Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Baussano, Iacopo; Sayinzoga, Felix; Tshomo, Ugyen; Tenet, Vanessa; Vorsters, Alex; ... More +
Baussano, Iacopo; Sayinzoga, Felix; Tshomo, Ugyen; Tenet, Vanessa; Vorsters, Alex; Heideman, Daniëlle A.M.; Gheit, Tarik; Tommasino, Massimo; Umulisa, Marie Chantal; Franceschi, Silvia; Clifford, Gary M.; Less -
Description:
Rwanda and Bhutan, 2 low- and middle-income countries, implemented primarily school-based national human papillomavirus (HPV) vaccination in 2011 (Rwanda) and 2010 (Bhutan). We estimated vaccination effectiveness through urine-based HPV prevalence surveys in schools in 2013-2014 and 2017. In Rwanda, 912 participants from baseline surveys and 1,087 from repeat surveys were included, and in Bhutan, 973 participants from baseline surveys and 909 from repeat surveys were included. The overall effectiveness against vaccine-targeted HPV types (i.e., HPV-6/11/16/18) was 78% (95% CI 51%-90%) in Rwanda, and 88% (6%-99%) in Bhutan and against other α-9 types was 58% (21-78) in Rwanda and 63% (27-82) in Bhutan. No effect against other HPV types was detectable. Prevalence of vaccine-targeted HPV types decreased significantly, as well as that of other α-9 types, suggesting cross-protection. These findings provide direct evidence from low- and middle-income countries of the marked effectiveness of high-coverage school-based, national HPV vaccination programs.
Subject:
[+]
Bhutan
Disease Control
Epidemiologic Monitoring
Human Papillomavirus Recombinant Vaccine Quadrivalent
Impact Of Human Papillomavirus Vaccination, Rwanda And Bhutan
Low-income Population
Papillomavirus Infections
Papillomavirus Vaccines
Rwanda
Synopsis
Type 6
Type 11
Type 16
Type 18
Vaccine-preventable Diseases
Vaccines
Viruses

Source:
Emerg Infect Dis. 27(1):1-9;
Pubmed ID:
33350922
Pubmed Central ID:
PMC7774553
Document Type:
Journal Article;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:55d842335455130638e6df4a93d926a6c6ab4316dae65b254c67d4d5b39978a4
File Type:

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