Maternal Area of Residence and Outcomes For Mother-Infant Dyads With Perinatal Opioid Exposure.

Details

• Alternative Title:
  American Journal of Perinatology, 2026, v. 43, no. 3: Maternal Area of Residence and Outcomes For Mother-Infant Dyads With Perinatal Opioid Exposure.
• Journal Article:
  American Journal of Perinatology
• Personal Author:
  Pahl, Adrienne ; Hu, Zhuopei ; Young, Leslie W. ; Ramsey, Kara Wong ; Whalen, Bonny L. ; Akshatha, Akshatha ; Benninger, Kristen L. ; Fung, Camille M. ; Howell, Meghan P. ; Markee, Sofia ; Das, Abhik ; Crawford, Margaret M. ; Trochinski, Lillian ; Greenberg, Rachel G. ; Smith, Brian ; Ounpraseuth, Songthip T. ; Merhar, Stephanie L. ; Devlin, Lori A. ; MacMillan, Kathryn Dee L.
• Description:
  Determine the relationship between maternal Social Deprivation Index (SDI), a composite measure of area-level deprivation, and maternal characteristics and infant outcomes for mother-infant dyads with perinatal opioid exposure.Post hoc secondary analysis of 1,298 mother-infant dyads in the ESC-NOW study, a multicenter, stepped-wedge cluster-randomized controlled trial (2020-2022) conducted at 26 U.S. study hospitals. The 2016 American Community Survey was used to develop SDI scores based on the maternal zip code of residence at the time of delivery. Outcomes evaluated included receipt of pharmacologic treatment for neonatal opioid withdrawal syndrome (PT), receipt of breastmilk during hospital stay, direct breastfeeding at discharge, discharge disposition, and length of stay for infants who received PT (length of hospital stay, LOS).The median SDI score was 62 on a scale of 100. The high SDI group, with a score above the SDI median and more social deprivation, was less likely to receive adequate prenatal care or medication for opioid use disorder and more likely to be Black and/or Hispanic. The mean proportion of infants in the high SDI group was 6.2% points (relative risk RR: 0.89; 95% confidence interval CI: 0.80, 0.98) less likely to receive breastmilk during the newborn hospitalization and 7.3% points (RR: 0.91; 95% CI: 0.87, 0.96) less likely to be discharged home with a biological parent. There was no difference between the high and low SDI groups in receipt of PT, direct breastfeeding at discharge, or LOS.Mothers from high SDI communities with opioid exposure during pregnancy were less likely to receive the established standard of care and more likely to be Black and/or Hispanic. Infants born to these mothers were less likely to receive breastmilk and/or to be discharged home with a biological parent. Targeting interventions to mitigate the impact of social deprivation in high SDI communities may improve outcomes for opioid-exposed infants and their mothers. · Living in an area with high social deprivation was associated with differences in health outcomes.. · Mothers were more likely to be Black and/or Hispanic.. · Mothers were less likely to receive the standard of care during pregnancy.. · Infants were less likely to receive breastmilk and/or be discharged home with a biological parent.. · Interventions designed to address community social deprivation may improve outcomes..
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Female
  • Pregnancy
  • Neonatal Abstinence Syndrome
  • Infant, Newborn
  • Adult
  • Opioid-Related Disorders
  • Breast Feeding
  • Length of Stay
  • Residence Characteristics
  More +
• Keywords:
  • Social Deprivation
  • Neonatal Abstinence Syndrome
  • Opioid
  • Perinatal Care
  • Neonatal Opioid Withdrawal Syndrome
  • Residence Characteristics
  • Sociodemographic Factors
• Source:
  American Journal of Perinatology, 2026, v. 43, no. 3
• DOI:
  https://doi.org/10.1055/a-2622-3839
• ISSN:
  0735-1631 ; 1098-8785
• Pubmed ID:
  40436395
• Pubmed Central ID:
  PMC12246980
• Document Type:
  Text
• Funding:
  3U2COD023375-06S1/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; 3U2COD023375-07S2/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; U2C OD023375/OD/NIH HHSUnited States/ ; UG1 HD087226/HD/NICHD NIH HHSUnited States/ ; UG1 OD024943/OD/NIH HHSUnited States/ ; UG1 OD024958/OD/NIH HHSUnited States/ ; UG1 HD68278/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; UG1 OD024942/OD/NIH HHSUnited States/ ; UG1 HD87226/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; UG1 HD112097/HD/NICHD NIH HHSUnited States/ ; UG1 OD024959/CD/ODCDC CDC HHSUnited States/ ; 2UG10D024947-03,3U2COD023375-06S1,3U2COD023375-07S2,U10 HD053089,U24 OD024957,UG1 HD27853,UG1 HD36790,UG1 HD68278,UG1 HD87226,UG1 OD024954,UG1 OD024955,UG1 OD024959,UL1 TR105,UL1 TR77/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; UG1 HD053109/HD/NICHD NIH HHSUnited States/ ; UG1 HD068263/HD/NICHD NIH HHSUnited States/ ; U24 OD024957/CD/ODCDC CDC HHSUnited States/ ; UL1 TR105/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; U01 HD036790/HD/NICHD NIH HHSUnited States/ ; UG1 HD36790/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; UG1 OD024953/OD/NIH HHSUnited States/ ; UG1 OD024950/OD/NIH HHSUnited States/ ; UG1 HD068244/HD/NICHD NIH HHSUnited States/ ; UG1 HD027853/HD/NICHD NIH HHSUnited States/ ; UG1 HD053089/HD/NICHD NIH HHSUnited States/ ; UG1 OD024947/OD/NIH HHSUnited States/ ; UG1 OD024948/OD/NIH HHSUnited States/ ; UG1 OD024954/CD/ODCDC CDC HHSUnited States/ ; UG1 OD024959/OD/NIH HHSUnited States/ ; U24 OD024957/OD/NIH HHSUnited States/ ; UG1 OD024954/OD/NIH HHSUnited States/ ; UG1 HD040492/HD/NICHD NIH HHSUnited States/ ; UG1 HD021364/HD/NICHD NIH HHSUnited States/ ; 2UG10D024947-03/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; UL1 TR001117/TR/NCATS NIH HHSUnited States/ ; UG1 OD024946/OD/NIH HHSUnited States/ ; UG1 HD090877/HD/NICHD NIH HHSUnited States/ ; UG1 HD27853/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; UG1 OD024956/OD/NIH HHSUnited States/ ; UG1 OD024955/CD/ODCDC CDC HHSUnited States/ ; U10 HD036790/HD/NICHD NIH HHSUnited States/ ; UL1 TR77/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; UG1 HD068278/HD/NICHD NIH HHSUnited States/ ; U24 HD095254/HD/NICHD NIH HHSUnited States/ ; UG1 OD024955/OD/NIH HHSUnited States/ ; U10 HD053089/HD/NICHD NIH HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  383-395 (22 pdf pages)
• Volume:
  43
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/261378/cdc_261378_DS1.pdf
• File Type:
  [PDF - 337.59 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:3f8773b51af3a31c716d29e21470334c58b1372d01408d68653dcc577a8583b24608428935171d79c1cf34122478e7dfd73a4d81e60f6da85263064f541eeb41