Prenatal Exposure to Air Toxics and Malignant Germ Cell Tumors in Young Children

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Hall, Clinton ; Heck, Julia E. ; Ritz, Beate ; Cockburn, Myles ; Escobedo, Loraine A. ; von Ehrenstein, Ondine S.
• Description:
  Objective:
  
  To assess prenatal air toxics exposure and risk for childhood germ cell tumors (GCTs) by histological subtype (yolk sac tumor and teratoma).
  
  Methods:
  
  In this case-control study, GCT cases <6 years (n=243) identified from California Cancer Registry records were matched by birth year to cancer-free population controls (n=147,100), 1984–2013. Routinely monitored air toxic exposures were linked to subjects’ birth address. Logistic regression estimated GCT risks per interquartile range increase in exposure.
  
  Results:
  
  Prenatal exposure to various highly-correlated, traffic-related air toxics during the second trimester increased GCT risk, particularly 1,3-butadiene (odds ratio [OR]=1.51; 95% confidence interval [CI]=1.01, 2.26) and meta/para-xylene (OR=1.56; 95% CI=1.10, 2.21). Analyses by subtype indicated elevated ORs for yolk sac tumors but not teratomas.
  
  Conclusion:
  
  Our estimated ORs are consistent with positive associations between some prenatal traffic-related air toxics and GCT risk, notably yolk sac tumors.
  
  
• Subjects:
  Air Pollutants Article BTEX Cancer Childhood Epidemiology Pregnancy Risk Factor Toxicity Vehicle Emissions Yolk Sac Tumor

  More +
• Source:
  J Occup Environ Med. 61(6):529-534
• Pubmed ID:
  31045852
• Pubmed Central ID:
  PMC6551274
• Document Type:
  Journal Article
• Funding:
  R21 ES025558/ES/NIEHS NIH HHS/United States ; HHSN261201000140C/CA/NCI NIH HHS/United States ; HHSN261201000035C/CA/NCI NIH HHS/United States ; R21 ES018960/ES/NIEHS NIH HHS/United States ; T42 OH008412/OH/NIOSH CDC HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; U58 DP003862/DP/NCCDPHP CDC HHS/United States ; T42OH008412/ACL/ACL HHS/United States ; R21 ES019986/ES/NIEHS NIH HHS/United States
• Volume:
  61
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5c6197b63914db68bb66ce9bad1fe5449c7af19fc49d11ca7f6f8265f843ad94
• Download URL:
  https://stacks.cdc.gov/view/cdc/88509/cdc_88509_DS1.pdf
• File Type:
  [PDF - 115.23 KB ]