Saprochaete clavata Outbreak Infecting Cancer Center through Dishwasher

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Menu, Estelle ; Criscuolo, Alexis ; Desnos-Ollivier, Marie ; Cassagne, Carole ; D’Incan, Evelyne ; Furst, Sabine ; Ranque, Stéphane ; Berger, Pierre ; Dromer, Françoise
• Description:
  Saprochaete clavata is a pathogenic yeast responsible for rare outbreaks involving immunocompromised patients, especially those with hematologic malignancies. During February 2016-December 2017, we diagnosed S. clavata infections in 9 patients (8 with fungemia), including 3 within 1 month, at a cancer center in Marseille, France. The patients (median age 58 years), 4 of 9 of whom had acute myeloid leukemia, were hospitalized in 3 different wards. Ten environmental samples, including from 2 dishwashers and 4 pitchers, grew S. clavata, but no contaminated food was discovered. The outbreak ended after contaminated utensils and appliances were discarded. Whole-genome sequencing analysis demonstrated that all clinical and environmental isolates belonged to the same phylogenetic clade, which was unrelated to clades from previous S. clavata outbreaks in France. We identified a dishwasher with a deficient heating system as the vector of contamination.
• Subjects:
  Acute Myeloid Leukemia France Fungemia Fungi Genome Sequencing Hematological Malignancies Pathogenic Yeasts Phylogenetic Clades Saprochaete Clavata Saprochaete Clavata Outbreak Infecting Cancer Center Through Dishwasher Synopsis

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• Source:
  Emerg Infect Dis. 26(9):2031-2038
• Pubmed ID:
  32818391
• Pubmed Central ID:
  PMC7454083
• Document Type:
  Journal Article
• Volume:
  26
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:89220a5bed82418500442573279419e82652234302a58c78c560ef8646f5e602
• Download URL:
  https://stacks.cdc.gov/view/cdc/92999/cdc_92999_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]