Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans

Sieber, Raphael N.; Urth, Tinna R.; Petersen, Andreas; Møller, Camilla H.; Price, Lance B.; Skov, Robert L.; Larsen, Anders R.; Stegger, Marc; Larsen, Jesper

Search our Collections

- Add this to...

Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans

Published Date:

Nov 2020

Source:

Emerg Infect Dis. 26(11):2578-2585

Language:

English

[PDF-873.66 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Sieber, Raphael N. ; Urth, Tinna R. ; Petersen, Andreas ; Møller, Camilla H. ; Price, Lance B. ; ... More ▼

Description:

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) can acquire phage-encoded immune modulators, such as the immune evasion cluster (IEC), which protects bacteria from components of the human innate immune system, and the enzyme TarP, which protects against antibody-mediated immune recognition. We used whole-genome sequencing and epidemiologic investigations to study the effects of IEC- and tarP-harboring phages on household transmission of LA-MRSA in North Denmark Region during 2004-2011. We reviewed information about all patients throughout Denmark who experienced LA-MRSA infection during 2007-2018 to determine whether IEC is associated with increased spread into the general population. Horizontal acquisition of IEC in the human host was associated with increased household transmission of LA-MRSA and spillover into the community and healthcare settings, whereas we found no evidence to suggest that IEC-positive LA-MRSA isolates have become self-sustainable in the general population. By contrast, TarP did not seem to influence household transmission of LA-MRSA.

Subject:

[+]

Pubmed ID:

33079052

Pubmed Central ID:

PMC7588543

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

File Type:

Supporting Files:

	20-1442-F1.gif	image/gif
	20-1442-F1.jpg	image/jpeg
	20-1442-F2.gif	image/gif
	20-1442-F2.jpg	image/jpeg
	20-1442-Techapp-s1.xlsx	application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
	20-1442-Techapp-s2.pdf	application/pdf
	20-1442.nxml	text/xml

No Related Documents.

Phage-Mediated Immune Evasion and Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus in Humans

Search our Collections

You May Also Like:

Have Questions?

CDC INFORMATION

CONNECT WITH CDC