Hearing and Neurodevelopmental Outcomes Among Children With Congenital Cytomegalovirus.

Details

• Alternative Title:
  International Journal of Pediatric Otorhinolaryngology, 2025, v. 195: Hearing and Neurodevelopmental Outcomes Among Children With Congenital Cytomegalovirus.
• Journal Article:
  International Journal of Pediatric Otorhinolaryngology
• Personal Author:
  Stout, Jordan C. ; Leung, Jessica ; Kfoury, Peter ; Germiller, John A. ; Park, Albert H. ; Lanzieri, Tatiana M.
• Description:
  Congenital cytomegalovirus (cCMV) infection is the most common congenital infection and the leading non-genetic cause of sensorineural hearing loss. We assessed demographics, clinical characteristics, hearing and neurodevelopmental outcomes by 6 years of age among U.S. children with possible cCMV.
  
  Retrospective cohort design.
  
  The Audiological and Genetic Database (AudGenDB) includes 175,216 pediatric patients who underwent audiology, otology or genetic visits during 2006-2019 in Children's Hospital of Philadelphia, Vanderbilt Children's Hospital, or Boston Children's Hospital.
  
  Children with possible cCMV were identified by diagnostic codes for cCMV infection and CMV disease up to 6 years of age. We examined clinical signs of cCMV during 0-45 days of birth and neurodevelopmental conditions (including hearing loss) up to 6 years of age. Hearing loss was defined as pure tone average or any frequency threshold ≥25 dB.
  
  A total of 180 (0.1 %) children with possible cCMV were identified; 70 % had diagnosis codes after 45 days of life. The proportions of Black and Hispanic/Latino children comprised a higher proportion in the possible cCMV group compared to the non-cCMV group. Overall, 129 (72 %) children with possible cCMV had diagnoses codes for neurodevelopmental conditions, including hearing loss (56), communication delays (45) and cerebral palsy (22). Hearing loss was diagnosed at a median age of 2 (1-4) years.
  
  Neurodevelopmental delays were common among children with possible cCMV included in this study. AudGenDB provides access to longitudinal outcomes for a large and diverse cohort that remains helpful in lieu of state-mandated screenings.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Cytomegalovirus Infections
  • Retrospective Studies
  • Female
  • Male
  • Child, Preschool
  • Infant
  • Child
  • Hearing Loss, Sensorineural
  • Infant, Newborn
  More +
• Keywords:
  • Congenital Cytomegalovirus Infection
  • Sensorineural Hearing Loss
  • Neurodevelopmental Disorders
  • Pediatric Audiology
  • Hearing Loss, Bilateral
  • Hearing Loss, Unilateral
  • Neurological Sequelae
• Source:
  International Journal of Pediatric Otorhinolaryngology, 2025, v. 195
• DOI:
  https://doi.org/10.1016/j.ijporl.2025.112408
• ISSN:
  0165-5876 ; 1872-8464
• Pubmed ID:
  40451107
• Pubmed Central ID:
  PMC12875388
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  112408 (14 pdf pages)
• Volume:
  195
• Download URL:
  https://stacks.cdc.gov/view/cdc/261371/cdc_261371_DS1.pdf
• File Type:
  [PDF - 438.14 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:c07931db15460e744e527a4ee471d38703a67d979fff9b05ead3d1d7e9df3e6f00bdfd514598c6320bdadca815b3e5b286d4d8b3fbd69d9df4bb8d7d4f56397e