Risk of Malignant Childhood Germ Cell Tumors in Relation to Demographic, Gestational, and Perinatal Characteristics

Details

• Personal Author:
  Cockburn M ; Davidson TB ; Hall C ; Heck JE ; Ritz B
• Description:
  Background: Childhood germ cell tumors (GCTs) are a rare assortment of neoplasms, with mostly unknown etiology, that are believed to originate very early in life. Few studies have examined risk factors by histologic subtype, despite evidence of different risk profiles. Materials and methods: In this population-based case-control study, 451 childhood malignant GCT cases ages 0-5 years were identified from the California Cancer Registry. Differentiating between common histologic subtypes, we identified 181 yolk sac tumors, 216 teratomas, and 54 rarer subtypes. Cases were linked to their birth certificates and 271,381 controls, frequency matched by birth year, were randomly selected from California birthrolls to investigate the contributions of demographic, gestational, and pregnancy factors using unconditional logistic regression analysis. Results: Compared to non-Hispanic whites, Asian/Pacific Islander children were at an increased risk for developing GCTs (odds ratio [OR] = 1.94; 95% confidence interval [CI] = 1.47, 2.56). Among pregnancy complications and procedures, yolk sac tumors were positively associated with the presence of fetopelvic disproportion (OR = 2.97; 95% CI = 1.55, 5.68), while teratomas were strongly associated with polyhydramnios or oligohydramnios (OR = 14.76; 95% CI = 7.21, 30.19) and the presence of an ear, face, or neck anomaly at birth (OR = 93.70; 95% CI = 42.14, 208.82). Conclusions: Malignant yolk sac tumors and malignant teratomas exhibited distinct demographic and gestational characteristics; additionally, complications in pregnancy and labor may be brought on by specific histologic subtypes. [Description provided by NIOSH]
• Subjects:
  Epidemiology Neoplasms Occupational Health Pregnancy Risk Assessment Risk Factors Safety Women
• Keywords:
  Author Keywords: Germ Cell Tumor Cancer Cancer Rates Childhood Children Congenital Malformation Etiology Germ Cells Perinatal Race Risk Factor Risk Factors Sociological Factors Sociology Teratoma Tumors Yolk Sac Tumor

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• ISSN:
  1877-7821
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  42-49
• Volume:
  46
• NIOSHTIC Number:
  nn:20050352
• Citation:
  Cancer Epidemiol 2017 Feb; 46:42-49
• Contact Point Address:
  Julia E. Heck, Department of Epidemiology, UCLA School of Public Health, 650 Charles E. Young Drive, Box 951772, Los Angeles, CA 90095-1772
• Email:
  jeheck@ucla.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Cancer Epidemiology
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:06fd8fd4398f5d5c67e2dd8297630d959e53930d494d15f37f32cc306e23b52f5e5417b0608c6cf875bbbd2589ce471263644d5c635de3088f863118d0ab8e4e
• Download URL:
  https://stacks.cdc.gov/view/cdc/210733/cdc_210733_DS1.pdf
• File Type:
  [PDF - 357.54 KB ]