Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Sieber, Raphael N. ; Urth, Tinna R. ; Petersen, Andreas ; Møller, Camilla H. ; Price, Lance B. ; ... More +
Sieber, Raphael N. ; Urth, Tinna R. ; Petersen, Andreas ; Møller, Camilla H. ; Price, Lance B. ; Skov, Robert L. ; Larsen, Anders R. ; Stegger, Marc ; Larsen, Jesper Less -
Description:
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) can acquire phage-encoded immune modulators, such as the immune evasion cluster (IEC), which protects bacteria from components of the human innate immune system, and the enzyme TarP, which protects against antibody-mediated immune recognition. We used whole-genome sequencing and epidemiologic investigations to study the effects of IEC- and tarP-harboring phages on household transmission of LA-MRSA in North Denmark Region during 2004-2011. We reviewed information about all patients throughout Denmark who experienced LA-MRSA infection during 2007-2018 to determine whether IEC is associated with increased spread into the general population. Horizontal acquisition of IEC in the human host was associated with increased household transmission of LA-MRSA and spillover into the community and healthcare settings, whereas we found no evidence to suggest that IEC-positive LA-MRSA isolates have become self-sustainable in the general population. By contrast, TarP did not seem to influence household transmission of LA-MRSA.
Subjects:
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Antimicrobial Resistance Bacteria Bacteriophages CHIPS Denmark Disease Transmission Humans Immune Evasion LA-MRSA Livestock Methicillin-resistant Staphylococcus Aureus MRSA MRSA And Other Staphylococci Phage-Mediated Immune Evasion And Transmission Of Livestock-Associated Methicillin-Resistant Staphylococcus Aureus In Humans Research SAK SCIN SEA SEP Zoonoses
Source:
Emerg Infect Dis. 26(11):2578-2585
Pubmed ID:
33079052
Pubmed Central ID:
PMC7588543
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:9e7b3358a56e33ebcb33901dd91e7a8655629f68ad73cb5ade6bd4d4bd8ddfdf
Download URL:
https://stacks.cdc.gov/view/cdc/96907/cdc_96907_DS1.pdf
File Type:

Supporting Files

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  	20-1442-Techapp-s2.pdf	pdf
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