Prenatal Exposure to Air Toxics and Malignant Germ Cell Tumors in Young Children

Details

• Personal Author:
  Cockburn M ; Escobedo LA ; Hall C ; Heck JE ; Ritz B ; von Ehrenstein OS
• Description:
  Objective: To assess prenatal air toxics exposure and risk for childhood germ cell tumors (GCTs) by histological subtype (yolk sac tumor and teratoma). Methods: In this case-control study, GCT cases less than 6 years (n = 243) identified from California Cancer Registry records were matched by birth year to cancer-free population controls (n = 147,100), 1984 to 2013. Routinely monitored air toxic exposures were linked to subjects' birth address. Logistic regression estimated GCT risks per interquartile range increase in exposure. Results: Prenatal exposure to various highly-correlated, traffic-related air toxics during the second trimester increased GCT risk, particularly 1,3-butadiene (odds ratio [OR] = 1.51; 95% confidence interval [CI] = 1.01, 2.26) and meta/para-xylene (OR = 1.56; 95% CI = 1.10, 2.21). Analyses by subtype indicated elevated ORs for yolk sac tumors but not teratomas. Conclusion: Our estimated ORs are consistent with positive associations between some prenatal traffic-related air toxics and GCT risk, notably yolk sac tumors. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Benzene Epidemiology Hazardous Substances Neoplasms Occupational Health Pregnancy Safety Toluene Women Xylenes

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• Keywords:
  Air Pollutants Author Keywords: Air Pollutants Benzene Benzenes Cancer Childhood Children Emission Sources Ethyl Benzene Ethyl Benzene, Xylene Germ Cells Prenatal Exposure Risk Factor, Toxicity Toluene Toluenes Toxins Tumors Vehicle Emissions Xylene Yolk Sac Tumor

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  61
• Issue:
  6
• NIOSHTIC Number:
  nn:20056157
• Citation:
  J Occup Environ Med 2019 Jun; 61(6):529-534
• Contact Point Address:
  Julia E. Heck, MPH, PhD, Department of Epidemiology, University of California, Los Angeles School of Public Health, 650 Charles E. Young Drive Box 951772, Los Angeles, CA 90095-1772
• Email:
  jeheck@ucla.edu
• CAS Registry Number:
  1,3-Butadiene (CAS RN 106-99-0) ; Benzene (CAS RN 71-43-2) ; Ethylbenzene (CAS RN 100-41-4) ; Toluene (CAS RN 108-88-3) ; Xylene (CAS RN 1330-20-7)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:92a3b04f9a4b6473b5943fd0c53200358d397f9b43e82440f1d8c24287a549ff47cae15f1fbef036e8dd395a29a467914da9de3fab8a5659be0370790b952273
• Download URL:
  https://stacks.cdc.gov/view/cdc/213815/cdc_213815_DS1.pdf
• File Type:
  [PDF - 155.25 KB ]