Susceptibility of Domestic Swine to Experimental Infection with Severe Acute Respiratory Syndrome Coronavirus 2

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pickering, Brad S. ; Smith, Greg ; Pinette, Mathieu M. ; Embury-Hyatt, Carissa ; Moffat, Estella ; Marszal, Peter ; Lewis, Charles E.
• Description:
  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease, has been shown to infect several species. The role of domestic livestock and associated risks for humans in close contact with food production animals remains unknown for many species. Determining the susceptibility of pigs to SARS-CoV-2 is critical to a One Health approach to manage potential risk for zoonotic transmission. We found that pigs are susceptible to SARS-CoV-2 after oronasal inoculation. Among 16 animals, we detected viral RNA in group oral fluids and in nasal wash from 2 pigs, but live virus was isolated from only 1 pig. Antibodies also were detected in only 2 animals at 11 and 13 days postinoculation but were detected in oral fluid samples at 6 days postinoculation, indicating antibody secretion. These data highlight the need for additional livestock assessment to determine the potential role of domestic animals in the SARS-CoV-2 pandemic.
• Subjects:
  Animals Antibodies, Neutralizing Antibodies, Viral Coronavirus Infections/veterinary COVID-19 Disease Susceptibility/veterinary Female Lymph Nodes Male Mouth Nasal Cavity Rectum RNA, Viral SARS-CoV-2 Swine Virus Shedding

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• Source:
  Emerg Infect Dis. 27(1):104-112
• Pubmed ID:
  33350904
• Pubmed Central ID:
  PMC7774549
• Document Type:
  Journal Article
• Volume:
  27
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5e984d75a9dee2c2c70e28ea5065c2a13a38813b1ab9bbc009ca9b7dbf6060b1
• Download URL:
  https://stacks.cdc.gov/view/cdc/99997/cdc_99997_DS1.pdf
• File Type:
  [PDF - 1.15 MB ]