Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Pérez-Nadales, Elena ; Alastruey-Izquierdo, Ana ; Linares-Sicilia, María José ; Soto-Debrán, Juan Carlos ; Abdala, Edson ; ... More +
Pérez-Nadales, Elena ; Alastruey-Izquierdo, Ana ; Linares-Sicilia, María José ; Soto-Debrán, Juan Carlos ; Abdala, Edson ; García-Rodríguez, Julio ; Montejo, Miguel ; Muñoz, Patricia ; Lletí, Miguel Salavert ; Rezusta, Antonio ; de Pipaón, Maite Ruiz Pérez ; Yáñez, Lucrecia ; Merino, Esperanza ; Campos-Herrero, María Isolina ; Costa-Mateo, José María ; Fortún, Jesús ; García-Lozano, Tomás ; Garcia-Vidal, Carolina ; Fernández-Ruiz, Mario ; Sánchez-Reus, Ferrán ; Castro-Méndez, Carmen ; Guerrero-Lozano, Inmaculada ; Soler-Palacín, Pere ; Aguado, José María ; Martínez-Martínez, Luis ; Torre-Cisneros, Julian ; Nucci, Marcio Less -
Corporate Authors:
Spanish Fusariosis Study Group
Description:
Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000-2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000-2009 to 0.22 cases per 100,000 admissions in 2010-2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy.
Subjects:
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Antifungal Agents Fusariosis Fusarium Humans Neutropenia Observational Studies As Topic
Source:
Emerg Infect Dis. 27(1):26-35
Pubmed ID:
33352085
Pubmed Central ID:
PMC7774531
Document Type:
Journal Article
Place as Subject:
Spain
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:497f89c6750e96e8d028833514181f4ae3260054a63e6d71efdce2c4009ef1c5
Download URL:
https://stacks.cdc.gov/view/cdc/99961/cdc_99961_DS1.pdf
File Type:

Supporting Files

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