Mixture Analysis of Associations Between Environmental and Workplace Toxins and Liver Damage and Telomere Length, Stratified by Race/ethnicity.

Details

• Alternative Title:
  Journal of Environmental Sciences (China), 2025, v. 155: Mixture Analysis of Associations Between Environmental and Workplace Toxins and Liver Damage and Telomere Length, Stratified by Race/ethnicity.
• Journal Article:
  Journal of Environmental Sciences (China)
• Personal Author:
  Ma, Ning ; Yip, Rowena ; Woodward, Mark ; Lewis, Sara ; Crane, Michael ; Jirapatnakul, Artit ; Aloman, Costica ; Bansal, Meena B. ; Dieterich, Douglas ; Gros, Louis ; Valvi, Damaskini ; Colicino, Elena ; Yankelevitz, David ; Henschke, Claudia ; Branch, Andrea D.
• Description:
  This study aimed to identify the worst "bad actors" in mixtures of pollutants contributing to liver damage and shorter telomeres in the U.S. population, using weighted quantile sum (WQS) modeling with stratification by race/ethnicity. We conducted a comprehensive cross-sectional analysis of mixtures of pollutants in National Health and Nutrition Examination Survey datasets: (1) 33,979 adults with blood levels of cadmium (Cd), lead (Pb), and mercury, including subsets with measurements of per-/polyfluoroalkyl substances (PFAS), and polychlorinated biphenyls (PCBs)/polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs); and (2) 7360 adults with measurements of telomeres, Cd, and Pb. Multivariable-adjusted WQS regression examined associations between WQS mixture indices and liver injury (alanine aminotransferase (ALT)-elevation), advanced liver-fibrosis (LF), and telomere length. WQS
  
  indices were associated with advanced-LF in all racial/ethnic groups. The top contributor was Cd in the total population and in non-Hispanic Whites (NHW), while Pb was the top contributor in non-Hispanic Blacks (NHB). The WQS
  
  index was associated with ALT-elevation, with PCB126, Cd and Pb as main contributors; the odds ratio (OR) per decile was 1.50 (95 % CI, 1.26-1.78), while the OR per decile of the WQS
  
  index was 1.03 (95 % CI, 0.98-1.05), not significant. WQS
  
  indices were associated with shorter telomeres. Cd was main contributor associated with advanced-LF in NHW, while Pb was the major bad actor in NHB, suggesting that NHB may be especially susceptible to Pb toxicity. Metals were associated with shorter telomeres. Metal and PCB/PCDD/F mixtures were associated with ALT-elevation. Heavy metals and organic chemicals may contribute to liver-related morbidity and healthcare disparities.
• Content Notes:
  Author manuscript
• Subjects:
  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Cadmium
  • Cross-Sectional Studies
  • Environmental Exposure
  • Environmental Pollutants
  • Ethnicity
  More +
• Keywords:
  • Lead (Pb)
  • Cadmium (Cd)
  • Polychlorinated biphenyls
  • Mixture analysis
  • Liver injury
  • Racial disparities
• Source:
  Journal of Environmental Sciences (China), 2025, v. 155
• DOI:
  https://doi.org/10.1016/j.jes.2024.08.020
• ISSN:
  1001-0742
• Pubmed ID:
  40246468
• Pubmed Central ID:
  PMC12006726
• Document Type:
  Text
• Funding:
  U01 OH012263/OH/NIOSH CDC HHSUnited States/ ; U01 OH011489/OH/NIOSH CDC HHSUnited States/ ; U01 CA288425/CA/NCI NIH HHSUnited States/ ; P30 ES023515/ES/NIEHS NIH HHSUnited States/ ; U01 OH012622/OH/NIOSH CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  316-328 (22 pdf pages)
• Volume:
  155
• Download URL:
  https://stacks.cdc.gov/view/cdc/261473/cdc_261473_DS1.pdf
• File Type:
  [PDF - 1.90 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:4bce40edcc34c22a1f866f998646ec566249dc579a23dde418bf3af623f617e9e017a3a1febe7f533f7ae9653c8ecdba2bbe0ac7bcfcb231a5151ec39a9598a3