Peripheral Neuropathy Incidence in Children, and Adolescents and Young Adults With Cancer and Medicaid Insurance in California.

Details

• Alternative Title:
  JCO Oncology Practice, 2026, v. 22, no. 2: Peripheral Neuropathy Incidence in Children, and Adolescents and Young Adults With Cancer and Medicaid Insurance in California.
• Journal Article:
  JCO Oncology Practice
• Personal Author:
  Abrahão, Renata ; Cooley, Julianne J.P. ; Kahn, Justine M. ; Brunson, Ann ; Alvarez, Elysia M. ; Mahajan, Anjlee ; Wun, Ted ; Verma, Rashmi ; Ruddy, Kathryn J. ; Keegan, Theresa H.M.
• Description:
  Chemotherapy-induced peripheral neuropathy is a potentially debilitating adverse effect of cancer therapy that can lead to delay, reduction, or discontinuation of cancer treatment. Population-based data on peripheral neuropathy incidence among young cancer survivors are lacking.
  
  Using a linkage between Medicaid, the California Cancer Registry, and hospitalization and emergency department data, we identified 6,028 adolescents and young adults (15-39 years) with Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), breast cancer, colorectal cancer, or testicular cancer and 418 children (<15 years) with HL or NHL during 2005-2017. We determined the cumulative incidence of peripheral neuropathy and its association with neurotoxic chemotherapy identified from Medicaid claims, using multivariable Cox proportional hazards regression models.
  
  Of 6,446 patients, 1,007 were diagnosed with peripheral neuropathy. Across each cancer type, incidence was higher among patients receiving neurotoxic drugs. For example, compared with non-neurotoxic agents, 5-year cumulative incidence was higher with oxaliplatin for colorectal cancer (24.0%
  
  6.2%) and paclitaxel for breast cancer (22.6%
  
  5.1%). In multivariable analysis, the agents most strongly associated with peripheral neuropathy were brentuximab (±other neurotoxic drugs) for HL (hazard ratio HR, 9.53 95% CI, 5.95 to 15.26); brentuximab (±vinca alkaloids; HR, 7.00 95% CI, 4.13 to 11.87) for NHL, paclitaxel for breast cancer (HR, 4.03 95% CI, 3.05 to 5.31); oxaliplatin for colorectal cancer (HR, 3.46 95% CI, 2.23 to 5.36); and cisplatin and etoposide for testicular cancer (HR, 2.06 95% CI, 1.37 to 3.11).
  
  The high incidence of peripheral neuropathy highlights the need for frequent monitoring, new supportive care approaches, and development of novel therapeutic agents to minimize toxicity while maintaining treatment efficacy.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Adolescent
  • Peripheral Nervous System Diseases
  • Male
  • Female
  • Incidence
  • Medicaid
  • Young Adult
  • Neoplasms
  • Adult
  More +
• Keywords:
  • Peripheral neuropathy
  • chemotherapy
  • cancer
  • children
  • adolescents and young adults
  • Medicaid
• Source:
  JCO Oncology Practice, 2026, v. 22, no. 2
• DOI:
  https://doi.org/10.1200/OP-24-00748
• ISSN:
  2688-1527 ; 2688-1535
• Pubmed ID:
  40262078
• Pubmed Central ID:
  PMC12283250
• Document Type:
  Text
• Funding:
  HHSN261201800009C/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; P01 CA233432/CA/NCI NIH HHSUnited States/ ; HHSN261201800032I/CA/NCI NIH HHSUnited States/ ; HHSN261201800015C/CA/NCI NIH HHSUnited States/ ; HHSN261201800009I/CA/NCI NIH HHSUnited States/ ; HHSN261201800032C/CA/NCI NIH HHSUnited States/ ; P30 CA093373/CA/NCI NIH HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  California ; United States
• Pages in Document:
  225-234 (19 pdf pages)
• Volume:
  22
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/261466/cdc_261466_DS1.pdf
• File Type:
  [PDF - 448.39 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:faaf59a875eaf243154076923cec833755f7fb055f0ff1bdc2bd46e4658e5ad89de1ec7591ea10d5d492ac21676131a1509a92edc372c79bb7ffac8842c43e1a