2025). https://doi.org/10.1097/DBP.0000000000001350.

Katz, Samuel M., et al. "Attention-Deficit/Hyperactivity Disorder and Teen Self-Report on Health Behaviors and Social-Emotional Wellbeing: United States, July 2021-December 2022." Journal of Developmental and Behavioral Pediatrics : JDBP, vol. 46, no. 2, 2025. Stacks. https://doi.org/10.1097/DBP.0000000000001350.
Export RIS Citation Information. TY - Journal Article AU - Katz, Samuel M. AU - Claussen, Angelika H. AU - Black, Lindsey I. AU - Leeb, Rebecca T. AU - Newsome, Kimberly AU - Danielson, Melissa L. AU - Zablotsky, Benjamin AB - Promoting health during adolescence can support long-term well-being, especially for teens diagnosed with attention-deficit/hyperactivity disorder (ADHD), who face increased risks due to the disorder's impact on development and health behaviors. ADHD is often associated with difficulties in social interactions, a higher likelihood of bullying involvement, and co-occurring mental health conditions. These factors may also be influenced by health factors such as physical activity, sleep quality, and screen time usage. Nationally representative teen self-reports provide a novel perspective on ADHD-related health outcomes compared with relying on parent reports. AB - We used nationally representative data from the National Health Interview Survey (NHIS) and NHIS-Teen from July 2021 to December 2022, to examine teen-reported health and well-being factors, stratified by parent-reported ADHD diagnoses among teens aged 12 to 17 years. Weighted prevalence estimates and adjusted prevalence ratios (aPR) adjusting for teen age, sex, and family income, all with 95% confidence intervals (CIs), were calculated. AB - Just over 10% of teens had ADHD and they reported higher prevalence of bullying victimization (aPR = 1.64, CI = 1.27-2.11), difficulties making friends (aPR = 1.83, CI = 1.15-2.90), difficulty getting out of bed (aPR = 1.29, CI = 1.02-1.64), irregular wake times (aPR = 2.17, CI = 1.45-3.25), and >4 hours daily screen time (aPR = 1.26, CI = 1.05-1.52) than teens without ADHD; teens with ADHD reported a lower prevalence of lacking peer support (aPR = 0.70, CI = 0.51-0.96). AB - Teens with ADHD face distinct challenges related to social-emotional well-being and health behaviors that support overall wellness. Findings may inform opportunities for health promotion among teens with ADHD. AB - Author manuscript AN - cdc:261479 C4 - PMC12011209 DO - https://doi.org/10.1097/DBP.0000000000001350 IS - 2 J2 - Journal of Developmental and Behavioral Pediatrics : JDBP KW - Child KW - Adolescent KW - Female KW - Attention Deficit Disorder with Hyperactivity KW - Bullying KW - Health Behavior KW - Male KW - Humans KW - Self Report KW - Crime Victims KW - Health Surveys KW - Adolescent Behavior KW - ADHD KW - interpersonal relations KW - health risk behaviors KW - adolescent KW - mental health KW - Humans KW - Adolescent KW - Attention Deficit Disorder with Hyperactivity KW - Male KW - Female KW - Self Report KW - Bullying KW - Child KW - Health Behavior KW - Adolescent Behavior KW - Health Surveys KW - Crime Victims LA - eng PY - 2025 T2 - Journal of Developmental and Behavioral Pediatrics : JDBP T2 - Journal of Developmental and Behavioral Pediatrics : JDBP, 2025, v. 46, no. 2 TI - Attention-Deficit/Hyperactivity Disorder and Teen Self-Report on Health Behaviors and Social-Emotional Wellbeing: United States, July 2021-December 2022. VL - 46 UR - https://stacks.cdc.gov/view/cdc/261479 ER -
Communication Practices to Support Frontline Workers During Public Health Threats.

Haas, Emily J. ;

Orstad, Stephanie L.

September 2025 | Workplace Health & Safety, 2025, v. 73, no. 9

Public health threats (PHTs) influence how and in what ways managers communicate with employees. Employee resources and information during uncertain times has been noted as a reoccurring gap, especially as it relates to personal protective equipment (PPE). This study explored general and PPE-specific communication practices with 22 healthcare and e ...

10/09/2026

Supporting Files

Title : Communication Practices to Support Frontline Workers During Public Health Threats. Personal Author(s) : Haas, Emily J.;Orstad, Stephanie L.; Published Date : September 2025 Pages in Document : 477-488 (21 pdf pages) Source : Workplace Health & Safety, 2025, v. 73, no. 9 DOI : https://doi.org/10.1177/21650799251334146 Journal Title : Workplace Health & Safety
Haas, E. J., & Orstad, S. L. (2025). Communication Practices to Support Frontline Workers During Public Health Threats. Workplace Health & Safety, 73(9). https://doi.org/10.1177/21650799251334146

Haas, Emily J. and Stephanie L. Orstad. "Communication Practices to Support Frontline Workers During Public Health Threats." Workplace Health & Safety 73, no. 9 (2025). https://doi.org/10.1177/21650799251334146.

Haas, Emily J., and Stephanie L. Orstad "Communication Practices to Support Frontline Workers During Public Health Threats." Workplace Health & Safety, vol. 73, no. 9, 2025. Stacks. https://doi.org/10.1177/21650799251334146.
Export RIS Citation Information. TY - Journal Article AU - Haas, Emily J. AU - Orstad, Stephanie L. AB - Public health threats (PHTs) influence how and in what ways managers communicate with employees. Employee resources and information during uncertain times has been noted as a reoccurring gap, especially as it relates to personal protective equipment (PPE). This study explored general and PPE-specific communication practices with 22 healthcare and emergency medical service (EMS) managers to support workers, particularly in the context of preparedness and response. AB - Data collection occurred in two phases that involved interviews and small group discussions to identify, examine, and better frame and execute communication practices. Qualitative analysis was informed by the 4i FACT framework and the social ecological model (SEM) to identify relevant communication practices and intervention points within health delivery settings. AB - Results elucidated perceived, effective leadership practices and interpersonal influences in the workplace. Tangible leadership communication practices were identified as important intervention points within the SEM, with a focus on proactive behaviors to procure necessary PPE and disseminate information. Participants emphasized one-on-one interactions with employees, and the use of trusted messengers to share health-related messages. They also highlighted the challenges of PPE shortages and the importance of access to resources across different job roles, organizations, and work settings. AB - This study contributes insights into communication practices during a public health emergency, offering a nuanced understanding of managerial approaches, PPE-related communication, and the broader contextual factors influencing information dissemination. Further, the integration of frameworks like 4i FACT and SEM provides a structured perspective for future communication strategies, supporting tailored approaches across organizations. AB - Author manuscript AN - cdc:261478 C4 - PMC12358980 DO - https://doi.org/10.1177/21650799251334146 IS - 9 J2 - Workplace Health & Safety KW - Female KW - Communication KW - Qualitative Research KW - Frontline Workers KW - Leadership KW - Public Health KW - Male KW - Humans KW - Middle Aged KW - Interviews as Topic KW - Personal Protective Equipment KW - Adult KW - 4i FACT framework KW - healthcare KW - personal protective equipment KW - public safety KW - qualitative data KW - public health threat KW - social ecological model KW - Adult KW - Female KW - Humans KW - Male KW - Middle Aged KW - Communication KW - Frontline Workers KW - Interviews as Topic KW - Leadership KW - Personal Protective Equipment KW - Public Health KW - Qualitative Research LA - eng PY - 2025 T2 - Workplace Health & Safety T2 - Workplace Health & Safety, 2025, v. 73, no. 9 TI - Communication Practices to Support Frontline Workers During Public Health Threats. VL - 73 UR - https://stacks.cdc.gov/view/cdc/261478 ER -
Randomized Study of Metformin and Intensive Lifestyle Intervention on Cancer Incidence Over 21 Years of Follow-up in the Diabetes Prevention Program.

Heckman-Stoddard, Brandy M ;

Crandall, Jill P

July 2025 | Cancer Prevention Research (Philadelphia, Pa.), 2025, v. 18, no. 7

Meta-analyses have reported a decrease in overall cancer incidence of approximately 10% to 40% with metformin use among individuals with diabetes. Lifestyle change could potentially reduce cancer incidence. The objective was to determine whether metformin or intensive lifestyle (ILS) intervention reduces the risk of cancer among adults at high risk ...

10/09/2026

Supporting Files

Title : Randomized Study of Metformin and Intensive Lifestyle Intervention on Cancer Incidence Over 21 Years of Follow-up in the Diabetes Prevention Program. Personal Author(s) : Heckman-Stoddard, Brandy M;Crandall, Jill P;Edelstein, Sharon L;Prorok, Philip C;Dabelea, Dana;Hamman, Richard;Hazuda, Helen P;Horton, Edward;Hoskin, Mary A;Perloff, Marjorie;Bowers, Anna;Knowler, William C;Ford, Leslie G;Temprosa, Marinella; Published Date : July 2025 Pages in Document : 401-411 (22 pdf pages) Source : Cancer Prevention Research (Philadelphia, Pa.), 2025, v. 18, no. 7 DOI : https://doi.org/10.1158/1940-6207.CAPR-23-0461 Journal Title : Cancer Prevention Research (Philadelphia, Pa.)
Heckman-Stoddard, B. M., Crandall, J. P., Edelstein, S. L., Prorok, P. C., Dabelea, D., Hamman, R., Hazuda, H. P., Horton, E., Hoskin, M. A., Perloff, M., Bowers, A., Knowler, W. C., Ford, L. G., & Temprosa, M. (2025). Randomized Study of Metformin and Intensive Lifestyle Intervention on Cancer Incidence Over 21 Years of Follow-up in the Diabetes Prevention Program. Cancer Prevention Research (Philadelphia, Pa.), 18(7). https://doi.org/10.1158/1940-6207.CAPR-23-0461

Heckman-Stoddard, Brandy M, Jill P Crandall, Sharon L Edelstein, Philip C Prorok, Dana Dabelea, Richard Hamman, and Helen P Hazuda, et al.. "Randomized Study of Metformin and Intensive Lifestyle Intervention on Cancer Incidence Over 21 Years of Follow-up in the Diabetes Prevention Program." Cancer Prevention Research (Philadelphia, Pa.) 18, no. 7 (2025). https://doi.org/10.1158/1940-6207.CAPR-23-0461.

Heckman-Stoddard, Brandy M, et al. "Randomized Study of Metformin and Intensive Lifestyle Intervention on Cancer Incidence Over 21 Years of Follow-up in the Diabetes Prevention Program." Cancer Prevention Research (Philadelphia, Pa.), vol. 18, no. 7, 2025. Stacks. https://doi.org/10.1158/1940-6207.CAPR-23-0461.
Export RIS Citation Information. TY - Journal Article AU - Heckman-Stoddard, Brandy M AU - Crandall, Jill P AU - Edelstein, Sharon L AU - Prorok, Philip C AU - Dabelea, Dana AU - Hamman, Richard AU - Hazuda, Helen P AU - Horton, Edward AU - Hoskin, Mary A AU - Perloff, Marjorie AU - Bowers, Anna AU - Knowler, William C AU - Ford, Leslie G AU - Temprosa, Marinella AB - Meta-analyses have reported a decrease in overall cancer incidence of approximately 10% to 40% with metformin use among individuals with diabetes. Lifestyle change could potentially reduce cancer incidence. The objective was to determine whether metformin or intensive lifestyle (ILS) intervention reduces the risk of cancer among adults at high risk of diabetes. The Diabetes Prevention Program (1996-2001) randomized 3,234 participants to ILS, metformin (850 mg twice daily), or blinded placebo. During follow-up through the Diabetes Prevention Program Outcomes Study, all participants were offered a modified lifestyle intervention, and metformin continued in an open-label metformin group. Participants reported cancer cases annually. Medical records were adjudicated for all reported events. The primary endpoint was total cancer incidence, comparing metformin versus placebo, with ILS versus placebo as a secondary objective. After a median follow-up of 21 years, 546 participants (173 metformin, 182 ILS, and 191 placebo) were diagnosed with a first incident cancer. Incidence rates of cancer were 9.8, 10.5, and 10.8 per 1,000 person-years in metformin, ILS, and placebo, respectively, with a HR of 0.90 (95% confidence interval, 0.73-1.10) for metformin compared with placebo and 0.96 (95% confidence interval, 0.79-1.18) for ILS compared with placebo. There were no differences between any treatment groups for obesity-related cancer or in sex-specific analyses. Neither assignment to metformin nor ILS reduced cancer incidence among adults at high risk of diabetes. These results may be impacted by increased nonstudy metformin usage over time due to the development of diabetes and reduced intensity of the ILS intervention over time. AB - This study examines both metformin and ILS intervention as primary cancer prevention interventions in people at high risk for type 2 diabetes. AB - Author manuscript AN - cdc:261477 C4 - PMC12213222 DO - https://doi.org/10.1158/1940-6207.CAPR-23-0461 IS - 7 J2 - Cancer Prevention Research (Philadelphia, Pa.) KW - Female KW - Metformin KW - Aged KW - Risk Reduction Behavior KW - Diabetes Mellitus, Type 2 KW - Life Style KW - Follow-Up Studies KW - Neoplasms KW - Incidence KW - Hypoglycemic Agents KW - Male KW - Humans KW - Middle Aged KW - Adult KW - Adult KW - Aged KW - Female KW - Humans KW - Male KW - Middle Aged KW - Diabetes Mellitus, Type 2 KW - Follow-Up Studies KW - Hypoglycemic Agents KW - Incidence KW - Life Style KW - Metformin KW - Neoplasms KW - Risk Reduction Behavior LA - eng PY - 2025 T2 - Cancer Prevention Research (Philadelphia, Pa.) T2 - Cancer Prevention Research (Philadelphia, Pa.), 2025, v. 18, no. 7 TI - Randomized Study of Metformin and Intensive Lifestyle Intervention on Cancer Incidence Over 21 Years of Follow-up in the Diabetes Prevention Program. VL - 18 UR - https://stacks.cdc.gov/view/cdc/261477 ER -
Ketone Body-supported Respiration in Murine Isolated Brain Mitochondria is Augmented by Alpha-ketoglutarate and is Optimized by Neuronal SCOT Expression.

Davis, Xin C ;

McCoin, Colin S

June 2025 | American Journal of Physiology. Endocrinology and Metabolism, 2025, v. 328, no. 6

Ketone bodies are increasingly examined as an alternative fuel source for the known decreases in glucose utilization that occur with neurodegeneration. Here, we established a protocol to maximize ketone body respiration in isolated brain mitochondria, while quantifying acetyl-CoA and energy charge via liquid chromatography-tandem mass spectrometry ...

10/09/2026

Supporting Files

Title : Ketone Body-supported Respiration in Murine Isolated Brain Mitochondria is Augmented by Alpha-ketoglutarate and is Optimized by Neuronal SCOT Expression. Personal Author(s) : Davis, Xin C;McCoin, Colin S;Morris, E. Matthew;Allen, Julie;Stierwalt, Harrison D;Franczak, Edziu;Queathem, Eric D;Fulghum, Kyle L;Puchalska, Patrycja;Crawford, Peter A;Thyfault, John P; Published Date : June 2025 Pages in Document : E822-E832 (21 pdf pages) Source : American Journal of Physiology. Endocrinology and Metabolism, 2025, v. 328, no. 6 DOI : https://doi.org/10.1152/ajpendo.00058.2025 Journal Title : American Journal of Physiology. Endocrinology and Metabolism
Davis, X. C., McCoin, C. S., Morris, E. M., Allen, J., Stierwalt, H. D., Franczak, E., Queathem, E. D., Fulghum, K. L., Puchalska, P., Crawford, P. A., & Thyfault, J. P. (2025). Ketone Body-supported Respiration in Murine Isolated Brain Mitochondria is Augmented by Alpha-ketoglutarate and is Optimized by Neuronal SCOT Expression. American Journal of Physiology. Endocrinology and Metabolism, 328(6). https://doi.org/10.1152/ajpendo.00058.2025

Davis, Xin C, Colin S McCoin, E. Matthew Morris, Julie Allen, Harrison D Stierwalt, Edziu Franczak, and Eric D Queathem, et al.. "Ketone Body-supported Respiration in Murine Isolated Brain Mitochondria is Augmented by Alpha-ketoglutarate and is Optimized by Neuronal SCOT Expression." American Journal of Physiology. Endocrinology and Metabolism 328, no. 6 (2025). https://doi.org/10.1152/ajpendo.00058.2025.

Davis, Xin C, et al. "Ketone Body-supported Respiration in Murine Isolated Brain Mitochondria is Augmented by Alpha-ketoglutarate and is Optimized by Neuronal SCOT Expression." American Journal of Physiology. Endocrinology and Metabolism, vol. 328, no. 6, 2025. Stacks. https://doi.org/10.1152/ajpendo.00058.2025.
Export RIS Citation Information. TY - Journal Article AU - Davis, Xin C AU - McCoin, Colin S AU - Morris, E. Matthew AU - Allen, Julie AU - Stierwalt, Harrison D AU - Franczak, Edziu AU - Queathem, Eric D AU - Fulghum, Kyle L AU - Puchalska, Patrycja AU - Crawford, Peter A AU - Thyfault, John P AB - Ketone bodies are increasingly examined as an alternative fuel source for the known decreases in glucose utilization that occur with neurodegeneration. Here, we established a protocol to maximize ketone body respiration in isolated brain mitochondria, while quantifying acetyl-CoA and energy charge via liquid chromatography-tandem mass spectrometry in control mice compared with mice with neuron-specific deletion of succinyl-CoA-3-oxoacid-CoA transferase (SCOT), required for CoA transfer from succinyl-CoA to acetoacetate (AcAc) to support its oxidation. Maximal ADP-dependent AcAc respiration occurred at 1 mM; however, the percent increase above basal was minimal (∼15%). Alpha-ketoglutarate (αKG) substantially increased AcAc-dependent respiration in isolated brain mitochondria, putatively through the generation of succinyl-CoA. Using mice with neuron-specific deletion of SCOT, we also examined brain mitochondrial respiration of AcAc and resulting acetyl CoA and energy charge (cellular energy availability via adenosine nucleotide ratios of ATP, ADP, and AMP). As expected, isolated brain mitochondria from SCOT-knockout (KO) mice had lower AcAc State 3 respiration than control mice. Surprisingly, we did not find differences in mitochondrial energy charge between SCOT control and neuron SCOT-KO mice despite decreased acetyl-CoA level in SCOT-KO mice when AcAc was used as the substrate. In conclusion, we show that αKG enhances ketone-supported respiration rate in isolated brain mitochondria and ketone metabolism in neurons affects acetyl-CoA level in brain mitochondria but not energy charge. Future work will determine whether diet, exercise, sex, or age impacts ketone-supported respiration rates in conjunction with differences in markers of brain health. AB - This paper established a protocol to maximize ketone body respiration in isolated brain mitochondria while quantifying acetyl-CoA and energy charge in control mice compared with mice with neuron-specific deletion of succinyl-CoA-3-oxoacid-CoA transferase (SCOT) enzyme, required for ketone body oxidation. Findings are that alpha-ketoglutarate substantially increased acetoacetate (AcAc)-dependent respiration and neuron SCOT-KO had lower AcAc state 3 respiration with a decreased acetyl-CoA level. AB - Author manuscript AN - cdc:261476 C4 - PMC12171989 DO - https://doi.org/10.1152/ajpendo.00058.2025 IS - 6 J2 - American Journal of Physiology. Endocrinology and Metabolism KW - Mice, Knockout KW - Acyl Coenzyme A KW - Animals KW - Neurons KW - Mice, Inbred C57BL KW - Acetyl Coenzyme A KW - Ketone Bodies KW - Mitochondria KW - Brain KW - Cell Respiration KW - Acetoacetates KW - Energy Metabolism KW - Male KW - Coenzyme A-Transferases KW - Ketoglutaric Acids KW - Mice KW - Brain KW - Ketone KW - Mitochondria respiration KW - SCOT KW - Animals KW - Ketone Bodies KW - Mice KW - Mitochondria KW - Brain KW - Neurons KW - Coenzyme A-Transferases KW - Ketoglutaric Acids KW - Mice, Knockout KW - Male KW - Acetyl Coenzyme A KW - Cell Respiration KW - Acetoacetates KW - Mice, Inbred C57BL KW - Energy Metabolism KW - Acyl Coenzyme A LA - eng PY - 2025 T2 - American Journal of Physiology. Endocrinology and Metabolism T2 - American Journal of Physiology. Endocrinology and Metabolism, 2025, v. 328, no. 6 TI - Ketone Body-supported Respiration in Murine Isolated Brain Mitochondria is Augmented by Alpha-ketoglutarate and is Optimized by Neuronal SCOT Expression. VL - 328 UR - https://stacks.cdc.gov/view/cdc/261476 ER -
Advancing Employer Cultures of Health and Well-being: Lessons For Business Coalitions and Employers.

Fabius, Raymond ;

Bildner, Michele

August 2025 | Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 8

The aim of the study was to determine the impact of a collaborative effort by employers to improve their organizations' cultures of health and well-being.The Centers for Disease Control and Prevention Foundation partnered with two organizations to help employers use an established methodology-an industry-validated baseline assessment, along with a ...

10/09/2026

Supporting Files

Title : Advancing Employer Cultures of Health and Well-being: Lessons For Business Coalitions and Employers. Personal Author(s) : Fabius, Raymond;Bildner, Michele;Goldfarb, Neil I.;Kirshenbaum, David;Thayer, Dixon;Kiwi, Ivor R.;Phares, Sharon E.; Published Date : August 2025 Pages in Document : 581-587 (20 pdf pages) Source : Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 8 DOI : https://doi.org/10.1097/JOM.0000000000003414 Journal Title : Journal of Occupational and Environmental Medicine
Fabius, R., Bildner, M., Goldfarb, N. I., Kirshenbaum, D., Thayer, D., Kiwi, I. R., & Phares, S. E. (2025). Advancing Employer Cultures of Health and Well-being: Lessons For Business Coalitions and Employers. Journal of Occupational and Environmental Medicine, 67(8). https://doi.org/10.1097/JOM.0000000000003414

Fabius, Raymond, Michele Bildner, Neil I. Goldfarb, David Kirshenbaum, Dixon Thayer, Ivor R. Kiwi, and Sharon E. Phares. "Advancing Employer Cultures of Health and Well-being: Lessons For Business Coalitions and Employers." Journal of Occupational and Environmental Medicine 67, no. 8 (2025). https://doi.org/10.1097/JOM.0000000000003414.

Fabius, Raymond, et al. "Advancing Employer Cultures of Health and Well-being: Lessons For Business Coalitions and Employers." Journal of Occupational and Environmental Medicine, vol. 67, no. 8, 2025. Stacks. https://doi.org/10.1097/JOM.0000000000003414.
Export RIS Citation Information. TY - Journal Article AU - Fabius, Raymond AU - Bildner, Michele AU - Goldfarb, Neil I. AU - Kirshenbaum, David AU - Thayer, Dixon AU - Kiwi, Ivor R. AU - Phares, Sharon E. AB - The aim of the study was to determine the impact of a collaborative effort by employers to improve their organizations' cultures of health and well-being. AB - The Centers for Disease Control and Prevention Foundation partnered with two organizations to help employers use an established methodology-an industry-validated baseline assessment, along with a strategic roadmap and guidance from physician executive experts. Employers implemented this approach and simultaneously participated in a structured monthly learning collaborative. AB - The average projected improvement in the culture of health scores from baseline to year end was 80 points, moving from 60% to 71% achievement of the benchmark score. AB - This research demonstrates that employers working collaboratively and following an appropriate sequence of scientific-based approaches can demonstrate a positive trend in organizational cultures of health and well-being scores pointing to the possibility of sustainable culture change. AB - Author manuscript AN - cdc:261475 C4 - PMC12321331 DO - https://doi.org/10.1097/JOM.0000000000003414 IS - 8 J2 - Journal of Occupational and Environmental Medicine KW - Organizational Culture KW - Humans KW - Occupational Health KW - Health Promotion KW - Cooperative Behavior KW - employers KW - culture of health KW - population health KW - occupational health KW - well-being KW - collaborative approach KW - community health KW - Humans KW - Organizational Culture KW - Occupational Health KW - Health Promotion KW - Cooperative Behavior LA - eng PY - 2025 T2 - Journal of Occupational and Environmental Medicine T2 - Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 8 TI - Advancing Employer Cultures of Health and Well-being: Lessons For Business Coalitions and Employers. VL - 67 UR - https://stacks.cdc.gov/view/cdc/261475 ER -
Use of Portable Air Cleaners Within an Ambulance Workspace.

Pena, Mirle ;

Neu, Dylan T.

April 17, 2025 | Journal of Occupational and Environmental Hygiene, April 2025

Emergency medical service (EMS) providers face significant exposure to infectious aerosols during outbreaks like the COVID-19 pandemic. Most ambulances lack ventilation controls to reduce EMS worker exposure to these aerosols. Ambulances are smaller than hospital rooms and handle numerous patients daily, increasing contact with potentially infectio ...

10/09/2026

Supporting Files

Title : Use of Portable Air Cleaners Within an Ambulance Workspace. Personal Author(s) : Pena, Mirle;Neu, Dylan T.;Amy Feng, H.;Hammond, Duane R.;Mead, Kenneth R.;Banerjee, Rupak K.; Published Date : April 17, 2025 Pages in Document : 1-14 (22 pdf pages) Source : Journal of Occupational and Environmental Hygiene, April 2025 DOI : https://doi.org/10.1080/15459624.2025.2485074 Journal Title : Journal of Occupational and Environmental Hygiene
Pena, M., Neu, D. T., Amy Feng, H., Hammond, D. R., Mead, K. R., & Banerjee, R. K. (2025). Use of Portable Air Cleaners Within an Ambulance Workspace. Journal of Occupational and Environmental Hygiene. https://doi.org/10.1080/15459624.2025.2485074

Pena, Mirle, Dylan T. Neu, H. Amy Feng, Duane R. Hammond, Kenneth R. Mead, and Rupak K. Banerjee. "Use of Portable Air Cleaners Within an Ambulance Workspace." Journal of Occupational and Environmental Hygiene (2025). https://doi.org/10.1080/15459624.2025.2485074.

Pena, Mirle, et al. "Use of Portable Air Cleaners Within an Ambulance Workspace." Journal of Occupational and Environmental Hygiene, 2025. Stacks. https://doi.org/10.1080/15459624.2025.2485074.
Export RIS Citation Information. TY - Journal Article AU - Pena, Mirle AU - Neu, Dylan T. AU - Amy Feng, H. AU - Hammond, Duane R. AU - Mead, Kenneth R. AU - Banerjee, Rupak K. AB - Emergency medical service (EMS) providers face significant exposure to infectious aerosols during outbreaks like the COVID-19 pandemic. Most ambulances lack ventilation controls to reduce EMS worker exposure to these aerosols. Ambulances are smaller than hospital rooms and handle numerous patients daily, increasing contact with potentially infectious individuals. Ventilation controls such as portable high-efficiency particulate air (HEPA) filtration can mitigate this risk. Few studies have assessed portable HEPA filters in ambulances. This study evaluated two HEPA filter models in an unoccupied, stationary research ambulance at the National Institute for Occupational Safety and Health (NIOSH) in Cincinnati. A tracer aerosol simulated patient aerosol generation, and optical particle counters (OPCs) measured aerosols. The HEPA units were tested individually, placed in the same location, and operated for 50 min. Results showed significant reductions in aerosol concentrations during the generation phase, with performance varying during the decay period. Overall, HEPA units reduced particle concentrations by around 50% during the generation phase and continued to be effective through the decay period. This demonstrates the potential of portable HEPA filters as an affordable and effective option for air cleaning in ambulance patient modules. AB - Author manuscript AN - cdc:261474 C4 - PMC12353224 DO - https://doi.org/10.1080/15459624.2025.2485074 J2 - Journal of Occupational and Environmental Hygiene KW - Respiratory Aerosols and Droplets KW - Pandemics KW - Hospitals KW - COVID-19 KW - Ambulances KW - Ambulance KW - bioaerosol KW - EMS KW - HEPA filtration KW - infection control KW - ventilation KW - Ambulances KW - COVID-19 KW - Pandemics KW - Respiratory Aerosols and Droplets KW - Hospitals LA - eng PY - 2025 T2 - Journal of Occupational and Environmental Hygiene T2 - Journal of Occupational and Environmental Hygiene, April 2025 TI - Use of Portable Air Cleaners Within an Ambulance Workspace. UR - https://stacks.cdc.gov/view/cdc/261474 ER -
Mixture Analysis of Associations Between Environmental and Workplace Toxins and Liver Damage and Telomere Length, Stratified by Race/ethnicity.

Ma, Ning ;

Yip, Rowena

September 2025 | Journal of Environmental Sciences (China), 2025, v. 155

This study aimed to identify the worst "bad actors" in mixtures of pollutants contributing to liver damage and shorter telomeres in the U.S. population, using weighted quantile sum (WQS) modeling with stratification by race/ethnicity. We conducted a comprehensive cross-sectional analysis of mixtures of pollutants in National Health and Nutrition Ex ...

10/09/2026

Supporting Files

Title : Mixture Analysis of Associations Between Environmental and Workplace Toxins and Liver Damage and Telomere Length, Stratified by Race/ethnicity. Personal Author(s) : Ma, Ning;Yip, Rowena;Woodward, Mark;Lewis, Sara;Crane, Michael;Jirapatnakul, Artit;Aloman, Costica;Bansal, Meena B.;Dieterich, Douglas;Gros, Louis;Valvi, Damaskini;Colicino, Elena;Yankelevitz, David;Henschke, Claudia;Branch, Andrea D.; Published Date : September 2025 Pages in Document : 316-328 (22 pdf pages) Source : Journal of Environmental Sciences (China), 2025, v. 155 DOI : https://doi.org/10.1016/j.jes.2024.08.020 Journal Title : Journal of Environmental Sciences (China)
Ma, N., Yip, R., Woodward, M., Lewis, S., Crane, M., Jirapatnakul, A., Aloman, C., Bansal, M. B., Dieterich, D., Gros, L., Valvi, D., Colicino, E., Yankelevitz, D., Henschke, C., & Branch, A. D. (2025). Mixture Analysis of Associations Between Environmental and Workplace Toxins and Liver Damage and Telomere Length, Stratified by Race/ethnicity. Journal of Environmental Sciences (China), 155. https://doi.org/10.1016/j.jes.2024.08.020

Ma, Ning, Rowena Yip, Mark Woodward, Sara Lewis, Michael Crane, Artit Jirapatnakul, and Costica Aloman, et al.. "Mixture Analysis of Associations Between Environmental and Workplace Toxins and Liver Damage and Telomere Length, Stratified by Race/ethnicity." Journal of Environmental Sciences (China) 155 (2025). https://doi.org/10.1016/j.jes.2024.08.020.

Ma, Ning, et al. "Mixture Analysis of Associations Between Environmental and Workplace Toxins and Liver Damage and Telomere Length, Stratified by Race/ethnicity." Journal of Environmental Sciences (China), vol. 155, 2025. Stacks. https://doi.org/10.1016/j.jes.2024.08.020.
Export RIS Citation Information. TY - Journal Article AU - Ma, Ning AU - Yip, Rowena AU - Woodward, Mark AU - Lewis, Sara AU - Crane, Michael AU - Jirapatnakul, Artit AU - Aloman, Costica AU - Bansal, Meena B. AU - Dieterich, Douglas AU - Gros, Louis AU - Valvi, Damaskini AU - Colicino, Elena AU - Yankelevitz, David AU - Henschke, Claudia AU - Branch, Andrea D. AB - This study aimed to identify the worst "bad actors" in mixtures of pollutants contributing to liver damage and shorter telomeres in the U.S. population, using weighted quantile sum (WQS) modeling with stratification by race/ethnicity. We conducted a comprehensive cross-sectional analysis of mixtures of pollutants in National Health and Nutrition Examination Survey datasets: (1) 33,979 adults with blood levels of cadmium (Cd), lead (Pb), and mercury, including subsets with measurements of per-/polyfluoroalkyl substances (PFAS), and polychlorinated biphenyls (PCBs)/polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs); and (2) 7360 adults with measurements of telomeres, Cd, and Pb. Multivariable-adjusted WQS regression examined associations between WQS mixture indices and liver injury (alanine aminotransferase (ALT)-elevation), advanced liver-fibrosis (LF), and telomere length. WQS AB - indices were associated with advanced-LF in all racial/ethnic groups. The top contributor was Cd in the total population and in non-Hispanic Whites (NHW), while Pb was the top contributor in non-Hispanic Blacks (NHB). The WQS AB - index was associated with ALT-elevation, with PCB126, Cd and Pb as main contributors; the odds ratio (OR) per decile was 1.50 (95 % CI, 1.26-1.78), while the OR per decile of the WQS AB - index was 1.03 (95 % CI, 0.98-1.05), not significant. WQS AB - indices were associated with shorter telomeres. Cd was main contributor associated with advanced-LF in NHW, while Pb was the major bad actor in NHB, suggesting that NHB may be especially susceptible to Pb toxicity. Metals were associated with shorter telomeres. Metal and PCB/PCDD/F mixtures were associated with ALT-elevation. Heavy metals and organic chemicals may contribute to liver-related morbidity and healthcare disparities. AB - Author manuscript AN - cdc:261473 C4 - PMC12006726 DO - https://doi.org/10.1016/j.jes.2024.08.020 J2 - Journal of Environmental Sciences (China) KW - Occupational Exposure KW - Female KW - White KW - Nutrition Surveys KW - Polychlorinated Biphenyls KW - Racial Groups KW - Cadmium KW - Telomere KW - Lead KW - Cross-Sectional Studies KW - Ethnicity KW - Environmental Pollutants KW - Liver KW - Male KW - Humans KW - Middle Aged KW - Environmental Exposure KW - Black or African American KW - Adult KW - Lead (Pb) KW - Cadmium (Cd) KW - Polychlorinated biphenyls KW - Mixture analysis KW - Liver injury KW - Racial disparities KW - Adult KW - Female KW - Humans KW - Male KW - Middle Aged KW - Cadmium KW - Cross-Sectional Studies KW - Environmental Exposure KW - Environmental Pollutants KW - Ethnicity KW - Lead KW - Liver KW - Nutrition Surveys KW - Occupational Exposure KW - Polychlorinated Biphenyls KW - Telomere KW - Racial Groups KW - White KW - Black or African American LA - eng PY - 2025 T2 - Journal of Environmental Sciences (China) T2 - Journal of Environmental Sciences (China), 2025, v. 155 TI - Mixture Analysis of Associations Between Environmental and Workplace Toxins and Liver Damage and Telomere Length, Stratified by Race/ethnicity. VL - 155 UR - https://stacks.cdc.gov/view/cdc/261473 ER -
Heavy Metals Are Liver Fibrosis Risk Factors in People Without Traditional Liver Disease Etiologies.

Ma, Ning ;

Bansal, Meena B.

September 2025 | Journal of Environmental Sciences (China), 2025, v. 155

Liver fibrosis is an important predictor of mortality. Liver disease case definitions changed in 2023. These definitions include an easily over-looked group with no traditional etiology (NTE) of liver disease and no steatosis. We analyzed heavy metals and cardiometabolic risk factors (CMRFs) as fibrosis risk factors in the NTE group and in people w ...

10/09/2026

Supporting Files

Title : Heavy Metals Are Liver Fibrosis Risk Factors in People Without Traditional Liver Disease Etiologies. Personal Author(s) : Ma, Ning;Bansal, Meena B.;Chu, Jaime;Woodward, Mark;Branch, Andrea D.; Published Date : September 2025 Pages in Document : 329-342 (24 pdf pages) Source : Journal of Environmental Sciences (China), 2025, v. 155 DOI : https://doi.org/10.1016/j.jes.2024.08.027 Journal Title : Journal of Environmental Sciences (China)
Ma, N., Bansal, M. B., Chu, J., Woodward, M., & Branch, A. D. (2025). Heavy Metals Are Liver Fibrosis Risk Factors in People Without Traditional Liver Disease Etiologies. Journal of Environmental Sciences (China), 155. https://doi.org/10.1016/j.jes.2024.08.027

Ma, Ning, Meena B. Bansal, Jaime Chu, Mark Woodward, and Andrea D. Branch. "Heavy Metals Are Liver Fibrosis Risk Factors in People Without Traditional Liver Disease Etiologies." Journal of Environmental Sciences (China) 155 (2025). https://doi.org/10.1016/j.jes.2024.08.027.

Ma, Ning, et al. "Heavy Metals Are Liver Fibrosis Risk Factors in People Without Traditional Liver Disease Etiologies." Journal of Environmental Sciences (China), vol. 155, 2025. Stacks. https://doi.org/10.1016/j.jes.2024.08.027.
Export RIS Citation Information. TY - Journal Article AU - Ma, Ning AU - Bansal, Meena B. AU - Chu, Jaime AU - Woodward, Mark AU - Branch, Andrea D. AB - Liver fibrosis is an important predictor of mortality. Liver disease case definitions changed in 2023. These definitions include an easily over-looked group with no traditional etiology (NTE) of liver disease and no steatosis. We analyzed heavy metals and cardiometabolic risk factors (CMRFs) as fibrosis risk factors in the NTE group and in people with another newly-defined condition, metabolic dysfunction-associated steatotic liver disease (MASLD). Two National Health and Nutrition Examination Survey (NHANES) datasets were analyzed. In NHANES III (1988-1994), fibrosis and steatosis were defined by Fibrosis-4 scores and ultrasound, respectively, in 12,208 adults. In NHANES 2017-2020, fibrosis and steatosis were defined by transient elastography and the controlled attenuation parameter (CAP) in 5525 adults. Fibrosis risk factors varied over time and by race/ethnicity. In the earlier dataset, NTE-fibrosis had a positive, non-significant, association with high blood levels of lead (Pb). MASLD-fibrosis was associated with Pb (OR = 2.5, 95 % CI, 1.4-4.4) and not with CMRFs in non-Hispanic Blacks but was associated with CMRFs in non-Hispanic Whites. Heavy metal exposures fell between the two time periods. In the later dataset, NTE-fibrosis was associated with Pb (OR = 4.2, 95 % CI, 2.6-6.8) and cadmium (OR = 1.8, 95 % CI, 1.1-3.0) in the total population, but not with most CMRFs. MASLD-fibrosis was strongly-significantly associated with CMRFs in every racial/ethnic group except non-Hispanic Blacks in whom CMRFs were only weakly associated with MASLD-fibrosis. Heavy metal pollution, which disproportionately impacts minoritized populations, decreased over time, but remained strongly associated with liver fibrosis in people lacking traditional etiological factors for liver disease. AB - Author manuscript AN - cdc:261472 C4 - PMC12007413 DO - https://doi.org/10.1016/j.jes.2024.08.027 J2 - Journal of Environmental Sciences (China) KW - Nutrition Surveys KW - Female KW - Environmental Pollutants KW - Risk Factors KW - Male KW - Metals, Heavy KW - Middle Aged KW - Humans KW - Environmental Exposure KW - Adult KW - Liver Cirrhosis KW - Metabolic dysfunction-associated steatotic liver disease (MASLD) KW - Fibrosis KW - Transient elastography KW - Racial disparities KW - Heavy metal KW - Cardiometabolic risk factors (CMRFs) KW - Humans KW - Metals, Heavy KW - Liver Cirrhosis KW - Risk Factors KW - Male KW - Adult KW - Middle Aged KW - Female KW - Nutrition Surveys KW - Environmental Exposure KW - Environmental Pollutants LA - eng PY - 2025 T2 - Journal of Environmental Sciences (China) T2 - Journal of Environmental Sciences (China), 2025, v. 155 TI - Heavy Metals Are Liver Fibrosis Risk Factors in People Without Traditional Liver Disease Etiologies. VL - 155 UR - https://stacks.cdc.gov/view/cdc/261472 ER -
Family-Based Interventions to Prevent Substance Use Among Youth: Community Guide Systematic Economic Review.

Jacob, Verughese ;

Reynolds, Jeffrey A.

July 2025 | American Journal of Preventive Medicine, 2025, v. 69, no. 1

This paper presents a systematic review of evidence from economic evaluations of family-based interventions that was recommended by the Community Preventive Services Task Force to prevent substance use among youth.The search covered studies published from inception of databases through October 2023 and was limited to those based in the U.S. and oth ...

10/09/2026

Supporting Files

Title : Family-Based Interventions to Prevent Substance Use Among Youth: Community Guide Systematic Economic Review. Personal Author(s) : Jacob, Verughese;Reynolds, Jeffrey A.;Chattopadhyay, Sajal K.;Hopkins, David P.;Peterson, Cora;Tenney, Bianca;Nadal, Nelia;Cuellar, Alison E.;Prosser, Lisa A.;Clymer, John M.;Stoddard, Sarah A.; Corporate Authors(s) : and the Community Preventive Services Task Force (CPSTF) Published Date : July 2025 Pages in Document : 107639 (25 pdf pages) Source : American Journal of Preventive Medicine, 2025, v. 69, no. 1 DOI : https://doi.org/10.1016/j.amepre.2025.04.009 Journal Title : American Journal of Preventive Medicine
Jacob, V., Reynolds, J. A., Chattopadhyay, S. K., Hopkins, D. P., Peterson, C., Tenney, B., Nadal, N., Cuellar, A. E., Prosser, L. A., Clymer, J. M., & Stoddard, S. A. (2025). Family-Based Interventions to Prevent Substance Use Among Youth: Community Guide Systematic Economic Review. American Journal of Preventive Medicine, 69(1). https://doi.org/10.1016/j.amepre.2025.04.009

Jacob, Verughese, Jeffrey A. Reynolds, Sajal K. Chattopadhyay, David P. Hopkins, Cora Peterson, Bianca Tenney, and Nelia Nadal, et al.. "Family-Based Interventions to Prevent Substance Use Among Youth: Community Guide Systematic Economic Review." American Journal of Preventive Medicine 69, no. 1 (2025). https://doi.org/10.1016/j.amepre.2025.04.009.

Jacob, Verughese, et al. "Family-Based Interventions to Prevent Substance Use Among Youth: Community Guide Systematic Economic Review." American Journal of Preventive Medicine, vol. 69, no. 1, 2025. Stacks. https://doi.org/10.1016/j.amepre.2025.04.009.
Export RIS Citation Information. TY - Journal Article AU - Jacob, Verughese AU - Reynolds, Jeffrey A. AU - Chattopadhyay, Sajal K. AU - Hopkins, David P. AU - Peterson, Cora AU - Tenney, Bianca AU - Nadal, Nelia AU - Cuellar, Alison E. AU - Prosser, Lisa A. AU - Clymer, John M. AU - Stoddard, Sarah A. A2 - and the Community Preventive Services Task Force (CPSTF) AB - This paper presents a systematic review of evidence from economic evaluations of family-based interventions that was recommended by the Community Preventive Services Task Force to prevent substance use among youth. AB - The search covered studies published from inception of databases through October 2023 and was limited to those based in the U.S. and other high-income countries. This review reports results from peer-reviewed studies and government reports as separate sources of evidence. Analyses were conducted in June 2023 through September 2024. Monetary values are in 2023 U.S. dollars. AB - The search yielded 11 peer-reviewed studies and 2 government reports: 1 from the Washington State Institute for Public Policy that evaluated 14 programs and 1 from the Substance Abuse and Mental Health Administration that evaluated 8 programs. The median intervention cost ranged from $655 to $1,672 per family and $677 to $753 per youth or participant across the 3 sources of evidence. The median benefit to cost ratio were 5.8, 3.9, and 8.9 from peer-reviewed studies, Washington State Institute for Public Policy, and Substance Abuse and Mental Health Administration, respectively, with all 3 estimates indicating that benefits exceed cost. Substance Abuse and Mental Health Administration's report found some interventions to be cost saving and the others to have a median cost per quality-adjusted life years gained of $21,426. AB - The Community Preventive Services Task Force determined that cost-benefit evidence across the 3 sources showed that societal benefits exceeded cost of family-based interventions to prevent substance use among youth. The Task Force determined that there were not enough studies to reach a conclusion about cost-effectiveness. AB - Author manuscript AN - cdc:261471 C4 - PMC12185227 DO - https://doi.org/10.1016/j.amepre.2025.04.009 IS - 1 J2 - American Journal of Preventive Medicine KW - Adolescent KW - Family KW - Humans KW - Cost-Benefit Analysis KW - Substance-Related Disorders KW - Humans KW - Substance-Related Disorders KW - Adolescent KW - Cost-Benefit Analysis KW - Family LA - eng PY - 2025 T2 - American Journal of Preventive Medicine T2 - American Journal of Preventive Medicine, 2025, v. 69, no. 1 TI - Family-Based Interventions to Prevent Substance Use Among Youth: Community Guide Systematic Economic Review. VL - 69 UR - https://stacks.cdc.gov/view/cdc/261471 ER -
Impact of Early Activity and Behavioral Management on Acute Concussion Recovery: a Randomized Controlled Trial.

Thomas, Danny George ;

Erpenbach, Holly

August 2025 | The Journal of Pediatrics, 2025, v. 283

To determine the efficacy of early physical activity and behavioral management for acute concussion in pediatric patients.A multicenter, prospective, 2 × 2 factorial randomized controlled trial was conducted among patients aged 11-24 years who presented within 72 hours of injury. Participants were randomized into 4 groups based on early physical ac ...

10/09/2026

Supporting Files

Title : Impact of Early Activity and Behavioral Management on Acute Concussion Recovery: a Randomized Controlled Trial. Personal Author(s) : Thomas, Danny George;Erpenbach, Holly;Smith, Clair N.;Hickey, Robert W.;Waltzman, Dana;Haarbauer-Krupa, Juiliet;Nelson, Lindsay D.;Patterson, Charity G.;McCrea, Michael;Collins, Michael W.;Kontos, Anthony P.; Published Date : August 2025 Pages in Document : 114596 (20 pdf pages) Source : The Journal of Pediatrics, 2025, v. 283 DOI : https://doi.org/10.1016/j.jpeds.2025.114596 Journal Title : The Journal of Pediatrics
Thomas, D. G., Erpenbach, H., Smith, C. N., Hickey, R. W., Waltzman, D., Haarbauer-Krupa, J., Nelson, L. D., Patterson, C. G., McCrea, M., Collins, M. W., & Kontos, A. P. (2025). Impact of Early Activity and Behavioral Management on Acute Concussion Recovery: a Randomized Controlled Trial. The Journal of Pediatrics, 283. https://doi.org/10.1016/j.jpeds.2025.114596

Thomas, Danny George, Holly Erpenbach, Clair N. Smith, Robert W. Hickey, Dana Waltzman, Juiliet Haarbauer-Krupa, and Lindsay D. Nelson, et al.. "Impact of Early Activity and Behavioral Management on Acute Concussion Recovery: a Randomized Controlled Trial." The Journal of Pediatrics 283 (2025). https://doi.org/10.1016/j.jpeds.2025.114596.

Thomas, Danny George, et al. "Impact of Early Activity and Behavioral Management on Acute Concussion Recovery: a Randomized Controlled Trial." The Journal of Pediatrics, vol. 283, 2025. Stacks. https://doi.org/10.1016/j.jpeds.2025.114596.
Export RIS Citation Information. TY - Journal Article AU - Thomas, Danny George AU - Erpenbach, Holly AU - Smith, Clair N. AU - Hickey, Robert W. AU - Waltzman, Dana AU - Haarbauer-Krupa, Juiliet AU - Nelson, Lindsay D. AU - Patterson, Charity G. AU - McCrea, Michael AU - Collins, Michael W. AU - Kontos, Anthony P. AB - To determine the efficacy of early physical activity and behavioral management for acute concussion in pediatric patients. AB - A multicenter, prospective, 2 × 2 factorial randomized controlled trial was conducted among patients aged 11-24 years who presented within 72 hours of injury. Participants were randomized into 4 groups based on early physical activity (or usual care [UC]) and behavioral management (or none). The early activity (EA) group was encouraged to meet step targets despite symptoms. The primary outcomes were postconcussion symptom severity and quality of life at 14 days postenrollment. AB - A total of 239 participants were randomized, and 210 completed all study procedures. The EA group demonstrated higher daily step counts compared with the UC group. However, no significant differences were observed in postconcussion symptom severity or quality of life at 14 days between groups. The EA group experienced higher daily postconcussion symptom severity during the first 7 days and took longer to recover compared with the UC group. Behavioral management showed no effect on outcomes. AB - Early prescribed physical activity and behavioral management did not improve postconcussion outcomes in the first 2 weeks following injury. Early prescribed activity despite symptoms was associated with delayed symptom resolution. AB - ClinicalTrials.gov NCT03869970. AB - Author manuscript AN - cdc:261470 C4 - PMC13249091 DO - https://doi.org/10.1016/j.jpeds.2025.114596 J2 - The Journal of Pediatrics KW - Behavior Therapy KW - Adolescent KW - Treatment Outcome KW - Female KW - Brain Concussion KW - Prospective Studies KW - Exercise Therapy KW - Young Adult KW - Post-Concussion Syndrome KW - Child KW - Recovery of Function KW - Exercise KW - Quality of Life KW - Male KW - Humans KW - Humans KW - Child KW - Adolescent KW - Male KW - Female KW - Brain Concussion KW - Prospective Studies KW - Quality of Life KW - Young Adult KW - Post-Concussion Syndrome KW - Recovery of Function KW - Behavior Therapy KW - Treatment Outcome KW - Exercise KW - Exercise Therapy LA - eng PY - 2025 T2 - The Journal of Pediatrics T2 - The Journal of Pediatrics, 2025, v. 283 TI - Impact of Early Activity and Behavioral Management on Acute Concussion Recovery: a Randomized Controlled Trial. VL - 283 UR - https://stacks.cdc.gov/view/cdc/261470 ER -
Duration of Illness in Children <18 Years Dying of Influenza in California: 2004-2023.

Zhu, Sophie ;

Quint, Joshua

March 2025 | Pediatrics, 2025, v. 155, no. 3

Annually, thousands of children in the United States are hospitalized and 35-200 die from influenza illness and its complications.1,2 Influenza vaccines are highly effective against life-threatening influenza in children.3 Even a partially effective influenza vaccine can avert symptomatic illness, hospitalization, and death, and reduce illness seve ...

10/09/2026

Supporting Files

Title : Duration of Illness in Children <18 Years Dying of Influenza in California: 2004-2023. Personal Author(s) : Zhu, Sophie;Quint, Joshua;Penton, Christina;Hoover, Cora;Murray, Erin L.; Published Date : March 2025 Pages in Document : 6 pdf pages Source : Pediatrics, 2025, v. 155, no. 3 DOI : https://doi.org/10.1542/peds.2024-069368 Journal Title : Pediatrics
Zhu, S., Quint, J., Penton, C., Hoover, C., & Murray, E. L. (2025). Duration of Illness in Children <18 Years Dying of Influenza in California: 2004-2023. Pediatrics, 155(3). https://doi.org/10.1542/peds.2024-069368

Zhu, Sophie, Joshua Quint, Christina Penton, Cora Hoover, and Erin L. Murray. "Duration of Illness in Children <18 Years Dying of Influenza in California: 2004-2023." Pediatrics 155, no. 3 (2025). https://doi.org/10.1542/peds.2024-069368.

Zhu, Sophie, et al. "Duration of Illness in Children <18 Years Dying of Influenza in California: 2004-2023." Pediatrics, vol. 155, no. 3, 2025. Stacks. https://doi.org/10.1542/peds.2024-069368.
Export RIS Citation Information. TY - Journal Article AU - Zhu, Sophie AU - Quint, Joshua AU - Penton, Christina AU - Hoover, Cora AU - Murray, Erin L. AB - Annually, thousands of children in the United States are hospitalized and 35-200 die from influenza illness and its complications.1,2 Influenza vaccines are highly effective against life-threatening influenza in children.3 Even a partially effective influenza vaccine can avert symptomatic illness, hospitalization, and death, and reduce illness severity if a child is infected. The Advisory Committee on Immunization Practices began recommending annual influenza vaccination of all children aged ≥6 months starting in 2010-2011. Vaccination rates among children <18 years of age vary, ranging from 33.4-62.6% during 2010-2019.4,5 Children who die from influenza often have an underlying condition known to increase the risk of influenza-associated complications and are unvaccinated.6 For children with severe influenza, or illness that can result in hospitalization or death, previous vaccination ≥2 weeks before illness reduces disease severity and risk of death.3 We described patient, vaccination, and influenza illness characteristics by underlying condition status among children aged <18 years who died from influenza during 2004-2023 in California. AB - Author manuscript AN - cdc:261469 C4 - PMC12007722 DO - https://doi.org/10.1542/peds.2024-069368 IS - 3 J2 - Pediatrics KW - Adolescent KW - Child KW - Patient Acuity KW - Immunization KW - Vaccination KW - Advisory Committees KW - Hospitalization KW - Influenza Vaccines KW - Influenza, Human KW - Child KW - Adolescent KW - Advisory Committees KW - Influenza Vaccines KW - Influenza, Human KW - Patient Acuity KW - Hospitalization KW - Immunization KW - Vaccination LA - eng PY - 2025 T2 - Pediatrics T2 - Pediatrics, 2025, v. 155, no. 3 TI - Duration of Illness in Children <18 Years Dying of Influenza in California: 2004-2023. VL - 155 UR - https://stacks.cdc.gov/view/cdc/261469 ER -
Using Deep Learning For Estimation of Time-since-injury in Pediatric Accidental Fractures.

Brink, Farah W. ;

Adler, Brent

May 2025 | Pediatric Radiology, 2025, v. 55, no. 6

Estimating time-since-injury of healing fractures is imprecise, encompassing excessively wide timeframes. Most injured children are evaluated at non-children's hospitals, yet pediatric radiologists can disagree with up to one in six skeletal imaging interpretations from referring community hospitals. There is a need to improve image interpretation ...

10/09/2026

Supporting Files

Title : Using Deep Learning For Estimation of Time-since-injury in Pediatric Accidental Fractures. Personal Author(s) : Brink, Farah W.;Adler, Brent;Bambach, Sven;Lo, Charmaine B.;Rust, Steven;Bartlett, Christopher W.;Bradshaw, Logan;Henry, M. Katherine;Messer, Diana; Published Date : May 2025 Pages in Document : 1257-1269 (21 pdf pages) Source : Pediatric Radiology, 2025, v. 55, no. 6 DOI : https://doi.org/10.1007/s00247-025-06223-4 Journal Title : Pediatric Radiology
Brink, F. W., Adler, B., Bambach, S., Lo, C. B., Rust, S., Bartlett, C. W., Bradshaw, L., Henry, M. K., & Messer, D. (2025). Using Deep Learning For Estimation of Time-since-injury in Pediatric Accidental Fractures. Pediatric Radiology, 55(6). https://doi.org/10.1007/s00247-025-06223-4

Brink, Farah W., Brent Adler, Sven Bambach, Charmaine B. Lo, Steven Rust, Christopher W. Bartlett, Logan Bradshaw, M. Katherine Henry, and Diana Messer. "Using Deep Learning For Estimation of Time-since-injury in Pediatric Accidental Fractures." Pediatric Radiology 55, no. 6 (2025). https://doi.org/10.1007/s00247-025-06223-4.

Brink, Farah W., et al. "Using Deep Learning For Estimation of Time-since-injury in Pediatric Accidental Fractures." Pediatric Radiology, vol. 55, no. 6, 2025. Stacks. https://doi.org/10.1007/s00247-025-06223-4.
Export RIS Citation Information. TY - Journal Article AU - Brink, Farah W. AU - Adler, Brent AU - Bambach, Sven AU - Lo, Charmaine B. AU - Rust, Steven AU - Bartlett, Christopher W. AU - Bradshaw, Logan AU - Henry, M. Katherine AU - Messer, Diana AB - Estimating time-since-injury of healing fractures is imprecise, encompassing excessively wide timeframes. Most injured children are evaluated at non-children's hospitals, yet pediatric radiologists can disagree with up to one in six skeletal imaging interpretations from referring community hospitals. There is a need to improve image interpretation by considering additional methods for fracture dating. AB - To train and validate deep learning models to correctly estimate the age of pediatric accidental long bone fractures. AB - This secondary data analysis used radiographic images of accidental long bone fractures in children <6 years at the time of injury seen at a large Midwestern children's hospital between 2000-2016. We built deep learning models both to classify fracture images into different age groups and to directly estimate fracture age (time-since-injury). We used cross-validation to evaluate model performance across various metrics, including confusion matrices, sensitivity/specificity, and activation maps for age classification, and mean absolute error (MAE) and root mean squared error (RMSE) for age estimation. AB - Our study cohort contained 2,328 radiographs from 399 patients. Overall, our models performed above baselines for fracture age classification and estimation, both when trained/validated across all bones and on specific bone types. The best model was able to estimate fracture age for any long bone with a MAE of 6.2 days and with 68% of estimates falling within 7 days of the correct fracture age. AB - Our study successfully demonstrated that, for radiographic dating of accidental fractures of long bones, deep learning models can estimate time-since-injury with above-baseline accuracy. AB - Author manuscript AN - cdc:261468 C4 - PMC12306432 DO - https://doi.org/10.1007/s00247-025-06223-4 IS - 6 J2 - Pediatric Radiology KW - Clavicle KW - Radiography KW - Deep Learning KW - Image Processing, Computer-Assisted KW - Fractures, Bone KW - Feasibility Studies KW - Software Validation KW - Accidental Injuries KW - Child KW - Infant KW - Humans KW - Radiographic Image Interpretation, Computer-Assisted KW - Child, Preschool KW - Time Factors KW - Artificial intelligence KW - Bone KW - Children KW - Dating KW - Deep learning KW - Fractures KW - Radiographs KW - Child KW - Child, Preschool KW - Humans KW - Infant KW - Clavicle KW - Deep Learning KW - Feasibility Studies KW - Fractures, Bone KW - Image Processing, Computer-Assisted KW - Radiography KW - Software Validation KW - Time Factors KW - Radiographic Image Interpretation, Computer-Assisted KW - Accidental Injuries LA - eng PY - 2025 T2 - Pediatric Radiology T2 - Pediatric Radiology, 2025, v. 55, no. 6 TI - Using Deep Learning For Estimation of Time-since-injury in Pediatric Accidental Fractures. VL - 55 UR - https://stacks.cdc.gov/view/cdc/261468 ER -
Pharmacokinetic and Clinical Associations Between Doravirine-Containing Antiretroviral Therapy and Injectable and Implantable Hormonal Contraceptive Methods Among Women Living With Human Immunodeficiency Virus in South Africa.

Patel, Rena C. ;

Ndlovu, Nkosiphile

July 2025 | The Journal of Infectious Diseases, 2025, v. 232, no. 1

Drug resistance and intolerance of dolutegravir-containing antiretroviral therapy (ART) are rising in low- and middle-income countries, resulting in a potentially increased use of doravirine-containing ART use. There are knowledge gaps regarding doravirine and hormonal contraceptive drug-drug interactions among women living with human immunodeficie ...

10/09/2026

Supporting Files

Title : Pharmacokinetic and Clinical Associations Between Doravirine-Containing Antiretroviral Therapy and Injectable and Implantable Hormonal Contraceptive Methods Among Women Living With Human Immunodeficiency Virus in South Africa. Personal Author(s) : Patel, Rena C.;Ndlovu, Nkosiphile;Maheria, Pooja;Kgoa, Reolebogile;Kew, Lindsay;Kapa, La-Donna;Reddy, Krishnaveni;Govindasami, Merusha;Matswake, Nomasonto;Sigcu, Nompumelelo;Seedat, Mohammed;Shale, Lerato;Yongo, Nashon;Hassan, Shukri A.;Williams, Tommy L.;Erikson, David W.;Scarsi, Kimberly K.;Palanee-Phillips, Thesla; Published Date : July 2025 Pages in Document : 79-89 (21 pdf pages) Source : The Journal of Infectious Diseases, 2025, v. 232, no. 1 DOI : https://doi.org/10.1093/infdis/jiaf196 Journal Title : The Journal of Infectious Diseases
Patel, R. C., Ndlovu, N., Maheria, P., Kgoa, R., Kew, L., Kapa, L. D., Reddy, K., Govindasami, M., Matswake, N., Sigcu, N., Seedat, M., Shale, L., Yongo, N., Hassan, S. A., Williams, T. L., Erikson, D. W., Scarsi, K. K., & Palanee-Phillips, T. (2025). Pharmacokinetic and Clinical Associations Between Doravirine-Containing Antiretroviral Therapy and Injectable and Implantable Hormonal Contraceptive Methods Among Women Living With Human Immunodeficiency Virus in South Africa. The Journal of Infectious Diseases, 232(1). https://doi.org/10.1093/infdis/jiaf196

Patel, Rena C., Nkosiphile Ndlovu, Pooja Maheria, Reolebogile Kgoa, Lindsay Kew, La-Donna Kapa, and Krishnaveni Reddy, et al.. "Pharmacokinetic and Clinical Associations Between Doravirine-Containing Antiretroviral Therapy and Injectable and Implantable Hormonal Contraceptive Methods Among Women Living With Human Immunodeficiency Virus in South Africa." The Journal of Infectious Diseases 232, no. 1 (2025). https://doi.org/10.1093/infdis/jiaf196.

Patel, Rena C., et al. "Pharmacokinetic and Clinical Associations Between Doravirine-Containing Antiretroviral Therapy and Injectable and Implantable Hormonal Contraceptive Methods Among Women Living With Human Immunodeficiency Virus in South Africa." The Journal of Infectious Diseases, vol. 232, no. 1, 2025. Stacks. https://doi.org/10.1093/infdis/jiaf196.
Export RIS Citation Information. TY - Journal Article AU - Patel, Rena C. AU - Ndlovu, Nkosiphile AU - Maheria, Pooja AU - Kgoa, Reolebogile AU - Kew, Lindsay AU - Kapa, La-Donna AU - Reddy, Krishnaveni AU - Govindasami, Merusha AU - Matswake, Nomasonto AU - Sigcu, Nompumelelo AU - Seedat, Mohammed AU - Shale, Lerato AU - Yongo, Nashon AU - Hassan, Shukri A. AU - Williams, Tommy L. AU - Erikson, David W. AU - Scarsi, Kimberly K. AU - Palanee-Phillips, Thesla AB - Drug resistance and intolerance of dolutegravir-containing antiretroviral therapy (ART) are rising in low- and middle-income countries, resulting in a potentially increased use of doravirine-containing ART use. There are knowledge gaps regarding doravirine and hormonal contraceptive drug-drug interactions among women living with human immunodeficiency virus (HIV). AB - We conducted a 5-parallel-group, prospective pharmacokinetic study among women living with HIV aged 18-45 years in Johannesburg, South Africa, between November 2021 and February 2024. We included a sixth, historical comparator group from a Kenyan study. After a ≥6-week lead-in period with doravirine-containing ART, participants initiated injectable medroxyprogesterone acetate (MPA), implantable etonogestrel (ENG), or nonhormonal intrauterine device contraception and were observed every 2-4 weeks for an additional 12 or 24 weeks. We analyzed serum MPA and ENG and plasma doravirine or dolutegravir concentrations per visit, using validated liquid chromatography-mass spectrometry assays. We assessed log-transformed concentrations of each drug with geometric mean ratios (90% confidence intervals) and a multivariate model adjusted for age and body mass index. We described safety, tolerability, and effectiveness (HIV RNA <40 copies/mL) of doravirine-containing ART. AB - A total of 128 participants are included in this analysis. There were no significant reductions in the MPA, ENG, or doravirine concentrations. A total of 8 (3%) adverse events grade ≥2 were considered attributable to doravirine-containing ART and 22 (8%) to the contraceptive method. ART satisfaction was 100%, and viral suppression at study exit ranged from 86% to 96%. AB - We found no detrimental bidirectional drug-drug interactions and few adverse events between doravirine and hormonal contraceptives. AB - Author manuscript AN - cdc:261467 C4 - PMC12447852 DO - https://doi.org/10.1093/infdis/jiaf196 IS - 1 J2 - The Journal of Infectious Diseases KW - Pyridones KW - Adolescent KW - Female KW - Anti-HIV Agents KW - Prospective Studies KW - Young Adult KW - Drug Interactions KW - Heterocyclic Compounds, 3-Ring KW - Oxazines KW - Desogestrel KW - Triazoles KW - Piperazines KW - Dolutegravir KW - Humans KW - Middle Aged KW - Adult KW - Anti-Retroviral Agents KW - Contraceptive Agents, Hormonal KW - HIV Infections KW - drug-drug interactions KW - pharmacokinetic study KW - hormonal contraception KW - doravirine-containing ART KW - South Africa KW - Humans KW - Female KW - Adult KW - Pyridones KW - HIV Infections KW - Prospective Studies KW - Middle Aged KW - Young Adult KW - Triazoles KW - Adolescent KW - Drug Interactions KW - Piperazines KW - Oxazines KW - Heterocyclic Compounds, 3-Ring KW - Desogestrel KW - Anti-HIV Agents KW - Anti-Retroviral Agents KW - Contraceptive Agents, Hormonal KW - Dolutegravir LA - eng PY - 2025 T2 - The Journal of Infectious Diseases T2 - The Journal of Infectious Diseases, 2025, v. 232, no. 1 TI - Pharmacokinetic and Clinical Associations Between Doravirine-Containing Antiretroviral Therapy and Injectable and Implantable Hormonal Contraceptive Methods Among Women Living With Human Immunodeficiency Virus in South Africa. VL - 232 UR - https://stacks.cdc.gov/view/cdc/261467 ER -
Peripheral Neuropathy Incidence in Children, and Adolescents and Young Adults With Cancer and Medicaid Insurance in California.

Abrahão, Renata ;

Cooley, Julianne J.P.

February 2026 | JCO Oncology Practice, 2026, v. 22, no. 2

Chemotherapy-induced peripheral neuropathy is a potentially debilitating adverse effect of cancer therapy that can lead to delay, reduction, or discontinuation of cancer treatment. Population-based data on peripheral neuropathy incidence among young cancer survivors are lacking.Using a linkage between Medicaid, the California Cancer Registry, and h ...

10/09/2026

Supporting Files

Title : Peripheral Neuropathy Incidence in Children, and Adolescents and Young Adults With Cancer and Medicaid Insurance in California. Personal Author(s) : Abrahão, Renata;Cooley, Julianne J.P.;Kahn, Justine M.;Brunson, Ann;Alvarez, Elysia M.;Mahajan, Anjlee;Wun, Ted;Verma, Rashmi;Ruddy, Kathryn J.;Keegan, Theresa H.M.; Published Date : February 2026 Pages in Document : 225-234 (19 pdf pages) Source : JCO Oncology Practice, 2026, v. 22, no. 2 DOI : https://doi.org/10.1200/OP-24-00748 Journal Title : JCO Oncology Practice
Abrahão, R., Cooley, J. J., Kahn, J. M., Brunson, A., Alvarez, E. M., Mahajan, A., Wun, T., Verma, R., Ruddy, K. J., & Keegan, T. H. (2026). Peripheral Neuropathy Incidence in Children, and Adolescents and Young Adults With Cancer and Medicaid Insurance in California. JCO Oncology Practice, 22(2). https://doi.org/10.1200/OP-24-00748

Abrahão, Renata, Julianne J.P. Cooley, Justine M. Kahn, Ann Brunson, Elysia M. Alvarez, Anjlee Mahajan, Ted Wun, Rashmi Verma, Kathryn J. Ruddy, and Theresa H.M. Keegan. "Peripheral Neuropathy Incidence in Children, and Adolescents and Young Adults With Cancer and Medicaid Insurance in California." JCO Oncology Practice 22, no. 2 (2026). https://doi.org/10.1200/OP-24-00748.

Abrahão, Renata, et al. "Peripheral Neuropathy Incidence in Children, and Adolescents and Young Adults With Cancer and Medicaid Insurance in California." JCO Oncology Practice, vol. 22, no. 2, 2026. Stacks. https://doi.org/10.1200/OP-24-00748.
Export RIS Citation Information. TY - Journal Article AU - Abrahão, Renata AU - Cooley, Julianne J.P. AU - Kahn, Justine M. AU - Brunson, Ann AU - Alvarez, Elysia M. AU - Mahajan, Anjlee AU - Wun, Ted AU - Verma, Rashmi AU - Ruddy, Kathryn J. AU - Keegan, Theresa H.M. AB - Chemotherapy-induced peripheral neuropathy is a potentially debilitating adverse effect of cancer therapy that can lead to delay, reduction, or discontinuation of cancer treatment. Population-based data on peripheral neuropathy incidence among young cancer survivors are lacking. AB - Using a linkage between Medicaid, the California Cancer Registry, and hospitalization and emergency department data, we identified 6,028 adolescents and young adults (15-39 years) with Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), breast cancer, colorectal cancer, or testicular cancer and 418 children (<15 years) with HL or NHL during 2005-2017. We determined the cumulative incidence of peripheral neuropathy and its association with neurotoxic chemotherapy identified from Medicaid claims, using multivariable Cox proportional hazards regression models. AB - Of 6,446 patients, 1,007 were diagnosed with peripheral neuropathy. Across each cancer type, incidence was higher among patients receiving neurotoxic drugs. For example, compared with non-neurotoxic agents, 5-year cumulative incidence was higher with oxaliplatin for colorectal cancer (24.0% AB - 6.2%) and paclitaxel for breast cancer (22.6% AB - 5.1%). In multivariable analysis, the agents most strongly associated with peripheral neuropathy were brentuximab (±other neurotoxic drugs) for HL (hazard ratio [HR], 9.53 [95% CI, 5.95 to 15.26]); brentuximab (±vinca alkaloids; HR, 7.00 [95% CI, 4.13 to 11.87]) for NHL, paclitaxel for breast cancer (HR, 4.03 [95% CI, 3.05 to 5.31]); oxaliplatin for colorectal cancer (HR, 3.46 [95% CI, 2.23 to 5.36]); and cisplatin and etoposide for testicular cancer (HR, 2.06 [95% CI, 1.37 to 3.11]). AB - The high incidence of peripheral neuropathy highlights the need for frequent monitoring, new supportive care approaches, and development of novel therapeutic agents to minimize toxicity while maintaining treatment efficacy. AB - Author manuscript AN - cdc:261466 C4 - PMC12283250 DO - https://doi.org/10.1200/OP-24-00748 IS - 2 J2 - JCO Oncology Practice KW - Adolescent KW - Child KW - Female KW - Neoplasms KW - Antineoplastic Agents KW - Incidence KW - Male KW - Humans KW - Young Adult KW - Medicaid KW - Peripheral Nervous System Diseases KW - Adult KW - Peripheral neuropathy KW - chemotherapy KW - cancer KW - children KW - adolescents and young adults KW - Medicaid KW - Humans KW - Adolescent KW - Peripheral Nervous System Diseases KW - Male KW - Female KW - Incidence KW - Medicaid KW - Young Adult KW - Neoplasms KW - Adult KW - Child KW - Antineoplastic Agents LA - eng PY - 2026 T2 - JCO Oncology Practice T2 - JCO Oncology Practice, 2026, v. 22, no. 2 TI - Peripheral Neuropathy Incidence in Children, and Adolescents and Young Adults With Cancer and Medicaid Insurance in California. VL - 22 UR - https://stacks.cdc.gov/view/cdc/261466 ER -
Effects of Different Sorting Table Heights on Low Back and Shoulders Biomechanical Loads During Dungeness Crab Sorting.

Salehi, Mina ;

Choi, Seobin

October 2025 | Applied Ergonomics, 2025, v. 128

West Coast Dungeness crab fishers suffer a high prevalence of musculoskeletal injuries, especially low back pain. Substantial trunk flexion and associated low back loads during crab sorting tasks have been attributed to awkward sorting table heights. This study examined how varying table heights affect biomechanical loads on the low back and should ...

10/09/2026

Supporting Files

Title : Effects of Different Sorting Table Heights on Low Back and Shoulders Biomechanical Loads During Dungeness Crab Sorting. Personal Author(s) : Salehi, Mina;Choi, Seobin;Kia, Kiana;Chan, Allen;Kincl, Laurel;Kim, Jeong Ho; Published Date : October 2025 Pages in Document : 104537 (23 pdf pages) Source : Applied Ergonomics, 2025, v. 128 DOI : https://doi.org/10.1016/j.apergo.2025.104537 Journal Title : Applied Ergonomics
Salehi, M., Choi, S., Kia, K., Chan, A., Kincl, L., & Kim, J. H. (2025). Effects of Different Sorting Table Heights on Low Back and Shoulders Biomechanical Loads During Dungeness Crab Sorting. Applied Ergonomics, 128. https://doi.org/10.1016/j.apergo.2025.104537

Salehi, Mina, Seobin Choi, Kiana Kia, Allen Chan, Laurel Kincl, and Jeong Ho Kim. "Effects of Different Sorting Table Heights on Low Back and Shoulders Biomechanical Loads During Dungeness Crab Sorting." Applied Ergonomics 128 (2025). https://doi.org/10.1016/j.apergo.2025.104537.

Salehi, Mina, et al. "Effects of Different Sorting Table Heights on Low Back and Shoulders Biomechanical Loads During Dungeness Crab Sorting." Applied Ergonomics, vol. 128, 2025. Stacks. https://doi.org/10.1016/j.apergo.2025.104537.
Export RIS Citation Information. TY - Journal Article AU - Salehi, Mina AU - Choi, Seobin AU - Kia, Kiana AU - Chan, Allen AU - Kincl, Laurel AU - Kim, Jeong Ho AB - West Coast Dungeness crab fishers suffer a high prevalence of musculoskeletal injuries, especially low back pain. Substantial trunk flexion and associated low back loads during crab sorting tasks have been attributed to awkward sorting table heights. This study examined how varying table heights affect biomechanical loads on the low back and shoulders. Twenty-five participants performed crab sorting tasks at three table heights while trunk and shoulder joint angles, moments, muscle activity, perceived exertion, and discomfort were measured. Increasing table height reduced trunk flexion and lumbosacral (L5/S1) joint moments but increased shoulder flexion moments and upper trapezius muscle activity. Table height did not affect perceived exertion or discomfort. These findings indicate that increasing sorting table height can reduce biomechanical load on the low back but results in increased shoulder strain. This trade-off underscores the importance of adopting ergonomic designs balancing low back and shoulder biomechanics to determine appropriate sorting table height. AB - Author manuscript AN - cdc:261465 C4 - PMC12489940 DO - https://doi.org/10.1016/j.apergo.2025.104537 J2 - Applied Ergonomics KW - Weight-Bearing KW - Female KW - Animals KW - Physical Exertion KW - Electromyography KW - Torso KW - Young Adult KW - Low Back Pain KW - Shoulder KW - Ergonomics KW - Lumbosacral Region KW - Male KW - Humans KW - Biomechanical Phenomena KW - Superficial Back Muscles KW - Brachyura KW - Shoulder Joint KW - Adult KW - Commercial fishing KW - Musculoskeletal disorders KW - Electromyography KW - 3-D motion capture KW - Humans KW - Biomechanical Phenomena KW - Male KW - Adult KW - Female KW - Low Back Pain KW - Young Adult KW - Weight-Bearing KW - Lumbosacral Region KW - Shoulder KW - Ergonomics KW - Superficial Back Muscles KW - Electromyography KW - Brachyura KW - Animals KW - Shoulder Joint KW - Physical Exertion KW - Torso LA - eng PY - 2025 T2 - Applied Ergonomics T2 - Applied Ergonomics, 2025, v. 128 TI - Effects of Different Sorting Table Heights on Low Back and Shoulders Biomechanical Loads During Dungeness Crab Sorting. VL - 128 UR - https://stacks.cdc.gov/view/cdc/261465 ER -
TEMI: Tissue-expansion Mass-spectrometry Imaging.

Zhang, Hua ;

Ding, Lang

May 24, 2025 | Nature Methods, 2025, v. 22, no. 5

The spatial distribution of diverse biomolecules in multicellular organisms is essential for their physiological functions. High-throughput in situ mapping of biomolecules is crucial for both basic and medical research, and requires high scanning speed, spatial resolution, and chemical sensitivity. Here we developed a tissue-expansion method compat ...

10/09/2026

Supporting Files

Title : TEMI: Tissue-expansion Mass-spectrometry Imaging. Personal Author(s) : Zhang, Hua;Ding, Lang;Hu, Amy;Shi, Xudong;Huang, Penghsuan;Lu, Haiyan;Tillberg, Paul W.;Wang, Meng C.;Li, Lingjun; Published Date : May 24, 2025 Pages in Document : 1051-1058 (25 pdf pages) Source : Nature Methods, 2025, v. 22, no. 5 DOI : https://doi.org/10.1038/s41592-025-02664-9 Journal Title : Nature Methods
Zhang, H., Ding, L., Hu, A., Shi, X., Huang, P., Lu, H., Tillberg, P. W., Wang, M. C., & Li, L. (2025). TEMI: Tissue-expansion Mass-spectrometry Imaging. Nature Methods, 22(5). https://doi.org/10.1038/s41592-025-02664-9

Zhang, Hua, Lang Ding, Amy Hu, Xudong Shi, Penghsuan Huang, Haiyan Lu, Paul W. Tillberg, Meng C. Wang, and Lingjun Li. "TEMI: Tissue-expansion Mass-spectrometry Imaging." Nature Methods 22, no. 5 (2025). https://doi.org/10.1038/s41592-025-02664-9.

Zhang, Hua, et al. "TEMI: Tissue-expansion Mass-spectrometry Imaging." Nature Methods, vol. 22, no. 5, 2025. Stacks. https://doi.org/10.1038/s41592-025-02664-9.
Export RIS Citation Information. TY - Journal Article AU - Zhang, Hua AU - Ding, Lang AU - Hu, Amy AU - Shi, Xudong AU - Huang, Penghsuan AU - Lu, Haiyan AU - Tillberg, Paul W. AU - Wang, Meng C. AU - Li, Lingjun AB - The spatial distribution of diverse biomolecules in multicellular organisms is essential for their physiological functions. High-throughput in situ mapping of biomolecules is crucial for both basic and medical research, and requires high scanning speed, spatial resolution, and chemical sensitivity. Here we developed a tissue-expansion method compatible with matrix-assisted laser desorption/ionization mass-spectrometry imaging (TEMI). TEMI reaches single-cell spatial resolution without sacrificing voxel throughput and enables the profiling of hundreds of biomolecules, including lipids, metabolites, peptides (proteins), and N-glycans. Using TEMI, we mapped the spatial distribution of biomolecules across various mammalian tissues and uncovered metabolic heterogeneity in tumors. TEMI can be easily adapted and broadly applied in biological and medical research, to advance spatial multi-omics profiling. AB - Author manuscript AN - cdc:261464 C4 - PMC12074994 DO - https://doi.org/10.1038/s41592-025-02664-9 IS - 5 J2 - Nature Methods KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization KW - Single-Cell Analysis KW - Animals KW - Humans KW - Mice KW - Metabolomics KW - Mass spectrometry KW - Molecular imaging KW - Lipidomics KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization KW - Animals KW - Mice KW - Humans KW - Single-Cell Analysis LA - eng PY - 2025 T2 - Nature Methods T2 - Nature Methods, 2025, v. 22, no. 5 TI - TEMI: Tissue-expansion Mass-spectrometry Imaging. VL - 22 UR - https://stacks.cdc.gov/view/cdc/261464 ER -
Impact of COVID-19 School Learning Model on STI Testing, Diagnosis Rates, and Related Behaviors.

Katz, David A. ;

Copen, Casey E.

September 2025 | Sexually Transmitted Diseases, 2025, v. 52, no. 9

The COVID-19 pandemic and associated changes in school learning model reshaped students' lives and may have impacted sexual behaviors and healthcare access.We used a difference-in-differences (DID) approach to compare changes in sexual behaviors, human immunodeficiency virus (HIV)/sexually transmitted infection (STI) testing, and STI diagnosis rate ...

10/09/2026

Supporting Files

Title : Impact of COVID-19 School Learning Model on STI Testing, Diagnosis Rates, and Related Behaviors. Personal Author(s) : Katz, David A.;Copen, Casey E.;Pampati, Sanjana;Fodeman, Ari;Haderxhanaj, Laura T.;Pepin, Dawn;Hamilton, Deven T.; Published Date : September 2025 Pages in Document : 569-576 (17 pdf pages) Source : Sexually Transmitted Diseases, 2025, v. 52, no. 9 DOI : https://doi.org/10.1097/OLQ.0000000000002169 Journal Title : Sexually Transmitted Diseases
Katz, D. A., Copen, C. E., Pampati, S., Fodeman, A., Haderxhanaj, L. T., Pepin, D., & Hamilton, D. T. (2025). Impact of COVID-19 School Learning Model on STI Testing, Diagnosis Rates, and Related Behaviors. Sexually Transmitted Diseases, 52(9). https://doi.org/10.1097/OLQ.0000000000002169

Katz, David A., Casey E. Copen, Sanjana Pampati, Ari Fodeman, Laura T. Haderxhanaj, Dawn Pepin, and Deven T. Hamilton. "Impact of COVID-19 School Learning Model on STI Testing, Diagnosis Rates, and Related Behaviors." Sexually Transmitted Diseases 52, no. 9 (2025). https://doi.org/10.1097/OLQ.0000000000002169.

Katz, David A., et al. "Impact of COVID-19 School Learning Model on STI Testing, Diagnosis Rates, and Related Behaviors." Sexually Transmitted Diseases, vol. 52, no. 9, 2025. Stacks. https://doi.org/10.1097/OLQ.0000000000002169.
Export RIS Citation Information. TY - Journal Article AU - Katz, David A. AU - Copen, Casey E. AU - Pampati, Sanjana AU - Fodeman, Ari AU - Haderxhanaj, Laura T. AU - Pepin, Dawn AU - Hamilton, Deven T. AB - The COVID-19 pandemic and associated changes in school learning model reshaped students' lives and may have impacted sexual behaviors and healthcare access. AB - We used a difference-in-differences (DID) approach to compare changes in sexual behaviors, human immunodeficiency virus (HIV)/sexually transmitted infection (STI) testing, and STI diagnosis rates from 2019-2021 between jurisdictions where high school was primarily virtual versus in-person for the 2020-2021 school year. We used behavioral data from local jurisdictions administering Youth Risk Behavior Survey and reported chlamydia and gonorrhea diagnosis rates for 15- to 19-year-olds in corresponding counties from AtlasPlus. Learning model was defined using the COVID-19 School Data Hub, school/governmental policies, news, or other documentation. We used survey-weighted logistic regression for behavioral outcomes and Poisson regression for diagnosis rates. The DID estimates were parameterized as the interaction between year and learning model. AB - Twenty-four local jurisdictions (16 virtual, 8 in-person) were included. Compared to in-person learning, virtual learning was significantly associated with a relative increase in condom use from 2019 to 2021 (DID odds ratio [DID-OR], 1.42; 95% confidence interval [95% CI], 1.12-1.79) and relative decreases in STI testing (DID-OR, 0.75; 95% CI, 0.59-0.96), chlamydia diagnoses (DID incidence rate ratio [DID-IRR], 0.86; 95% CI, 0.84-0.88), and gonorrhea diagnoses (DID-IRR, 0.83; 95% CI, 0.79-0.87). Learning model was not significantly associated with changes in sexual intercourse ever or in past 3 months, multiple sex partners in past 3 months, alcohol/drug use before last sex, or ever HIV testing. AB - Efforts are needed to maintain access to sexual health services during and after public health emergencies involving schools and increase STI testing access for students, especially those who attended school virtually. AB - Author manuscript AN - cdc:261463 C4 - PMC12768133 DO - https://doi.org/10.1097/OLQ.0000000000002169 IS - 9 J2 - Sexually Transmitted Diseases KW - Adolescent KW - Schools KW - Female KW - Gonorrhea KW - Mass Screening KW - Chlamydia Infections KW - Sexually Transmitted Diseases KW - SARS-CoV-2 KW - COVID-19 KW - Young Adult KW - Condoms KW - Students KW - Male KW - Humans KW - Sexual Behavior KW - HIV Infections KW - Humans KW - COVID-19 KW - Adolescent KW - Sexually Transmitted Diseases KW - Sexual Behavior KW - Male KW - Female KW - Young Adult KW - Schools KW - SARS-CoV-2 KW - Students KW - Gonorrhea KW - Condoms KW - Chlamydia Infections KW - HIV Infections KW - Mass Screening LA - eng PY - 2025 T2 - Sexually Transmitted Diseases T2 - Sexually Transmitted Diseases, 2025, v. 52, no. 9 TI - Impact of COVID-19 School Learning Model on STI Testing, Diagnosis Rates, and Related Behaviors. VL - 52 UR - https://stacks.cdc.gov/view/cdc/261463 ER -

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