Multicenter Retrospective Study of Invasive Fusariosis in Intensive Care Units, France

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Demonchy, Jordane ; Biard, Lucie ; Clere-Jehl, Raphaël ; Wallet, Florent ; Mokart, Djamel ; Moreau, Anne-Sophie ; Argaud, Laurent ; Verlhac, Camille ; Pène, Frédéric ; Lautrette, Alexandre ; Bige, Naïke ; de Jong, Audrey ; Canet, Emmanuel ; Quenot, Jean-Pierre ; Issa, Nahéma ; Zerbib, Yoann ; Bouard, Inès ; Picard, Muriel ; Zafrani, Lara
• Description:
  Invasive fusariosis can be life-threatening, especially in immunocompromised patients who require intensive care unit (ICU) admission. We conducted a multicenter retrospective study to describe clinical and biologic characteristics, patient outcomes, and factors associated with death and response to antifungal therapy. We identified 55 patients with invasive fusariosis from 16 ICUs in France during 2002----2020. The mortality rate was high (56%). Fusariosis-related pneumonia occurred in 76% of patients, often leading to acute respiratory failure. Factors associated with death included elevated sequential organ failure assessment score at ICU admission or history of allogeneic hematopoietic stem cell transplantation or hematologic malignancies. Neither voriconazole treatment nor disseminated fusariosis were strongly associated with response to therapy. Invasive fusariosis can lead to multiorgan failure and is associated with high mortality rates in ICUs. Clinicians should closely monitor ICU patients with a history of hematologic malignancies or stem cell transplantation because of higher risk for death.
• Subjects:
  Fusariosis Hematologic Neoplasms Humans Intensive Care Units Multicenter Studies As Topic Retrospective Studies
• Keywords:
  Antimicrobial Resistance France Fungi Fusarium Hematologic Malignancy Intensive Care Unit Invasive Fusariosis
• Source:
  Emerg Infect Dis. 2024; 30(2):215-224
• Pubmed ID:
  38270146
• Pubmed Central ID:
  PMC10826781
• Document Type:
  Journal Article
• Place as Subject:
  France
• Volume:
  30
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9214e3afa5d80d8f3ad6d529767c5e3212aaca6b2defa5de77360c12fc0c354d
• Download URL:
  https://stacks.cdc.gov/view/cdc/147366/cdc_147366_DS1.pdf
• File Type:
  [PDF - 1.68 MB ]