Occupational and leisure-time physical activity differentially predict 6-year incidence of stroke and transient ischemic attack in women

Details

• Alternative Title:
  Scand J Work Environ Health
• Personal Author:
  Hall, Clinton ; Heck, Julia E ; Sandler, Dale P ; Ritz, Beate ; Chen, Honglei ; Krause, Niklas
• Description:
  Objectives
  
  Recent meta-analyses suggest a physical activity health paradox: high levels of occupational physical activity (OPA) increase cardiovascular disease (CVD) risk, while leisure-time physical activity (LTPA) decreases risk. However, studies of women and cerebrovascular disease are limited. This report examines physical activity effects on stroke and transient ischemic attack (TIA) among working women in the United States.
  
  Methods
  
  OPA history, health status, and lifestyle were assessed by baseline interviews of 31 270 employed Sister Study participants aged 35–74 years. OPA was assessed at six intensity levels (lowest: “mostly sitting”); the highest three were combined as “high intensity work.” Independent OPA and LTPA effects on 6-year cerebrovascular disease incidence were estimated in adjusted Cox proportional hazard models.
  
  Results
  
  Stroke (N=441) and TIA (N=274) risk increased with more standing and higher intensity work at current and longest held job. Compared with mostly sitting, high intensity work at the current job increased TIA risk by 57% [hazard ratio (HR) 1.57, 95% confidence interval (CI) 1.04–2.38]. High intensity OPA at the longest held job increased risk for stroke by 44% (HR 1.44; 95% CI 1.08–1.93). Among women with CVD, sitting and standing equally, especially at the current job, increased risks up to two-fold (TIA HR 1.98, 95% CI 1.10–3.55) compared with mostly sitting at work. LTPA showed inverse associations.
  
  Conclusions
  
  Higher intensity levels of OPA increased stroke and TIA risks, while LTPA decreased risks; results corroborate the physical activity health paradox for women and cerebrovascular disease. More standing at work increased cerebrovascular disease risks, especially for women with CVD.
  
  
• Subjects:
  Employment Exercise Female Humans Incidence Interviews As Topic Ischemic Attack, Transient Leisure Activities Longitudinal Studies Middle Aged Occupational Health Prospective Studies Risk Factors Sedentary Behavior Self Report Stroke Surveys And Questionnaires Time Factors United States

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• Keywords:
  Cerebrovascular Disease Cohort Epidemiology Ischemic Heart Disease Physical Activity Health Paradox Prospective Work Posture
• Source:
  Scand J Work Environ Health. 45(3):267-279
• Pubmed ID:
  30448859
• Pubmed Central ID:
  PMC7748381
• Document Type:
  Journal Article
• Funding:
  T42 OH008412/OH/NIOSH CDC HHSUnited States/
• Volume:
  45
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:65dd8b2a25cc13a56eb089526630bfa77dc2529adb093c16c2a4c67ad805a05e
• Download URL:
  https://stacks.cdc.gov/view/cdc/99057/cdc_99057_DS1.pdf
• File Type:
  [PDF - 384.02 KB ]