Molecular Epidemiology of Underreported Emerging Zoonotic Pathogen Streptococcus suis in Europe

Brizuela, Jaime; Roodsant, Thomas J.; Hasnoe, Qureisha; van der Putten, Boas C.L.; Kozakova, Jana; Slotved, Hans-Christian; van der Linden, Mark; de Beer-Schuurman, Ilse G.A.; Sadowy, Ewa; Sáez-Nieto, Juan Antonio; Chalker, Victoria J.; van der Ark, Kees C.H.; Schultsz, Constance

doi:10.3201/eid3003.230348

i

Molecular Epidemiology of Underreported Emerging Zoonotic Pathogen Streptococcus suis in Europe

Supporting Files Public Domain

3 2024
By Brizuela, Jaime ; Roodsant, Thomas J. ; Hasnoe, Qureisha ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Brizuela, Jaime ; Roodsant, Thomas J. ; Hasnoe, Qureisha ; van der Putten, Boas C.L. ; Kozakova, Jana ; Slotved, Hans-Christian ; van der Linden, Mark ; de Beer-Schuurman, Ilse G.A. ; Sadowy, Ewa ; Sáez-Nieto, Juan Antonio ; Chalker, Victoria J. ; van der Ark, Kees C.H. ; Schultsz, Constance
Description:

Streptococcus suis, a zoonotic bacterial pathogen circulated through swine, can cause severe infections in humans. Because human S. suis infections are not notifiable in most countries, incidence is underestimated. We aimed to increase insight into the molecular epidemiology of human S. suis infections in Europe. To procure data, we surveyed 7 reference laboratories and performed a systematic review of the scientific literature. We identified 236 cases of human S. suis infection from those sources and an additional 87 by scanning gray literature. We performed whole-genome sequencing to type 46 zoonotic S. suis isolates and combined them with 28 publicly available genomes in a core-genome phylogeny. Clonal complex (CC) 1 isolates accounted for 87% of typed human infections; CC20, CC25, CC87, and CC94 also caused infections. Emergence of diverse zoonotic clades and notable severity of illness in humans support classifying S. suis infection as a notifiable condition.
Subjects:

Animals Humans Molecular Epidemiology Phylogeny Swine Whole Genome Sequencing
Keywords:

Bacteria Molecular Epidemiology Pathogens Pigs Porcine Diseases Pork Streptococcus Suis Swine Systematic Review Whole Genome Sequencing Zoonoses
Source:

Emerg Infect Dis. 2024; 30(3):413-422
Pubmed ID:

38407169
Pubmed Central ID:

PMC10902550
Document Type:

Journal Article
Place as Subject:

Europe
Volume:

30
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:c6055a10b3f4cffcb89a77e59c08e22cf1e653000a58e8607fa2f92d68ca368f
Download URL:

https://stacks.cdc.gov/view/cdc/148772/cdc_148772_DS1.pdf
File Type:

[PDF - 2.15 MB ]

File Language:

English

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