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Saprochaete clavata Outbreak Infecting Cancer Center through Dishwasher
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Sep 2020
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Source: Emerg Infect Dis. 26(9):2031-2038
[PDF-1.31 MB]
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Alternative Title:Emerg Infect Dis
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Description:Saprochaete clavata is a pathogenic yeast responsible for rare outbreaks involving immunocompromised patients, especially those with hematologic malignancies. During February 2016-December 2017, we diagnosed S. clavata infections in 9 patients (8 with fungemia), including 3 within 1 month, at a cancer center in Marseille, France. The patients (median age 58 years), 4 of 9 of whom had acute myeloid leukemia, were hospitalized in 3 different wards. Ten environmental samples, including from 2 dishwashers and 4 pitchers, grew S. clavata, but no contaminated food was discovered. The outbreak ended after contaminated utensils and appliances were discarded. Whole-genome sequencing analysis demonstrated that all clinical and environmental isolates belonged to the same phylogenetic clade, which was unrelated to clades from previous S. clavata outbreaks in France. We identified a dishwasher with a deficient heating system as the vector of contamination.
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Pubmed ID:32818391
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Pubmed Central ID:PMC7454083
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Document Type:
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Volume:26
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Issue:9
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