Molecular Characterization of Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Colonization and Infection Isolates in a Veterans Affairs Hospital

Details

• Personal Author:
  Carrel M ; Eko KE ; Forshey BM ; Perencevich EN ; Schweizer ML ; Smith TC
• Description:
  Background: Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) is associated with increased infection risk, yet colonization and infection isolates are rarely compared within the same study. The objectives of this study were to compare colonization and infection isolates from a Veterans Administration hospital in Iowa, and to determine the prevalence of livestock-associated MRSA (LA-MRSA) colonization and infection in a state with high livestock density. Methods: All patients with available MRSA isolates collected through routine nasal screening (73%; n=397) and from infections (27%; n=148) between December 2010 and August 2012 were included and tested for spa type and presence of PVL and mecA genes. Clinical isolates were tested for antibiotic resistance patterns. Paired colonization and infection isolates were compared for genetic and phenotypic congruity. Results: The most common spa types were t002 (and other CC5-associated strains; 65%) and t008 (and other CC8-associated strains; 20%). No classic LA-MRSA spa types were identified. CC5-associated strains were less likely to be associated with infections (22%; 77/353) compared with CC8-associated strains (49%; 53/109). MRSA colonization was more common among patients with infections (71%) compared with the general screening population (7%). In most cases (82%; 28/34), paired colonization and infection isolates were genetically and phenotypically indistinguishable. Conclusions: Our data demonstrate a direct link between antecedent nasal colonization and subsequent MRSA infection. Further, our data indicate variability in colonization and infection efficiency among MRSA genotypes, which points to the need to define the molecular determinants underlying emergence of S. aureus strains in the community and nosocomial setting. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Livestock Microbiology Nose Occupational Health Safety Sense Organs
• Keywords:
  Antimicrobial Resistance Author Keywords: Staphylococcus Aureus Bacteria Bacterial Infections Disease Incidence Disease Transmission Hospital Acquired Infections Infection Control Infectious Diseases Livestock Industry Methicillin Resistant Staphylococcus Aureus MRSA Nasal Cavity Nosocomial Infections

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• ISSN:
  2047-2994
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; Ohio ; OSHA Region 5 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  10
• Volume:
  4
• NIOSHTIC Number:
  nn:20053850
• Citation:
  Antimicrob Resist Infect Control 2015 Apr; 4:10
• Contact Point Address:
  Tara C. Smith, Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52246, USA
• Email:
  tsmit176@kent.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20100801
• Source Full Name:
  Antimicrobial Resistance and Infection Control
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0e2c1dfa14b1049106876b27d28c201799643c198d7b9f8052f6a92b239b507cb6a9d8b34dc1defe5a66f7ddcf7cedaaa9cdcab0d88be5519cbd57a6cfa734d1
• Download URL:
  https://stacks.cdc.gov/view/cdc/216539/cdc_216539_DS1.pdf
• File Type:
  [PDF - 502.87 KB ]