Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 Between Pigs and Humans, United States

Details

• Personal Author:
  Aziz M ; Carroll KC ; Davis MF ; Hall D ; Heaney CD ; Kaya H ; Larsen J ; Love DC ; Miller LS ; Mohr D ; Nadimpalli ML ; Ordak C ; Perl TM ; Pisanic N ; Price LB ; Randad PR ; Rhodes S ; Stewart JR
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• Description:
  Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHOs) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0-34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina. Description provided by NIOSH
• Subjects:
  • Bacteria
  • Livestock
  • Occupational Health
  • Safety
• Keywords:
  • Bacterial infections
  • Disease transmission
  • Livestock
  • Antimicrobial resistance
  • MRSA
  • Methicillin Resistant Staphylococcus aureus
  • Zoonoses
  • Author Keywords: Staphylococcus aureus
  • livestock-associated diseases
  • antimicrobial resistance
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• ISSN:
  1080-6040
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Maryland ; Massachusetts ; North Carolina ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  27
• Issue:
  3
• NIOSHTIC Number:
  nn:20063051
• Citation:
  Emerg Infect Dis 2021 Mar; 27(3):740-748
• Contact Point Address:
  Pranay R. Randad, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolf St, Baltimore, MD 21205
• Email:
  prandad1@jhmi.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Emerging Infectious Diseases
• End Date:
  20280630
• Download URL:
  https://stacks.cdc.gov/view/cdc/226180/cdc_226180_DS1.pdf
• File Type:
  [PDF - 1.97 MB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f65dabe6c2728241635d26273e1df79217c6326d7be821a5b7d49aa05792adecfe5454ad42d6b8a1b12255b1d909807d62a2a8e279aa0180dfccbf5ce71d23e9