Radical Change in Zoonotic Abilities of Atypical BSE Prion Strains as Evidenced by Crossing of Sheep Species Barrier in Transgenic Mice

Marín-Moreno, Alba; Huor, Alvina; Espinosa, Juan Carlos; Douet, Jean Yves; Aguilar-Calvo, Patricia; Aron, Naima; Píquer, Juan; Lugan, Sévérine; Lorenzo, Patricia; Tillier, Cecile; Cassard, Hervé; Andreoletti, Olivier; Torres, Juan María

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Radical Change in Zoonotic Abilities of Atypical BSE Prion Strains as Evidenced by Crossing of Sheep Species Barrier in Transgenic Mice

Supporting Files Public Domain

Jun 2020
By Marín-Moreno, Alba ; Huor, Alvina ; Espinosa, Juan Carlos

File Language:

English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Marín-Moreno, Alba ; Huor, Alvina ; Espinosa, Juan Carlos ; Douet, Jean Yves ; Aguilar-Calvo, Patricia ; Aron, Naima ; Píquer, Juan ; Lugan, Sévérine ; Lorenzo, Patricia ; Tillier, Cecile ; Cassard, Hervé ; Andreoletti, Olivier ; Torres, Juan María
Description:

Classical bovine spongiform encephalopathy (BSE) is the only zoonotic prion disease described to date. Although the zoonotic potential of atypical BSE prions have been partially studied, an extensive analysis is still needed. We conducted a systematic study by inoculating atypical BSE isolates from different countries in Europe into transgenic mice overexpressing human prion protein (PrP): TgMet|, TgMet/Val|, and TgVal|. L-type BSE showed a higher zoonotic potential in TgMet| mice than classical BSE, whereas Val|-PrP variant was a strong molecular protector against L-type BSE prions, even in heterozygosis. H-type BSE could not be transmitted to any of the mice. We also adapted 1 H- and 1 L-type BSE isolate to sheep-PrP transgenic mice and inoculated them into human-PrP transgenic mice. Atypical BSE prions showed a modification in their zoonotic ability after adaptation to sheep-PrP producing agents able to infect TgMet| and TgVal|, bearing features that make them indistinguishable of sporadic Creutzfeldt-Jakob disease prions.
Subjects:
Source:

Emerg Infect Dis. 26(6):1130-1139
Pubmed ID:

32441630
Pubmed Central ID:

PMC7258450
Document Type:

Journal Article
Volume:

26
Issue:

6
Download URL:

https://stacks.cdc.gov/view/cdc/88864/cdc_88864_DS1.pdf
File Type:

[PDF - 1.33 MB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:788c26bf94580d6b89ebbf55675984348ce6258787e1a06c6b98b5569bf463e7

File Language:

English

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